Detailed information for compound 57688

Basic information

Technical information
  • TDR Targets ID: 57688
  • Name: 2-[(Z)-4-[4-(1,2-benzothiazol-3-yl)piperazin- 1-yl]but-2-enyl]-3H-isoindol-1-one
  • MW: 404.528 | Formula: C23H24N4OS
  • H donors: 0 H acceptors: 2 LogP: 3.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(C/C=C\CN2CCN(CC2)c2nsc3c2cccc3)Cc2c1cccc2
  • InChi: 1S/C23H24N4OS/c28-23-19-8-2-1-7-18(19)17-27(23)12-6-5-11-25-13-15-26(16-14-25)22-20-9-3-4-10-21(20)29-24-22/h1-10H,11-17H2/b6-5-
  • InChiKey: HDAOSJDKRACLFF-WAYWQWQTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(Z)-4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]but-2-enyl]isoindolin-1-one
  • 2-[(Z)-4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]but-2-enyl]-1-isoindolinone
  • 2-[(Z)-4-[4-(1,2-benzothiazol-3-yl)piperazino]but-2-enyl]isoindolin-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 2 (5-HT2) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.005 0.0074
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.005 0.0074
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.119 0.5849
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0039 0.0039
Schistosoma mansoni dep domain containing protein 0.0009 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Onchocerca volvulus Huntingtin homolog 0.0122 0.1076 0.6058
Onchocerca volvulus 0.001 0.0039 0.0222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.005 0.0074
Schistosoma mansoni histamine h1 receptor 0.0011 0.005 0.0074
Brugia malayi G-protein coupled receptor 0.0011 0.005 0.0245
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi Dopamine receptor protein 2 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0376
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.0359
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.1388
Echinococcus multilocularis serotonin receptor 0.0159 0.1416 0.2117
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0113
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.005 0.0245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0136
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.1388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0076 0.0037
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0023 0.0034
Onchocerca volvulus 0.0014 0.0076 0.043
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0076 0.0186
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0397 0.1633
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.005 0.0074
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0076 0.0022
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0076 0.0155
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0125 0.1104 0.1215
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.005 0.0074
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0023 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.1388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0112 0.0167
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.005 0.0074
Echinococcus granulosus allatostatin A receptor 0.0011 0.005 0.0074
Echinococcus granulosus g protein coupled receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.119 0.5849
Schistosoma mansoni adenoreceptor 0.0011 0.005 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074
Brugia malayi topoisomerase 0.001 0.0039 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0039 0.0039
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0076 0.0376
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0376
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0112 1
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.005 0.0074
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.005 0.0074
Echinococcus granulosus fmrfamide receptor 0.0011 0.005 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.0359
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.005 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0002
Echinococcus granulosus sex peptide receptor 0.0011 0.005 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0039 0.0194
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0194
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0076 0.0376
Toxoplasma gondii hypothetical protein 0.0134 0.119 1
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.005 0.0245
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.005 0.0245
Loa Loa (eye worm) carbonic anhydrase 3 0.0225 0.2034 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.005 0.028
Toxoplasma gondii exonuclease III APE 0.0018 0.0112 0.0763
Onchocerca volvulus 0.0011 0.005 0.028
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0397 0.0359
Schistosoma mansoni hypothetical protein 0.0034 0.0263 0.0393
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.119 0.5849
Brugia malayi larval opioid receptor 0.0011 0.005 0.0245
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0397 0.0359
Echinococcus multilocularis g protein coupled receptor 0.0011 0.005 0.0074
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.005 0.0074
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.119 0.1779
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0397 0.1496
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Echinococcus multilocularis neuropeptide receptor 0.0011 0.005 0.0074
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.005 0.0074
Brugia malayi RE15519p 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.1388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0264 0.0239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0076 0.0076
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0023 0.0113
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.005 0.0074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0136
Mycobacterium ulcerans integral membrane transporter 0.0031 0.0235 0.0196
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0023 0.0113
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0076 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi DKFZp564C0469 protein 0.001 0.0039 0.0194
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0282 1
Echinococcus granulosus serotonin receptor 0.0011 0.005 0.0074
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.005 0.0074
Schistosoma mansoni hypothetical protein 0.0011 0.005 0.0074
Onchocerca volvulus 0.0011 0.005 0.028
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.005 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi sulfakinin receptor protein 0.0011 0.005 0.0245
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.2985
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0039 0.0039
Trypanosoma brucei carbonic anhydrase-like protein 0.0225 0.2034 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.119 0.5849
Onchocerca volvulus 0.0028 0.0201 0.1131
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0076 0.0322
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0023 0.0034
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0282 1
Brugia malayi Dopamine receptor 0.0011 0.005 0.0245
Schistosoma mansoni dishevelled 0.0009 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0159 0.1416 0.6959
Onchocerca volvulus 0.0011 0.005 0.028
Echinococcus granulosus nibrin 0.001 0.0039 0.0059
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.6689 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0112 0.046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.005 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074
Echinococcus granulosus microtubule associated protein 2 0.0726 0.6689 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0194
Echinococcus multilocularis g protein coupled receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.005 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0023 0.0034
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Brugia malayi Melatonin receptor type 1A 0.0011 0.005 0.0245
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0039 0.0141
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0039 0.0194
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0076 0.1525
Onchocerca volvulus 0.0009 0.0023 0.0129
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0076 0.0114
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0023 0.0129
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0023 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.005 0.0074
Echinococcus granulosus GPCR family 2 0.0016 0.0091 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0076 0.0022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1952
Loa Loa (eye worm) hypothetical protein 0.0134 0.119 0.5849
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1952
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0039 0.0039
Schistosoma mansoni topbp1 0.001 0.0039 0.0059
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0225 0.2034 0.3042
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.005 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0039 0.0194
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.005 0.0074
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0225 0.2034 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0076 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.005 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Entamoeba histolytica carbonic anhydrase, putative 0.0268 0.2431 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0076 0.0022
Leishmania major carbonic anhydrase-like protein 0.0225 0.2034 0.8315
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.005 0.0074
Brugia malayi hypothetical protein 0.001 0.0039 0.0194
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0031 0.0235 0.1156
Brugia malayi Serotonin receptor 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni neuropeptide receptor 0.0011 0.005 0.0074
Echinococcus granulosus somatostatin receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni cpg binding protein 0.0029 0.0216 0.0322
Schistosoma mansoni neuropeptide receptor 0.0011 0.005 0.0074
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0007 0.0011
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0031 0.0235 0.0981
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0007 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0112 0.0151
Echinococcus granulosus carbonic anhydrase 0.0134 0.119 0.1779
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0023 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0002
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0225 0.2034 1
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.005 0.0074
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.005 0.0074
Brugia malayi Serotonin receptor 0.0011 0.005 0.0245
Schistosoma mansoni neuropeptide receptor 0.0011 0.005 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0039 0.0039
Brugia malayi hypothetical protein 0.0009 0.0023 0.0113
Mycobacterium ulcerans carbonic anhydrase 0.0268 0.2431 0.2401
Echinococcus granulosus carbonic anhydrase II 0.0225 0.2034 0.3042
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0076 0.0376
Onchocerca volvulus 0.0011 0.005 0.028
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0076 0.0376
Echinococcus multilocularis carbonic anhydrase II 0.0225 0.2034 0.3042
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0076 0.0459
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0228 0.206 0.2324
Brugia malayi AKH receptor 0.0011 0.005 0.0245
Brugia malayi neuropeptide F receptor 0.0011 0.005 0.0245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0264 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0076 0.0022
Brugia malayi putative neuropeptide receptor 0.0011 0.005 0.0245
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0007 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.005 0.0074
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.005 0.0074
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0076 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.055
Brugia malayi DIX domain containing protein 0.0009 0.0023 0.0113
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0263 0.1291
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0031 0.0235 0.1701
Schistosoma mansoni carbonic anhydrase 0.0268 0.2431 0.3635
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.005 0.0074
Schistosoma mansoni carbonic anhydrase 0.0134 0.119 0.1779
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0023 0.0034
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.005 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0397 0.1633
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Echinococcus granulosus hypothetical protein 0.0011 0.005 0.0074
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.005 0.0074
Echinococcus granulosus g protein coupled receptor 0.0011 0.005 0.0074
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.005 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0091 0.0447
Onchocerca volvulus Huntingtin homolog 0.0122 0.1076 0.6058
Onchocerca volvulus 0.0011 0.005 0.028
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.005 0.0245
Echinococcus granulosus g-protein coupled receptor 0.0011 0.005 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0397 0.0394
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0023 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1362
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1952
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.005 0.0074
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.005 0.0074
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Onchocerca volvulus 0.0011 0.005 0.028
Schistosoma mansoni cpg binding protein 0.0029 0.0216 0.0322
Schistosoma mansoni opsin-like receptor 0.0011 0.005 0.0074
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0076 0.0459
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0112 0.055
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.005 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0076 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.005 0.0245
Brugia malayi G protein-coupled receptor 0.0011 0.005 0.0245
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.005 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0002
Echinococcus granulosus replication factor c subunit 1 0.001 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Echinococcus multilocularis sex peptide receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni cpg binding protein 0.0028 0.0201 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0076 0.0376
Echinococcus multilocularis fmrfamide receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0194
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.005 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0091 0.0447
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.005 0.0074
Onchocerca volvulus 0.0011 0.005 0.028
Loa Loa (eye worm) hypothetical protein 0.005 0.041 0.2017
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1952
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Echinococcus multilocularis allatostatin A receptor 0.0011 0.005 0.0074
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.005 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0112 0.055
Echinococcus granulosus g protein coupled receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.1388
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi hypothetical protein 0.0122 0.1076 0.5289
Schistosoma mansoni amine GPCR 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0076 0.0022
Brugia malayi CXXC zinc finger family protein 0.0028 0.0201 0.0987
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.041 0.2017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0397 0.0359
Onchocerca volvulus 0.0011 0.005 0.028
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.041 0.2017
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0225 0.2034 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0076 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Onchocerca volvulus 0.0011 0.005 0.028
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni amine GPCR 0.0011 0.005 0.0074
Echinococcus granulosus carbonic anhydrase 0.0134 0.119 0.1779
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.005 0.0074
Entamoeba histolytica hypothetical protein 0.001 0.0039 0.0162
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0076 0.0114
Onchocerca volvulus 0.0014 0.0076 0.043
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0076 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0023 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0076 0.0022
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0031 0.0235 0.1818
Loa Loa (eye worm) hypothetical protein 0.0134 0.119 0.5849
Onchocerca volvulus 0.0011 0.005 0.028
Onchocerca volvulus 0.0011 0.005 0.028
Schistosoma mansoni biogenic amine receptor 0.0011 0.005 0.0074
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.1416 0.2117
Echinococcus multilocularis carbonic anhydrase 0.0134 0.119 0.1779
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1362
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0076 0.0037
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0076 0.0186
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.005 0.0074
Echinococcus multilocularis g protein coupled receptor 0.0011 0.005 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0091 0.0447
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni hypothetical protein 0.0011 0.005 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0282 0.0244
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0076 0.0376
Loa Loa (eye worm) oxidoreductase 0.0014 0.0076 0.0376
Onchocerca volvulus 0.0011 0.005 0.028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0264 0.0239
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.119 0.1779
Echinococcus granulosus neuropeptide receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0194
Echinococcus multilocularis nibrin 0.001 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.094 0.8673 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.005 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.005 0.0074
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.0167
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0225 0.2034 0.3042
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.1291
Echinococcus multilocularis cpg binding protein 0.0029 0.0216 0.0322
Mycobacterium ulcerans hypothetical protein 0.0049 0.0397 0.0359
Echinococcus multilocularis carbonic anhydrase 0.0134 0.119 0.1779
Brugia malayi GnHR receptor homolog 0.0011 0.005 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Echinococcus multilocularis somatostatin receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.005 0.0245
Brugia malayi hypothetical protein 0.0009 0.0023 0.0113
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.005 0.0074
Echinococcus granulosus cpg binding protein 0.0029 0.0216 0.0322
Onchocerca volvulus 0.0197 0.1776 1
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1952
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Echinococcus multilocularis orexin receptor type 2 0.0011 0.005 0.0074
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0282 0.0261
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0431 0.35
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0282 0.2112
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1362
Echinococcus granulosus carbonic anhydrase 0.0134 0.119 0.1779
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0011 0.005 0.0074
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0039 0.0194
Plasmodium falciparum carbonic anhydrase 0.0134 0.119 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0091 0.0136
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0023 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0112 0.0073
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0031 0.0235 0.0196
Loa Loa (eye worm) hypothetical protein 0.0174 0.1563 0.7684
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0076 0.0376
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0136
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0039 0.0059
Schistosoma mansoni dishevelled 0.0009 0.0023 0.0034
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0076 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.005 0.0074
Schistosoma mansoni myosin xvIII 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0076 0.0314
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0225 0.2034 1
Trichomonas vaginalis conserved hypothetical protein 0.1083 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0112 0.0167
Brugia malayi G-protein coupled receptor 0.0011 0.005 0.0245
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0112 0.0063
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.005 0.028
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0023 0.0034
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0007 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074
Schistosoma mansoni topbp1 0.001 0.0039 0.0059
Chlamydia trachomatis sulfate transporter 0.0031 0.0235 0.8055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0112
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0023 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0076 0.0376
Schistosoma mansoni biogenic amine receptor 0.0011 0.005 0.0074
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.005 0.0074
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.005 0.0074
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.005 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0397 0.1496
Schistosoma mansoni hypothetical protein 0.0134 0.119 0.1779
Brugia malayi follicle stimulating hormone receptor 0.0011 0.005 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0039 0.0039
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0076 0.0155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0225 0.2034 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.005 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Plasmodium vivax sulfate transporter, putative 0.0031 0.0235 0.8055
Schistosoma mansoni hypothetical protein 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0091 0.0447
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0076 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0076 0.0376
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.049 0.0732
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0023 0.0034
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Onchocerca volvulus 0.0011 0.005 0.028
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.0122 0.1076 0.5289
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0159 0.1416 0.6959
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0371 0.3387 0.3864
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0364
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0076 0.0022
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.005 0.0245
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.005 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0011 0.005 0.0074
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.005 0.0074
Echinococcus granulosus orexin receptor type 2 0.0011 0.005 0.0074
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.119 0.5849
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0076 0.0376
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0076 0.0037
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.005 0.0074
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.119 0.1779
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.005 0.0245
Leishmania major carbonic anhydrase family protein, putative 0.0268 0.2431 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0076 0.0037
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0112 0.055
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.005 0.0245
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0136
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.005 0.0074
Schistosoma mansoni DNA ligase IV 0.001 0.0039 0.0059
Onchocerca volvulus 0.0011 0.005 0.028
Onchocerca volvulus 0.0011 0.005 0.028
Schistosoma mansoni opsin-like receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0122 0.1076 0.5289
Schistosoma mansoni neuropeptide receptor 0.0011 0.005 0.0074
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0002 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0136
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0201 0.0987
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.005 0.0074
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.119 0.5849
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.119 0.5849
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0076 0.0376
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0076 0.0037
Schistosoma mansoni hypothetical protein 0.0011 0.005 0.0074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0112 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.005 0.0074
Brugia malayi ORL1-like opioid receptor 0.0011 0.005 0.0245
Onchocerca volvulus 0.0014 0.0076 0.043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.005 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.005 0.0245
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.063
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.005 0.0074
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0031 0.0235 0.1156
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.005 0.0074
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.005 0.0245
Brugia malayi hypothetical protein 0.001 0.0039 0.0194
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.1563 0.8802
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0039 0.0194
Brugia malayi hypothetical protein 0.0011 0.005 0.0245
Brugia malayi N-terminal motif family protein 0.0174 0.1563 0.7684
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0397 0.1633
Onchocerca volvulus 0.0011 0.005 0.028
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.005 0.0074
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0023 0.0113
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0022 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.1083 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0023 0.0034
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0023 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0076 0.0376
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.005 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0011 0.005 0.0074
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0023 0.0113
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.005 0.0074
Onchocerca volvulus 0.0049 0.0397 0.2236
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0194
Echinococcus multilocularis fmrfamide receptor 0.0011 0.005 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0039 0.0194
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0397 0.0394
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0031 0.0235 0.0196
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0039 0.0141
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0023 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.0359
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0039 0.0162
Onchocerca volvulus 0.0011 0.005 0.028
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0039 0.0059
Brugia malayi neuropeptide F receptor 0.0011 0.005 0.0245
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0112 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.005 0.0074
Schistosoma mansoni amine GPCR 0.0011 0.005 0.0074
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0076 0.0076
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.6689 1
Echinococcus multilocularis neuropeptide receptor 0.0011 0.005 0.0074
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.005 0.0074
Echinococcus granulosus neuropeptide receptor 0.0011 0.005 0.0074
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.005 0.0074
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0076 0.0459
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.005 0.0074
Mycobacterium leprae Probable transmembrane transport protein 0.0228 0.206 0.8449
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.005 0.0074
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0136
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0268 0.2431 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0076 0.0037
Onchocerca volvulus Putative sulfate transporter 0.0197 0.1776 1
Echinococcus multilocularis carbonic anhydrase 0.0134 0.119 0.1779
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0264 0.0239
Brugia malayi Dopamine receptor protein 1 0.0011 0.005 0.0245
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0076 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.005 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.041 0.2017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.005 0.0245
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0245
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0194
Trichomonas vaginalis helicase, putative 0.0006 0.0002 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0397 0.0359
Echinococcus multilocularis serotonin receptor 0.0159 0.1416 0.2117
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0076 0.0037
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0023 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1952
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.005 0.0074
Onchocerca volvulus 0.0014 0.0076 0.043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.1416 0.2117
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.005 0.0074

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 13.9 mg kg-1 In vivo inhibition of apomorphine-induced climbing response in mice. ChEMBL. 8568802
ED50 (functional) = 13.9 mg kg-1 In vivo inhibition of apomorphine-induced climbing response in mice. ChEMBL. 8568802
IC50 (binding) = 5.5 nM Inhibition of [3H]-ketanserin binding at 5-hydroxytryptamine 2 receptor from rat frontal cortex. ChEMBL. 8568802
IC50 (binding) = 5.5 nM Inhibition of [3H]-ketanserin binding at 5-hydroxytryptamine 2 receptor from rat frontal cortex. ChEMBL. 8568802
IC50 (binding) = 43 nM Inhibition of [3H]-raclopride binding at Dopamine receptor D2 from rat striata. ChEMBL. 8568802
IC50 (binding) = 43 nM Inhibition of [3H]-raclopride binding at Dopamine receptor D2 from rat striata. ChEMBL. 8568802
IC50 (binding) = 44 nM Inhibition of [3H]-8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue. ChEMBL. 8568802
IC50 (binding) = 44 nM Inhibition of [3H]-8-OH-DPAT binding at serotonin 5-hydroxytryptamine 1A receptor from rat hippocampus tissue. ChEMBL. 8568802

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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