Detailed information for compound 628364

Basic information

Technical information
  • TDR Targets ID: 628364
  • Name: 4-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)-N -(6-nitro-1,3-benzothiazol-2-yl)benzamide
  • MW: 494.543 | Formula: C23H18N4O5S2
  • H donors: 1 H acceptors: 6 LogP: 4.05 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N1CCc2c(C1)cccc2)Nc1nc2c(s1)cc(cc2)[N+](=O)[O-]
  • InChi: 1S/C23H18N4O5S2/c28-22(25-23-24-20-10-7-18(27(29)30)13-21(20)33-23)16-5-8-19(9-6-16)34(31,32)26-12-11-15-3-1-2-4-17(15)14-26/h1-10,13H,11-12,14H2,(H,24,25,28)
  • InChiKey: KMOYIMGCDRNFLR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_598408
  • ChemDiv1_005071
  • EU-0006146

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.0424
Plasmodium vivax lysine--tRNA ligase, putative 0.0071 0.0457 0.0457
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.0261 0.1136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0153
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0061 0.0428
Plasmodium falciparum calcium-dependent protein kinase 3 0.0097 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0061 0.0107
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0651 0.5013
Schistosoma mansoni protein kinase 0.0097 0.0654 0.1146
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0038 0.1181
Onchocerca volvulus 0.0032 0.0168 0.5541
Brugia malayi Sugar transporter family protein 0.0045 0.0261 0.1136
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0179 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma cruzi sugar transporter, putative 0.0045 0.0261 0.1064
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0278 0.1206
Echinococcus granulosus cathepsin l1 0.0019 0.0068 0.0119
Echinococcus multilocularis lysyl tRNA synthetase 0.0071 0.0457 0.0801
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0216 0.0379
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0038 0.0163
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.01 0.0787
Giardia lamblia Threonyl-tRNA synthetase 0.0018 0.0061 0.0849
Schistosoma mansoni cpg binding protein 0.0032 0.0168 0.0295
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Brugia malayi AMP-binding enzyme family protein 0.0023 0.01 0.0433
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0061 0.0107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0038 0.0122
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0011 0.0008 0.0003
Leishmania major glucose transporter, lmgt3 0.0098 0.0664 0.2678
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0651 0.5013
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0061 0.0107
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0261 0.1136
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Brugia malayi hypothetical protein 0.0229 0.1643 0.7139
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0664 0.2885
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0513 0.3763 0.3763
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0284 0.1153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0079 0.0342
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.0261 0.183
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.01 0.1523
Echinococcus multilocularis solute carrier family 22 0.0045 0.0261 0.0458
Brugia malayi glutathione reductase 0.0042 0.0245 0.1063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0235
Leishmania major mitochondrial DNA polymerase beta 0.0339 0.2458 1
Onchocerca volvulus 0.0019 0.0068 0.1752
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0022 0.0094
Schistosoma mansoni ap endonuclease 0.002 0.0079 0.0138
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0071 0.0457 0.1861
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0049 0.0095
Brugia malayi Cathepsin L-like precursor 0.0019 0.0068 0.0296
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0216 0.0379
Schistosoma mansoni glucose transport protein 0.0318 0.2301 0.403
Echinococcus granulosus solute carrier family 22 0.0045 0.0261 0.0458
Echinococcus granulosus histidyl tRNA synthetase 0.0011 0.0008 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.2458 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0095 0.064 0.8664
Brugia malayi hypothetical protein 0.0024 0.0111 0.048
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0731 0.5673
Brugia malayi CXXC zinc finger family protein 0.0032 0.0168 0.0732
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0061 0.0266
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0097 0.0655 0.0977
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0061 0.0249
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0111 0.0111
Onchocerca volvulus 0.0045 0.0261 0.9056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.01 0.0787
Leishmania major glucose transporter/membrane transporter D2, putative 0.0098 0.0664 0.2678
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.2458 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0061 0.0081
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0011 0.0008 0.0121
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.0261 0.0383
Giardia lamblia Hexose transporter 0.0045 0.0261 0.4016
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0011 0.0008 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.01 0.0735
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0038 0.0239
Onchocerca volvulus 0.0045 0.0261 0.9056
Plasmodium vivax calcium-dependent protein kinase, putative 0.0097 0.0655 0.0655
Brugia malayi AMP-binding enzyme family protein 0.0023 0.01 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0049 0.0095
Brugia malayi major facilitator superfamily protein 0.0045 0.0261 0.1136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0079 0.032
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0097 0.0654 0.1146
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0079 0.4138
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0095 0.064 0.278
Entamoeba histolytica protein kinase, putative 0.0097 0.0654 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.064 0.112
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0651 0.5013
Plasmodium vivax aspartate--tRNA ligase, putative 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0038 0.0239
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0097 0.0654 0.2662
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.01 0.0376
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0111 0.045
Leishmania major hypothetical protein, conserved 0.0016 0.0046 0.0156
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0097 0.0654 0.2837
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0261 0.1128
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0416 0.1692
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.0424
Loa Loa (eye worm) ctsf protein 0.0019 0.0068 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Echinococcus multilocularis calcium dependent protein kinase 0.0091 0.0609 0.1068
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.0261 0.2026
Onchocerca volvulus 0.0045 0.0261 0.9056
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0068 0.1752
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0061 0.0194
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0056 0.0388
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0056 0.1081
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.01 0.0735
Toxoplasma gondii sugar transporter ST2 0.0045 0.0261 0.0383
Echinococcus multilocularis hedgehog 0.0186 0.1315 0.2303
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0038 0.0163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0042 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0111 0.0111
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0068 0.0119
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.01 0.0735
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0061 0.0257
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0079 0.0079
Treponema pallidum glycyl-tRNA synthetase 0.0011 0.0008 0.002
Echinococcus multilocularis cpg binding protein 0.0034 0.0182 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0122
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0068 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0046 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.0261 0.2026
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0061 0.2114
Schistosoma mansoni protein kinase 0.0097 0.0654 0.1146
Brugia malayi Hint module family protein 0.005 0.0304 0.1323
Onchocerca volvulus 0.0019 0.0068 0.1752
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0.0008 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0046 0.0186
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0111 0.0155
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0079 0.0342
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.0758 0.3082
Loa Loa (eye worm) hypothetical protein 0.005 0.0304 0.1315
Onchocerca volvulus 0.0048 0.0286 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0068 0.0286
Loa Loa (eye worm) hypothetical protein 0.0095 0.064 0.2773
Leishmania major cathepsin L-like protease 0.0072 0.0462 0.1855
Echinococcus granulosus Desert hedgehog protein 0.0186 0.1315 0.2303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0235
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0071 0.0457 0.1861
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Plasmodium falciparum calcium-dependent protein kinase 1 0.0097 0.0655 0.0655
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0758 0.3061
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0068 0.0296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0042 0.0074
Brugia malayi Cathepsin L-like precursor 0.0013 0.0022 0.0094
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.01 0.0735
Loa Loa (eye worm) hypothetical protein 0.0048 0.0289 0.1249
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0261 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0261 0.1136
Onchocerca volvulus 0.0045 0.0261 0.9056
Plasmodium falciparum calcium-dependent protein kinase 2 0.0097 0.0655 0.0655
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0068 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Onchocerca volvulus 0.0019 0.0068 0.1752
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0079 0.1201
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0.0008 0.0014
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0664 0.27
Brugia malayi Thioredoxin reductase 0.0042 0.0245 0.1063
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0061 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0085
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0038 0.0045
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0249 0.0436
Echinococcus granulosus microtubule associated protein 2 0.0774 0.5709 1
Schistosoma mansoni hypothetical protein 0.0135 0.0938 0.1643
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0289 0.1257
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0061 0.0219
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0042 0.0074
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.064 0.112
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0061 0.0257
Echinococcus granulosus solute carrier family 22 0.0045 0.0261 0.0458
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0751
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0664 0.2885
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0068 0.0119
Entamoeba histolytica hypothetical protein 0.0071 0.0457 0.699
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0122
Toxoplasma gondii thioredoxin reductase 0.0042 0.0245 0.0358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0049 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Plasmodium falciparum hexose transporter 0.0318 0.2301 0.2301
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0179 0.3815
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0079 0.0138
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0462 0.188
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.0758 0.3082
Trypanosoma brucei histidyl-tRNA synthetase 0.0011 0.0008 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0046 0.0186
Echinococcus granulosus General substrate transporter 0.0273 0.1967 0.3446
Toxoplasma gondii exonuclease III APE 0.002 0.0079 0.0107
Entamoeba histolytica protein kinase, putative 0.0097 0.0654 1
Onchocerca volvulus 0.0019 0.0068 0.1752
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0074
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0462 0.188
Echinococcus granulosus dnaJ subfamily B 0.0459 0.3355 0.5876
Schistosoma mansoni microtubule-associated protein tau 0.0774 0.5709 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0438 0.0767
Entamoeba histolytica hypothetical protein 0.0039 0.0216 0.3306
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0061 0.0061
Schistosoma mansoni cpg binding protein 0.0034 0.0182 0.0319
Leishmania major hypothetical protein, conserved 0.0016 0.0046 0.0156
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0039 0.022 0.0948
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0284 0.1153
Echinococcus granulosus solute carrier family 22 0.0045 0.0261 0.0458
Giardia lamblia Glycyl-tRNA synthetase 0.0018 0.0061 0.0849
Mycobacterium ulcerans hypothetical protein 0.0023 0.01 0.0735
Leishmania major protein kinase, putative 0.0097 0.0654 0.264
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0286 0.0502
Leishmania major hypothetical protein, conserved 0.0024 0.0111 0.042
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0038 0.0038
Toxoplasma gondii anticodon binding domain-containing protein 0.0011 0.0008 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0168 0.0723
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0.0008 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Trypanosoma cruzi hexose transporter 0.0098 0.0664 0.27
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.0261 0.0458
Leishmania major glycyl tRNA synthetase, putative 0.0011 0.0008 0.0001
Plasmodium falciparum thioredoxin reductase 0.0015 0.0038 0.0038
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0061 0.0266
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0261 0.1136
Trypanosoma brucei glucose transporter 2A 0.0098 0.0664 0.27
Schistosoma mansoni glucose transporter 0.0045 0.0261 0.0458
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0011 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0008 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0068 0.1039
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0095 0.064 0.9775
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0056 0.0056
Brugia malayi Cathepsin L-like precursor 0.0019 0.0068 0.0296
Schistosoma mansoni ap endonuclease 0.002 0.0079 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.01 0.0376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0079 0.0567
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0074
Loa Loa (eye worm) 63kd antigen 0.0011 0.0008 0.0024
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.0261 0.0458
Plasmodium falciparum asparagine--tRNA ligase 0.0011 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0039 0.0216 0.3306
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0038 0.0153
Leishmania major lysyl-tRNA synthetase, putative 0.0071 0.0457 0.1836
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0071 0.0457 0.1988
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0022 0.0331
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.0261 0.1136
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0056 0.0056
Chlamydia trachomatis lysine--tRNA ligase 0.0071 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0664 0.27
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0066
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0011 0.0008 0.0013
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.001 0.0017
Schistosoma mansoni survival motor neuron protein 0.0047 0.0278 0.0486
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0097 0.0655 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Echinococcus granulosus lysyl tRNA synthetase 0.0071 0.0457 0.0801
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0038 0.0038
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0664 0.2885
Plasmodium vivax histidine--tRNA ligase, putative 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Giardia lamblia Prolyl-tRNA synthetase 0.0095 0.064 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.01 0.0376
Plasmodium vivax asparagine--tRNA ligase, putative 0.0011 0.0008 0.0008
Schistosoma mansoni sugar transporter 0.0045 0.0261 0.0458
Onchocerca volvulus 0.0045 0.0261 0.9056
Echinococcus granulosus cpg binding protein 0.0034 0.0182 0.0319
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0074
Echinococcus granulosus calcium dependent protein kinase 0.0091 0.0609 0.1068
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0062 0.0392 0.1704
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0348 0.1415
Brugia malayi lysyl-tRNA synthetase 0.0071 0.0457 0.1988
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0153
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1125 0.4561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Plasmodium falciparum calcium-dependent protein kinase 4 0.0097 0.0655 0.0655
Plasmodium falciparum glutathione reductase 0.0015 0.0038 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0153
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.0261 0.0458
Plasmodium falciparum glutathione reductase 0.0042 0.0245 0.0245
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Leishmania major cathepsin L-like protease 0.0019 0.0068 0.0247
Echinococcus granulosus solute carrier family 22 0.0045 0.0261 0.0458
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0249 0.0436
Loa Loa (eye worm) hypothetical protein 0.0048 0.0286 0.1236
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0038 0.0122
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0318 0.2301 0.403
Onchocerca volvulus 0.0023 0.01 0.2947
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0071 0.0457 0.6005
Plasmodium vivax CDK-related protein kinase 6, putative 0.1348 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0068 0.1039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.0424
Schistosoma mansoni sugar transporter 0.0045 0.0261 0.0458
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.3355 0.5876
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0061 0.3127
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0068 0.0068
Onchocerca volvulus 0.0045 0.0261 0.9056
Plasmodium falciparum lysine--tRNA ligase 0.0071 0.0457 0.0457
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0038 0.0153
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0339 0.2458 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.0261 0.183
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0245 0.1693
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0011 0.0008 0.0033
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0011 0.0008 0.0013
Leishmania major glucose transporter, lmgt1 0.0098 0.0664 0.2678
Brugia malayi Cathepsin L-like precursor 0.0019 0.0068 0.0296
Loa Loa (eye worm) fibroinase 0.0019 0.0068 0.0286
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0095 0.064 0.112
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Trypanosoma brucei sugar transporter, putative 0.0045 0.0261 0.1064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0079 0.1124
Onchocerca volvulus 0.0045 0.0261 0.9056
Onchocerca volvulus 0.0045 0.0261 0.9056
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0245 0.0245
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0042 0.0183
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Echinococcus multilocularis solute carrier family 22 0.0045 0.0261 0.0458
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Brugia malayi cathepsin L-like precursor 0.0013 0.0022 0.0094
Plasmodium falciparum mitogen-activated protein kinase 2 0.0513 0.3763 0.3763
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.1261 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0068 0.0119
Plasmodium vivax glutathione reductase, putative 0.0042 0.0245 0.0245
Loa Loa (eye worm) glutathione reductase 0.0042 0.0245 0.1055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0022 0.0094
Trypanosoma cruzi histidyl-tRNA synthetase 0.0011 0.0008 0.0032
Brugia malayi Cathepsin L-like precursor 0.0019 0.0068 0.0296
Plasmodium vivax sugar transporter, putative 0.0045 0.0261 0.0261
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Treponema pallidum NADH oxidase 0.0015 0.0038 0.1747
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0261 0.1128
Brugia malayi hypothetical protein 0.0016 0.0046 0.0199
Brugia malayi hypothetical protein 0.0045 0.0261 0.1136
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1125 0.4578
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0462 0.188
Brugia malayi Cam kinase protein 1 0.0097 0.0654 0.2844
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Schistosoma mansoni threonyl-tRNA synthetase 0.0011 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0457 0.1981
Onchocerca volvulus Putative transporter 0.0045 0.0261 0.9056
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0079 0.0332
Schistosoma mansoni glucose transport protein 0.0318 0.2301 0.403
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0095 0.064 0.112
Leishmania major trypanothione reductase 0.0042 0.0245 0.0967
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0079 0.0336
Onchocerca volvulus 0.0045 0.0261 0.9056
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0664 0.2885
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.0261 0.1064
Schistosoma mansoni glucose transport protein 0.0318 0.2301 0.403
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0046 0.0058
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Brugia malayi hypothetical protein 0.0045 0.0261 0.1136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0085
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0011 0.0008 0.0116
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0175 0.076
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0097 0.0655 0.0655
Mycobacterium tuberculosis Probable reductase 0.0097 0.0651 0.5013
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0046 0.0186
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0022 0.0094
Plasmodium falciparum aspartate--tRNA ligase 0.0011 0.0008 0.0008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0038 0.0038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0731 0.5673
Schistosoma mansoni hypothetical protein 0.0318 0.2301 0.403
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0079 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Plasmodium falciparum thioredoxin reductase 0.0042 0.0245 0.0245
Echinococcus multilocularis General substrate transporter 0.0273 0.1967 0.3446
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0378 0.278
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0284 0.1153
Toxoplasma gondii sugar transporter ST3 0.0045 0.0261 0.0383
Toxoplasma gondii protein kinase, putative 0.0897 0.6633 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0513 0.3763 0.5668
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.1125 0.4578
Plasmodium vivax proline--tRNA ligase, putative 0.0111 0.0758 0.0758
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Mycobacterium ulcerans hypothetical protein 0.0178 0.1261 1
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0066
Plasmodium falciparum histidine--tRNA ligase, putative 0.0011 0.0008 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0731 0.5673
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0651 0.5013
Onchocerca volvulus 0.0019 0.0068 0.1752
Plasmodium vivax vivapain-2 0.0019 0.0068 0.0068
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0061 0.0249
Brugia malayi hypothetical protein 0.0045 0.0261 0.1136
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0095 0.064 0.278
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0008 0.0037
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0011 0.0008 0.0013
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0061 0.2114
Leishmania major cathepsin L-like protease 0.0019 0.0068 0.0247
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0079 0.2798
Plasmodium vivax vivapain-2 0.0019 0.0068 0.0068
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Onchocerca volvulus 0.0019 0.0068 0.1752
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.006 0.0378 0.278
Onchocerca volvulus 0.0045 0.0261 0.9056
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0664 0.2885
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0079 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0664 0.27
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0068 0.0296
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.01 0.1523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0235
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0664 0.27
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0068 0.0247
Onchocerca volvulus 0.0047 0.0278 0.9665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Onchocerca volvulus 0.0045 0.0261 0.9056
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.001 0.0017
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0061 0.0227
Schistosoma mansoni hypothetical protein 0.0039 0.0216 0.0379
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0038 0.0045
Echinococcus multilocularis GPCR, family 2 0.0015 0.0042 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0079 0.0342
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0038 0.1181
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0001 0.0005
Echinococcus multilocularis solute carrier family 22 0.0045 0.0261 0.0458
Leishmania major histidyl-tRNA synthetase, putative 0.0011 0.0008 0.0001
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.0261 0.2026
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0038 0.0163
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.01 0.0735
Leishmania major cathepsin L-like protease 0.0019 0.0068 0.0247
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0457 0.359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Leishmania major cathepsin L-like protease 0.0019 0.0068 0.0247
Loa Loa (eye worm) hypothetical protein 0.0097 0.0654 0.2837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0068 0.0119
Brugia malayi Hint module family protein 0.005 0.0304 0.1323
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0046 0.0186
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0011 0.0008 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0462 0.188
Echinococcus granulosus tumor protein p63 0.0328 0.2378 0.4166
Leishmania major glucose transporter, lmgt2 0.0098 0.0664 0.2678
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0068 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.01 0.1523
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0731 1
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0261 0.1064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Onchocerca volvulus 0.0045 0.0261 0.9056
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0457 0.0801
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0038 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.005 0.0304 0.1315
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0654 0.1146
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0068 0.0277
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0068 0.0068
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0097 0.0654 0.2844
Plasmodium vivax asparagine--tRNA ligase, putative 0.0011 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0045 0.0261 0.1036
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0097 0.0655 0.0655
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0042 0.0183
Loa Loa (eye worm) sugar transporter 0.0318 0.2301 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.0261 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.0261 0.0458
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1643 0.2877
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0384 0.0568
Onchocerca volvulus 0.0045 0.0261 0.9056
Schistosoma mansoni protein kinase 0.0097 0.0654 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0664 0.2885
Brugia malayi Cathepsin L-like precursor 0.0019 0.0068 0.0296
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.0261 0.1036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0261 0.1136
Onchocerca volvulus 0.0045 0.0261 0.9056
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0664 0.27
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0085
Entamoeba histolytica hypothetical protein 0.0039 0.0216 0.3306
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0928 0.4027
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0758 0.3082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0457 0.0801
Schistosoma mansoni sugar transporter 0.0045 0.0261 0.0458
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0011 0.0008 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0.0008 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0056 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Giardia lamblia Lysyl-tRNA synthetase 0.0071 0.0457 0.7117
Echinococcus multilocularis cysteine protease 0.0019 0.0068 0.0119
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0017
Brugia malayi MH2 domain containing protein 0.0134 0.0928 0.4033
Echinococcus multilocularis histidyl tRNA synthetase 0.0011 0.0008 0.0014
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.0261 0.0458
Brugia malayi major facilitator superfamily protein 0.0045 0.0261 0.1136
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0038 0.0666
Loa Loa (eye worm) sugar transporter 0.0045 0.0261 0.1128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0174
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0042 0.0174
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0068 0.1752
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Echinococcus multilocularis tumor protein p63 0.0328 0.2378 0.4166
Loa Loa (eye worm) hypothetical protein 0.0077 0.0506 0.2193
Brugia malayi Sugar transporter family protein 0.0045 0.0261 0.1136
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1643 0.2877
Echinococcus granulosus GPCR family 2 0.0015 0.0042 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0049 0.0095
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0664 0.27
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0038 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0111 0.045
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0061 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0261 0.1136
Schistosoma mansoni hypothetical protein 0.0047 0.0278 0.0486
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0257
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0068 0.1752
Entamoeba histolytica cysteine protease, putative 0.0019 0.0068 0.1039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0654 0.2844
Brugia malayi hypothetical protein 0.0039 0.0216 0.094
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0651 0.8823
Toxoplasma gondii sugar transporter ST1 0.0045 0.0261 0.0383
Leishmania major cathepsin L-like protease 0.0072 0.0462 0.1855
Schistosoma mansoni sugar transporter 0.0045 0.0261 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0046 0.0186
Toxoplasma gondii facilitative glucose transporter GT1 0.0318 0.2301 0.3462
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0457 0.359
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0061 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.2301 1
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0664 0.2885
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Loa Loa (eye worm) hypothetical protein 0.0095 0.064 0.2773
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0306
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0068 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0038 0.0153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0046 0.0067
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0097 0.0655 0.0655
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.01 0.0508
Toxoplasma gondii lysine-tRNA ligase 0.0071 0.0457 0.0679
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0061 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0153
Toxoplasma gondii cathepsin CPL 0.0019 0.0068 0.0091
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0011 0.0008 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0004
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0061 0.0936
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0068 0.0068
Brugia malayi Aspartyl-tRNA synthetase 0.0011 0.0008 0.0033
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0022 0.0038
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0038 0.0153
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0245 0.0995
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Plasmodium falciparum protein kinase 7 0.0897 0.6633 0.6633
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0011 0.0008 0.0001
Leishmania major cathepsin L-like protease 0.0019 0.0068 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0235
Loa Loa (eye worm) hypothetical protein 0.0229 0.1643 0.7136
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0061 0.0249
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0011 0.0008 0.0014
Onchocerca volvulus 0.0045 0.0261 0.9056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0079 0.032
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0378 0.4841
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0318 0.2301 0.403
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0095 0.064 0.278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0042 0.0074
Plasmodium vivax hexose transporter 0.0318 0.2301 0.2301
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0261 0.1136
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0361 0.147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0068 0.0296
Trypanosoma brucei glucose transporter 1E 0.0098 0.0664 0.27
Mycobacterium ulcerans sugar transporter 0.0045 0.0261 0.2026
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0046 0.0199
Schistosoma mansoni aspartyl-tRNA synthetase 0.0011 0.0008 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.01 0.0735
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0651 0.5013
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0153
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0239
Brugia malayi Cathepsin L-like precursor 0.0019 0.0068 0.0296
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0011 0.0008 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.01 0.0508
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0061 0.0266
Toxoplasma gondii hypothetical protein 0.0055 0.0336 0.0495
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0079 0.0138
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0079 0.029
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0061 0.1193
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0011 0.0008 0.0033
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0654 0.1146
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0111 0.045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0068 0.0296
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0216 0.0379
Trypanosoma brucei trypanothione reductase 0.0042 0.0245 0.0995
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Plasmodium falciparum calcium-dependent protein kinase 5 0.0097 0.0655 0.0655
Trypanosoma cruzi hexose transporter, putative 0.0054 0.033 0.1343
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.0261 0.0261
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0111 0.0758 0.1132
Giardia lamblia Sugar-proton symporter 0.0045 0.0261 0.4016
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0061 0.0266
Plasmodium falciparum asparagine--tRNA ligase 0.0011 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0928 0.4027
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0097 0.0655 0.0977
Echinococcus multilocularis cysteine protease 0.0019 0.0068 0.0119
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0061 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0046 0.0199
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.0471
Brugia malayi Cathepsin L-like precursor 0.0013 0.0022 0.0094
Loa Loa (eye worm) cysteine protease 0.0019 0.0068 0.0286
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0011 0.0008 0.0013
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0011 0.0008 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0284 0.1153
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0179 0.137
Plasmodium falciparum glycine--tRNA ligase 0.0011 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0459 0.3355 0.5876
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0111 0.0111
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0758 0.3061
Echinococcus granulosus cathepsin l1 0.0013 0.0022 0.0038
Onchocerca volvulus 0.0019 0.0068 0.1752
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0289 0.1257
Brugia malayi Sugar transporter family protein 0.0318 0.2301 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0068 0.0119
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0011 0.0008 0.0031
Onchocerca volvulus 0.0045 0.0261 0.9056
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0061 0.0936
Trypanosoma cruzi glucose transporter, putative 0.0045 0.0261 0.1064
Chlamydia trachomatis histidine--tRNA ligase 0.0011 0.0008 0.0008
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0097 0.0654 0.2837
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0066
Trypanosoma brucei glucose transporter, putative 0.0098 0.0664 0.27
Plasmodium falciparum proline--tRNA ligase 0.0111 0.0758 0.0758
Echinococcus multilocularis solute carrier family 22 0.0045 0.0261 0.0458
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.01 0.0735
Mycobacterium ulcerans hypothetical protein 0.0016 0.0046 0.0304
Schistosoma mansoni cpg binding protein 0.0034 0.0182 0.0319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0462 0.188
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0261 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0261 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0068 0.0296
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0245 0.1055
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0045 0.0261 0.1128
Echinococcus multilocularis microtubule associated protein 2 0.0774 0.5709 1
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0011 0.0008 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0038 0.0153
Leishmania major cathepsin L-like protease 0.0072 0.0462 0.1855
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0289 0.1249
Brugia malayi AMP-binding enzyme family protein 0.0023 0.01 0.0433
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0261 0.1136
Entamoeba histolytica hypothetical protein 0.0039 0.0216 0.3306

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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