Detailed information for compound 568107

Basic information

Technical information
  • TDR Targets ID: 568107
  • Name: benzoate
  • MW: 121.113 | Formula: C7H5O2-
  • H donors: 0 H acceptors: 2 LogP: 2.1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)c1ccccc1
  • InChi: 1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1
  • InChiKey: WPYMKLBDIGXBTP-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • Benzoates
  • Benzoic Acid
  • Sodium Benzoate
  • 766-76-7
  • BENZOATE ION
  • Benzoic acid, ion(1-)
  • benzoic acid anion
  • Benzene formic acid
  • Benzenemethonic acid
  • Diacylic acid
  • Oracyclic acid
  • Phenyl carboxylic acid
  • Retarded ba
  • Tennplas
  • c0121
  • CHEBI:16150
  • benzoate anion
  • ZINC00001011
  • Salvo
  • InChI=1/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0189 0.1376
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0009 0.0041 0.0073
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0016 0.0149 0.1161
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0009 0.0041 0.0149
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0041 0.0041
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0009 0.0041 0.0195
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0016 0.0149 0.0149
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0009 0.0041 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0478
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0043 0.0108
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1275 0.1275
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.1081 0.1081
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.0377
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0041 0.0316
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0866 0.6727
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0866 0.2185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0478
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0377
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1275 0.9912
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.3045 0.8966
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Echinococcus granulosus GPCR family 3 C terminal 0.0008 0.0029 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0185 0.0468
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0075
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0041 0.0149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.3394 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0041 0.0316
Onchocerca volvulus 0.0093 0.1259 0.9283
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0659
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0659
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3962 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0802 0.2933
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0016 0.0149 0.1161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0583 0.1471
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0185 0.1367
Onchocerca volvulus 0.0007 0.0016 0.0119
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0786 0.0786
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0009 0.0041 0.012
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0016 0.0149 0.1161
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.1356 0.3424
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0185 0.0546
Schistosoma mansoni fad oxidoreductase 0.0016 0.0149 0.0149
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.039 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0009 0.0041 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0507 0.0507
Echinococcus granulosus CREB binding protein 0.0016 0.0148 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Schistosoma mansoni ap endonuclease 0.0019 0.0185 0.0185
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.039 0.3031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0261 0.0955
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0866 0.0866
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.1356 0.1356
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.039 0.1149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0009 0.0041 0.0073
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0016 0.0059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.039 0.3031
Entamoeba histolytica disulphide oxidoreductase, putative 0.0009 0.0041 0.0195
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.3394 1
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0016 0.0149 0.1058
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0016 0.0149 0.1101
Schistosoma mansoni tyrosinase precursor 0.0093 0.1259 0.1259
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.039 0.039
Brugia malayi TAZ zinc finger family protein 0.0098 0.1337 0.3376
Echinococcus multilocularis CREB binding protein 0.0067 0.089 0.089
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0041 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0009 0.0041 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0185 0.1454
Plasmodium vivax ferrodoxin reductase, putative 0.0009 0.0041 0.0316
Onchocerca volvulus Poor gastrulation protein homolog 0.0008 0.0029 0.0216
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0261 0.0955
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.0955
Echinococcus multilocularis CREB binding protein 0.0016 0.0148 0.0148
Onchocerca volvulus 0.0029 0.0334 0.2463
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0019 0.0189 0.1472
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0185 0.1441
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0173 0.1347
Mycobacterium ulcerans membrane transporter 0.0019 0.0189 0.0693
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0041 0.0195
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0259 0.0654
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0016 0.0048
Schistosoma mansoni glutamate synthase 0.0009 0.0041 0.0041
Schistosoma mansoni CREB-binding protein 2 0.0098 0.1337 0.1337
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0016 0.0149 0.1161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0583 0.0583
Onchocerca volvulus 0.0019 0.0189 0.1396
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.039 0.3031
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0041 0.0316
Leishmania major hypothetical protein, conserved 0.0016 0.0149 0.1161
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0802 0.2933
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0016 0.0016
Loa Loa (eye worm) glutathione reductase 0.0095 0.1287 0.3248
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0016 0.0048
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Mycobacterium ulcerans ferredoxin reductase 0.0009 0.0041 0.0149
Leishmania major Na/H antiporter-like protein 0.0019 0.0189 0.1472
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Onchocerca volvulus 0.0093 0.1259 0.9283
Loa Loa (eye worm) tyrosinase 1 0.0093 0.1259 0.3178
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0041 0.0316
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0041 0.0041
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.039 0.1427
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0041 0.0195
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1356 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0786 0.0786
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0802 0.0802
Leishmania major NADH dehydrogenase, putative 0.0009 0.0041 0.0316
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0041 0.0319
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0016 0.0048
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0189 0.0478
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0583 0.0583
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0016 0.0149 0.1101
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0016 0.0125
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.0149
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0019 0.0189 0.1472
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Toxoplasma gondii hypothetical protein 0.0016 0.0149 0.1161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0261 0.0769
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.039 0.3058
Echinococcus granulosus CREB binding protein 0.0016 0.0148 0.0148
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.3045 0.8971
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.039 0.3031
Brugia malayi hypothetical protein 0.0019 0.0189 0.0478
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0093 0.1259 0.3178
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1275 0.1275
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0719 0.0719
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.1356 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Echinococcus granulosus CREB binding protein 0.0061 0.0792 0.0792
Mycobacterium ulcerans monoxygenase 0.0009 0.0041 0.0149
Echinococcus granulosus cpg binding protein 0.0031 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0016 0.0149 0.1161
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.147
Plasmodium falciparum thioredoxin reductase 0.0095 0.1287 1
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0016 0.0016
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0507 0.0507
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0041 0.0319
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0041 0.0041
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Onchocerca volvulus 0.0007 0.0016 0.0119
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0074
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.039 0.3031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0583 0.0583
Schistosoma mansoni kinase 0.0048 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0007 0.0016 0.0041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Plasmodium falciparum glutathione reductase 0.0095 0.1287 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.039 0.1427
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.3045 0.8971
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.039 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.0002 0.0006
Treponema pallidum NADH oxidase 0.0033 0.039 1
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.1356 0.1356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0185 0.1441
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0009 0.0041 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0041 0.0041
Echinococcus multilocularis CREB binding protein 0.0016 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.01 0.1356 0.3424
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0173 0.1347
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0127
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0185 0.1441
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0735 0.5708
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0009 0.0041 0.0316
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0173 0.3798
Schistosoma mansoni Slc9a7 protein 0.0019 0.0189 0.0189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Schistosoma mansoni NAD dehydrogenase 0.0016 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0009 0.0041 0.0316
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.1287 0.1287
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0016 0.0149 0.0149
Brugia malayi Thioredoxin reductase 0.0095 0.1287 0.3248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0583 0.0583
Toxoplasma gondii selenide, water dikinase 0.0009 0.0041 0.0316
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0659
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0583 0.1471
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0276 0.206
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Giardia lamblia Glutamate synthase 0.0009 0.0041 0.03
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0189 0.1472
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.039 0.3031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Leishmania major hypothetical protein, conserved 0.0009 0.0041 0.0316
Echinococcus multilocularis cpg binding protein 0.0031 0.0358 0.0358
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0334 0.0843
Onchocerca volvulus 0.0007 0.0016 0.0119
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0013 0.0096 0.0242
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1356 0.1356
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.039 0.0984
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0866 0.0866
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0588 0.4611
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.3045 0.8971
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Schistosoma mansoni glutamate synthase 0.0009 0.0041 0.0041
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1275 0.9912
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0189 0.0478
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0041 0.0041
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0016 0.0149 0.0377
Loa Loa (eye worm) CBP-B 0.0068 0.0903 0.2279
Echinococcus multilocularis CREB binding protein 0.0016 0.0148 0.0148
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0185 0.0185
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0041 0.0041
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.1287 0.3248
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0264 0.0666
Schistosoma mansoni hypothetical protein 0.0019 0.0189 0.0189
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1275 0.9403
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0805 0.0805
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0149 0.1161
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0041 0.0316
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0189 0.1472
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0041 0.0041
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0016 0.0149 0.0377
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0802 0.2362
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.039 0.039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0802 0.2933
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0098 0.1337 0.1337
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0149 0.1161
Mycobacterium ulcerans hypothetical protein 0.0024 0.0261 0.0955
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.1081 0.1081
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0041 0.0316
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0179 0.2498 0.7361
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.2028
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.1161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0583 0.0583
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0465 0.0465
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0149 0.0547
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0016 0.0059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.1287 0.3791
Plasmodium falciparum thioredoxin reductase 0.0033 0.039 0.3031
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0041 0.012
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0866 0.6727
Leishmania major hypothetical protein, conserved 0.0016 0.0149 0.1161
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0016 0.0059
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0016 0.0048
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0093 0.1259 0.3178
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0866 0.0866
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0016 0.0059
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0866 0.2185
Loa Loa (eye worm) hypothetical protein 0.0007 0.0016 0.0041
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0041 0.0041
Onchocerca volvulus Putative fad oxidoreductase 0.0016 0.0149 0.1101
Schistosoma mansoni cpg binding protein 0.0029 0.0334 0.0334
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1275 0.9912
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.1287 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0185 0.4144
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0659
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0041 0.0041
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0195 0.2733 0.8044
Onchocerca volvulus 0.0009 0.0041 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0016 0.0149 0.0547
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0041 0.0103
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1275 1
Brugia malayi glutamate synthase 0.0009 0.0041 0.0103
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0041 0.0041
Schistosoma mansoni ap endonuclease 0.0019 0.0185 0.0185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0866 0.6727
Leishmania major trypanothione reductase 0.0095 0.1287 1
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0016 0.0149 0.1161
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0009 0.0041 0.0316
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0173 0.0511
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.1259 0.3178
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0185 0.1344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Onchocerca volvulus 0.0019 0.0189 0.1396
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0016 0.0149 0.0547
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.039 0.3031
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.039 0.1427
Onchocerca volvulus 0.0093 0.1259 0.9283
Plasmodium vivax glutathione reductase, putative 0.0095 0.1287 1
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0016 0.0149 0.1161
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.3045 0.8971
Echinococcus granulosus CREB binding protein 0.0098 0.1337 0.1337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0659
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0185 0.1441
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0041 0.0319
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.1259 0.3178
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.1287 0.1287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0189 0.0189
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0016 0.0149 0.0149
Mycobacterium ulcerans potassium/proton antiporter 0.0019 0.0189 0.0693
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0377
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1356 0.1356
Trichomonas vaginalis helicase, putative 0.0007 0.001 0.0075
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.039 0.2875
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0041 0.1042
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0261 0.0955
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0019 0.0189 0.1472
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.039 0.3031
Schistosoma mansoni tyrosinase precursor 0.0093 0.1259 0.1259
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.1356 0.1356
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0041 0.0316
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0019 0.0189 0.1472
Loa Loa (eye worm) hypothetical protein 0.0093 0.1259 0.3178
Mycobacterium ulcerans hypothetical protein 0.0009 0.0041 0.0149
Mycobacterium leprae probable conserved integral membrane transport protein 0.0019 0.0189 0.0513
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0189 0.0189
Brugia malayi RE18450p 0.0016 0.0149 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1275 0.1275
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1259 0.3178
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0189 0.1472
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0041 0.0316
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0016 0.0059
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0041 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0185 0.0468
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0041 0.0041
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0041 0.0103
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0016 0.0041
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0261 0.0769
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0016 0.0149 0.1161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0261 0.1944
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0041 0.0073
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0802 0.0802
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1275 0.3219
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1275 0.3219
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0659
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0041 0.0103
Leishmania major hypothetical protein, conserved 0.0009 0.0041 0.0316
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0264 0.0666
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0185 0.1441
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.2028
Loa Loa (eye worm) NHE-3 0.01 0.1356 0.3424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.0697 1 1
Schistosoma mansoni d-amino acid oxidase 0.0195 0.2733 0.2733
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Entamoeba histolytica thioredoxin reductase, putative 0.0009 0.0041 0.0195
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0276 0.2032
Loa Loa (eye worm) glutamate receptor 0.0049 0.0622 0.157
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0195 0.2733 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0009 0.0041 0.012
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0149 0.1161
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0009 0.0041 0.0316
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.1287 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.0112
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0009 0.0041 0.0073
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0009 0.0041 0.0316
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1259 0.3178
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0149 0.044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0019 0.0019
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0189 0.0558
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0261 0.0725
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0009 0.0041 0.1042
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0507 0.0507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.039 0.3031
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.1356 0.1356
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0041 0.0316
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0016 0.0059
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.039 0.3031
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0261 0.0955
Toxoplasma gondii thioredoxin reductase 0.0095 0.1287 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0185 0.1454
Chlamydia trachomatis D-amino acid dehydrogenase 0.0016 0.0149 0.3113
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0016 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.0955
Mycobacterium ulcerans ion antiporter, NhaP 0.0019 0.0189 0.0693
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0016 0.0149 0.1161
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.039 0.3031
Brugia malayi CXXC zinc finger family protein 0.0029 0.0334 0.0843
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0016 0.0149 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0173 0.0634
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Brugia malayi Common central domain of tyrosinase family protein 0.0093 0.1259 0.3178
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0185 0.0678
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0583 0.0583
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0016 0.0048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0096 0.0242
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0016 0.0059
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0189 0.1376
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0041 0.0319
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0009 0.0041 0.0316
Loa Loa (eye worm) glutamate receptor 0.0019 0.0193 0.0487
Loa Loa (eye worm) hypothetical protein 0.01 0.1356 0.3424
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0041 0.0319
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0008 0.0029 0.0216
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0588 0.4611
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0261 0.1944
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0041 0.0316
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0041 0.0316
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0261 0.1944
Loa Loa (eye worm) hypothetical protein 0.0195 0.2733 0.69
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0866 0.6727
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0009 0.0041 0.012
Loa Loa (eye worm) hypothetical protein 0.01 0.1356 0.3424
Plasmodium falciparum ferrodoxin reductase-like protein 0.0009 0.0041 0.0316
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Schistosoma mansoni glutamate synthase 0.0009 0.0041 0.0041
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.3394 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.039 0.3031
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Schistosoma mansoni cpg binding protein 0.0031 0.0358 0.0358
Brugia malayi glutathione reductase 0.0095 0.1287 0.3248
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0096 0.0242
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0802 0.0802
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Schistosoma mansoni cpg binding protein 0.0031 0.0358 0.0358
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.039 0.039
Echinococcus multilocularis GPCR, family 3, C terminal 0.0008 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0019 0.0189 0.1472
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0189 0.0189
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0041 0.0316
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.3045 0.8971
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.1356 0.3424
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.039 0.3058
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.2028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Mycobacterium ulcerans glutamate synthase subunit beta 0.0009 0.0041 0.0149
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0016 0.0059
Schistosoma mansoni hypothetical protein 0.0019 0.0189 0.0189
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0261 0.0725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0019 0.0019
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0016 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0583 0.0583
Mycobacterium ulcerans dehydrogenase 0.0009 0.0041 0.0149
Wolbachia endosymbiont of Brugia malayi Kef-type K+ transport system, membrane component 0.0019 0.0189 0.4857
Echinococcus multilocularis microtubule associated protein 2 0.0697 1 1
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0189 0.0189
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0019 0.0189 0.1472
Loa Loa (eye worm) hypothetical protein 0.006 0.0786 0.1983
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Plasmodium falciparum glutathione reductase 0.0033 0.039 0.3031
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0041 0.0041
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0009 0.0041 0.0316
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0019 0.0019
Schistosoma mansoni fad oxidoreductase 0.0016 0.0149 0.0149
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0016 0.0016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0041 0.0103
Echinococcus multilocularis glutamate synthase 0.0009 0.0041 0.0041
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0016 0.0059
Loa Loa (eye worm) oxidoreductase 0.0007 0.0016 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0802 0.6231
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0041 0.0316
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0094
Toxoplasma gondii exonuclease III APE 0.0019 0.0185 0.1441
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0185 0.4754
Mycobacterium ulcerans NADH dehydrogenase 0.0009 0.0041 0.0149
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0008 0.0029 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1356 1
Trypanosoma brucei NADH dehydrogenase 0.0009 0.0041 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Onchocerca volvulus 0.0007 0.0016 0.0119
Schistosoma mansoni hypothetical protein 0.0008 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0019 0.0189 0.0558
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0189 0.1472
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0259 0.0259
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0009 0.0041 0.0195
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0016 0.0149 0.0394
Echinococcus granulosus glutamate synthase 0.0009 0.0041 0.0041
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1356 0.1356
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0016 0.0125
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0465 0.0465
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Giardia lamblia Thioredoxin reductase 0.0009 0.0041 0.03
Mycobacterium tuberculosis Probable reductase 0.0216 0.3045 0.8971
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0041 0.0319
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0041 0.0149
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0555 0.1402
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.0547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.039 0.3031
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0016 0.0149 0.1161
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0013 0.0096 0.0242
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0189 0.0189
Brugia malayi cDNA sequence BC016226 0.0016 0.0149 0.0377
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.039 1
Brugia malayi ShTK domain containing protein 0.0093 0.1259 0.3178
Trypanosoma brucei polo-like protein kinase 0.0094 0.1275 0.9912
Schistosoma mansoni hypothetical protein 0.0009 0.0041 0.0041
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.1356 0.3424
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1356 1
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0016 0.0149 0.0149
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0377
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0016 0.0149 0.1161
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0016 0.0041
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0149 0.0394
Leishmania major hypothetical protein, conserved 0.0009 0.0041 0.0316
Giardia lamblia Kinase, PLK 0.0094 0.1275 0.9403
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0016 0.0048
Onchocerca volvulus 0.0024 0.0261 0.1924
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.039 0.3031
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0622 0.157
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0185 0.1441
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0041 0.0319
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0041 0.1042
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0127
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.039 0.3031
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.0955
Trypanosoma brucei trypanothione reductase 0.0095 0.1287 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0075
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0802 0.6231
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1259 0.3178
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0019 0.0189 0.1472
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.3394 1
Onchocerca volvulus 0.0093 0.1259 0.9283
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0016 0.0149 0.1161
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0185 0.0185
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0009 0.0041 0.012
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.1356 0.1356
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0866 0.6745
Brugia malayi follicle stimulating hormone receptor 0.028 0.3962 1
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0189 0.0478
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0009 0.0041 0.012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0802 0.0802
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0041 0.0316

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

13 literature references were collected for this gene.

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