Detailed information for compound 619001

Basic information

Technical information
  • TDR Targets ID: 619001
  • Name: 2-fluoro-N-[5-[2-[(4-methoxyphenyl)amino]-2-o xoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzam ide
  • MW: 418.465 | Formula: C18H15FN4O3S2
  • H donors: 2 H acceptors: 4 LogP: 3.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CSc1nnc(s1)NC(=O)c1ccccc1F
  • InChi: 1S/C18H15FN4O3S2/c1-26-12-8-6-11(7-9-12)20-15(24)10-27-18-23-22-17(28-18)21-16(25)13-4-2-3-5-14(13)19/h2-9H,10H2,1H3,(H,20,24)(H,21,22,25)
  • InChiKey: WWTCRTRFBNMYGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-fluoro-N-[5-[2-[(4-methoxyphenyl)amino]-2-oxo-ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
  • 2-fluoro-N-[5-[[2-[(4-methoxyphenyl)amino]-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide
  • 2-fluoro-N-[5-[[2-keto-2-[(4-methoxyphenyl)amino]ethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide
  • Oprea1_714655

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0571 0.0604
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1377 0.1989
Toxoplasma gondii ABC1 family protein 0.007 0.1377 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0203 0.1014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.1042 0.1698
Echinococcus granulosus dnaJ subfamily B 0.0424 0.9452 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0364 0.0593
Mycobacterium ulcerans glutaminase 0.0279 0.614 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0168 0.0178
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.0288 0.0096
Entamoeba histolytica hypothetical protein 0.0038 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2484 0.4046
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2412 0.3928
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Mycobacterium ulcerans beta-lactamase 0.007 0.1377 0.1989
Schistosoma mansoni lamin 0.0055 0.1042 0.1103
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.0288 0.0096
Echinococcus granulosus Aminotransferase class III 0.0022 0.0288 0.0305
Echinococcus granulosus cpg binding protein 0.0033 0.0537 0.0568
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0314 0.0332
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0038 0.0645 1
Schistosoma mansoni hypothetical protein 0.0023 0.0312 0.033
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0005 0.0008
Brugia malayi hypothetical protein 0.001 0.0005 0.0008
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0233 0.0379
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.0288 0.0158
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0203 0.0215
Brugia malayi PHD-finger family protein 0.0026 0.0366 0.0596
Echinococcus multilocularis muscleblind protein 0.0146 0.3114 0.3295
Echinococcus granulosus GPCR family 2 0.0017 0.0157 0.0166
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0157 0.0166
Echinococcus granulosus lamin 0.0055 0.1042 0.1103
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2412 0.3928
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0157 0.0166
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0005 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0194 0.0628
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0387 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0203 0.0215
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0008
Echinococcus multilocularis musashi 0.0055 0.1042 0.1103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.509 0.8289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.0256
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0167 0.0272
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0288 0.0305
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.1103
Echinococcus multilocularis cpg binding protein 0.0033 0.0537 0.0568
Brugia malayi hypothetical protein 0.0052 0.097 0.1579
Schistosoma mansoni cpg binding protein 0.003 0.0456 0.0482
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0979 0.1595
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0005 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1377 0.1206
Onchocerca volvulus 0.001 0.0005 0.002
Schistosoma mansoni hypothetical protein 0.0017 0.0157 0.0166
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.0288 0.0096
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0005 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0194 0.0205
Loa Loa (eye worm) hypothetical protein 0.0146 0.3114 0.5072
Schistosoma mansoni hypothetical protein 0.0424 0.9452 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.007 0.1377 0.1989
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0154 0.0162
Mycobacterium tuberculosis Conserved protein 0.007 0.1377 0.1206
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1116 0.7795
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0455 0.074
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0005 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0194 0.0205
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1377 0.2236
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Schistosoma mansoni zinc finger protein 0.0015 0.0115 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.1234
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0005 0.0005
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0288 0.121
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.097 0.6882
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0005 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0456 0.0743
Brugia malayi Bromodomain containing protein 0.0074 0.1473 0.2399
Loa Loa (eye worm) hypothetical protein 0.0019 0.0203 0.0331
Mycobacterium leprae conserved hypothetical protein 0.007 0.1377 0.353
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0203 0.0215
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0194 0.0308
Schistosoma mansoni cpg binding protein 0.0033 0.0537 0.0568
Echinococcus granulosus intermediate filament protein 0.0055 0.1042 0.1103
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1377 0.2236
Loa Loa (eye worm) hypothetical protein 0.0052 0.097 0.1579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.509 0.5385
Loa Loa (eye worm) beta-lactamase 0.007 0.1377 0.2242
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.097 1
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0288 0.0305
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0005 0.0005
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0158 0.3373 0.5489
Loa Loa (eye worm) hypothetical protein 0.0036 0.0599 0.0975
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0005 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0645 0.0682
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0154 0.0162
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0194 0.0308
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0288 0.0793
Onchocerca volvulus 0.0055 0.1042 0.4196
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0288 0.0793
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1377 0.1457
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0154 0.0162
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0288 0.0469
Brugia malayi hypothetical protein 0.0119 0.2484 0.4046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0157 0.0166
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.0288 0.0158
Schistosoma mansoni cpg binding protein 0.0033 0.0537 0.0568
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.097 0.6774
Loa Loa (eye worm) hypothetical protein 0.007 0.1377 0.2242
Schistosoma mansoni hypothetical protein 0.002 0.0233 0.0246
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0288 0.0305
Onchocerca volvulus 0.0055 0.1042 0.4196
Brugia malayi hypothetical protein 0.0038 0.0645 0.105
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0005 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0203 0.0323
Trichomonas vaginalis esterase, putative 0.007 0.1377 0.2236
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0005 0.0005
Brugia malayi CXXC zinc finger family protein 0.003 0.0456 0.0743
Brugia malayi beta-lactamase family protein 0.007 0.1377 0.2242
Echinococcus granulosus muscleblind protein 0.0146 0.3114 0.3295
Schistosoma mansoni hypothetical protein 0.0036 0.0599 0.0634
Schistosoma mansoni hypothetical protein 0.0038 0.0645 0.0682
Schistosoma mansoni bromodomain containing protein 0.0063 0.1214 0.1284
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0194 0.0944
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0203 0.1014
Onchocerca volvulus 0.001 0.0005 0.002
Echinococcus multilocularis GPCR, family 2 0.0017 0.0157 0.0166
Schistosoma mansoni ap endonuclease 0.0018 0.0194 0.0205
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0203 0.0331
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0288 0.0158
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1377 0.1206
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1377 0.2242
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.007 0.1377 0.2242
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.097 0.6774
Loa Loa (eye worm) hypothetical protein 0.0037 0.0625 0.1017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1135 0.1201
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0005 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1377 0.1457
Loa Loa (eye worm) hypothetical protein 0.007 0.1377 0.2242
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0017 0.0157 0.0166
Schistosoma mansoni hypothetical protein 0.0017 0.0157 0.0166
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.097 0.6558
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0005 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.509 0.5385
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0008
Brugia malayi Muscleblind-like protein 0.0146 0.3114 0.5072
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0154 0.0162
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0194 0.5
Brugia malayi MH2 domain containing protein 0.0116 0.2412 0.3928
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1377 0.1206
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0203 0.1014
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0203 0.3099
Schistosoma mansoni ap endonuclease 0.0018 0.0194 0.0205
Schistosoma mansoni intermediate filament proteins 0.0055 0.1042 0.1103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0364 0.0593
Echinococcus multilocularis lamin 0.0055 0.1042 0.1103
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0288 0.0305
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0005 0.0008
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.097 0.6558
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.509 0.5385
Onchocerca volvulus 0.007 0.1377 0.5542
Brugia malayi Bromodomain containing protein 0.0037 0.0623 0.1015
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0005 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1377 1
Loa Loa (eye worm) glutaminase 2 0.0279 0.614 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0194 0.2956
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1377 0.1206
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1377 0.1206
Loa Loa (eye worm) hypothetical protein 0.007 0.1377 0.2242
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1377 1
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.9452 1
Schistosoma mansoni hypothetical protein 0.0015 0.0115 0.0121
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0314 0.0332
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0571 0.0604
Loa Loa (eye worm) hypothetical protein 0.0055 0.1042 0.1698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0168 0.0178
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0005 0.0005
Echinococcus multilocularis muscleblind protein 1 0.0146 0.3114 0.3295
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0203 0.0331
Brugia malayi hypothetical protein 0.0034 0.0547 0.0891
Loa Loa (eye worm) glutaminase 0.0279 0.614 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0194 0.0316
Echinococcus granulosus dna polymerase eta 0.0019 0.0203 0.0215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0157 0.0256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.509 0.8289
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1377 0.2236
Loa Loa (eye worm) hypothetical protein 0.0146 0.3114 0.5072
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1377 0.1206
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0203 0.07
Echinococcus granulosus geminin 0.0173 0.3721 0.3937
Onchocerca volvulus 0.007 0.1377 0.5542
Loa Loa (eye worm) hypothetical protein 0.0027 0.0387 0.0631
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0005 0.0008
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0203 0.0215
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0005 0.0008
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.0119 0.2484 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0005 0.0005
Brugia malayi G-protein alpha subunit 0.001 0.0005 0.0008
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0158 0.3373 0.3241
Brugia malayi glutaminase DH11.1 0.0279 0.614 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0203 0.0015
Echinococcus multilocularis expressed protein 0.001 0.0005 0.0005
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0312 0.033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.07
Schistosoma mansoni lamin 0.0055 0.1042 0.1103
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.4896 0.7973
Plasmodium vivax hypothetical protein, conserved 0.007 0.1377 1
Brugia malayi beta-lactamase family protein 0.007 0.1377 0.2242
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0168 0.0178
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1135 0.1201
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0158 0.3373 0.5345
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.0288 0.0096
Mycobacterium tuberculosis Conserved protein 0.007 0.1377 0.1206
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0026 0.0043
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0455 0.074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0194 0.0628
Loa Loa (eye worm) hypothetical protein 0.007 0.1377 0.2242
Echinococcus granulosus zinc finger protein 0.0021 0.0248 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1377 0.2236
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0158 0.3373 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1019 0.166
Mycobacterium ulcerans hypothetical protein 0.0158 0.3373 0.5345
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0005 0.0008
Schistosoma mansoni hypothetical protein 0.0017 0.0157 0.0166
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0194 0.0316
Mycobacterium leprae Probable lipase LipE 0.007 0.1377 0.353
Onchocerca volvulus 0.003 0.0456 0.1835
Loa Loa (eye worm) hypothetical protein 0.007 0.1377 0.2242
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0203 0.0331
Leishmania major hypothetical protein, conserved 0.007 0.1377 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1377 0.1457
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0979 0.1595
Echinococcus multilocularis zinc finger protein 0.0021 0.0248 0.0262
Entamoeba histolytica hypothetical protein 0.0038 0.0645 1
Schistosoma mansoni zinc finger protein 0.0021 0.0248 0.0262
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0203 0.0015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0157 0.0166
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0203 0.0009
Schistosoma mansoni glutaminase 0.0279 0.614 0.6496
Giardia lamblia DINP protein human, muc B family 0.0019 0.0203 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0005 0.0005
Leishmania major DNA polymerase eta, putative 0.0019 0.0203 0.07
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Trypanosoma brucei ISWI complex protein 0.0015 0.0115 0.0337
Schistosoma mansoni hypothetical protein 0.0173 0.3721 0.3937
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1377 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0314 0.0332
Echinococcus granulosus dna polymerase kappa 0.0019 0.0203 0.0215
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0288 0.0158
Mycobacterium ulcerans lipase LipD 0.007 0.1377 0.1989
Echinococcus multilocularis dna polymerase eta 0.0019 0.0203 0.0215
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0005 0.0008
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0005 0.0005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0203 0.0323
Loa Loa (eye worm) hypothetical protein 0.0119 0.2484 0.4046
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.0288 0.0158
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1377 0.1457
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.0288 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0387 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.509 0.5385
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1377 0.2242
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0203 0.1014
Trichomonas vaginalis glutaminase, putative 0.0279 0.614 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0203 0.0215
Mycobacterium tuberculosis Conserved protein 0.007 0.1377 0.1206
Brugia malayi beta-lactamase 0.007 0.1377 0.2242
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0645 0.0682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0157 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.509 0.5385
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1377 0.1989
Onchocerca volvulus Huntingtin homolog 0.0119 0.2484 1
Echinococcus multilocularis geminin 0.0173 0.3721 0.3937
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0168 0.0178
Leishmania major hypothetical protein, conserved 0.0052 0.097 0.6774
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0288 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0979 0.1595
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.097 1
Echinococcus multilocularis lamin dm0 0.0055 0.1042 0.1103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.1014
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0069 0.134 0.2182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.07
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.0288 0.0158
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0005 0.0005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0312 0.033
Schistosoma mansoni DNA polymerase eta 0.0019 0.0203 0.0215
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0288 0.0305
Echinococcus granulosus lamin dm0 0.0055 0.1042 0.1103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.509 0.5385
Leishmania major DNA polymerase kappa, putative 0.0019 0.0203 0.07
Loa Loa (eye worm) hypothetical protein 0.0053 0.0979 0.1595
Onchocerca volvulus 0.007 0.1377 0.5542
Brugia malayi intermediate filament protein 0.0055 0.1042 0.1698
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0005 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.1042 0.1698
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0599 0.0975
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.07
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.509 0.5385
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.07
Onchocerca volvulus 0.001 0.0005 0.002
Loa Loa (eye worm) intermediate filament protein 0.0055 0.1042 0.1698
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1218 0.1288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1377 0.1206
Schistosoma mansoni hypothetical protein 0.0173 0.3721 0.3937
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0157 0.0256
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0005 0.0005
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable aminotransferase 0.0158 0.3373 0.3241
Entamoeba histolytica hypothetical protein 0.0038 0.0645 1
Echinococcus granulosus expressed protein 0.001 0.0005 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0224 0.4896 0.7973
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0194 0.0628
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0005 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0203 0.07
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0645 0.0682
Trypanosoma brucei unspecified product 0.0019 0.0203 0.1014
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1377 0.2236
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0203 0.0009

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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