Detailed information for compound 581958

Basic information

Technical information
  • TDR Targets ID: 581958
  • Name: ethyl (2S)-2-[(2-acetoxybenzoyl)amino]-3-phen yl-propanoate
  • MW: 355.384 | Formula: C20H21NO5
  • H donors: 1 H acceptors: 3 LogP: 3.23 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)[C@@H](NC(=O)c1ccccc1OC(=O)C)Cc1ccccc1
  • InChi: 1S/C20H21NO5/c1-3-25-20(24)17(13-15-9-5-4-6-10-15)21-19(23)16-11-7-8-12-18(16)26-14(2)22/h4-12,17H,3,13H2,1-2H3,(H,21,23)/t17-/m0/s1
  • InChiKey: KMAAFJXQASELNT-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2-acetoxyphenyl)-oxomethyl]amino]-3-phenylpropanoic acid ethyl ester
  • ethyl (2S)-2-[(2-acetyloxyphenyl)carbonylamino]-3-phenyl-propanoate
  • (2S)-2-[(2-acetoxybenzoyl)amino]-3-phenyl-propionic acid ethyl ester
  • ethyl (2S)-2-[(2-acetyloxybenzoyl)amino]-3-phenylpropanoate
  • aspirin phenylalanine ethyl ester
  • 76748-72-6
  • APAEE
  • L-Phenylalanine, N-(2-(acetyloxy)benzoyl)-, ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0578 0.0907
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.7021 0.6911
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0741 0.0398
Brugia malayi hypothetical protein 0.0025 0.0195 0.0277
Schistosoma mansoni hypothetical protein 0.0042 0.0638 0.0638
Brugia malayi glutathione reductase 0.0046 0.0741 0.1056
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0578 0.3377
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0266 0.0379
Loa Loa (eye worm) glutathione reductase 0.0046 0.0741 0.1056
Leishmania major DNA polymerase eta, putative 0.0082 0.1713 1
Brugia malayi Disintegrin family protein 0.0133 0.3051 0.4345
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.1042 0.0709
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.1042 0.1042
Schistosoma mansoni zinc finger protein 0.0041 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0067 0.1316 0.1875
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0061
Loa Loa (eye worm) hypothetical protein 0.0126 0.2863 0.4078
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0216 0.0331
Trypanosoma brucei ISWI complex protein 0.0031 0.0352 0.2054
Brugia malayi Bromodomain containing protein 0.0078 0.1585 0.2258
Loa Loa (eye worm) hypothetical protein 0.0103 0.2245 0.3197
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0741 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0308
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.1042 0.1654
Schistosoma mansoni hypothetical protein 0.0031 0.0358 0.0358
Brugia malayi Bromodomain containing protein 0.0154 0.3596 0.5121
Mycobacterium tuberculosis Probable reductase 0.0104 0.2292 0.3669
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0578 0.3377
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0386 0.055
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0366 0.2137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0462 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.7021 0.7021
Loa Loa (eye worm) glutaminase 0.0264 0.6528 0.9297
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0573 0.3345
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Trypanosoma cruzi ISWI complex protein 0.0031 0.0352 0.2054
Loa Loa (eye worm) disintegrin family protein 0.0066 0.1285 0.1831
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0245 0.6007 0.6007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1458 0.1142
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2292 0.3669
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0462 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.109 0.109
Leishmania major DNA polymerase eta, putative 0.0043 0.0671 0.3918
Mycobacterium tuberculosis Conserved protein 0.004 0.0578 0.0907
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Echinococcus multilocularis dna polymerase kappa 0.0057 0.1042 0.0709
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0578 0.0344
Echinococcus multilocularis zinc finger protein 0.0041 0.0623 0.0275
Brugia malayi angiogenesis inhibito 0.0078 0.1584 0.2256
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0216 0.0331
Schistosoma mansoni zinc finger protein 0.0031 0.0352 0.0352
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0578 0.0578
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0446 0.0092
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0671 0.6386
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.1042 0.1096
Schistosoma mansoni cpg binding protein 0.0028 0.0266 0.0266
Echinococcus granulosus dna polymerase kappa 0.0057 0.1042 0.0709
Schistosoma mansoni hypothetical protein 0.0067 0.1316 0.1316
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0782 0.0782
Loa Loa (eye worm) hypothetical protein 0.0035 0.0462 0.0658
Schistosoma mansoni glutaminase 0.0264 0.6528 0.6528
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0578 0.0886
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0358 0.0509
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0028 0.0271 0.0271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.7021 0.6911
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0061
Brugia malayi Thioredoxin reductase 0.0046 0.0741 0.1056
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0195 0.2626
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0462 0.0108
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0216 0.0331
Loa Loa (eye worm) hypothetical protein 0.0083 0.1716 0.2444
Echinococcus granulosus geminin 0.0349 0.8752 0.8705
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.7021 0.7021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0271 0.0385
Schistosoma mansoni hypothetical protein 0.0396 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.26 0.4165
Echinococcus multilocularis geminin 0.0349 0.8752 0.8705
Echinococcus multilocularis disintegrin and metalloproteinase 0.0133 0.3051 0.2793
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0245 0.6007 0.5859
Echinococcus granulosus adam 0.0176 0.4176 0.3961
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0578 0.0344
Trypanosoma cruzi ISWI complex protein 0.0031 0.0352 0.2054
Giardia lamblia DINP protein human, muc B family 0.0057 0.1042 1
Schistosoma mansoni hypothetical protein 0.0349 0.8752 0.8752
Echinococcus granulosus disintegrin and metalloproteinase 0.0133 0.3051 0.2793
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.26 0.4165
Loa Loa (eye worm) hypothetical protein 0.004 0.0578 0.0824
Schistosoma mansoni hypothetical protein 0.0031 0.0358 0.0358
Brugia malayi Reprolysin 0.0178 0.4241 0.6041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0308
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1458 0.1142
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0216 0.0324
Onchocerca volvulus 0.004 0.0578 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.1042 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0061
Schistosoma mansoni rotamase 0.0032 0.0386 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Mycobacterium ulcerans hypothetical protein 0.004 0.0578 0.0886
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0782 0.044
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0216 0.0308
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0216 0.0331
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0216 0.1263
Trichomonas vaginalis esterase, putative 0.004 0.0578 0.0344
Trypanosoma brucei unspecified product 0.0039 0.0573 0.3345
Leishmania major hypothetical protein, conserved 0.0031 0.0352 0.2054
Brugia malayi CXXC zinc finger family protein 0.0028 0.0266 0.0379
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.2143 0.3051
Echinococcus granulosus dna polymerase eta 0.0082 0.1713 0.1405
Loa Loa (eye worm) hypothetical protein 0.0088 0.186 0.265
Brugia malayi PHD-finger family protein 0.0052 0.0909 0.1295
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0741 0.117
Schistosoma mansoni hypothetical protein 0.0031 0.0358 0.0358
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0358 0.0509
Schistosoma mansoni hypothetical protein 0.0349 0.8752 0.8752
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0043 0.5
Echinococcus multilocularis cpg binding protein 0.0033 0.0411 0.0055
Plasmodium falciparum thioredoxin reductase 0.0046 0.0741 1
Loa Loa (eye worm) glutaminase 2 0.0264 0.6528 0.9297
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.2775 0.2507
Schistosoma mansoni bromodomain containing protein 0.013 0.2967 0.2967
Echinococcus multilocularis dna polymerase eta 0.0082 0.1713 0.1405
Loa Loa (eye worm) hypothetical protein 0.0099 0.2143 0.3051
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0195 0.1137
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0216 0.0308
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.26 1
Mycobacterium ulcerans beta-lactamase 0.004 0.0578 0.0886
Echinococcus granulosus expressed protein 0.0032 0.0386 0.003
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0578 0.0907
Brugia malayi glutaminase DH11.1 0.0264 0.6528 0.9297
Schistosoma mansoni DNA polymerase eta 0.0082 0.1713 0.1713
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0578 0.0824
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.1042 0.1096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0578 0.0824
Brugia malayi hypothetical protein 0.0176 0.4176 0.5948
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0366 0.2137
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0216 0.1263
Loa Loa (eye worm) hypothetical protein 0.0143 0.3324 0.4734
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0277
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Loa Loa (eye worm) metalloprotease 0.0028 0.0271 0.0385
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0366 0.1814
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0176 0.4176 0.4176
Loa Loa (eye worm) hypothetical protein 0.004 0.0578 0.0824
Trypanosoma brucei unspecified product 0.0039 0.0573 0.3345
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2292 0.3669
Loa Loa (eye worm) hypothetical protein 0.0078 0.1584 0.2256
Brugia malayi metalloprotease 0.0028 0.0271 0.0385
Loa Loa (eye worm) hypothetical protein 0.004 0.0578 0.0824
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0103 0.2245 0.1957
Brugia malayi ADAMTS-like protease 0.0078 0.1584 0.2256
Loa Loa (eye worm) angiogenesis inhibito 0.0028 0.0271 0.0385
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.1042 0.1654
Schistosoma mansoni cpg binding protein 0.0033 0.0411 0.0411
Toxoplasma gondii thioredoxin reductase 0.0046 0.0741 0.7056
Loa Loa (eye worm) hypothetical protein 0.004 0.0578 0.0824
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0578 0.0229
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0216 0.0331
Loa Loa (eye worm) hypothetical protein 0.004 0.0578 0.0824
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0741 0.433
Brugia malayi ADAM-TS Spacer 1 family protein 0.0078 0.1584 0.2256
Brugia malayi beta-lactamase family protein 0.004 0.0578 0.0824
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0446 0.0446
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2292 0.3669
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0578 0.0229
Echinococcus granulosus zinc finger protein 0.0041 0.0623 0.0275
Schistosoma mansoni cpg binding protein 0.0033 0.0411 0.0411
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1316 0.1875
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0366 0.2137
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0671 0.3918
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0216 0.0331
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0366 0.3483
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.1042 0.1483
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.2775 0.2507
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0578 0.0886
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.7021 1
Leishmania major trypanothione reductase 0.0046 0.0741 0.433
Mycobacterium tuberculosis Conserved protein 0.004 0.0578 0.0907
Toxoplasma gondii ABC1 family protein 0.004 0.0578 0.5503
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0195 0.1137
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Onchocerca volvulus 0.004 0.0578 1
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0638 0.0908
Loa Loa (eye worm) hypothetical protein 0.005 0.0845 0.1203
Schistosoma mansoni dihydroceramide desaturase 0.0133 0.3051 0.3051
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.1042 0.1596
Schistosoma mansoni hypothetical protein 0.0031 0.0358 0.0358
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0578 0.0344
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0741 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.7021 0.6911
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0216 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0578 0.3377
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1042 0.6082
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0103 0.2245 0.1957
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0578 0.0578
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0479 0.0682
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0578 0.0907
Onchocerca volvulus 0.0028 0.0266 0.1381
Mycobacterium leprae Probable lipase LipE 0.004 0.0578 0.1519
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0216 0.0324
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.2143 0.3051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.7021 0.6911
Brugia malayi beta-lactamase family protein 0.004 0.0578 0.0824
Mycobacterium leprae conserved hypothetical protein 0.004 0.0578 0.1519
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.1042 0.1042
Trypanosoma brucei unspecified product 0.0057 0.1042 0.6082
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.7021 1
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0245 0.6007 0.5859
Echinococcus multilocularis adam 0.0176 0.4176 0.3961
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.1042 0.1596
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0043 0.0066
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0195 0.1137
Trichomonas vaginalis rotamase, putative 0.0032 0.0386 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0195 0.2626
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1042 0.6082
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0578 0.0344
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0043 0.0582
Mycobacterium ulcerans lipase LipD 0.004 0.0578 0.0886
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0446 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0308
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1051 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0578 0.0824
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.1042 0.1483
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.2143 0.3051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.1042 0.6082
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.1713 0.2439
Plasmodium vivax hypothetical protein, conserved 0.004 0.0578 0.7799
Trichomonas vaginalis glutaminase, putative 0.0264 0.6528 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0358 0.0509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.7021 0.7021
Trypanosoma brucei trypanothione reductase 0.0046 0.0741 0.433
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0573 0.3345
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2292 0.3669
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0741 0.1056
Mycobacterium ulcerans hypothetical protein 0.0026 0.0216 0.0331
Mycobacterium ulcerans glutaminase 0.0264 0.6528 1
Leishmania major hypothetical protein, conserved 0.004 0.0578 0.3377
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0578 0.0907
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0462 0.0462
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0195 0.2626
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1042 0.6082
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0245 0.6007 0.6007
Brugia malayi beta-lactamase 0.004 0.0578 0.0824
Echinococcus granulosus cpg binding protein 0.0033 0.0411 0.0055
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2292 0.3669
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0578 0.0907
Loa Loa (eye worm) beta-lactamase 0.004 0.0578 0.0824
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0082 0.1713 0.2439
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0043 0.0582
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0043 0.0045
Mycobacterium tuberculosis Conserved protein 0.004 0.0578 0.0907
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0578 0.0344
Plasmodium vivax glutathione reductase, putative 0.0046 0.0741 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0782 0.044
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.6221 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0386 0.055
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0216 0.0308
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0578 0.0907
Echinococcus multilocularis dnaJ subfamily B 0.0396 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0216 0.1263
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.1713 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.2292 0.8708
Loa Loa (eye worm) reprolysin 0.0245 0.6007 0.8555
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0195 0.1853
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0386 0.0033
Loa Loa (eye worm) hypothetical protein 0.0078 0.1584 0.2256
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0578 0.0907
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.26 0.4165
Echinococcus granulosus adam 17 protease 0.0067 0.1297 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0366 0.2137
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.1042 0.0709
Leishmania major DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Leishmania major hypothetical protein, conserved 0.0025 0.0195 0.1137
Echinococcus multilocularis expressed protein 0.0032 0.0386 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0573 0.3345
Plasmodium falciparum glutathione reductase 0.0046 0.0741 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.1042 0.6082
Onchocerca volvulus 0.004 0.0578 1
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.1713 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1589 0.2263
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0358 0.0509
Schistosoma mansoni hypothetical protein 0.0031 0.0352 0.0352

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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