Detailed information for compound 575815

Basic information

Technical information
  • TDR Targets ID: 575815
  • Name: 1,3,8,9-tetrahydroxybenzofuro[3,2-c]chromen-6 -one
  • MW: 300.22 | Formula: C15H8O7
  • H donors: 4 H acceptors: 5 LogP: 2.05 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(O)c2c(c1)oc(=O)c1c2oc2c1cc(c(c2)O)O
  • InChi: 1S/C15H8O7/c16-5-1-9(19)13-11(2-5)22-15(20)12-6-3-7(17)8(18)4-10(6)21-14(12)13/h1-4,16-19H
  • InChiKey: LUTYTNLPIUCKBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3,8,9-tetrahydroxy-6-benzofuro[3,2-c][1]benzopyranone
  • 1,3,8,9-tetrahydroxy-[1]benzofuro[3,2-c]chromen-6-one
  • demethylwedelolactone
  • 1,3,8,9-tetrahydroxy-[1]benzoxolo[3,2-c]chromen-6-one
  • 1,3,8,9-tetrahydroxybenzofurano[3,2-c]chromen-6-one
  • 1,3,8,9-tetrahydroxy-6-benzofurano[3,2-c]chromenone
  • 6468-55-9
  • 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 1,3,8,9-tetrahydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0333
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.0112 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1392
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0078 0.0096 0.9323
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0015 0.0273
Loa Loa (eye worm) hypothetical protein 0.011 0.0146 0.1334
Trichomonas vaginalis glutathione reductase, putative 0.0078 0.0096 0.2799
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0225 0.0325 0.0959
Brugia malayi TAR-binding protein 0.0131 0.0179 0.1643
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0069 0.0199
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.002 0.0437
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0038 0.1083
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0112 0.1019
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0038 0.0993
Brugia malayi RNA binding protein 0.0131 0.0179 0.1643
Loa Loa (eye worm) RNA binding protein 0.0131 0.0179 0.164
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0514 0.0776 0.2292
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0031 0.0783
Loa Loa (eye worm) hypothetical protein 0.0709 0.108 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0047 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0179 0.0179
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0029 0.0081
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0179 0.164
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0078 0.0096 0.929
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.0112 0.3312
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0047 0.0136
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0006 0.0043
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0038 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0112 0.3281
Mycobacterium ulcerans lipase LipD 0.0041 0.0038 0.0108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0051 0.0053 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0038 0.0993
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2442
Trichomonas vaginalis apoptosis inducing factor, putative 0.0021 0.0006 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2442
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0078 0.0096 0.2803
Treponema pallidum thioredoxin reductase (trxB) 0.0021 0.0006 0.0471
Echinococcus multilocularis survival motor neuron protein 1 0.0709 0.108 0.1079
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0078 0.0096 0.0094
Mycobacterium ulcerans monoxygenase 0.0021 0.0006 0.0014
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0006 0.0101
Loa Loa (eye worm) hypothetical protein 0.0047 0.0047 0.0421
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0179 0.164
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2187 0.3386 1
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0015 0.0014
Trichomonas vaginalis glutamate synthase, putative 0.0021 0.0006 0.0141
Echinococcus granulosus GPCR family 2 0.0051 0.0053 0.0052
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0015 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0556
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0015 0.0014
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0437
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.002 0.0018
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0021 0.0006 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0021 0.0006 0.0101
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0078 0.0096 0.2803
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0021 0.0006 0.0014
Brugia malayi beta-lactamase family protein 0.0041 0.0038 0.0337
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.0225 0.2072
Schistosoma mansoni thyroid hormone receptor 0.0164 0.023 0.023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0078 0.0096 0.2803
Schistosoma mansoni apoferritin-2 0.0018 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.0027 0.0015 0.0015
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0021 0.0006 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0078 0.0096 0.9323
Brugia malayi hypothetical protein 0.0027 0.0017 0.0141
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.0112 0.011
Mycobacterium ulcerans beta-lactamase 0.0041 0.0038 0.0108
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.002 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0164 0.023 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0015 0.0273
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0021 0.0006 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0225 0.0325 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0015 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0015 0.0128
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0058 0.0057
Mycobacterium ulcerans transcriptional regulator 0.2187 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Schistosoma mansoni ferritin light chain 0.0018 0.0001 0.0001
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2187 0.3386 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 0.0299
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0038 0.0038
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0021 0.0006 0.0141
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0248
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0072
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0078 0.0096 0.0872
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0514 0.0776 0.2292
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.004 0.0039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.0112 0.3312
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0514 0.0776 0.2292
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0015 0.0015
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0194 0.0193
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0128 0.1172
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.0225 0.2075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0072
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0021 0.0006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0015 0.0123
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0006 0.0141
Trichomonas vaginalis mercuric reductase, putative 0.0078 0.0096 0.2799
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0021 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0352
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0039 0.1032
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.0341 0.3147
Schistosoma mansoni hypothetical protein 0.0137 0.0188 0.0188
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0571 0.0865 0.2552
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0021 0.0006 0.0039
Schistosoma mansoni glutamate synthase 0.0021 0.0006 0.0006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0066 0.0064
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0021 0.0006 0.0014
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0165
Trypanosoma cruzi trypanothione reductase, putative 0.0078 0.0096 0.2803
Brugia malayi hypothetical protein 0.0107 0.0141 0.1295
Onchocerca volvulus 0.0027 0.0015 0.0275
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0056 0.1631
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0078 0.0096 0.0096
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0069 0.1965
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0137
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0333
Schistosoma mansoni ferritin light chain 0.0018 0.0001 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0015 0.0014
Brugia malayi steroid hormone receptor 0.0027 0.0015 0.0127
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0437
Brugia malayi Pre-SET motif family protein 0.0205 0.0294 0.271
Schistosoma mansoni ferritin 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0233 0.0338 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0047 0.0424
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0006 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0027 0.0017 0.0331
Echinococcus granulosus survival motor neuron protein 1 0.0709 0.108 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0056 0.1607
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0058 0.0168
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0084 0.243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0072
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0015 0.0273
Brugia malayi nuclear receptor NHR-88 0.0027 0.0015 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0015 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0179 0.0179
Echinococcus multilocularis microtubule associated protein 2 0.6426 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.002 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0294 0.2707
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0047 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0047 0.1289
Onchocerca volvulus 0.0041 0.0038 0.0955
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0333
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.0112 0.7829
Echinococcus multilocularis expressed conserved protein 0.0093 0.0119 0.0117
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0021 0.0006 0.0471
Mycobacterium tuberculosis Probable oxidoreductase 0.0571 0.0865 0.2557
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0021 0.0006 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0015 0.0015
Plasmodium falciparum glutathione reductase 0.0225 0.0325 1
Onchocerca volvulus 0.0047 0.0047 0.124
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.0112 0.011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0571 0.0865 0.2557
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0015 0.0123
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0047 0.3048
Mycobacterium tuberculosis Conserved protein 0.0041 0.0038 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.002 0.0521
Brugia malayi CHE-14 protein 0.0042 0.004 0.0356
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0047 0.0424
Plasmodium vivax SET domain protein, putative 0.0029 0.002 0.0425
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0018 0.0376
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0069 0.2046
Echinococcus granulosus Protein patched homolog 1 0.0042 0.004 0.0039
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0021 0.0006 0.0014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0058 0.0168
Mycobacterium ulcerans hypothetical protein 0.0021 0.0006 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0006 0.0141
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0021 0.0006 0.0014
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.0006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0006 0.0141
Mycobacterium ulcerans dehydrogenase 0.0021 0.0006 0.0014
Toxoplasma gondii selenide, water dikinase 0.0021 0.0006 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0015 0.0127
Schistosoma mansoni survival motor neuron protein 0.0145 0.02 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0117
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0057 0.0063 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0281
Onchocerca volvulus 0.0041 0.0038 0.0955
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0006 0.0101
Plasmodium falciparum thioredoxin reductase 0.0225 0.0325 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0226 0.0327 0.0326
Echinococcus multilocularis lamin dm0 0.0027 0.0015 0.0014
Entamoeba histolytica hypothetical protein 0.0107 0.0141 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0112 0.3312
Entamoeba histolytica hypothetical protein 0.0107 0.0141 1
Brugia malayi Probable ClpP-like protease 0.0082 0.0103 0.0936
Mycobacterium tuberculosis Conserved protein 0.0041 0.0038 0.0108
Onchocerca volvulus 0.0029 0.002 0.0409
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.049
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.002 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0015 0.0123
Mycobacterium tuberculosis Probable dehydrogenase 0.0514 0.0776 0.2292
Giardia lamblia GTOR 0.0088 0.0112 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1392
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0021 0.0006 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0556
Loa Loa (eye worm) hypothetical protein 0.021 0.0302 0.2783
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2442
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0015 0.0014
Echinococcus granulosus tar DNA binding protein 0.0131 0.0179 0.0177
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0015 0.0014
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0021 0.0006 0.0101
Schistosoma mansoni microtubule-associated protein tau 0.6426 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0015 0.0127
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0038 0.0108
Brugia malayi MH2 domain containing protein 0.0235 0.0341 0.3149
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0021 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0047 0.0421
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0057 0.0063 0.0573
Echinococcus granulosus tumor protein p63 0.1437 0.2216 0.2215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0006 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0053 0.0481
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0047 0.0136
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0021 0.0006 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0066 0.1931
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 1
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0015 0.0015
Echinococcus multilocularis protein dispatched 1 0.0048 0.0049 0.0048
Brugia malayi jmjC domain containing protein 0.0059 0.0066 0.0597
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.02 0.1835
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0333
Plasmodium falciparum glutathione reductase 0.0078 0.0096 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0179 0.0179
Brugia malayi glutathione reductase 0.0225 0.0325 0.3002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0092 0.2682
Trichomonas vaginalis glutamate synthase, putative 0.0021 0.0006 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0112 0.3281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0556
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0053 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0038 0.0108
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0103 0.3018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.0112 0.0112
Brugia malayi Thioredoxin reductase 0.0225 0.0325 0.3002
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0084 0.243
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.004 0.0352
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0006 0.0005
Loa Loa (eye worm) glutathione reductase 0.0225 0.0325 0.2999
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0053 0.0052
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0038 0.0108
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0066 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0045
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0103 0.3088
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0078 0.0096 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0179 0.0179
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0571 0.0865 0.2557
Echinococcus multilocularis tumor protein p63 0.1437 0.2216 0.2215
Schistosoma mansoni hypothetical protein 0.011 0.0146 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0141 0.0141
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0015 0.0015
Echinococcus granulosus geminin 0.017 0.0239 0.0238
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0015 0.0014
Brugia malayi beta-lactamase family protein 0.0041 0.0038 0.0337
Mycobacterium ulcerans NADH dehydrogenase 0.0021 0.0006 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1395
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0333
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0038 0.0993
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0179 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0018 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0056 0.1631
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.0112 0.7829
Toxoplasma gondii thioredoxin reductase 0.0225 0.0325 1
Schistosoma mansoni ferritin 0.0018 0.0001 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0128 0.0127
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0103 0.0299
Schistosoma mansoni hypothetical protein 0.017 0.0239 0.0239
Plasmodium vivax glutathione reductase, putative 0.0225 0.0325 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0015 0.0124
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0103 0.0103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0015 0.0124
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0047 0.1289
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0179 0.0179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0015 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0248
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0015 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1395
Brugia malayi ecdysteroid receptor 0.0027 0.0015 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0017 0.0331
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0038 0.0108
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0017 0.0331
Loa Loa (eye worm) hypothetical protein 0.0051 0.0053 0.0477
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0069 0.0067
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0078 0.0096 0.2803
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0017 0.0331
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0047 0.0136
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0333
Schistosoma mansoni ferritin 0.0018 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0437
Treponema pallidum oxidoreductase 0.0021 0.0006 0.0471
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0051 0.0053 0.0053
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0066 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0015 0.0127
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0038 0.0108
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0047 0.3048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0015 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0112 0.3281
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0021 0.0006 0.0471
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0078 0.0096 0.0278
Brugia malayi beta-lactamase 0.0041 0.0038 0.0337
Mycobacterium ulcerans hypothetical protein 0.0041 0.0038 0.0108
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.0077 0.2282
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0015 0.0014
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0338 1
Brugia malayi nuclear hormone receptor 0.0027 0.0015 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.0341 0.3147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0015 0.0015
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0021 0.0006 0.0141
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0078 0.0096 0.0279
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0038 0.0993
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Trichomonas vaginalis esterase, putative 0.0041 0.0038 0.1083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0015 0.0127
Loa Loa (eye worm) hypothetical protein 0.0082 0.0103 0.0932
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0015 0.0014
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.013 0.013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0069 0.0199
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0128 0.902
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0015 0.0127
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0437
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0038 0.0108
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0018 0.0376
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0047 0.0424
Giardia lamblia NADH oxidase lateral transfer candidate 0.0078 0.0096 0.8465
Echinococcus granulosus lamin dm0 0.0027 0.0015 0.0014
Brugia malayi glutamate synthase 0.0021 0.0006 0.0043
Schistosoma mansoni glutamate synthase 0.0021 0.0006 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0017 0.0331
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0038 0.1083
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0029 0.0707
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0058 0.0168
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.002 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.1243 0.1242
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0038 0.0108
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0248
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0015 0.0123
Mycobacterium ulcerans glutamate synthase subunit beta 0.0021 0.0006 0.0014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0015 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0006 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0038 0.1083
Loa Loa (eye worm) thioredoxin reductase 0.0225 0.0325 0.2999
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0248
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0018 0.1657
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0038 0.0337
Loa Loa (eye worm) hypothetical protein 0.0047 0.0047 0.0421
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0248
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0078 0.0096 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2442
Toxoplasma gondii NADPH-glutathione reductase 0.0078 0.0096 0.2876
Schistosoma mansoni intermediate filament proteins 0.0027 0.0015 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0066 0.0066
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.0112 0.3312
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0066 0.0066
Loa Loa (eye worm) programmed cell death 8 0.0021 0.0006 0.0039
Schistosoma mansoni ferritin 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0514 0.0776 0.2292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1392
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0078 0.0096 0.2803
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0017 0.0331
Schistosoma mansoni hypothetical protein 0.0145 0.02 0.02
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0383 0.1129
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0047 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0053 0.0481
Treponema pallidum NADH oxidase 0.0078 0.0096 0.9323
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1395
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0179 0.1643
Schistosoma mansoni lamin 0.0027 0.0015 0.0015
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0078 0.0096 0.2803
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0047 0.0136
Mycobacterium ulcerans hypothetical protein 0.0047 0.0047 0.0136
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0066 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0194 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0556
Brugia malayi intermediate filament protein 0.0027 0.0015 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0015 0.0014
Echinococcus multilocularis geminin 0.017 0.0239 0.0238
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0047 0.3048
Plasmodium falciparum thioredoxin reductase 0.0078 0.0096 0.2803
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0021 0.0006 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0078 0.0096 0.2876
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0017 0.0428
Trypanosoma brucei trypanothione reductase 0.0225 0.0325 1
Toxoplasma gondii ABC1 family protein 0.0041 0.0038 0.1083
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0006 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.1145
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0078 0.0096 0.2803
Mycobacterium ulcerans ferredoxin reductase 0.0021 0.0006 0.0014
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0038 0.0036
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2183 0.3379 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0029 0.0707
Onchocerca volvulus 0.0027 0.0015 0.0275
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0021 0.0006 0.0014
Schistosoma mansoni hypothetical protein 0.0107 0.0141 0.0141
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0056 0.1607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0069 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0038 0.1083
Echinococcus multilocularis glutamate synthase 0.0021 0.0006 0.0005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0161 0.0225 0.2072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Schistosoma mansoni apoferritin-2 0.0018 0.0001 0.0001
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0021 0.0006 0.0005
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0021 0.0006 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0017 0.0331
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0078 0.0096 0.2803
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0021 0.0006 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0038 0.0333
Loa Loa (eye worm) hypothetical protein 0.0099 0.0128 0.1168
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.0112 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Schistosoma mansoni hypothetical protein 0.017 0.0239 0.0239
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.023 0.0228
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.002 0.0168
Echinococcus multilocularis thioredoxin glutathione reductase 0.0226 0.0327 0.0326
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0069 0.0069
Mycobacterium ulcerans TetR family transcriptional regulator 0.2187 0.3386 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0047 0.0136
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.0225 0.2075
Schistosoma mansoni cellular tumor antigen P53 0.021 0.0302 0.0302
Leishmania major trypanothione reductase 0.0225 0.0325 1
Echinococcus multilocularis protein patched 0.0042 0.004 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0047 0.1289
Leishmania major hypothetical protein, conserved 0.0041 0.0038 0.0993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0056 0.1631
Mycobacterium leprae Probable lipase LipE 0.0041 0.0038 0.0108
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0029 0.2343
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0058 0.0057
Entamoeba histolytica hypothetical protein 0.0107 0.0141 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0039
Entamoeba histolytica hypothetical protein 0.0107 0.0141 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0015 0.0127
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0021 0.0006 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0015 0.0127
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0021 0.0006 0.0141
Schistosoma mansoni disulfide oxidoreductase 0.0021 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0015 0.0123
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0038 0.0108
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0015 0.0127
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0015 0.0015
Echinococcus multilocularis lamin 0.0027 0.0015 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0015 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.002 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0015 0.0127
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0069 0.0069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0141 0.014
Onchocerca volvulus 0.0145 0.02 0.5825
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0015 0.0127
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0038 0.0108
Brugia malayi hypothetical protein 0.0709 0.108 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0078 0.0096 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0006 0.0141
Schistosoma mansoni glutamate synthase 0.0021 0.0006 0.0006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0069 0.02
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0103 0.0101
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0021 0.0006 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0047 0.0136
Schistosoma mansoni hypothetical protein 0.0051 0.0053 0.0053
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0021 0.0006 0.0014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 0.0299
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0047 0.0136
Echinococcus granulosus expressed conserved protein 0.0093 0.0119 0.0117
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0021 0.0006 0.0005
Brugia malayi jmjC domain containing protein 0.0059 0.0066 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0015 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0124
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0103 0.3088
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0103 0.0101
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0021 0.0006 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0078 0.0096 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0063 0.1843
Onchocerca volvulus 0.021 0.0302 0.8915
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0021 0.0006 0.0005
Mycobacterium tuberculosis Conserved protein 0.0041 0.0038 0.0108
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0103 0.3018
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0047 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0015 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0038 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0146 0.1337
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0021 0.0006 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0225 0.0325 1
Schistosoma mansoni patched 1 0.0042 0.004 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0112 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Onchocerca volvulus 0.0041 0.0038 0.0955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0015 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0029 0.0081
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0006 0.0005
Schistosoma mansoni lamin 0.0027 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.223
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0015 0.0015
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.002 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0078 0.0096 0.0278
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0514 0.0776 0.2287
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0141 0.014
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0038 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0048 0.1395
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0066 0.0064
Echinococcus multilocularis GPCR, family 2 0.0051 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0051 0.0053 0.0053
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.0188 0.0187
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0078 0.0096 0.2803
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0015 0.0127
Echinococcus granulosus lamin 0.0027 0.0015 0.0014
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0053 0.0477
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0015 0.0127
Echinococcus multilocularis musashi 0.0027 0.0015 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0078 0.0096 0.0278
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0021 0.0006 0.0014
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0021 0.0006 0.0014
Onchocerca volvulus 0.0027 0.0015 0.0273
Brugia malayi Pre-SET motif family protein 0.0029 0.002 0.0169
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.002 0.0437
Echinococcus granulosus glutamate synthase 0.0021 0.0006 0.0005
Mycobacterium tuberculosis Probable reductase 0.0514 0.0776 0.2292
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0015 0.0015
Loa Loa (eye worm) beta-lactamase 0.0041 0.0038 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2442
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0084 0.243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0015 0.0127
Toxoplasma gondii hypothetical protein 0.0028 0.0018 0.0473
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0021 0.0006 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0006 0.0141
Echinococcus granulosus intermediate filament protein 0.0027 0.0015 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0069 0.0199
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0078 0.0096 0.2803
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0128 0.0127

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of ERK 1/2 phosphorylation in human MDA-MB-231 cells at 5 to 20 uM after 12 hrs by Western blot analysis ChEMBL. 22926226
Inhibition (binding) Inhibition of IkappaBalpha phosphorylation in human MDA-MB-231 cells after 12 hrs by Western blot analysis ChEMBL. 22926226
Inhibition (binding) Inhibition of MMP9 in human MDA-MB-231 cells at 20 uM up to 12 hrs by gelatin-zymogrphy ChEMBL. 22926226
Inhibition (binding) Inhibition of IkappaBalpha phosphorylation in human MDA-MB-231 cells at 5 to 20 uM after 3 to 24 hrs by Western blot analysis ChEMBL. 22926226
Inhibition (binding) Inhibition of MMP2 in human MDA-MB-231 cells at 20 uM up to 12 hrs by gelatin-zymogrphy ChEMBL. 22926226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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