Detailed information for compound 583762

Basic information

Technical information
  • TDR Targets ID: 583762
  • Name: benzenesulfonohydrazide
  • MW: 172.205 | Formula: C6H8N2O2S
  • H donors: 2 H acceptors: 2 LogP: 0.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNS(=O)(=O)c1ccccc1
  • InChi: 1S/C6H8N2O2S/c7-8-11(9,10)6-4-2-1-3-5-6/h1-5,8H,7H2
  • InChiKey: VJRITMATACIYAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzenesulfohydrazide
  • 80-17-1
  • Benzenesulfonic acid hydrazide
  • Benzenesulfonyl hydrazine
  • Benzenesulphonohydrazide
  • EINECS 201-255-2
  • Hydrazide BSG
  • NSC 643
  • Nitropore OBSH
  • ZINC00154607
  • STK331034
  • 532320_ALDRICH
  • Polystyrene sulfonyl hydrazide resin
  • p-Toluenesulfonyl hydrazide, polymer-bound
  • 532339_ALDRICH
  • B3809_ALDRICH
  • BENZENE SULFOHYDRAZIDE
  • 12650_FLUKA
  • Benzenesulfonic acid, hydrazide
  • Benzenesulfonic hydrazide
  • Benzenesulfonyl hydrazide
  • Benzenesulfonylhydrazine
  • Benzensulfonylhydrazine
  • Celogen BSH
  • ChKhZ 9
  • Genitron BSH
  • NSC643
  • Phenylsulfohydrazide
  • Phenylsulfonyl hydrazide
  • Phenylsulfonylhydrazine
  • Porofor
  • Porofor BSH
  • Porofor ChKhZ 9
  • Porofor-BSH-Pulver
  • AIDS-009175
  • AIDS009175
  • 564397_ALDRICH
  • MP-TsNHNH2
  • Sulfonyl hydrazine, polymer-bound
  • Benzene sulphonohydrazide
  • 4-11-00-00094 (Beilstein Handbook Reference)
  • AI3-52515
  • BRN 0640079
  • BSH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0229 0.0281
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0125 0.0601
Schistosoma mansoni sphingosine kinase A B 0.0685 0.8153 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0125 0.0154
Brugia malayi beta-lactamase family protein 0.0037 0.0322 0.1543
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0072 0.0742 0.091
Onchocerca volvulus 0.0031 0.0247 0.6161
Echinococcus granulosus carbonic anhydrase 0.0086 0.0914 0.1121
Echinococcus granulosus ceramide kinase 0.0027 0.0195 0.0239
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0103 0.0126
Echinococcus granulosus Diacylglycerol kinase theta 0.0027 0.0195 0.0239
Echinococcus granulosus zinc finger protein 0.0023 0.0149 0.0183
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0125 0.0154
Schistosoma mansoni zinc finger protein 0.0016 0.0072 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0125 0.0154
Brugia malayi beta-lactamase family protein 0.0037 0.0322 0.1543
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0125 0.0601
Brugia malayi hypothetical protein 0.0072 0.0742 0.3552
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0125 0.0154
Echinococcus granulosus neuropeptide s receptor 0.0498 0.5896 0.7232
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0095 0.0116
Onchocerca volvulus 0.0037 0.0322 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0095 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0125 0.0154
Brugia malayi CXXC zinc finger family protein 0.0031 0.0247 0.1181
Brugia malayi Diacylglycerol kinase protein 2 0.0027 0.0195 0.0934
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0098 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.0027 0.0195 0.0934
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0195 0.0934
Leishmania major hypothetical protein, conserved 0.0037 0.0322 0.1543
Brugia malayi hypothetical protein 0.0026 0.0192 0.0919
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0125 0.0154
Trypanosoma brucei ISWI complex protein 0.0016 0.0072 0.0344
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0322 0.0395
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0125 0.0154
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0125 0.0154
Loa Loa (eye worm) ceramide kinase 0.0027 0.0195 0.0239
Schistosoma mansoni sphingoid long chain base kinase 0.0685 0.8153 1
Schistosoma mansoni hypothetical protein 0.0048 0.045 0.0551
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0195 0.0239
Trypanosoma cruzi Sphingosine kinase 0.0027 0.0195 0.0934
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0027 0.0195 0.0934
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0742 0.091
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.2745 0.3367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0395
Loa Loa (eye worm) diacylglycerol kinase 2 0.0027 0.0195 0.0239
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.003
Mycobacterium tuberculosis Conserved protein 0.0037 0.0322 0.0395
Trichomonas vaginalis sphingosine kinase, putative 0.0027 0.0195 0.4326
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0125 0.0125
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0098 0.0098
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0098 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0008
Plasmodium falciparum diacylglycerol kinase, putative 0.0027 0.0195 0.1189
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.5896 0.5896
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0125 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0125 0.0601
Echinococcus multilocularis GPCR, family 2 0.0048 0.045 0.045
Schistosoma mansoni hypothetical protein 0.0027 0.0195 0.0239
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0192 0.4183
Echinococcus granulosus carbonic anhydrase II 0.0183 0.2089 0.2562
Brugia malayi hypothetical protein 0.0027 0.0195 0.0934
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0151 0.1696 0.208
Loa Loa (eye worm) hypothetical protein 0.0044 0.0403 0.0495
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0395
Schistosoma mansoni carbonic anhydrase 0.0086 0.0914 0.1121
Trypanosoma brucei carbonic anhydrase-like protein 0.0183 0.2089 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0027 0.0195 0.4326
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0395
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0098 0.047
Schistosoma mansoni ap endonuclease 0.0019 0.0098 0.012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0098 0.012
Echinococcus granulosus carbonic anhydrase 0.0086 0.0914 0.1121
Schistosoma mansoni hypothetical protein 0.0086 0.0914 0.1121
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0195 0.012
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0183 0.2089 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0098 0.012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0192 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0125 0.0601
Brugia malayi hypothetical protein 0.0011 0.0006 0.003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0008
Mycobacterium ulcerans beta-lactamase 0.0037 0.0322 0.0395
Trichomonas vaginalis bmru protein, putative 0.0027 0.0195 0.4326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.045 0.2152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Schistosoma mansoni hypothetical protein 0.0048 0.045 0.0551
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0742 0.0742
Schistosoma mansoni zinc finger protein 0.0023 0.0149 0.0183
Schistosoma mansoni carbonic anhydrase-related 0.0086 0.0914 0.1121
Schistosoma mansoni bromodomain containing protein 0.007 0.0718 0.0881
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0125 0.0154
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0098 0.012
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0322 1
Brugia malayi Ceramide kinase 0.0027 0.0195 0.0934
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0195 0.012
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0125 0.0601
Brugia malayi nuclear hormone receptor 0.0021 0.0125 0.0601
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0125 0.0601
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0322 0.0322
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0125 0.0154
Mycobacterium ulcerans diacylglycerol kinase 0.0027 0.0195 0.0239
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0098 0.047
Schistosoma mansoni hypothetical protein 0.0048 0.045 0.0551
Echinococcus multilocularis carbonic anhydrase 0.0086 0.0914 0.0914
Leishmania major sphingosine kinase A, B, putative 0.0027 0.0195 0.0934
Echinococcus multilocularis zinc finger protein 0.0023 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0048 0.045 0.0551
Echinococcus multilocularis sphingosine kinase 1 0.0685 0.8153 0.8153
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1696 0.208
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0125 0.0601
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0027 0.0195 0.0934
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0183 0.2089 0.2562
Trypanosoma cruzi ISWI complex protein 0.0016 0.0072 0.0344
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0086 0.0914 0.4374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0322 0.0395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.045 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0125 0.0154
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0141 0.0173
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0027 0.0195 0.2136
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0322 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0322 0.0395
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0239
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0322 0.0395
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0019
Brugia malayi steroid hormone receptor 0.0021 0.0125 0.0601
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0027 0.0195 0.4326
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0322 0.1543
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0341 0.0341
Toxoplasma gondii hypothetical protein 0.0086 0.0914 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0322 0.0395
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0322 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0188 0.0188
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0086 0.0914 0.1121
Trypanosoma brucei diacylglycerol kinase, putative 0.0027 0.0195 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0195 0.4326
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0086 0.0914 0.4374
Leishmania major hypothetical protein, conserved 0.0026 0.0192 0.0919
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0322 0.0395
Trichomonas vaginalis sphingosine kinase, putative 0.0027 0.0195 0.4326
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0098 0.047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0322 0.0395
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0195 0.012
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0188 0.023
Brugia malayi diacylglycerol kinase 0.0027 0.0195 0.0934
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0008
Trichomonas vaginalis diacylglycerol kinase, putative 0.0027 0.0195 0.4326
Schistosoma mansoni cpg binding protein 0.0031 0.0247 0.0303
Echinococcus multilocularis carbonic anhydrase II 0.0183 0.2089 0.2089
Plasmodium falciparum carbonic anhydrase 0.0086 0.0914 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0322 1
Entamoeba histolytica hypothetical protein, conserved 0.0685 0.8153 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0322 0.0395
Loa Loa (eye worm) hypothetical protein 0.0041 0.0372 0.0457
Brugia malayi PHD-finger family protein 0.0029 0.0218 0.1046
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0183 0.2089 1
Mycobacterium tuberculosis Diacylglycerol kinase 0.0027 0.0195 0.0239
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0086 0.0914 0.1121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1696 0.8119
Mycobacterium ulcerans lipase LipD 0.0037 0.0322 0.0395
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0612 0.67
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0103 0.0126
Mycobacterium tuberculosis Conserved protein 0.0037 0.0322 0.0395
Trypanosoma cruzi diacylglycerol kinase, putative 0.0027 0.0195 0.0934
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0125 0.0154
Mycobacterium ulcerans hypothetical protein 0.0037 0.0322 0.0395
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0125 0.0125
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0322 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0666 0.0817
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0125 0.0154
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0192 0.2101
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0086 0.0914 0.1121
Entamoeba histolytica hypothetical protein 0.0072 0.0742 0.0799
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0395
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Schistosoma mansoni coup transcription factor 0.0021 0.0125 0.0154
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0125 0.0154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.045 0.0551
Schistosoma mansoni ap endonuclease 0.0019 0.0098 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0125 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0098 0.047
Echinococcus multilocularis ceramide kinase 0.0027 0.0195 0.0195
Brugia malayi hypothetical protein 0.0017 0.0079 0.0377
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0672 0.0824
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0322 0.1543
Onchocerca volvulus 0.0037 0.0322 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0192 0.0919
Leishmania major hypothetical protein, conserved 0.0016 0.0072 0.0344
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0125 0.0154
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0192 0.0919
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0125 0.0154
Onchocerca volvulus 0.0027 0.0195 0.3541
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0125 0.0601
Toxoplasma gondii ABC1 family protein 0.0037 0.0322 0.3527
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0322 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1305 0.16
Brugia malayi Latrophilin receptor protein 2 0.0048 0.045 0.2152
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0322 0.0395
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0125 0.0601
Trichomonas vaginalis esterase, putative 0.0037 0.0322 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0188 0.023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.045 0.0551
Toxoplasma gondii diacylglycerol kinase, putative 0.0027 0.0195 0.2136
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0027 0.0195 0.2136
Loa Loa (eye worm) carbonic anhydrase 3 0.0183 0.2089 0.2562
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0086 0.0914 0.4374
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0125 0.0601
Leishmania major diacylglycerol kinase, putative 0.0027 0.0195 0.0934
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0027 0.0195 0.4326
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0086 0.0914 0.4374
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0098 0.047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.045 0.0551
Brugia malayi Bromodomain containing protein 0.0083 0.0871 0.4169
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0098 0.012
Toxoplasma gondii exonuclease III APE 0.0019 0.0098 0.1075
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.5896 0.5896
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0192 0.1149
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0006 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0012 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0672 0.0672
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0027 0.0195 0.0239
Onchocerca volvulus 0.0037 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0195 0.0934
Brugia malayi Bromodomain containing protein 0.0041 0.0372 0.1779
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0125 0.0154
Entamoeba histolytica hypothetical protein 0.0072 0.0742 0.0799
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0103 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.003
Leishmania major diacylglycerol kinase-like protein 0.0027 0.0195 0.0934
Schistosoma mansoni hypothetical protein 0.0103 0.1119 0.1373
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1119 0.5357
Trypanosoma brucei Sphingosine kinase 0.0027 0.0195 0.0934
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0341 0.0418
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0195 0.0239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1696 0.8119
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0195 0.012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0016 0.0016
Echinococcus multilocularis cpg binding protein 0.0035 0.0293 0.0293
Brugia malayi Cytochrome P450 family protein 0.0029 0.0229 0.1096
Plasmodium vivax diacylglycerol kinase, putative 0.0027 0.0195 0.4326
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0125 0.0154
Brugia malayi MH2 domain containing protein 0.0118 0.1305 0.6245
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0027 0.0195 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0125 0.0601
Leishmania major hypothetical protein, conserved 0.0027 0.0195 0.0934
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1305 0.16
Entamoeba histolytica hypothetical protein 0.0072 0.0742 0.0799
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.5896 0.7232
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0192 0.0919
Plasmodium falciparum diacylglycerol kinase, putative 0.0027 0.0195 0.1189
Schistosoma mansoni hypothetical protein 0.0022 0.0141 0.0173
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0322 0.0395
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0125 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0103 0.0126
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0027 0.0195 0.0239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0322 0.0395
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0125 0.0125
Leishmania major carbonic anhydrase-like protein 0.0183 0.2089 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0322 0.0395
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0395
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0086 0.0914 0.4374
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0008
Schistosoma mansoni carbonic anhydrase-related 0.0086 0.0914 0.1121
Leishmania major hypothetical protein, conserved 0.0027 0.0195 0.0934
Brugia malayi nuclear receptor NHR-88 0.0021 0.0125 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0125 0.0601
Brugia malayi diacylglycerol kinase 0.0027 0.0195 0.0934
Echinococcus granulosus sphingosine kinase 1 0.0685 0.8153 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0125 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0125 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0322 0.1543
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0125 0.0154
Echinococcus granulosus carbonic anhydrase 0.0086 0.0914 0.1121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0125 0.0125
Schistosoma mansoni cpg binding protein 0.0035 0.0293 0.0359
Echinococcus multilocularis carbonic anhydrase 0.0086 0.0914 0.0914
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0322 0.0395
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0239
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0183 0.2089 1
Entamoeba histolytica hypothetical protein 0.0072 0.0742 0.0799
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0192 0.1149
Mycobacterium tuberculosis Conserved protein 0.0037 0.0322 0.0395
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0322 1
Trypanosoma cruzi Sphingosine kinase 0.0027 0.0195 0.0934
Brugia malayi ecdysteroid receptor 0.0021 0.0125 0.0601
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0183 0.2089 0.2562
Onchocerca volvulus Ceramide kinase 1 homolog 0.0027 0.0195 0.3541
Loa Loa (eye worm) hypothetical protein 0.0048 0.045 0.0551
Echinococcus granulosus Diacylglycerol kinase zeta 0.0027 0.0195 0.0239
Schistosoma mansoni hypothetical protein 0.0048 0.045 0.0551
Trypanosoma cruzi ISWI complex protein 0.0016 0.0072 0.0344
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0183 0.2089 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Echinococcus granulosus cpg binding protein 0.0035 0.0293 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0125 0.0601
Brugia malayi Eye-specific diacylglycerol kinase 0.0027 0.0195 0.0934
Plasmodium vivax diacylglycerol kinase, putative 0.0027 0.0195 0.4326
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0125 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0125 0.0125
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0322 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0125 0.0154
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0183 0.2089 0.2562
Schistosoma mansoni cpg binding protein 0.0035 0.0293 0.0359
Schistosoma mansoni carbonic anhydrase-related 0.0086 0.0914 0.1121
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0125 0.0154
Brugia malayi beta-lactamase 0.0037 0.0322 0.1543
Loa Loa (eye worm) hypothetical protein 0.0086 0.0914 0.1121
Echinococcus granulosus GPCR family 2 0.0048 0.045 0.0551
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0027 0.0195 0.0934
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.0076 0.0794 0.0974
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0125 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0322 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0322 0.1543
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0027 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0685 0.8153 1
Brugia malayi hypothetical protein 0.0011 0.0006 0.003
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0027 0.0195 0.4326
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.045 0.045
Trichomonas vaginalis bmru protein, putative 0.0027 0.0195 0.4326
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0095 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0742 0.091
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0027 0.0195 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0125 0.0601
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0027 0.0195 0.0195
Echinococcus multilocularis Diacylglycerol kinase theta 0.0027 0.0195 0.0195
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.0103 0.1119 0.1373
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0027 0.0195 0.0934
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0247 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0125 0.0601
Mycobacterium tuberculosis Conserved protein 0.0685 0.8153 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0685 0.8153 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0395
Echinococcus multilocularis carbonic anhydrase 0.0086 0.0914 0.0914

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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