Detailed information for compound 574309

Basic information

Technical information
  • TDR Targets ID: 574309
  • Name: (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-h ydroxy-4-(3-thienyloxy)but-1-enyl]cyclopentyl ]hept-5-enoic acid
  • MW: 396.498 | Formula: C20H28O6S
  • H donors: 4 H acceptors: 5 LogP: 1.73 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/C(COc1cscc1)O)O
  • InChi: 1S/C20H28O6S/c21-14(12-26-15-9-10-27-13-15)7-8-17-16(18(22)11-19(17)23)5-3-1-2-4-6-20(24)25/h1,3,7-10,13-14,16-19,21-23H,2,4-6,11-12H2,(H,24,25)/b3-1-,8-7+/t14?,16-,17-,18+,19-/m1/s1
  • InChiKey: FYBFDIIAPRHIQS-JRSBLEPXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-4-(3-thienyloxy)but-1-enyl]cyclopentyl]-5-heptenoic acid
  • (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-4-thiophen-3-yloxy-but-1-enyl]cyclopentyl]hept-5-enoic acid
  • (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-4-thiophen-3-yloxybut-1-enyl]cyclopentyl]hept-5-enoic acid
  • tiaprost
  • 62251-61-0
  • 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-thienyloxy)-1-butenyl)cyclopentyl)-, (1alpha(Z),2beta(1E,3R*),3alpha,5alpha)-
  • 9alpha,11alpha,15alpha-Trihydroxy-16-(3-thienyloxy)-17,18,19,20-tetranor-5Z,13E-prostadienoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0203
Plasmodium vivax SET domain protein, putative 0.0029 0.002 0.0563
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0109
Schistosoma mansoni hypothetical protein 0.0033 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0184 0.019 0.1035
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0025 0.0025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Echinococcus granulosus cathepsin L 0.0026 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.1643 0.1794 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0238 0.0249 0.0249
Leishmania major acetyl-CoA synthetase, putative 0.0048 0.0041 0.1367
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0015 0.0385
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 1
Onchocerca volvulus 0.0048 0.0041 0.0603
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.019 0.7732
Trypanosoma cruzi major cysteine proteinase, putative 0.0153 0.0155 0.7656
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.019 0.1035
Mycobacterium ulcerans hypothetical protein 0.0184 0.019 0.0585
Leishmania major 4-coumarate:coa ligase-like protein 0.0165 0.0169 0.8271
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0203
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0033 0.1127
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2865 0.3137 1
Loa Loa (eye worm) ctsf protein 0.0051 0.0044 0.0219
Brugia malayi CHE-14 protein 0.0043 0.0035 0.0169
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0238 0.0249 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0041 0.1782
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0041 0.0109
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.0115
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0048 0.0041 0.0109
Onchocerca volvulus 0.0034 0.0025 0.0151
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0048 0.0041 0.0041
Onchocerca volvulus 0.0233 0.0243 0.642
Loa Loa (eye worm) hypothetical protein 0.0051 0.0044 0.0219
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.002 0.002
Onchocerca volvulus 0.0051 0.0044 0.0683
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0033 0.1127
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0048 0.0041 0.0109
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0044 0.0744
Onchocerca volvulus 0.0051 0.0044 0.0683
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0016 0.0016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0048 0.0041 0.0203
Loa Loa (eye worm) hypothetical protein 0.0184 0.019 0.1035
Schistosoma mansoni ferritin 0.0017 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.019 0.7732
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0041 0.0203
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0041 0.0109
Loa Loa (eye worm) hypothetical protein 0.0123 0.0123 0.0663
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0169
Schistosoma mansoni hypothetical protein 0.0041 0.0033 0.0033
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0165 0.0169 0.0519
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0165 0.0169 0.0519
Schistosoma mansoni ferritin 0.0017 0.0007 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.019 0.019
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0048 0.0041 0.0668
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0004 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1174 0.1279 0.4064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0165 0.0169 0.0519
Leishmania major cathepsin L-like protease 0.0051 0.0044 0.1516
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 0.0776
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.019 0.0585
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.019 0.0585
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0358 0.0382 0.0382
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.019 0.0585
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0028 0.007
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.0201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0016 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0041 0.0203
Brugia malayi Inositol-1 0.0042 0.0033 0.0161
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0116 0.0349
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0048 0.0041 0.0109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0044 0.0219
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1638 0.1788 0.1788
Mycobacterium ulcerans transcriptional regulator 0.2865 0.3137 1
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0033 0.0033
Onchocerca volvulus 0.0048 0.0041 0.0603
Brugia malayi beta-lactamase family protein 0.0184 0.019 0.1035
Onchocerca volvulus 0.0051 0.0044 0.0683
Plasmodium vivax vivapain-3 0.0026 0.0016 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.019 0.7732
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0044 0.0219
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0062
Echinococcus multilocularis cysteine protease 0.0051 0.0044 0.0044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0212 0.1162
Schistosoma mansoni hypothetical protein 0.0041 0.0033 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.9105 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0044 0.1924
Mycobacterium ulcerans acetyl-CoA synthetase 0.0048 0.0041 0.0109
Plasmodium vivax acetyl-CoA synthetase, putative 0.0048 0.0041 0.1427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.019 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0416
Loa Loa (eye worm) oxidoreductase 0.0048 0.0041 0.0203
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.0249 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0004 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0358 0.0382 0.0382
Mycobacterium tuberculosis Conserved protein 0.0184 0.019 0.0585
Brugia malayi Cathepsin L-like precursor 0.0034 0.0025 0.0115
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0025 0.0781
Entamoeba histolytica acyl-coA synthetase, putative 0.0165 0.0169 0.4177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0048 0.0041 0.1084
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0041 0.0109
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0078 0.2947
Loa Loa (eye worm) hypothetical protein 0.0165 0.0169 0.0919
Echinococcus granulosus expressed conserved protein 0.0094 0.0091 0.0091
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0078 0.2932
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.002 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0116 0.0626
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0184 0.019 0.1035
Mycobacterium leprae Probable lipase LipE 0.0184 0.019 0.0585
Echinococcus granulosus tumor protein p63 0.2364 0.2587 0.2587
Entamoeba histolytica hypothetical protein 0.0358 0.0382 1
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0097 0.0519
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.019 0.9418
Onchocerca volvulus 0.0051 0.0044 0.0683
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0033 0.1395
Entamoeba histolytica hypothetical protein 0.0358 0.0382 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0116 0.0349
Leishmania major cathepsin L-like protease 0.0194 0.0201 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0228
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0044 0.0044
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0048 0.0041 0.1367
Leishmania major cathepsin L-like protease 0.0051 0.0044 0.1516
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0044 0.0744
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Schistosoma mansoni thyroid hormone receptor 0.0134 0.0134 0.0134
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0048 0.0041 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.019 0.1035
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.019 0.7732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0165 0.0169 0.0519
Plasmodium vivax vivapain-1 0.0026 0.0016 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.019 0.0585
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0097 0.0097
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.01 0.0097 0.0519
Loa Loa (eye worm) hypothetical protein 0.0123 0.0123 0.0663
Leishmania major cathepsin L-like protease 0.0051 0.0044 0.1516
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0335 0.0356 0.1965
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0048 0.0041 0.0203
Mycobacterium ulcerans hypothetical protein 0.0165 0.0169 0.0519
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0041 0.0109
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0203
Echinococcus multilocularis ferritin 0.0017 0.0007 0.0007
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0048 0.0041 0.1782
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 0.0776
Echinococcus multilocularis tumor protein p63 0.2364 0.2587 0.2587
Trichomonas vaginalis esterase, putative 0.0184 0.019 0.7732
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Onchocerca volvulus 0.0184 0.019 0.4878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0048 0.0041 0.1084
Trichomonas vaginalis antibiotic synthetase, putative 0.0048 0.0041 0.1446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Plasmodium vivax vivapain-2 0.0051 0.0044 0.1541
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0033 0.0085
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0165 0.0169 0.4177
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0048 0.0041 0.0109
Echinococcus multilocularis cysteine protease 0.0051 0.0044 0.0044
Echinococcus multilocularis peptidase Clp (S14 family) 0.0156 0.0159 0.0159
Echinococcus granulosus cathepsin l1 0.0034 0.0025 0.0025
Echinococcus granulosus cathepsin l1 0.0051 0.0044 0.0044
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0044 0.0044
Loa Loa (eye worm) cysteine protease 0.0051 0.0044 0.0219
Brugia malayi Cathepsin L-like precursor 0.0034 0.0025 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0165 0.0169 0.0919
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.019 0.9418
Brugia malayi hypothetical protein 0.0358 0.0382 0.2108
Brugia malayi AMP-binding enzyme family protein 0.0165 0.0169 0.0919
Leishmania major cathepsin L-like protease 0.0051 0.0044 0.1516
Brugia malayi Cathepsin L-like precursor 0.0051 0.0044 0.0219
Brugia malayi beta-lactamase 0.0184 0.019 0.1035
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0041 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0033 0.1127
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.0249 1
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0016 0.053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.019 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0165 0.0169 0.0919
Onchocerca volvulus 0.0051 0.0044 0.0683
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0078 0.2664
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.002 0.002
Onchocerca volvulus 0.0165 0.0169 0.4283
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0243 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Schistosoma mansoni microtubule-associated protein tau 0.9105 1 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0123 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0033 0.0461
Schistosoma mansoni hypothetical protein 0.0335 0.0356 0.0356
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0016 0.0016
Brugia malayi MH2 domain containing protein 0.0117 0.0116 0.0626
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0116 0.0626
Brugia malayi cathepsin L-like precursor 0.0034 0.0025 0.0115
Schistosoma mansoni thyroid hormone receptor 0.0134 0.0134 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Schistosoma mansoni ferritin 0.0017 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0016 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0165 0.0169 0.8271
Schistosoma mansoni hypothetical protein 0.0124 0.0123 0.0123
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0015 0.0481
Leishmania major acetyl-CoA synthetase, putative 0.0048 0.0041 0.1367
Brugia malayi beta-lactamase family protein 0.0184 0.019 0.1035
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0044 0.0683
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0041 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.019 0.0585
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0015 0.0481
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0156 0.0159 0.0488
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0086
Onchocerca volvulus 0.0048 0.0041 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.002 0.002
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0033 0.096
Plasmodium vivax acyl-CoA synthetase, putative 0.0123 0.0123 0.4806
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0165 0.0169 0.0519
Echinococcus granulosus survival motor neuron protein 1 0.1643 0.1794 0.1794
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0048 0.0041 0.0109
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0044 0.0219
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0048 0.0041 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0016 0.0067
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2865 0.3137 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0041 0.1367
Loa Loa (eye worm) hypothetical protein 0.0184 0.019 0.1035
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0006 0.0009
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0035 0.0035
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0097 0.2213
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0177 0.0182 0.905
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0016 0.0041
Echinococcus multilocularis protein dispatched 1 0.0049 0.0041 0.0041
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0016 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Loa Loa (eye worm) hypothetical protein 0.0123 0.0123 0.0663
Plasmodium falciparum acyl-CoA synthetase 0.0123 0.0123 0.4598
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0025 0.0115
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0006 0.0009
Brugia malayi hypothetical protein 0.0025 0.0015 0.0062
Onchocerca volvulus 0.0335 0.0356 0.9654
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0116 0.0349
Loa Loa (eye worm) hypothetical protein 0.0184 0.019 0.1035
Schistosoma mansoni ferritin 0.0017 0.0007 0.0007
Echinococcus multilocularis expressed protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0035 0.0169
Brugia malayi Cathepsin L-like precursor 0.0051 0.0044 0.0219
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0016 0.053
Plasmodium vivax vivapain-2 0.0051 0.0044 0.1541
Loa Loa (eye worm) hypothetical protein 0.0123 0.0123 0.0663
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.0044 0.1202
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0048 0.0041 0.0041
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0044 0.0044
Echinococcus granulosus ferritin 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.019 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.0044 0.1202
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0048 0.0041 0.0109
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.019 0.0585
Echinococcus granulosus cysteine protease 0.0026 0.0016 0.0016
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0048 0.0041 0.0109
Leishmania major 4-coumarate:coa ligase-like protein 0.0165 0.0169 0.8271
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0048 0.0041 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Schistosoma mansoni hypothetical protein 0.0041 0.0033 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0123 0.0123 0.0372
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0082 0.0078 0.0228
Toxoplasma gondii hypothetical protein 0.0082 0.0078 0.2664
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0041 0.0203
Leishmania major cathepsin L-like protease 0.0051 0.0044 0.1516
Trichomonas vaginalis antibiotic synthetase, putative 0.0048 0.0041 0.1446
Loa Loa (eye worm) hypothetical protein 0.0165 0.0169 0.0919
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.0201 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0041 0.0203
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0156 0.0159 0.0488
Plasmodium vivax hypothetical protein, conserved 0.0184 0.019 0.7541
Brugia malayi Cathepsin L-like precursor 0.0051 0.0044 0.0219
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0099 0.0099
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.019 0.019
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.0249 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.019 0.7732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0048 0.0041 0.0109
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0165 0.0169 0.0519
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0016 0.053
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0041 0.0109
Brugia malayi Pre-SET motif family protein 0.0029 0.002 0.0086
Schistosoma mansoni hypothetical protein 0.0041 0.0033 0.0033
Onchocerca volvulus 0.0051 0.0044 0.0683
Toxoplasma gondii ABC1 family protein 0.0184 0.019 0.7443
Mycobacterium tuberculosis Conserved protein 0.0184 0.019 0.0585
Brugia malayi Probable ClpP-like protease 0.0238 0.0249 0.137
Onchocerca volvulus 0.0184 0.019 0.4878
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0044 0.0683
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0041 0.0203
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0165 0.0169 0.0519
Entamoeba histolytica hypothetical protein 0.0358 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.019 0.1035
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0048 0.0041 0.0109
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0048 0.0041 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0165 0.0169 0.0519
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.002 0.0186
Schistosoma mansoni patched 1 0.0043 0.0035 0.0035
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0238 0.0249 0.0249
Brugia malayi hypothetical protein 0.1643 0.1794 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Mycobacterium ulcerans beta-lactamase 0.0184 0.019 0.0585
Schistosoma mansoni inositol monophosphatase 0.0042 0.0033 0.0033
Mycobacterium ulcerans lipase LipD 0.0184 0.019 0.0585
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0123 0.0123 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0025 0.0781
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0044 0.0683
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0009
Plasmodium vivax unspecified product 0.0026 0.0016 0.0425
Echinococcus granulosus peptidase Clp S14 family 0.0156 0.0159 0.0159
Mycobacterium leprae conserved hypothetical protein 0.0184 0.019 0.0585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0156 0.0159 0.0488
Brugia malayi Cathepsin L-like precursor 0.0051 0.0044 0.0219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0041 0.0203
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0033 0.1395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0044 0.1563
Entamoeba histolytica cysteine protease, putative 0.0051 0.0044 0.0744
Toxoplasma gondii propionate-CoA ligase 0.0048 0.0041 0.1084
Schistosoma mansoni cathepsin s 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0019 0.0019
Brugia malayi Pre-SET motif family protein 0.0204 0.0212 0.1162
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0144 0.0144
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0048 0.0041 0.0203
Trypanosoma cruzi cruzipain precursor, putative 0.0194 0.0201 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0028 0.007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0238 0.0249 1
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0048 0.0041 0.0109
Leishmania major cysteine peptidase A (CPA) 0.0051 0.0044 0.1516
Entamoeba histolytica acyl-CoA synthetase, putative 0.0165 0.0169 0.4177
Schistosoma mansoni survival motor neuron protein 0.0335 0.0356 0.0356
Mycobacterium ulcerans acyl-CoA synthetase 0.0165 0.0169 0.0519
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0144 0.0144
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0016 0.053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0009
Leishmania major cathepsin L-like protease 0.0194 0.0201 1
Echinococcus granulosus GPCR family 2 0.0015 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Onchocerca volvulus 0.0346 0.0368 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0041 0.1782
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.019 0.0585
Schistosoma mansoni cellular tumor antigen P53 0.0346 0.0368 0.0368
Toxoplasma gondii cathepsin CPL 0.0051 0.0044 0.1202
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0048 0.0041 0.1084
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0123 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.0358 0.0382 0.0382
Brugia malayi Cathepsin L-like precursor 0.0051 0.0044 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Loa Loa (eye worm) beta-lactamase 0.0184 0.019 0.1035
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0048 0.0041 0.0109
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0009
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0238 0.0249 0.0776
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0033 0.0761
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0041 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0024 0.0109
Onchocerca volvulus 0.0048 0.0041 0.0603
Echinococcus multilocularis protein patched 0.0043 0.0035 0.0035
Echinococcus multilocularis expressed conserved protein 0.0094 0.0091 0.0091
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0123 0.0123
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0033 0.1099
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.0044 0.1202
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0346 0.0368 0.2032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0165 0.0169 0.0519
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0116 0.0349
Leishmania major cathepsin L-like protease 0.0194 0.0201 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0004 0.0004
Loa Loa (eye worm) fibroinase 0.0051 0.0044 0.0219
Mycobacterium tuberculosis Conserved protein 0.0184 0.019 0.0585
Onchocerca volvulus 0.0184 0.019 0.4878
Entamoeba histolytica hypothetical protein 0.0358 0.0382 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0041 0.1367
Leishmania major hypothetical protein, conserved 0.0184 0.019 0.9389
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0048 0.0041 0.0203
Schistosoma mansoni hypothetical protein 0.0358 0.0382 0.0382
Brugia malayi Cathepsin L-like precursor 0.0051 0.0044 0.0219
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0025 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0033 0.096
Echinococcus granulosus expressed protein 0.0017 0.0007 0.0007
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0048 0.0041 0.1782
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.0134 0.0134
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0201 1
Loa Loa (eye worm) inositol-1 0.0042 0.0033 0.0161
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.019 0.9389
Schistosoma mansoni acetyl-CoA synthetase 0.0048 0.0041 0.0041
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0016 0.0067
Loa Loa (eye worm) hypothetical protein 0.0238 0.0249 0.137
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0016 0.0005 0.0007
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2865 0.3137 1
Onchocerca volvulus 0.0051 0.0044 0.0683
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0044 0.1563
Mycobacterium ulcerans TetR family transcriptional regulator 0.2865 0.3137 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0033 0.0086
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0048 0.0041 0.0109
Loa Loa (eye worm) hypothetical protein 0.0165 0.0169 0.0919
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0035 0.1185
Schistosoma mansoni inositol monophosphatase 0.0042 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0165 0.0169 0.0519
Echinococcus multilocularis survival motor neuron protein 1 0.1643 0.1794 0.1794
Echinococcus multilocularis cathepsin L 0.0026 0.0016 0.0016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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