Detailed information for compound 575847

Basic information

Technical information
  • TDR Targets ID: 575847
  • Name: dialuminum trioxido(trioxidosilyloxy)silane
  • MW: 228.178 | Formula: Al2H6O7Si2
  • H donors: 0 H acceptors: 6 LogP: -3.28 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][Si](O[Si]([O-])([O-])[O-])([O-])[O-].[AlH3+3].[AlH3+3]
  • InChi: 1S/2Al.O7Si2/c;;1-8(2,3)7-9(4,5)6/q2*+3;-6
  • InChiKey: RUYJNKYXOHIGPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dialuminum tris(oxidanidyl)-tris(oxidanidyl)silyloxy-silane
  • dialuminum trioxido-trioxidosilyloxysilane
  • dialuminum trioxido-trioxidosilyloxy-silane
  • 22708-90-3
  • 233672-63-4
  • Silicic acid (H6Si2O7), aluminum salt (1:2)
  • Anhydrous aluminum silicate
  • Silicic acid, aluminum salt
  • EINECS 245-167-2
  • Dialuminium silicate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0093 0.2877
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0014 0.0125
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.0113 0.3499
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.9811
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0006 0.0394
Plasmodium vivax thioredoxin reductase, putative 0.0222 0.0323 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0172 0.0172
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0077 0.0095 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0038 0.1121
Schistosoma mansoni hypothetical protein 0.0148 0.0207 0.0207
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0067 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0014 0.0125
Entamoeba histolytica hypothetical protein 0.011 0.0146 1
Schistosoma mansoni hypothetical protein 0.011 0.0146 0.0146
Mycobacterium tuberculosis Probable oxidoreductase 0.0562 0.0859 0.2744
Echinococcus multilocularis tumor protein p63 0.1384 0.2154 0.2154
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0172 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0006 0.0179
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.9799
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0077 0.0095 0.0301
Toxoplasma gondii selenide, water dikinase 0.002 0.0006 0.0179
Plasmodium falciparum glutathione reductase 0.0222 0.0323 1
Schistosoma mansoni hypothetical protein 0.005 0.0052 0.0052
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0067 0.0067
Onchocerca volvulus 0.0041 0.0038 0.0969
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.004 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2475
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0006 0.0179
Toxoplasma gondii thioredoxin reductase 0.0222 0.0323 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.0113 0.3381
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.002 0.002
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0077 0.0095 0.2803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0038 0.0121
Echinococcus multilocularis musashi 0.0027 0.0016 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.6364 1 1
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.002 0.0006 0.0017
Brugia malayi TAR-binding protein 0.0126 0.0172 0.1539
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0013 0.0416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2475
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0297 0.2659
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0631
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.0006 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1429
Echinococcus multilocularis protein patched 0.0042 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0113 0.331
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0006 0.0006
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0506 0.077 0.246
Leishmania major hypothetical protein, conserved 0.0025 0.0013 0.0241
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0077 0.0095 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0179
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0038 0.0343
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0014 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0077 0.0095 0.2932
Brugia malayi jmjC domain containing protein 0.0059 0.0067 0.0597
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.0429
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0052 0.0052
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0006 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Echinococcus granulosus tumor protein p63 0.1384 0.2154 0.2154
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0056 0.0063 0.0561
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0048 0.0152
Mycobacterium ulcerans dehydrogenase 0.002 0.0006 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.0345 0.3088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0038 0.0038
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0006 0.0052
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.002 0.0006 0.0018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0006 0.0169
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.002 0.0006 0.0581
Schistosoma mansoni glutamate synthase 0.002 0.0006 0.0006
Mycobacterium ulcerans glutamate synthase subunit beta 0.002 0.0006 0.0017
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.0006 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0057 0.1667
Schistosoma mansoni glutamate synthase 0.002 0.0006 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.004 0.004
Echinococcus multilocularis glutamate synthase 0.002 0.0006 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.007 0.0221
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.002 0.0006 0.0017
Echinococcus granulosus lamin 0.0027 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.0429
Brugia malayi CHE-14 protein 0.0042 0.004 0.0362
Brugia malayi Pre-SET motif family protein 0.0029 0.002 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0343
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0077 0.0095 0.2932
Entamoeba histolytica hypothetical protein 0.011 0.0146 1
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0146 0.0146
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.0113 0.0113
Brugia malayi nuclear receptor NHR-88 0.0026 0.0014 0.0125
Echinococcus granulosus thioredoxin glutathione reductase 0.0223 0.0325 0.0325
Trypanosoma brucei trypanothione reductase 0.0222 0.0323 1
Mycobacterium ulcerans hypothetical protein 0.002 0.0006 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0038 0.1025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0064 0.1878
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0013 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0597
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.002 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.0207 0.1852
Schistosoma mansoni lamin 0.0027 0.0016 0.0016
Treponema pallidum oxidoreductase 0.002 0.0006 0.0581
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0048 0.0152
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0048 0.3266
Loa Loa (eye worm) hypothetical protein 0.0203 0.0293 0.2623
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0597
Schistosoma mansoni microtubule-associated protein tau 0.6364 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0172 0.1539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0014 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0013 0.0241
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0057 0.1667
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0052 0.0052
Echinococcus multilocularis survival motor neuron protein 1 0.0725 0.1116 0.1116
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0014 0.0125
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.002 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0343
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0048 0.0152
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0013 0.0416
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0562 0.0859 0.2739
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0113 0.3499
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0048 0.0152
Trypanosoma cruzi trypanothione reductase, putative 0.0222 0.0323 1
Schistosoma mansoni glutamate synthase 0.002 0.0006 0.0006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0562 0.0859 0.2744
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0015 0.0282
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.002 0.0006 0.0017
Echinococcus granulosus expressed conserved protein 0.0093 0.012 0.012
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.0113 0.7716
Mycobacterium tuberculosis Conserved protein 0.0041 0.0038 0.0121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0631
Mycobacterium tuberculosis Conserved protein 0.0041 0.0038 0.0121
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0038 0.0121
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0067 0.0067
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.002 0.0006 0.0018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0006 0.0169
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0006 0.0394
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0562 0.0859 0.2744
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0172 0.0172
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.0345 0.3088
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.004 0.004
Schistosoma mansoni patched 1 0.0042 0.004 0.004
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0006 0.0394
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0077 0.0095 0.2932
Schistosoma mansoni lamin 0.0027 0.0016 0.0016
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0006 0.0179
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0048 0.3266
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0006 0.0006
Onchocerca volvulus 0.0233 0.0341 1
Schistosoma mansoni cellular tumor antigen P53 0.0203 0.0293 0.0293
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.002 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0014 0.0125
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.0006 0.0179
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.007 0.0221
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0077 0.0095 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0056 0.1643
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.011 0.0146 1
Plasmodium vivax SET domain protein, putative 0.0029 0.002 0.0448
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0077 0.0095 0.2803
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0067 0.0067
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0077 0.0095 0.0095
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0006 0.0169
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2008 0.3137 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0014 0.0125
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0497
Mycobacterium ulcerans transcriptional regulator 0.2008 0.3137 1
Brugia malayi hypothetical protein 0.0025 0.0013 0.012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0222 0.0323 0.1031
Brugia malayi steroid hormone receptor 0.0026 0.0014 0.0125
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0006 0.0169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0014 0.0125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0221 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0597
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0113 0.1013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0082
Loa Loa (eye worm) hypothetical protein 0.0157 0.0221 0.1977
Echinococcus granulosus glutamate synthase 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0343
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0129 0.0129
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0196 0.0196
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0014 0.0014
Mycobacterium tuberculosis Probable reductase 0.0506 0.077 0.246
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0362
Giardia lamblia GTOR 0.0088 0.0113 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.002 0.0006 0.0017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0506 0.077 0.246
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.2747
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0014 0.0125
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0006 0.0169
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0038 0.0121
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0006 0.0179
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0006 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.002 0.0597
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0014 0.0014
Onchocerca volvulus 0.0027 0.0016 0.029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0052 0.0464
Schistosoma mansoni sulfide quinone reductase 0.002 0.0006 0.0006
Schistosoma mansoni coup transcription factor 0.0026 0.0014 0.0014
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2008 0.3137 1
Schistosoma mansoni hypothetical protein 0.0126 0.0172 0.0172
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0014 0.0014
Onchocerca volvulus 0.0047 0.0048 0.1253
Mycobacterium ulcerans ferredoxin reductase 0.002 0.0006 0.0017
Treponema pallidum thioredoxin reductase (trxB) 0.002 0.0006 0.0581
Trichomonas vaginalis glutathione reductase, putative 0.0077 0.0095 0.2773
Loa Loa (eye worm) hypothetical protein 0.0725 0.1116 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0006 0.0006
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0093 0.2747
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0014 0.0014
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0006 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2932
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0221 0.1977
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0213 0.0213
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0038 0.0038
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.002 0.0006 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.0095 0.2932
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.0006 0.0394
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.9799
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.002 0.002
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.002 0.0006 0.0018
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0461
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0014 0.0125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.026
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0172 0.0172
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0048 0.0429
Brugia malayi hypothetical protein 0.0725 0.1116 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0032 0.0976
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0506 0.077 0.246
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0172 0.1539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0172 0.1539
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0038 0.1121
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.0113 0.7716
Brugia malayi beta-lactamase family protein 0.0041 0.0038 0.0343
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.002 0.0631
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.007 0.2155
Plasmodium vivax glutathione reductase, putative 0.0222 0.0323 1
Brugia malayi RNA binding protein 0.0126 0.0172 0.1539
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2803
Brugia malayi hypothetical protein 0.011 0.0146 0.1312
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0093 0.0295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0113 0.331
Mycobacterium ulcerans hypothetical protein 0.0041 0.0038 0.0121
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0077 0.0095 0.2803
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.0006 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2475
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0085 0.262
Mycobacterium ulcerans lipase LipD 0.0041 0.0038 0.0121
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.005 0.0052 0.0052
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.0113 0.3499
Brugia malayi beta-lactamase 0.0041 0.0038 0.0343
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0343
Giardia lamblia NADH oxidase lateral transfer candidate 0.0077 0.0095 0.8292
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.002 0.0006 0.0018
Mycobacterium ulcerans hypothetical protein 0.0047 0.0048 0.0152
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0113 0.331
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0172 0.0172
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0093 0.0093
Schistosoma mansoni sulfide quinone reductase 0.002 0.0006 0.0006
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.002 0.0006 0.0017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.0295
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0014 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0052 0.0165
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0013 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0172 0.0172
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0077 0.0095 0.0095
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0015 0.0282
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0052 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1432
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0038 0.1185
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0052 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0067 0.1966
Loa Loa (eye worm) hypothetical protein 0.0107 0.0142 0.1276
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0506 0.077 0.246
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.002 0.0461
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0076 0.0093 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0014 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0129 0.1158
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.007 0.007
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0006 0.0169
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0014 0.0014
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0006 0.0006
Echinococcus multilocularis lamin 0.0027 0.0016 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0016 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0084 0.2475
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0085 0.262
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0003 0.0093
Toxoplasma gondii ABC1 family protein 0.0041 0.0038 0.1185
Onchocerca volvulus 0.0026 0.0014 0.0245
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0506 0.077 0.2455
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.0006 0.0179
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.002 0.0619
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.002 0.002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0014 0.0014
Brugia malayi Pre-SET motif family protein 0.0205 0.0297 0.2659
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0056 0.0063 0.0561
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0077 0.0095 0.2932
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0077 0.0095 0.0302
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0006 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Schistosoma mansoni intermediate filament proteins 0.0027 0.0016 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0077 0.0095 0.2803
Brugia malayi ecdysteroid receptor 0.0026 0.0014 0.0125
Brugia malayi jmjC domain containing protein 0.0059 0.0067 0.0597
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0000000019412 0.0000000019412
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0006 0.0052
Echinococcus multilocularis expressed conserved protein 0.0093 0.012 0.012
Plasmodium falciparum glutathione reductase 0.0077 0.0095 0.2803
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0048 0.1326
Trypanosoma brucei NADH dehydrogenase 0.002 0.0006 0.0179
Brugia malayi Latrophilin receptor protein 2 0.005 0.0052 0.0464
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0048 0.3266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2932
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0006 0.0179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.007 0.0221
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0006 0.0179
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0013 0.0416
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.026
Brugia malayi beta-lactamase family protein 0.0041 0.0038 0.0343
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.0077 0.2393
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.004 0.1225
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.0113 0.3381
Leishmania major trypanothione reductase 0.0222 0.0323 1
Loa Loa (eye worm) programmed cell death 8 0.002 0.0006 0.0052
Entamoeba histolytica hypothetical protein 0.011 0.0146 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0048 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0343
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0077 0.0095 0.0848
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0006 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0014 0.0014
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0006 0.0169
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0014 0.0014
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0006 0.0169
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0006 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0014 0.0125
Schistosoma mansoni hypothetical protein 0.0107 0.0142 0.0142
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.002 0.0006 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0014 0.0125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0146 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0057 0.1667
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0038 0.1185
Echinococcus multilocularis GPCR, family 2 0.005 0.0052 0.0052
Mycobacterium ulcerans beta-lactamase 0.0041 0.0038 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0048 0.0152
Plasmodium falciparum thioredoxin reductase 0.0222 0.0323 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.004 0.004
Onchocerca volvulus 0.0203 0.0293 0.855
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0213 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0048 0.0152
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.007 0.007
Mycobacterium ulcerans TetR family transcriptional regulator 0.2008 0.3137 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0223 0.0325 0.0325
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0006 0.0169
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.002 0.0006 0.0179
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2803
Echinococcus granulosus survival motor neuron protein 1 0.0725 0.1116 0.1116
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0014 0.0125
Onchocerca volvulus 0.0148 0.0207 0.5986
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0142 0.1276
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.007 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0014 0.0125
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0015 0.153
Toxoplasma gondii hypothetical protein 0.0026 0.0015 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0014 0.0125
Leishmania major hypothetical protein, conserved 0.0041 0.0038 0.1025
Loa Loa (eye worm) RNA binding protein 0.0126 0.0172 0.1539
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0038 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0006 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.007 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0146 0.0146
Mycobacterium ulcerans NADH dehydrogenase 0.002 0.0006 0.0017
Schistosoma mansoni hypothetical protein 0.005 0.0052 0.0052
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0006 0.0169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0014 0.0014
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0029 0.0735
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2004 0.3131 1
Brugia malayi glutamate synthase 0.002 0.0006 0.0052
Mycobacterium leprae Probable lipase LipE 0.0041 0.0038 0.0121
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.1184
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.0006 0.0394
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.002 0.0631
Echinococcus granulosus geminin 0.017 0.0241 0.0241
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0221 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.0113 0.3499
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0129 0.8825
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0038 0.1121
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0006 0.0006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0077 0.0095 0.0301
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0014 0.0125
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0006 0.0169
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0077 0.0095 0.2803
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0006 0.0006
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0006 0.0179
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0093 0.0093
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0213 0.0213
Echinococcus granulosus tar DNA binding protein 0.0126 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1432
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0006 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0077 0.0095 0.2932
Loa Loa (eye worm) hypothetical protein 0.005 0.0052 0.0464
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.0429
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0387 0.1234
Schistosoma mansoni survival motor neuron protein 0.0148 0.0207 0.0207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0014 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2932
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0006 0.0169
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0014 0.0125
Brugia malayi Thioredoxin reductase 0.0222 0.0323 0.2894
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0014 0.0245
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0038 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2932
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0006 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0048 0.0152
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0077 0.0095 0.2932
Schistosoma mansoni hypothetical protein 0.017 0.0241 0.0241
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0014 0.0245
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0016 0.0139
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.002 0.002
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0196 0.0196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0067 0.0067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0048 0.0152
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0048 0.1326
Trichomonas vaginalis mercuric reductase, putative 0.0077 0.0095 0.2773
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0014 0.0014
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.002 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0014 0.0245
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0029 0.2621
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0077 0.0095 0.2932
Mycobacterium tuberculosis Conserved protein 0.0041 0.0038 0.0121
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.1255 0.1255
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.002 0.0006 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0038 0.1121
Onchocerca volvulus 0.0029 0.002 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0056 0.1643
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0029 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0014 0.0125
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0006 0.0179
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0014 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0048 0.0429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1429
Mycobacterium tuberculosis Probable dehydrogenase 0.0506 0.077 0.246
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0006 0.0179
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.0006 0.0394
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0067 0.0067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.0113 0.0113
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0095 0.2932
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0085 0.2486
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0077 0.0095 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0029 0.0735
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0048 0.0152
Loa Loa (eye worm) beta-lactamase 0.0041 0.0038 0.0343
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0018 0.0018
Loa Loa (eye worm) glutathione reductase 0.0222 0.0323 0.2894
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0029 0.0092
Trichomonas vaginalis esterase, putative 0.0041 0.0038 0.1121
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.002 0.0006 0.0581
Brugia malayi nuclear hormone receptor 0.0026 0.0014 0.0125
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0341 1
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0014 0.0125
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0093 0.9811
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0093 0.2877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0006 0.0179
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0006 0.0179
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0038 0.0121
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0038 0.0121
Brugia malayi Probable ClpP-like protease 0.0076 0.0093 0.0832
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.002 0.0006 0.0581
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0113 0.1013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0125
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0048 0.0152
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0014 0.0125
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0067 0.0597
Echinococcus granulosus GPCR family 2 0.005 0.0052 0.0052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0038 0.0121
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.002 0.0006 0.0017
Brugia malayi intermediate filament protein 0.0027 0.0016 0.0139
Echinococcus granulosus lamin dm0 0.0027 0.0016 0.0016
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0016 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0038 0.1185
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0014 0.0125
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0129 0.0129
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.007 0.2013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0132 0.0132
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0014 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0077 0.0095 0.2932
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0014 0.0125
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0038 0.0121
Trichomonas vaginalis ferritin, putative 0.0017 0 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0093 0.2713
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0015 0.0046
Plasmodium falciparum thioredoxin reductase 0.0077 0.0095 0.2803
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0343
Brugia malayi MH2 domain containing protein 0.0235 0.0345 0.3088
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0172 0.0172
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0014 0.0014
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0048 0.0152
Treponema pallidum NADH oxidase 0.0077 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0139
Brugia malayi glutathione reductase 0.0222 0.0323 0.2894
Echinococcus multilocularis geminin 0.017 0.0241 0.0241
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0077 0.0095 0.2803
Loa Loa (eye worm) hypothetical protein 0.0099 0.0129 0.1158
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0006 0.0006
Loa Loa (eye worm) thioredoxin reductase 0.0222 0.0323 0.2894
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0052 0.0052
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.0113 0.0113
Echinococcus granulosus intermediate filament protein 0.0027 0.0016 0.0016
Onchocerca volvulus 0.0027 0.0016 0.029
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0013 0.0241
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0038 0.1121
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0172 0.0172
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0052 0.0165
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0038 0.0121
Onchocerca volvulus 0.0041 0.0038 0.0969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1432
Mycobacterium ulcerans monoxygenase 0.002 0.0006 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0038 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.017 0.0241 0.0241
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0006 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.002 0.0183
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.0006 0.0179
Onchocerca volvulus 0.0041 0.0038 0.0969
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0048 0.1326
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0014 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0014 0.0125
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0038 0.0343
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0077 0.0095 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.007 0.007
Schistosoma mansoni hypothetical protein 0.005 0.0052 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0077 0.2264
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0003 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0014 0.0125
Echinococcus multilocularis protein dispatched 1 0.0048 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0014 0.0014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0014 0.0014
Echinococcus multilocularis lamin dm0 0.0027 0.0016 0.0016

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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