Detailed information for compound 602150

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 548.501 | Formula: C23H22F6N4O3S
  • H donors: 2 H acceptors: 4 LogP: 2.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CN1CCCc2c(C1)cc(cc2)NC(=O)c1ccc(s1)c1cc(nn1C)C(F)(F)F
  • InChi: 1S/C21H21F3N4OS.C2HF3O2/c1-27-9-3-4-13-5-6-15(10-14(13)12-27)25-20(29)18-8-7-17(30-18)16-11-19(21(22,23)24)26-28(16)2;3-2(4,5)1(6)7/h5-8,10-11H,3-4,9,12H2,1-2H3,(H,25,29);(H,6,7)
  • InChiKey: MNIQGCQCXCQQLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0501 0.1211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0995 0.1503
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0106 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Schistosoma mansoni intermediate filament proteins 0.0029 0.0211 0.0305
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0021
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1069 0.1059
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0501 0.4566
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0349 0.62
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0192 0.1793
Schistosoma mansoni hypothetical protein 0.0518 0.6555 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0349 0.0827
Onchocerca volvulus 0.0022 0.0118 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0481 0.1161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0106 0.0155
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0624 0.1006
Echinococcus multilocularis geminin 0.0518 0.6555 0.6551
Onchocerca volvulus 0.0076 0.0814 0.2029
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0106 0.0145
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0224 0.0213
Echinococcus granulosus dna polymerase eta 0.0019 0.0077 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0525 0.3107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0118 0.1691
Echinococcus multilocularis lamin dm0 0.0029 0.0211 0.02
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0349 0.0827
Echinococcus granulosus Glycosyl transferase family 35 0.0319 0.3967 0.6045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0627 0.0941
Echinococcus multilocularis snurportin 1 0.0352 0.4398 0.4392
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0106 0.0145
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0077 0.0515
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1069 0.1617
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0118 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0106 0.0162
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1069 0.2653
Schistosoma mansoni cpg binding protein 0.0028 0.0198 0.0285
Brugia malayi ecdysteroid receptor 0.0021 0.0106 0.0155
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0814 0.131
Echinococcus multilocularis Niemann Pick C1 protein 0.0297 0.3682 0.3675
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0501 0.0748
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0032 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0106 0.0145
Trichomonas vaginalis set domain proteins, putative 0.0271 0.3353 0.8442
Loa Loa (eye worm) STAT protein 0.0127 0.1479 0.24
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.2172 0.2163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.2487 0.4038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.128 0.1938
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.003 0.0224 0.0354
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0099 0.1119 0.1693
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0118 0.0545
Brugia malayi excitatory GABA receptor EXP-1A 0.003 0.0224 0.0347
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.028 0.4856
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0481 0.4377
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.2172 0.2163
Leishmania major hypothetical protein, conserved 0.0028 0.0192 0.1613
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0118 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.028 0.0411
Brugia malayi hypothetical protein 0.005 0.0481 0.0766
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Brugia malayi TAR-binding protein 0.0061 0.0624 0.0999
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0773
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0093 0.0133
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0224 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0624 0.0936
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0077 0.0107
Brugia malayi Cation transporter family protein 0.0099 0.1119 0.1808
Trypanosoma brucei protein kinase, putative 0.0052 0.0501 0.4682
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0257 0.2405
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.128 0.127
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0224 0.0347
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0176 0.0389
Brugia malayi nuclear receptor NHR-88 0.0021 0.0106 0.0155
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.003 0.0224 0.0347
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.5076 0.5071
Onchocerca volvulus Glycogen phosphorylase homolog 0.0319 0.3967 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0138 0.1618 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0089 0.0986 0.0976
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.005 0.0481 0.5
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0118 0.1107
Loa Loa (eye worm) RNA binding protein 0.0061 0.0624 0.1006
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0624 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0106 0.0155
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0814 0.2006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0565 0.091
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0077 0.0718
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.035 0.0517
Loa Loa (eye worm) hypothetical protein 0.0076 0.0814 0.1316
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0903 0.1363
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0106 0.024
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0349 0.0827
Onchocerca volvulus 0.0054 0.0529 0.131
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0106 0.024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0089 0.0986 0.1597
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0349 0.0516
Toxoplasma gondii ATPase, AAA family protein 0.005 0.0481 0.8778
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0016 0.0042 0.005
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0106 0.0145
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0118 0.1622
Echinococcus multilocularis survival motor neuron protein 1 0.0486 0.6142 0.6138
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.003 0.0224 0.0354
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0023 0.0029
Echinococcus granulosus survival motor neuron protein 1 0.0486 0.6142 0.9369
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0565 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1069 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Loa Loa (eye worm) hypothetical protein 0.0205 0.2487 0.4043
Schistosoma mansoni hypothetical protein 0.0032 0.0242 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0106 0.0162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0106 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0481 0.4377
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1117 0.1803
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0106 0.0145
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0349 0.3117
Onchocerca volvulus 0.005 0.0481 0.1187
Onchocerca volvulus 0.0034 0.0271 0.0657
Brugia malayi hypothetical protein 0.0486 0.6142 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.003 0.0224 0.0354
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.2003 0.5034
Onchocerca volvulus 0.0021 0.0106 0.024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0106 0.0145
Schistosoma mansoni alpha glucosidase 0.004 0.0349 0.0516
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0106 0.0155
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0106 0.0155
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0118 0.0242
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0349 0.0551
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0224 0.0325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0995 0.0985
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0106 0.0155
Trichomonas vaginalis glycogen phosphorylase, putative 0.0319 0.3967 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0032
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0118 0.0175
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0077 0.0283
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0077 0.0515
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0242 0.0384
Schistosoma mansoni cpg binding protein 0.003 0.0219 0.0317
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.3142 0.5107
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0501 0.1211
Schistosoma mansoni DNA polymerase eta 0.0019 0.0077 0.01
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0106 0.0095
Plasmodium falciparum phd finger protein, putative 0.0032 0.0242 0.3938
Loa Loa (eye worm) hypothetical protein 0.0054 0.0529 0.0852
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0501 0.4566
Brugia malayi hypothetical protein 0.0028 0.0192 0.0294
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.2487 0.4038
Onchocerca volvulus Alhambra homolog 0.0032 0.0242 0.0583
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.003 0.0224 0.0347
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0624 0.1006
Trypanosoma cruzi FHA domain containing protein, putative 0.005 0.0481 0.4377
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0176 0.1466
Loa Loa (eye worm) hypothetical protein 0.0109 0.1247 0.2021
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0773
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0565 0.0241
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0814 0.2006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1181 0.1171
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0242 0.4105
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0118 0.027
Echinococcus granulosus snurportin 1 0.0352 0.4398 0.6703
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0481 0.1161
Schistosoma mansoni hypothetical protein 0.0086 0.0945 0.1426
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0023 0.0214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0814 0.493
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0501 0.4566
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0224 0.0325
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0349 0.0827
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0544 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0118 0.1107
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0144 0.2195
Echinococcus multilocularis replication factor c subunit 1 0.005 0.0481 0.047
Schistosoma mansoni neurotransmitter gated ion channel 0.0016 0.0042 0.0047
Echinococcus multilocularis Glycosyl transferase, family 35 0.0319 0.3967 0.3961
Schistosoma mansoni lamin 0.0029 0.0211 0.0305
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0118 0.1691
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0995 0.1604
Entamoeba histolytica hypothetical protein 0.005 0.0481 0.1161
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0501 0.4566
Echinococcus multilocularis musashi 0.0029 0.0211 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0099 0.1119 0.1693
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Schistosoma mansoni hypothetical protein 0.0112 0.128 0.1938
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0106 0.0145
Onchocerca volvulus 0.0271 0.3353 0.8447
Brugia malayi MH2 domain containing protein 0.013 0.1519 0.2459
Echinococcus multilocularis glycogen phosphorylase 0.0319 0.3967 0.3961
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0118 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0481 0.1161
Loa Loa (eye worm) ACC-1 protein 0.003 0.0224 0.0354
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0011
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Schistosoma mansoni hypothetical protein 0.0518 0.6555 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0118 0.027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0106 0.0155
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0106 0.0095
Loa Loa (eye worm) hypothetical protein 0.0057 0.0565 0.091
Brugia malayi Pax transcription activation domain interacting protein 0.005 0.0481 0.0766
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0814 0.756
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0106 0.0155
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.028 0.0269
Schistosoma mansoni cpg binding protein 0.003 0.0219 0.0317
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0014 0.0011 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0106 0.0155
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0016 0.0042 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.028 0.0411
Echinococcus granulosus Protein patched homolog 1 0.0089 0.0986 0.149
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0118 0.0913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0118 0.0913
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0481 0.1161
Brugia malayi Cation transporter family protein 0.003 0.0224 0.0347
Brugia malayi intermediate filament protein 0.0029 0.0211 0.0326
Echinococcus multilocularis lamin 0.0029 0.0211 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Brugia malayi jmjC domain containing protein 0.0104 0.1181 0.1908
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0077 0.0137
Onchocerca volvulus 0.0099 0.1117 0.2795
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0106 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0995 0.1503
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0814 0.4782
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Schistosoma mansoni lamin 0.0029 0.0211 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Schistosoma mansoni chromosome transmission fidelity factor 0.005 0.0481 0.0718
Entamoeba histolytica glycogen phosphorylase, putative 0.0138 0.1618 0.4045
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.035 0.0517
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0118 0.0175
Loa Loa (eye worm) hypothetical protein 0.0029 0.0211 0.0333
Loa Loa (eye worm) hypothetical protein 0.0028 0.0192 0.0302
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3142 0.7908
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0329 0.0318
Echinococcus granulosus intermediate filament protein 0.0029 0.0211 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0224 0.0325
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.003 0.0224 0.0213
Echinococcus granulosus cpg binding protein 0.003 0.0219 0.0317
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0773
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0118 0.0545
Brugia malayi STAT protein, DNA binding domain containing protein 0.0127 0.1479 0.2394
Plasmodium falciparum importin beta, putative 0.0033 0.0257 0.4226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0027
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.003 0.0224 0.0347
Loa Loa (eye worm) hypothetical protein 0.0035 0.028 0.0446
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0118 0.0545
Treponema pallidum DNA ligase (lig) 0.005 0.0481 0.5
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0118 0.0164
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0349 0.3117
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0011 0.0008
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0118 0.0913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0525 0.3107
Echinococcus granulosus lamin 0.0029 0.0211 0.0305
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0224 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0118 0.0913
Echinococcus granulosus importin subunit beta 1 0.0033 0.0257 0.0376
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0773
Brugia malayi nuclear hormone receptor 0.0021 0.0106 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.028 0.0269
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0077 0.0515
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0077 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0077 0.0718
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0814 0.493
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0565 0.3361
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0042 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.003 0.0224 0.0325
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0118 0.027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0349 0.0827
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0501 0.049
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0118 0.0545
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0814 0.4782
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0118 0.0175
Loa Loa (eye worm) hypothetical protein 0.0076 0.0814 0.1316
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0106 0.0145
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0118 0.027
Loa Loa (eye worm) hypothetical protein 0.0089 0.0986 0.1597
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0106 0.0095
Schistosoma mansoni kinase 0.0049 0.0463 0.069
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.4398 0.7157
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0118 0.0175
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0106 0.0145
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0349 0.0827
Onchocerca volvulus 0.0022 0.0118 0.0271
Echinococcus multilocularis nAChR subunit 0.003 0.0224 0.0213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Echinococcus granulosus sterol regulatory element binding protein 0.0089 0.0986 0.149
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0349 0.0558
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0106 0.0095
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0224 0.0213
Onchocerca volvulus 0.0035 0.028 0.068
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0144 0.1349
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0077 0.0066
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0032 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0106 0.0095
Brugia malayi carbohydrate phosphorylase 0.0319 0.3967 0.6453
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0224 0.0325
Onchocerca volvulus 0.0028 0.0198 0.0471
Leishmania major importin beta-1 subunit, putative 0.0027 0.0176 0.1466
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0118 0.0913
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0257 0.2405
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0501 0.0805
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0224 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.067 0.1007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0106 0.0155
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0034 0.0044
Brugia malayi topoisomerase 0.005 0.0481 0.0766
Schistosoma mansoni topbp1 0.005 0.0481 0.0718
Leishmania major DNA polymerase eta, putative 0.0019 0.0077 0.0515
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0032 0.0021
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0501 0.0748
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.003 0.0224 0.0347
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0501 0.9163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0773
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3142 0.7908
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0106 0.0145
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0481 0.1161
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0118 0.027
Brugia malayi hypothetical protein 0.0018 0.0063 0.0085
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1181 0.1787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0106 0.0162
Trypanosoma brucei unspecified product 0.0019 0.0077 0.0718
Loa Loa (eye worm) hypothetical protein 0.0057 0.0565 0.091
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1069 0.1726
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.003 0.0224 0.0325
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0032 0.0299
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0077 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0446 0.1073
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0077 0.0115
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.003 0.0224 0.0347
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Loa Loa (eye worm) hypothetical protein 0.0065 0.067 0.1082
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0481 0.1161
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0204 0.0322
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0242 0.0353
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0144 0.116
Mycobacterium ulcerans hypothetical protein 0.0076 0.0814 0.4782
Schistosoma mansoni patched 1 0.0089 0.0986 0.149
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0995 0.1503
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0814 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0349 0.3117
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0118 0.0545
Echinococcus granulosus expressed conserved protein 0.0195 0.2362 0.3592
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0118 0.0545
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0257 0.4404
Plasmodium vivax importin-beta 2, putative 0.0033 0.0257 0.4226
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0349 0.0827
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0118 0.027
Echinococcus granulosus peregrin 0.0032 0.0242 0.0353
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.003 0.0224 0.0354
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0624 0.0936
Brugia malayi Pre-SET motif family protein 0.0035 0.028 0.0439
Chlamydia trachomatis glycogen phosphorylase 0.0319 0.3967 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0349 0.0827
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0118 0.0242
Schistosoma mansoni hypothetical protein 0.0285 0.3525 0.5369
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0106 0.0155
Onchocerca volvulus 0.0104 0.1184 0.2965
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.003 0.0224 0.0325
Schistosoma mansoni glycogen phosphorylase 0.0138 0.1618 0.2456
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.5761 0.5756
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0501 0.1211
Giardia lamblia Kinase, PLK 0.0096 0.1069 0.2551
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.005 0.0481 0.0766
Echinococcus granulosus replication factor c subunit 1 0.005 0.0481 0.0718
Brugia malayi Bromodomain containing protein 0.0032 0.0242 0.0376
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0211 0.0333
Schistosoma mansoni hypothetical protein 0.0086 0.0945 0.1426
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Brugia malayi RNA, U transporter 1 0.0094 0.1046 0.1688
Brugia malayi hypothetical protein 0.005 0.0481 0.0766
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.003 0.0224 0.0213
Loa Loa (eye worm) oxidoreductase 0.0022 0.0118 0.0182
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0192 0.1613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0106 0.0155
Onchocerca volvulus Putative nachr subunit 0.003 0.0224 0.0537
Schistosoma mansoni alpha-glucosidase 0.0155 0.1846 0.2803
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0118 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0118 0.0164
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.003 0.0224 0.0325
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0106 0.0145
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0814 0.2006
Schistosoma mansoni hypothetical protein 0.0065 0.067 0.1007
Schistosoma mansoni DNA ligase IV 0.005 0.0481 0.0718
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0211 0.2567 0.3906
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0224 0.0213
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0144 0.0133
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0118 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0106 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0995 0.161
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0814 0.4782
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.003 0.0224 0.0213
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.003 0.0224 0.0325
Schistosoma mansoni hypothetical protein 0.0065 0.067 0.1007
Entamoeba histolytica hypothetical protein 0.0016 0.0042 0.0048
Entamoeba histolytica glycogenphosphorylase, putative 0.0138 0.1618 0.4045
Echinococcus granulosus Niemann Pick C1 protein 0.0297 0.3682 0.561
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0118 0.027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0106 0.0095
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.3142 0.511
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0034 0.0037
Echinococcus multilocularis GPCR, family 2 0.0065 0.067 0.066
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0773
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Echinococcus granulosus dna polymerase kappa 0.0019 0.0077 0.01
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0224 0.0213
Schistosoma mansoni survival motor neuron protein 0.0099 0.1117 0.169
Giardia lamblia Replication factor C, subunit 1 0.005 0.0481 0.1039
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0118 0.0545
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0256 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0624 0.0936
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Entamoeba histolytica hypothetical protein 0.0112 0.128 0.3186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0525 0.3107
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.028 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0565 0.3167
Schistosoma mansoni ran 0.0024 0.0144 0.0203
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0106 0.0162
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0501 0.1089
Echinococcus granulosus nAChR subunit 0.003 0.0224 0.0325
Schistosoma mansoni glycogen phosphorylase 0.0319 0.3967 0.6045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0814 1
Plasmodium vivax replication factor C subunit 1, putative 0.005 0.0481 0.8422
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0192 0.1613
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0814 0.131
Entamoeba histolytica Ran family GTPase 0.0024 0.0144 0.0308
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.005 0.0481 0.1161
Echinococcus granulosus GPCR family 2 0.0065 0.067 0.1007
Loa Loa (eye worm) LGC-31 protein 0.003 0.0224 0.0354
Echinococcus granulosus X box binding protein 1 0.0285 0.3525 0.5369
Echinococcus multilocularis protein dispatched 1 0.0102 0.115 0.114
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0042 0.005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0224 0.0347
Echinococcus multilocularis expressed conserved protein 0.0195 0.2362 0.2353
Brugia malayi CXXC zinc finger family protein 0.0028 0.0198 0.0304
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0118 0.0242
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.2926 0.4759
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0078 0.0292
Trypanosoma brucei glucosidase, putative 0.004 0.0349 0.3264
Onchocerca volvulus 0.0029 0.0211 0.0505
Loa Loa (eye worm) hypothetical protein 0.0085 0.0938 0.1517
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0072 0.0093
Schistosoma mansoni importin beta-1 0.0033 0.0257 0.0376
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.003 0.0224 0.0347
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0118 0.0913
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.5761 0.8786
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0192 0.2996
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.0225
Giardia lamblia PHD finger protein 15 0.0032 0.0242 0.0424
Loa Loa (eye worm) hypothetical protein 0.0054 0.0537 0.0864
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Echinococcus multilocularis Niemann Pick C1 protein 0.0208 0.2525 0.2517
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0481 0.1161
Schistosoma mansoni topbp1 0.005 0.0481 0.0718
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1069 0.1732
Entamoeba histolytica hypothetical protein 0.0112 0.128 0.3186
Schistosoma mansoni ran 0.0024 0.0144 0.0203
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0106 0.0145
Loa Loa (eye worm) hypothetical protein 0.0076 0.0814 0.1316
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0106 0.0155
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0144 0.0203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0208 0.2525 0.3842
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0013 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0995 0.0985
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0106 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0501 0.1211
Echinococcus granulosus glycogen phosphorylase 0.0319 0.3967 0.6045
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.0217
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0565 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0032 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0224 0.0347
Entamoeba histolytica hypothetical protein 0.0112 0.128 0.3186
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0224 0.0325
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.003 0.0224 0.0325
Onchocerca volvulus 0.0022 0.0118 0.0271
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0349 0.0827
Brugia malayi Pre-SET motif family protein 0.0239 0.2926 0.4755
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0118 0.0545
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0118 0.1691
Echinococcus granulosus tar DNA binding protein 0.0061 0.0624 0.0936
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1519 0.2465
Brugia malayi jmjC domain containing protein 0.004 0.035 0.0552
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Schistosoma mansoni hypothetical protein 0.0086 0.0945 0.1426
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0118 0.0175
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0118 0.1622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0106 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.212 0.5316
Echinococcus granulosus tumor protein p63 0.0368 0.4612 0.703
Brugia malayi Latrophilin receptor protein 2 0.0065 0.067 0.1075
Loa Loa (eye worm) hypothetical protein 0.0057 0.0565 0.091
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0013 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0814 0.4782
Echinococcus multilocularis cpg binding protein 0.003 0.0219 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1069 0.1617
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0042 0.005
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.005 0.0481 0.5212
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0106 0.0145
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0106 0.024
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.212 0.5316
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0077 0.0137
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0077 0.0718
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1069 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0192 0.2996
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Loa Loa (eye worm) acetylcholine receptor protein 0.0014 0.0011 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0481 0.4377
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0525 0.3107
Leishmania major DNA polymerase kappa, putative 0.0019 0.0077 0.0515
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.2172 0.3524
Loa Loa (eye worm) hypothetical protein 0.0057 0.0565 0.091
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.035 0.0517
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0106 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Brugia malayi RNA binding protein 0.0061 0.0624 0.0999
Entamoeba histolytica glycogen phosphorylase, putative 0.0138 0.1618 0.4045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0106 0.0162
Echinococcus granulosus neuropeptide s receptor 0.0457 0.5761 0.8786
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0144 0.2106
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0299
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3142 0.7908
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.067 0.1075
Onchocerca volvulus 0.0029 0.0211 0.0505
Entamoeba histolytica hypothetical protein 0.0112 0.128 0.3186
Schistosoma mansoni alpha-glucosidase 0.0155 0.1846 0.2803
Loa Loa (eye worm) hypothetical protein 0.0208 0.2525 0.4105
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0814 0.756
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1519 0.2465
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0501 0.4682
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0224 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3142 0.7908
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0224 0.0325
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.5761 0.5756
Entamoeba histolytica hypothetical protein 0.0027 0.0176 0.0389
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Schistosoma mansoni glycogen phosphorylase 0.0319 0.3967 0.6045
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0481 0.4498
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0624 0.0936
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Echinococcus multilocularis tumor protein p63 0.0368 0.4612 0.4606
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0176 0.0389
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0242 0.3938
Trypanosoma brucei polo-like protein kinase 0.0096 0.1069 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.2487 0.4043
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0176 0.0389
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Echinococcus multilocularis protein patched 0.0089 0.0986 0.0976
Schistosoma mansoni hypothetical protein 0.0352 0.4398 0.6703
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0224 0.0347
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0404 0.0393
Echinococcus multilocularis glycogen phosphorylase 0.0319 0.3967 0.3961
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0106 0.0145
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.005 0.0481 0.2622
Onchocerca volvulus 0.0099 0.1119 0.2801
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0814 0.4782
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0077 0.01
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0404 0.0599
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0077 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0118 0.027
Loa Loa (eye worm) hypothetical protein 0.0486 0.6142 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0182
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.003 0.0224 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1069 0.2653
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0501 0.4566
Giardia lamblia Glycogen phosphorylase 0.0319 0.3967 1
Schistosoma mansoni hypothetical protein 0.0065 0.067 0.1007
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0077 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0624 0.0936
Loa Loa (eye worm) hypothetical protein 0.0099 0.1119 0.1814
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0404 0.5076 0.774
Echinococcus multilocularis nibrin 0.005 0.0481 0.047
Entamoeba histolytica glycogen phosphorylase, putative 0.0319 0.3967 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0182
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.005 0.0481 0.8778
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0224 0.0325
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Brugia malayi CHE-14 protein 0.0089 0.0986 0.159
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.003 0.0224 0.0325
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0144 0.116
Schistosoma mansoni hypothetical protein 0.0086 0.0945 0.1426
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0224 0.0347
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1646 0.2666
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0501 0.4566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0106 0.0162
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0349 0.0827
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0106 0.0145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0198 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0446 0.1073
Schistosoma mansoni hypothetical protein 0.014 0.1646 0.2498
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0077 0.01
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0814 0.4782
Brugia malayi Niemann-Pick C1 protein precursor 0.0208 0.2525 0.4101
Schistosoma mansoni nAChR subunit 0.003 0.0224 0.0325
Onchocerca volvulus 0.003 0.0224 0.0537
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0077 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0986 0.2442
Schistosoma mansoni hypothetical protein 0.0065 0.067 0.1007
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1069 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.003 0.0224 0.0354
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0106 0.0145
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0529 0.0792
Echinococcus granulosus glycogen phosphorylase 0.0319 0.3967 0.6045
Onchocerca volvulus 0.003 0.0224 0.0537
Echinococcus multilocularis dna polymerase eta 0.0019 0.0077 0.0066
Entamoeba histolytica glycogen phosphorylase, putative 0.0319 0.3967 1
Onchocerca volvulus 0.0099 0.1119 0.2801
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0224 0.0347
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.067 0.066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0224 0.0347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.003 0.0224 0.0354
Echinococcus granulosus nibrin 0.005 0.0481 0.0718
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0208 0.2525 0.6344
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0077 0.0718
Trichomonas vaginalis glycogen phosphorylase, putative 0.0319 0.3967 1
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.2172 0.3302
Onchocerca volvulus 0.0016 0.0042 0.0077
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0138 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0257 0.0246
Echinococcus granulosus lamin dm0 0.0029 0.0211 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0106 0.0155
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0224 0.0325
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0501 0.0748
Echinococcus multilocularis peregrin 0.0032 0.0242 0.0231
Plasmodium vivax SET domain protein, putative 0.0035 0.028 0.466
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0192 0.3123
Schistosoma mansoni hypothetical protein 0.0099 0.1117 0.169
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0106 0.0162
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0624 0.0999
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0814 0.756
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3142 0.7908
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0106 0.0095
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0077 0.0718
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0087
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.128 0.1938
Onchocerca volvulus 0.003 0.0224 0.0537
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0023 0.0019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0349 0.0827
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0106 0.0145
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0106 0.0145
Echinococcus granulosus geminin 0.0518 0.6555 1
Echinococcus granulosus nAChR subunit 0.0016 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0257 0.0409
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0242 0.4105
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0501 0.049
Trichomonas vaginalis ran, putative 0.0024 0.0144 0.0308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.2106
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.035 0.0559
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0192 0.2996
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0106 0.0155
Leishmania major GTP-binding protein, putative 0.0024 0.0144 0.116
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0681 0.11
Brugia malayi DKFZp564C0469 protein 0.005 0.0481 0.0766
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0224 0.0347
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.067 0.066
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0481 0.1161
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0118 0.027
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0349 0.0338
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1069 0.2675
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0106 0.0155
Echinococcus multilocularis X box binding protein 1 0.0285 0.3525 0.3518
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.003 0.0224 0.0213
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0224 0.0213
Brugia malayi steroid hormone receptor 0.0021 0.0106 0.0155
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.2172 0.3529
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.067 0.1007
Brugia malayi PHD-finger family protein 0.0032 0.0242 0.0376
Plasmodium falciparum replication factor C subunit 1, putative 0.005 0.0481 0.8422
Brugia malayi hypothetical protein 0.0112 0.128 0.2069
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0032 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2003 0.502
Onchocerca volvulus 0.0099 0.1119 0.2801
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0016 0.0042 0.005
Schistosoma mansoni hypothetical protein 0.0404 0.5076 0.774
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.028 0.0411
Echinococcus multilocularis nAChR subunit 0.0016 0.0042 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0814 0.131
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0211 0.0333
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0224 0.0347
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0118 0.0182
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0242 0.0353
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0814 0.4782
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0211 0.0326
Loa Loa (eye worm) GABA receptor subunit 0.0016 0.0042 0.0057
Schistosoma mansoni coup transcription factor 0.0021 0.0106 0.0145
Loa Loa (eye worm) hypothetical protein 0.0099 0.1119 0.1814
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0481 0.1161
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0057
Onchocerca volvulus 0.0016 0.0042 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0118 0.0175
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0224 0.0213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.067 0.1082
Loa Loa (eye worm) hypothetical protein 0.014 0.1646 0.2672
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0242 0.0231
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0118 0.0913
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0995 0.1503
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0077 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0995 0.1503
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.028 0.0411
Brugia malayi MAP kinase sur-1 0.0052 0.0501 0.0798
Brugia malayi Cation transporter family protein 0.003 0.0224 0.0347
Brugia malayi Importin beta-1 subunit 0.0033 0.0257 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Trichomonas vaginalis replication factor C large subunit, putative 0.005 0.0481 0.1161
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0354
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0118 0.0545
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.3142 0.7908
Loa Loa (eye worm) ACC-1 protein 0.003 0.0224 0.0354
Loa Loa (eye worm) hypothetical protein 0.0032 0.0242 0.0384
Loa Loa (eye worm) glycogen phosphorylase 0.0319 0.3967 0.6456
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0077 0.0515

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -2.38 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1.85 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.28 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 16 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 34 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 88 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 3.45 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 16 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 34 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 88 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.06 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.88042 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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