Detailed information for compound 603073

Basic information

Technical information
  • TDR Targets ID: 603073
  • Name: STOCK1S-66533
  • MW: 470.629 | Formula: C28H30N4OS
  • H donors: 0 H acceptors: 3 LogP: 6.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Sc1nnc2n1c1c3ccccc3CC3(c1c(=O)n2c1ccc(cc1)C)CCCCC3)C
  • InChi: 1S/C28H30N4OS/c1-18(2)34-27-30-29-26-31(21-13-11-19(3)12-14-21)25(33)23-24(32(26)27)22-10-6-5-9-20(22)17-28(23)15-7-4-8-16-28/h5-6,9-14,18H,4,7-8,15-17H2,1-3H3
  • InChiKey: VDBHXADMNVQAKV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0006 0.0007
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0248 0.0306
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis solute carrier family 22 0.003 0.0121 0.0139
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0987 0.1329
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1365 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0239 0.1491
Schistosoma mansoni hypothetical protein 0.0034 0.016 0.0216
Schistosoma mansoni amine GPCR 0.0043 0.0264 0.0356
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.019 0.0498
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Brugia malayi F/Y-rich N-terminus family protein 0.0087 0.0755 0.0929
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0006 0.0012
Loa Loa (eye worm) runx1 0.0055 0.0398 0.079
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.0246 0.0488
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0006 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1334 0.1641
Brugia malayi jmjC domain containing protein 0.0074 0.0605 0.0744
Onchocerca volvulus 0.003 0.0121 0.0258
Echinococcus multilocularis serotonin receptor 0.0043 0.0264 0.0303
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0184 0.1838 0.2474
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.052 0.052
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0045 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0168 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Onchocerca volvulus 0.0043 0.0264 0.0564
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0264 0.0303
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0987 0.7146
Echinococcus multilocularis jumonji domain containing 1A 0.0074 0.0605 0.0694
Onchocerca volvulus Alhambra homolog 0.0228 0.233 0.4968
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0121 0.024
Loa Loa (eye worm) hypothetical protein 0.0053 0.0369 0.0733
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.032 0.2943
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.016 0.0183
Leishmania major hypothetical protein, conserved 0.003 0.0121 0.084
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0108 0.0222
Plasmodium vivax hypothetical protein, conserved 0.0228 0.233 0.233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0074 0.0605 0.5958
Echinococcus granulosus neuropeptide receptor 0.0043 0.0264 0.0325
Brugia malayi 6-phosphofructokinase 0.0108 0.0987 0.1215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0043 0.0264 0.0303
Onchocerca volvulus 0.003 0.0121 0.0258
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0264 0.0325
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0987 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0121 0.0045
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1365 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.0264 0.0524
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.032 0.0394
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0121 0.0139
Echinococcus multilocularis PHD finger protein rhinoceros 0.0228 0.233 0.2672
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0168 0.0168
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0006 0.0008
Brugia malayi AKH receptor 0.0043 0.0264 0.0325
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0108 0.0101
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0529 0.1446
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.064
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0121 0.0149
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0006 0.0007
Schistosoma mansoni amine GPCR 0.0043 0.0264 0.0356
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Onchocerca volvulus 0.003 0.0121 0.0258
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0987 0.1957
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0264 0.0325
Brugia malayi sulfakinin receptor protein 0.0043 0.0264 0.0325
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus granulosus cpg binding protein 0.0034 0.0161 0.0198
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.0264 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0529 0.1446
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0505 0.3501
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi hypothetical protein 0.003 0.0121 0.0149
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Schistosoma mansoni jumonji domain containing protein 0.0594 0.6412 0.8631
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0121 0.0045
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.7429 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Brugia malayi G-protein coupled receptor 0.0043 0.0264 0.0325
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0006 0.0008
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0625 0.5815
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.019 0.1571
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0577 0.071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0121 0.06
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0006 0.0007
Echinococcus granulosus g protein coupled receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0006 0.0012
Onchocerca volvulus 0.0043 0.0264 0.0564
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.0264 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0006 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0264 0.0524
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus multilocularis General substrate transporter 0.0185 0.1852 0.2123
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.019 0.0234
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0121 0.0045
Schistosoma mansoni metabotropic glutamate receptor 0.0136 0.1297 0.1746
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.0264 0.0325
Giardia lamblia PHD finger protein 15 0.0228 0.233 0.7629
Echinococcus multilocularis allatostatin A receptor 0.0043 0.0264 0.0303
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.052 0.0731
Onchocerca volvulus 0.003 0.0121 0.0258
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0625 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0006 0.0012
Echinococcus multilocularis protein dispatched 1 0.0048 0.0314 0.036
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.032 0.0431
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.0264 0.0524
Brugia malayi Metabotropic glutamate receptor precursor. 0.0162 0.159 0.1957
Brugia malayi jmjC domain containing protein 0.0282 0.2927 0.3601
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.019 0.0256
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0264 0.0303
Trypanosoma brucei glucose transporter 1E 0.0067 0.0529 0.5157
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.019 0.0802
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.019 0.0282
Schistosoma mansoni amine GPCR 0.0043 0.0264 0.0356
Schistosoma mansoni transcription factor btf3 0.0035 0.0168 0.0226
Brugia malayi Serotonin receptor 0.0043 0.0264 0.0325
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0006 0.0007
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4315 0.5309
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0474 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0006 0.0007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0079 0.0665 0.0763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Schistosoma mansoni opsin-like receptor 0.0043 0.0264 0.0356
Schistosoma mansoni biogenic amine receptor 0.0043 0.0264 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0335 0.0664
Leishmania major hypothetical protein, conserved 0.003 0.0121 0.0836
Loa Loa (eye worm) hypothetical protein 0.0097 0.0868 0.1721
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0006 0.0007
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0076 0.0087
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0885 0.1191
Brugia malayi steroid hormone receptor 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1334 0.1529
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus granulosus zinc finger protein 0.004 0.0234 0.0287
Onchocerca volvulus 0.003 0.0121 0.0258
Echinococcus granulosus fmrfamide receptor 0.0043 0.0264 0.0325
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus multilocularis Protein lozenge 0.0055 0.0398 0.0457
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0529 0.1446
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Loa Loa (eye worm) hypothetical protein 0.0081 0.0683 0.1354
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0349 0.3673 0.555
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0006 0.0007
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.0264 0.0325
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0529 0.4715
Echinococcus granulosus g-protein coupled receptor 0.0043 0.0264 0.0325
Brugia malayi Bromodomain containing protein 0.0076 0.0629 0.0774
Leishmania major basic transcription factor 3a, putative 0.0035 0.0168 0.1336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.0264 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0168 0.0206
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0987 0.1957
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0264 0.0356
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0043 0.0264 0.0524
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0076 0.0635 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0006 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0045 0.0057
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.3021 1
Echinococcus granulosus g protein coupled receptor 0.0043 0.0264 0.0325
Echinococcus granulosus phd:f box containing protein 0.0074 0.0605 0.0744
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.0264 0.0325
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.219 0.2695
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0121 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0006 0.0007
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0505 0.1362
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0748 0.8127 0.9319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0006 0.0007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0108
Giardia lamblia Hexose transporter 0.003 0.0121 0.0045
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0121 0.0149
Schistosoma mansoni jumonji/arid domain-containing protein 0.0282 0.2927 0.394
Schistosoma mansoni neuropeptide receptor 0.0043 0.0264 0.0356
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0264 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Schistosoma mansoni protein kinase 0.0066 0.052 0.07
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0121 0.0628
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0264 0.0524
Brugia malayi jmjC domain containing protein 0.0074 0.0605 0.0744
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0006 0.0007
Schistosoma mansoni sugar transporter 0.003 0.0121 0.0163
Plasmodium vivax JmjC domain containing protein 0.0074 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0065 0.0505 0.1001
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0168 0.0424
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0045 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.016 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0006 0.0013
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0299 0.0403
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0006 0.0007
Schistosoma mansoni glucose transporter 0.003 0.0121 0.0163
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.019 0.0234
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0168 0.0333
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0264 0.0356
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0121 0.0628
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0121 0.0149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Plasmodium vivax sugar transporter, putative 0.003 0.0121 0.0121
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0108
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0168 0.0545
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0264 0.0356
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.0264 0.0303
Schistosoma mansoni adenoreceptor 0.0043 0.0264 0.0356
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0074 0.0605 0.0814
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0987 0.3173
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) hypothetical protein 0.005 0.0335 0.0664
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi nuclear receptor NHR-88 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0121 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0167 0.0224
Schistosoma mansoni hypothetical protein 0.004 0.0232 0.0312
Brugia malayi putative neuropeptide receptor 0.0043 0.0264 0.0325
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0264 0.0303
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.032 0.0367
Onchocerca volvulus 0.0029 0.0101 0.0215
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.019 0.0282
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0264 0.0303
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.032 0.2943
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.019 0.1571
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0076 0.0094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.0596
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0529 0.4715
Trypanosoma brucei ISWI complex protein 0.003 0.0121 0.0836
Loa Loa (eye worm) sugar transporter 0.0216 0.219 0.4342
Schistosoma mansoni protein kinase 0.0066 0.052 0.07
Brugia malayi metabotropic glutamate receptor type 2 0.0079 0.0664 0.0817
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.052 0.1031
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0625 0.0625
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.0264 0.0325
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Schistosoma mansoni hypothetical protein 0.004 0.0232 0.0312
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0264 0.0356
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0006 0.0013
Echinococcus multilocularis phd:f box containing protein 0.0074 0.0605 0.0694
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.112 0.1285
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0505 0.068
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.0264 0.0356
Echinococcus multilocularis lysine specific demethylase 6a 0.0074 0.0605 0.0694
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0625 0.5815
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0248 0.0482
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Schistosoma mansoni hypothetical protein 0.0406 0.4315 0.5808
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.0108
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0199 0.2008 0.2303
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0045 0.0057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.032 0.032
Onchocerca volvulus 0.002 0.0006 0.0013
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.052 0.064
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.0264 0.0564
Brugia malayi jmjC domain containing protein 0.0074 0.0605 0.0744
Schistosoma mansoni jumonji/arid domain-containing protein 0.0282 0.2927 0.394
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.052 0.052
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0121 0.0121
Brugia malayi 6-phosphofructokinase 0.0108 0.0987 0.1215
Plasmodium vivax hexose transporter 0.0216 0.219 0.219
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.0264 0.0325
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.032 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0987 0.3017
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0043 0.0264 0.0356
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0006 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0006 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0987 0.3017
Onchocerca volvulus 0.0043 0.0264 0.0564
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Onchocerca volvulus Putative transporter 0.003 0.0121 0.0258
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0045 0.0057
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0239 0.1491
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Schistosoma mansoni phd/f-box containing protein 0.0074 0.0605 0.0814
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.052 0.052
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.0264 0.0303
Loa Loa (eye worm) hypothetical protein 0.0228 0.233 0.4621
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0045 0.0057
Echinococcus multilocularis solute carrier family 22 0.003 0.0121 0.0139
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0505 0.0621
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Schistosoma mansoni hypothetical protein 0.0043 0.0264 0.0356
Brugia malayi RE15519p 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0034 0.0167 0.033
Loa Loa (eye worm) hypothetical protein 0.0074 0.0605 0.12
Brugia malayi Melatonin receptor type 1A 0.0043 0.0264 0.0325
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0505 0.1554
Schistosoma mansoni hypothetical protein 0.0228 0.233 0.3137
Entamoeba histolytica protein kinase, putative 0.0066 0.052 0.1605
Echinococcus granulosus solute carrier family 22 0.003 0.0121 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0056
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0121 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0006 0.0012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.0264 0.0356
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0045 0.0057
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.0596
Toxoplasma gondii PHD-finger domain-containing protein 0.0075 0.0615 0.0877
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Schistosoma mansoni hypothetical protein 0.0075 0.0615 0.0828
Echinococcus granulosus General substrate transporter 0.0185 0.1852 0.2278
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0529 0.5157
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0006 0.0007
Echinococcus granulosus jumonji domain containing protein 0.0318 0.3328 0.4095
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.0264 0.0325
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.016 0.0215
Echinococcus granulosus PHD finger protein rhinoceros 0.0228 0.233 0.2867
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0121 0.0045
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0108 0.249
Onchocerca volvulus 0.0043 0.0264 0.0564
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.032 0.0728
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.019 0.0218
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.032 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0006 0.0008
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0299 0.0368
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0987 0.7146
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0625 0.6165
Loa Loa (eye worm) PHD-finger family protein 0.0228 0.233 0.4621
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus granulosus jumonji domain containing 1A 0.0074 0.0605 0.0744
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0505 0.0579
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.0264 0.0303
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.064
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.019 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.052 0.07
Trichomonas vaginalis glucose transporter, putative 0.003 0.0121 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0006 0.0007
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi Bromodomain containing protein 0.0233 0.2383 0.2932
Echinococcus granulosus microtubule associated protein 2 0.0685 0.7429 0.9141
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.016 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0167 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.0264 0.0564
Schistosoma mansoni opsin-like receptor 0.0043 0.0264 0.0356
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0264 0.0325
Schistosoma mansoni biogenic amine receptor 0.0043 0.0264 0.0356
Onchocerca volvulus 0.003 0.0121 0.0258
Brugia malayi beta-NAC-like protein 0.0035 0.0168 0.0207
Brugia malayi hypothetical protein 0.0122 0.114 0.1403
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0264 0.0303
Onchocerca volvulus 0.003 0.0121 0.0258
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0108 0.0101
Echinococcus multilocularis cpg binding protein 0.0034 0.0161 0.0185
Trypanosoma cruzi sugar transporter, putative 0.003 0.0121 0.0004
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.0264 0.0325
Onchocerca volvulus Huntingtin homolog 0.0122 0.114 0.2431
Trypanosoma cruzi glucose transporter, putative 0.003 0.0121 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0246 0.0488
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0987 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0045 0.0027
Schistosoma mansoni glucose transport protein 0.0216 0.219 0.2948
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.032 0.0425
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0264 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0264 0.0524
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0043 0.0264 0.0325
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0704 0.0866
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.052 0.052
Plasmodium falciparum mitogen-activated protein kinase 2 0.0349 0.3673 0.3673
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.0264 0.0303
Schistosoma mansoni glucose transport protein 0.0216 0.219 0.2948
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0147 0.142 0.1748
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0248 0.0306
Onchocerca volvulus 0.0043 0.0264 0.0564
Loa Loa (eye worm) hypothetical protein 0.0037 0.019 0.0377
Echinococcus multilocularis solute carrier family 22 0.003 0.0121 0.0139
Brugia malayi major facilitator superfamily protein 0.003 0.0121 0.0149
Schistosoma mansoni glucose transport protein 0.0216 0.219 0.2948
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0987 0.3017
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Schistosoma mansoni amine GPCR 0.0043 0.0264 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Echinococcus multilocularis somatostatin receptor 0.0043 0.0264 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.0102
Onchocerca volvulus 0.0083 0.0704 0.1501
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.016 0.0196
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0006 0.0007
Onchocerca volvulus 0.0043 0.0264 0.0564
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.052 0.052
Brugia malayi major facilitator superfamily protein 0.003 0.0121 0.0149
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0121 0.06
Brugia malayi jmjC domain containing protein 0.0074 0.0605 0.0744
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.3021 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.052 0.0731
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Onchocerca volvulus 0.0043 0.0264 0.0564
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0529 0.5157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0006 0.0007
Plasmodium falciparum phd finger protein, putative 0.0228 0.233 0.233
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.8721 1
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.7429 0.8519
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0121 0.084
Echinococcus granulosus sex peptide receptor 0.0043 0.0264 0.0325
Echinococcus granulosus peregrin 0.0233 0.2383 0.2932
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0228 0.233 0.3137
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.219 0.2695
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.0264 0.0524
Brugia malayi neuropeptide F receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Schistosoma mansoni hypothetical protein 0.0043 0.0264 0.0356
Plasmodium falciparum hexose transporter 0.0216 0.219 0.219
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.0264 0.0356
Trypanosoma brucei glucose transporter 2A 0.0067 0.0529 0.5157
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0006 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0006 0.0008
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0042 0.0042
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.052 0.0731
Loa Loa (eye worm) hypothetical protein 0.0076 0.0631 0.1251
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.0264 0.0325
Toxoplasma gondii sugar transporter ST3 0.003 0.0121 0.0121
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.0264 0.0303
Schistosoma mansoni neuropeptide receptor 0.0043 0.0264 0.0356
Onchocerca volvulus 0.0024 0.0045 0.0097
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.052 0.1031
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0074 0.0605 0.559
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0216 0.219 0.2511
Schistosoma mansoni opsin-like receptor 0.0043 0.0264 0.0356
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0868 0.0995
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.0264 0.0303
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0625 0.6165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0335 0.0412
Schistosoma mansoni protein phosphatase 2C 0.0074 0.0605 0.0814
Echinococcus granulosus neuropeptide receptor 0.0043 0.0264 0.0325
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1365 1
Schistosoma mansoni patched 1 0.0042 0.0248 0.0334
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0121 0.084
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0167 0.0191
Onchocerca volvulus 0.003 0.0121 0.0258
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0136 0.1297 0.1487
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Onchocerca volvulus 0.003 0.0121 0.0258
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0264 0.0303
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0042 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Brugia malayi CXXC zinc finger family protein 0.0029 0.0101 0.0124
Echinococcus multilocularis protein patched 0.0042 0.0248 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Schistosoma mansoni cpg binding protein 0.0034 0.0161 0.0217
Echinococcus granulosus solute carrier family 22 0.003 0.0121 0.0149
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.0264 0.0325
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0075 0.0615 0.6068
Echinococcus granulosus JmjC domain containing protein 4 0.0074 0.0605 0.0744
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.019 0.0256
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0168 0.0168
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0505 0.0621
Onchocerca volvulus 0.003 0.0121 0.0258
Echinococcus multilocularis orexin receptor type 2 0.0043 0.0264 0.0303
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0704 0.0948
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0264 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.052 0.064
Brugia malayi PHD-finger family protein 0.008 0.0676 0.0831
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0042 0.003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0074 0.0605 0.559
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis zinc finger protein 0.004 0.0234 0.0268
Leishmania major hypothetical protein, conserved 0.0074 0.0605 0.5958
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Entamoeba histolytica hypothetical protein 0.0035 0.0168 0.0424
Brugia malayi PHD-finger family protein 0.0228 0.233 0.2867
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0625 0.6165
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.009
Brugia malayi nuclear hormone receptor 0.002 0.0006 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0605 0.12
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.0264 0.0356
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0529 0.4715
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0239 0.0473
Brugia malayi Sugar transporter family protein 0.0216 0.219 0.2695
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.016 0.0215
Echinococcus multilocularis jumonji domain containing protein 0.0318 0.3328 0.3817
Loa Loa (eye worm) hypothetical protein 0.0042 0.0248 0.0492
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0529 0.1446
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Plasmodium vivax CDK-related protein kinase 6, putative 0.0916 1 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Loa Loa (eye worm) hypothetical protein 0.0074 0.0605 0.12
Loa Loa (eye worm) hypothetical protein 0.0051 0.0353 0.07
Loa Loa (eye worm) jmjC domain-containing protein 0.0472 0.5043 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0987 0.3017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0264 0.0356
Trypanosoma cruzi hexose transporter, putative 0.003 0.0121 0.0004
Schistosoma mansoni nuclear hormone receptor 0.002 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.004 0.0232 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.052 0.1413
Brugia malayi G protein-coupled receptor 0.0043 0.0264 0.0325
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.0596
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.0264 0.0325
Echinococcus multilocularis transcription factor btf3 0.0035 0.0168 0.0193
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.052 0.052
Onchocerca volvulus 0.0043 0.0264 0.0564
Schistosoma mansoni cpg binding protein 0.0029 0.0101 0.0136
Schistosoma mansoni myosin xvIII 0.0043 0.0264 0.0356
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0704 0.0866
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0264 0.0303
Toxoplasma gondii sugar transporter ST2 0.003 0.0121 0.0121
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0121 0.0163
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0108 0.249
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0625 0.0891
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.032 0.2127
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0042 0.003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0529 0.1446
Echinococcus granulosus hypothetical protein 0.0043 0.0264 0.0325
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.052 0.052
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0264 0.0356
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.0264 0.0325
Trypanosoma brucei sugar transporter, putative 0.003 0.0121 0.084
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0605 0.12
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0299 0.0343
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0191 0.0808
Loa Loa (eye worm) hypothetical protein 0.044 0.469 0.93
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0458 0.0616
Schistosoma mansoni sugar transporter 0.003 0.0121 0.0163
Echinococcus multilocularis solute carrier family 22 0.003 0.0121 0.0139
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0121 0.024
Loa Loa (eye worm) hypothetical protein 0.0199 0.2008 0.3982
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi jmjC domain containing protein 0.0748 0.8127 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0006 0.0012
Leishmania major glucose transporter, lmgt1 0.0067 0.0529 0.5157
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.0264 0.0325
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0045 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.0228 0.233 0.3498
Loa Loa (eye worm) hypothetical protein 0.0086 0.0743 0.1474
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.019 0.0218
Brugia malayi Cam kinase protein 1 0.0066 0.052 0.064
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0264 0.0325
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0045 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0264 0.0303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.219 0.2695
Schistosoma mansoni sugar transporter 0.003 0.0121 0.0163
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0605 0.0814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0505 0.1362
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.0264 0.0303
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0438 0.0605
Echinococcus granulosus g protein coupled receptor 0.0043 0.0264 0.0325
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0216 0.219 0.2695
Echinococcus granulosus solute carrier family 22 0.003 0.0121 0.0149
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.0264 0.0325
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0121 0.0149
Schistosoma mansoni amine GPCR 0.0043 0.0264 0.0356
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.019 0.0234
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0173 0.0343
Toxoplasma gondii sugar transporter ST1 0.003 0.0121 0.0121
Onchocerca volvulus 0.0043 0.0264 0.0564
Toxoplasma gondii facilitative glucose transporter GT1 0.0216 0.219 0.3284
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0121 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0282 0.2927 0.5803
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0246 0.0303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0987 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0006 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.0264 0.0356
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0168 0.0193
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0264 0.0303
Brugia malayi Dopamine receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0065 0.0505 0.1001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0006 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Onchocerca volvulus 0.0043 0.0264 0.0564
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0075 0.0615 0.6068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0006 0.0007
Onchocerca volvulus 0.003 0.0121 0.0258
Onchocerca volvulus Poor gastrulation protein homolog 0.0026 0.0076 0.0162
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0075 0.0615 0.0877
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.0264 0.0325
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0043 0.0264 0.0303
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.0264 0.0524
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0529 0.1446
Onchocerca volvulus 0.0043 0.0264 0.0564
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Brugia malayi ORL1-like opioid receptor 0.0043 0.0264 0.0325
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.032 0.2103
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0868 0.1068
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.0038
Entamoeba histolytica hypothetical protein 0.0048 0.032 0.0934
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Brugia malayi AF-10 protein 0.0075 0.0615 0.0757
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0254 0.05
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0045 0.0012
Toxoplasma gondii protein kinase, putative 0.061 0.6584 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0006 0.0008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0045 0.0057
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0748 0.8127 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.032 0.2299
Echinococcus granulosus metabotropic glutamate receptor 2 0.0136 0.1297 0.1596
Schistosoma mansoni phosphatidylserine receptor 0.0074 0.0605 0.0814
Onchocerca volvulus 0.003 0.0121 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0121 0.0139
Loa Loa (eye worm) glutamate receptor 0.0162 0.159 0.3153
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0264 0.0303
Schistosoma mansoni sugar transporter 0.003 0.0121 0.0163
Echinococcus granulosus neuropeptide s receptor 0.0043 0.0264 0.0325
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0168 0.0545
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.0264 0.0524
Brugia malayi Serotonin receptor 0.0043 0.0264 0.0325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0694 0.0935
Schistosoma mansoni neuropeptide receptor 0.0043 0.0264 0.0356
Brugia malayi larval opioid receptor 0.0043 0.0264 0.0325
Giardia lamblia Sugar-proton symporter 0.003 0.0121 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0101 0.02
Schistosoma mansoni hypothetical protein 0.004 0.0232 0.0312
Brugia malayi hypothetical protein 0.003 0.0121 0.0149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0108 0.0236
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.0264 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.219 0.7147
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi CHE-14 protein 0.0042 0.0248 0.0306
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0121 0.0628
Loa Loa (eye worm) hypothetical protein 0.0083 0.0704 0.1396
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0987 0.7154
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0151
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0264 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0121 0.0045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0006 0.0013
Schistosoma mansoni bromodomain containing protein 0.0127 0.1199 0.1615
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.019 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Brugia malayi follicle stimulating hormone receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0264 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0987 0.3182
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0868 0.1068
Echinococcus multilocularis expressed conserved protein 0.0091 0.0802 0.092
Onchocerca volvulus 0.003 0.0121 0.0258
Schistosoma mansoni zinc finger protein 0.003 0.0121 0.0163
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0987 0.1132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0264 0.0303
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0026 0.0076 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0006 0.0007
Echinococcus multilocularis peregrin 0.0233 0.2383 0.2732
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0248 0.0285
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.0264 0.0356
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.0264 0.0303
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0239 0.1491
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.0264 0.0524
Schistosoma mansoni neuropeptide receptor 0.0043 0.0264 0.0356
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.0038
Mycobacterium ulcerans sugar transporter 0.003 0.0121 0.0628
Echinococcus granulosus serotonin receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Echinococcus granulosus solute carrier family 22 0.003 0.0121 0.0149
Brugia malayi lysyl-tRNA synthetase 0.0048 0.032 0.0394
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.112 0.1379
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Plasmodium falciparum JmjC domain-containing protein, putative 0.0074 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis sex peptide receptor 0.0043 0.0264 0.0303
Loa Loa (eye worm) hypothetical protein 0.008 0.0676 0.134
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0529 0.5157
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0079 0.0665 0.0819
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.0264 0.0356
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.052 0.5057
Brugia malayi Bromodomain containing protein 0.015 0.1458 0.1795
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Brugia malayi Dopamine receptor protein 1 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Brugia malayi GnHR receptor homolog 0.0043 0.0264 0.0325
Echinococcus granulosus allatostatin A receptor 0.0043 0.0264 0.0325
Brugia malayi G-protein coupled receptor 0.0043 0.0264 0.0325
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0577 0.0661
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0987 0.1215
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0474 0.0544
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0121 0.0149
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0264 0.0356
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.0246 0.0488
Schistosoma mansoni hypothetical protein 0.003 0.0121 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0216 0.219 0.2948
Echinococcus multilocularis JmjC domain containing protein 4 0.0074 0.0605 0.0694
Mycobacterium ulcerans hypothetical protein 0.0024 0.0045 0.0057
Onchocerca volvulus 0.0043 0.0264 0.0564
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0505 0.0621
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0335 0.0412
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0168 0.1336
Schistosoma mansoni histamine h1 receptor 0.0043 0.0264 0.0356
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.0264 0.0325
Brugia malayi ecdysteroid receptor 0.002 0.0006 0.0007
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0505 0.068
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0529 0.1446
Schistosoma mansoni zinc finger protein 0.004 0.0234 0.0314
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.0264 0.0356
Onchocerca volvulus 0.003 0.0121 0.0258
Schistosoma mansoni hypothetical protein 0.0041 0.0239 0.0321
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0167 0.0205
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Schistosoma mansoni hypothetical protein 0.0043 0.0264 0.0356
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0006 0.0007
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0391 0.0449
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0529 0.5157
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.032 0.0728
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0868 0.2773
Entamoeba histolytica protein kinase, putative 0.0066 0.052 0.1605
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.052 0.052
Leishmania major glucose transporter, lmgt2 0.0067 0.0529 0.5157
Onchocerca volvulus 0.003 0.0121 0.0258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0264 0.0356
Echinococcus granulosus expressed conserved protein 0.0091 0.0802 0.0987
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.0664 0.0894
Echinococcus multilocularis lysine specific demethylase 5A 0.0276 0.2867 0.3287
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0264 0.0325
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.0108
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0605 0.12
Toxoplasma gondii PHD-finger domain-containing protein 0.0228 0.233 0.3498
Onchocerca volvulus 0.003 0.0121 0.0258
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.032 0.0431
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0987 0.3173
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4315 0.4948
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Schistosoma mansoni lipoxygenase 0.0055 0.0391 0.0527
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0349 0.3673 0.3673
Echinococcus granulosus orexin receptor type 2 0.0043 0.0264 0.0325
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0987 0.1957
Trichomonas vaginalis sugar transporter, putative 0.003 0.0121 0.0045
Brugia malayi phosphofructokinase 0.0108 0.0987 0.1215
Onchocerca volvulus 0.0043 0.0264 0.0564
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0168 0.0206
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0264 0.0303
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0045 0.0012
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.0264 0.0303
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0074 0.0605 0.0861
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.019 0.0234
Schistosoma mansoni coup transcription factor 0.002 0.0006 0.0008
Schistosoma mansoni lozenge 0.0055 0.0398 0.0536
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0042 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0122 0.114 0.2261
Echinococcus granulosus somatostatin receptor 0.0043 0.0264 0.0325
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0066 0.052 0.1031
Echinococcus granulosus FTZ F1 alpha 0.002 0.0006 0.0007
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0987 0.3173
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0264 0.0325
Schistosoma mansoni cpg binding protein 0.0034 0.0161 0.0217
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.019 0.0802
Onchocerca volvulus Huntingtin homolog 0.0122 0.114 0.2431
Echinococcus granulosus metabotropic glutamate receptor 5 0.0199 0.2008 0.2471
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0076 0.0094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0045 0.0027
Loa Loa (eye worm) sugar transporter 0.003 0.0121 0.024
Trypanosoma brucei glucose transporter, putative 0.0067 0.0529 0.5157
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.0264 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0006 0.0012
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0391 0.0481
Schistosoma mansoni biogenic amine receptor 0.0043 0.0264 0.0356
Echinococcus granulosus lysine specific demethylase 6a 0.0074 0.0605 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0006 0.0007
Onchocerca volvulus 0.0043 0.0264 0.0564
Echinococcus multilocularis serotonin receptor 0.0043 0.0264 0.0303
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.019 0.0282
Brugia malayi neuropeptide F receptor 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Loa Loa (eye worm) hypothetical protein 0.014 0.1346 0.2668
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.0264 0.0303
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.052 0.0596
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0264 0.0524
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.024
Loa Loa (eye worm) hypothetical protein 0.044 0.469 0.93
Schistosoma mansoni hypothetical protein 0.0043 0.0264 0.0356
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0074 0.0605 0.0861
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.0264 0.0303
Echinococcus granulosus transcription factor btf3 0.0035 0.0168 0.0207
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.052 0.052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3021 1
Onchocerca volvulus 0.0043 0.0264 0.0564
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0264 0.0325
Brugia malayi hypothetical protein 0.0043 0.0264 0.0325
Loa Loa (eye worm) glutamate receptor 0.0064 0.0494 0.0979
Brugia malayi Sugar transporter family protein 0.003 0.0121 0.0149
Trypanosoma cruzi hexose transporter 0.0067 0.0529 0.4715
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Plasmodium falciparum protein kinase 7 0.061 0.6584 0.6584
Loa Loa (eye worm) hypothetical protein 0.0392 0.4151 0.823
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0216 0.219 0.2511
Echinococcus granulosus lysine specific demethylase 5A 0.0282 0.2927 0.3601
Loa Loa (eye worm) hypothetical protein 0.0048 0.032 0.0635
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.032 0.2127
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.0264 0.0356
Schistosoma mansoni thyroid hormone receptor 0.002 0.0006 0.0008
Leishmania major glucose transporter, lmgt3 0.0067 0.0529 0.5157
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0079 0.0157
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0108 0.0101
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.0264 0.0356
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0006 0.0008
Onchocerca volvulus 0.0043 0.0264 0.0564
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0264 0.0303
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0216 0.219 0.2511
Brugia malayi hypothetical protein 0.044 0.469 0.5771
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.0264 0.0325
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0264 0.0303
Brugia malayi hypothetical protein 0.003 0.0121 0.0149
Brugia malayi Sugar transporter family protein 0.003 0.0121 0.0149
Brugia malayi PHD-finger family protein 0.0051 0.0351 0.0432
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0264 0.0303
Brugia malayi Dopamine receptor protein 2 0.0043 0.0264 0.0325
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0635 0.0635
Schistosoma mansoni protein kinase 0.0066 0.052 0.07
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0248 0.0492
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0987 0.1329
Onchocerca volvulus 0.044 0.469 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0704 0.0807
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0012
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.0264 0.0303
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.0264 0.0325
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0216 0.219 0.2511
Onchocerca volvulus 0.0043 0.0264 0.0564
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0042 0.0042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0006 0.0007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.0264 0.0325
Loa Loa (eye worm) hypothetical protein 0.0122 0.114 0.2261
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524
Leishmania major protein kinase, putative 0.0066 0.052 0.5057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0524

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 5.47 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 6.98 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 7.08 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 8 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 88 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 95 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 0 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 8 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 88 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 95 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.02 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.94576 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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