Detailed information for compound 646945

Basic information

Technical information
  • TDR Targets ID: 646945
  • Name: 2-[[4-chloro-3-(trifluoromethyl)phenyl]-pheny lsulfonylamino]-N-[(2-methylphenyl)methyl]ace tamide
  • MW: 496.93 | Formula: C23H20ClF3N2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.34 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccccc1)c1ccc(c(c1)C(F)(F)F)Cl)NCc1ccccc1C
  • InChi: 1S/C23H20ClF3N2O3S/c1-16-7-5-6-8-17(16)14-28-22(30)15-29(33(31,32)19-9-3-2-4-10-19)18-11-12-21(24)20(13-18)23(25,26)27/h2-13H,14-15H2,1H3,(H,28,30)
  • InChiKey: URGGNVWFSSDODB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-chloro-3-(trifluoromethyl)phenyl]-phenylsulfonyl-amino]-N-[(2-methylphenyl)methyl]acetamide
  • 2-[[4-chloro-3-(trifluoromethyl)phenyl]-phenylsulfonyl-amino]-N-(2-methylbenzyl)acetamide
  • 2-[[4-chloro-3-(trifluoromethyl)phenyl]-phenylsulfonyl-amino]-N-[(2-methylphenyl)methyl]ethanamide
  • ZINC01183955

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0005 0.0004
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0048 0.1231
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0102 0.3489
Schistosoma mansoni tar DNA-binding protein 0.007 0.0105 0.01
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0025 0.0557
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0053 0.0052
Onchocerca volvulus 0.0073 0.0111 0.2063
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.0102 0.2813
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.0951 0.095
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0025 0.0544
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2193 0.4199 1
Echinococcus multilocularis lamin 0.0032 0.0033 0.0032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.0102 0.2803
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.0238 0.0237
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0018 0.0006 0.0006
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0018 0.0006 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0162 0.0283 0.8055
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0105 0.1067
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0102 0.2804
Mycobacterium ulcerans NADH dehydrogenase 0.0018 0.0006 0.0001
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0018 0.0006 0.0014
Trypanosoma brucei trypanothione reductase 0.0196 0.0349 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0017 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.5202 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0012
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0751
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0054 0.139
Loa Loa (eye worm) hypothetical protein 0.0162 0.0283 0.2972
Schistosoma mansoni hypothetical protein 0.0041 0.005 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0526
Mycobacterium tuberculosis Conserved protein 0.0073 0.0111 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0018 0.0006 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.042
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0017 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0111 0.0106
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0162 0.1663
Leishmania major hypothetical protein, conserved 0.0018 0.0006 0.0001
Entamoeba histolytica hypothetical protein 0.012 0.0203 1
Brugia malayi Pre-SET motif family protein 0.0036 0.004 0.0375
Mycobacterium tuberculosis Probable oxidoreductase 0.0497 0.093 0.2209
Echinococcus granulosus ferritin 0.0018 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0006 0.0007
Mycobacterium ulcerans hypothetical protein 0.0073 0.0111 0.0252
Leishmania major trypanothione reductase 0.0196 0.0349 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0067 0.0665
Entamoeba histolytica hypothetical protein 0.012 0.0203 1
Schistosoma mansoni survival motor neuron protein 0.0104 0.0171 0.0165
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0497 0.093 0.2201
Loa Loa (eye worm) hypothetical protein 0.0106 0.0176 0.1852
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0179
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0066 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0317 0.6085
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0018 0.0006 0.0001
Brugia malayi TAR-binding protein 0.007 0.0105 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0054 0.0938
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0025 0.0543
Mycobacterium ulcerans TetR family transcriptional regulator 0.2197 0.4208 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.0102 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0033 0.0538
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.9101
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0054 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0054 0.0938
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0017 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0066 0.0694
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0054 0.139
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.9101
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0017 0.0325
Brugia malayi glutathione reductase 0.0196 0.0349 0.3645
Plasmodium falciparum glutathione reductase 0.0068 0.0102 0.2813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0041 0.0686
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0018 0.0006 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Leishmania major hypothetical protein, conserved 0.0028 0.0025 0.0544
Schistosoma mansoni intermediate filament proteins 0.0032 0.0033 0.0028
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.0102 0.2804
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.0102 0.2804
Echinococcus multilocularis glutamate synthase 0.0018 0.0006 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0244 0.0243
Loa Loa (eye worm) hypothetical protein 0.0042 0.0053 0.0557
Trypanosoma cruzi NADH dehydrogenase, putative 0.0018 0.0006 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0209 0.2195
Plasmodium vivax ferrodoxin reductase, putative 0.0018 0.0006 0.0014
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0018 0.0006 0.0008
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0057
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0018 0.0006 0.0005
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0006 0.0001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0014 0.0241
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0017 0.0032
Brugia malayi MH2 domain containing protein 0.0123 0.0209 0.2159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0017 0.0564
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.0102 0.2813
Echinococcus granulosus glutamate synthase 0.0018 0.0006 0.0005
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0162 0.0283 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0018 0.0006 0.0005
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0006 0.0005
Brugia malayi hypothetical protein 0.0508 0.0951 1
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.9101
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0018 0.0006 0.0001
Toxoplasma gondii thioredoxin reductase 0.0196 0.0349 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0033 0.035
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0033 0.0305
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0018 0.0006 0.0001
Schistosoma mansoni thyroid hormone receptor 0.015 0.0259 0.0254
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0111 0.0257
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0244 0.0243
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0106 0.0175 0.0404
Echinococcus multilocularis expressed conserved protein 0.0093 0.015 0.0149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.004 0.0991
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0102 0.2804
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0111 0.2069
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0017 0.0133
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0075 0.0074
Plasmodium falciparum thioredoxin reductase 0.0068 0.0102 0.2813
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0075 0.2005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0017 0.0027
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0018 0.0006 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0111 0.2069
Brugia malayi hypothetical protein 0.012 0.0203 0.21
Mycobacterium ulcerans beta-lactamase 0.0073 0.0111 0.0252
Schistosoma mansoni hypothetical protein 0.0049 0.0066 0.006
Mycobacterium tuberculosis Probable reductase 0.0447 0.0834 0.1979
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0018 0.0006 0.0001
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0075 0.2005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0054 0.0938
Schistosoma mansoni hypothetical protein 0.0106 0.0176 0.0171
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.0102 0.023
Onchocerca volvulus 0.0024 0.0017 0.0218
Plasmodium falciparum glutathione reductase 0.0196 0.0349 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0018 0.0006 0.0005
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0018 0.0006 0.0014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 0.066
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0006 0.0001
Trichomonas vaginalis esterase, putative 0.0073 0.0111 0.2069
Schistosoma mansoni tar DNA-binding protein 0.007 0.0105 0.01
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0018 0.0006 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0162 0.0161
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0018 0.0006 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0196 0.0349 1
Echinococcus multilocularis microtubule associated protein 2 0.5202 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0111 0.3073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0111 0.011
Trichomonas vaginalis set domain proteins, putative 0.0283 0.0517 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0006 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0066 0.0694
Plasmodium falciparum thioredoxin reductase 0.0196 0.0349 1
Echinococcus multilocularis tumor protein p63 0.1095 0.2082 0.2081
Schistosoma mansoni thyroid hormone receptor 0.015 0.0259 0.0254
Schistosoma mansoni lamin 0.0032 0.0033 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0018 0.0006 0.0001
Brugia malayi CHE-14 protein 0.0042 0.0053 0.0513
Entamoeba histolytica hypothetical protein 0.012 0.0203 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.0102 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0054 0.0938
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0037 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0075 0.349
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0018 0.0006 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.0421
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.0102 0.2813
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0006 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0111 0.2069
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0018 0.0006 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0447 0.0834 0.1979
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0111 0.1131
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0017 0.0028
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.0102 0.023
Loa Loa (eye worm) TAR-binding protein 0.007 0.0105 0.1109
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0075 0.2005
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0006 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0102 0.2804
Echinococcus granulosus lamin 0.0032 0.0033 0.0032
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0075 0.0786
Giardia lamblia GTOR 0.0054 0.0075 0.7149
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0111 0.0257
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.0238 0.0237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.004 0.0034
Brugia malayi Probable ClpP-like protease 0.0162 0.0283 0.2939
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0075 0.0069
Schistosoma mansoni peptidase Clp (S14 family) 0.0162 0.0283 0.0277
Plasmodium vivax glutathione reductase, putative 0.0196 0.0349 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0018 0.0006 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0111 0.2069
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0018 0.0006 0.0016
Treponema pallidum thioredoxin reductase (trxB) 0.0018 0.0006 0.0014
Toxoplasma gondii hypothetical protein 0.0056 0.0078 0.2111
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0018 0.0006 0.0005
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0018 0.0006 0.0001
Echinococcus multilocularis peptidase Clp (S14 family) 0.0106 0.0175 0.0174
Schistosoma mansoni tar DNA-binding protein 0.007 0.0105 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0179
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0111 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0006 0.0007
Onchocerca volvulus 0.0073 0.0111 0.2063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0075 0.1353
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0018 0.0006 0.0006
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0033 0.035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0249 0.0451 0.4744
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0057
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0447 0.0834 0.1979
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0176 0.1814
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0017 0.0133
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0017 0.0325
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0017 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0111 0.1172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0197 0.0351 0.0349
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0078 0.2631
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0102 0.2804
Schistosoma mansoni hypothetical protein 0.0041 0.005 0.0045
Echinococcus multilocularis lamin dm0 0.0032 0.0033 0.0032
Schistosoma mansoni tar DNA-binding protein 0.007 0.0105 0.01
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0018 0.0006 0.0005
Schistosoma mansoni patched 1 0.0042 0.0053 0.0047
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0162 0.7905
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0105 0.1109
Brugia malayi RNA binding protein 0.007 0.0105 0.1067
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0018 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0111 0.1172
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0018 0.0006 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 0.066
Schistosoma mansoni hypothetical protein 0.0138 0.0238 0.0233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0271 0.2816
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0497 0.093 0.2209
Echinococcus granulosus tumor protein p63 0.1095 0.2082 0.2081
Trichomonas vaginalis apoptosis inducing factor, putative 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0111 0.0257
Schistosoma mansoni hypothetical protein 0.012 0.0203 0.0198
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0004 0.0047
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.0102 0.2804
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0006 0.0008
Onchocerca volvulus 0.0032 0.0033 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0075 0.1353
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0165 0.0159
Trichomonas vaginalis glutamate synthase, putative 0.0018 0.0006 0.0008
Brugia malayi Thioredoxin reductase 0.0196 0.0349 0.3645
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0271 0.285
Mycobacterium leprae Probable lipase LipE 0.0073 0.0111 0.0252
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0075 0.2005
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0111 0.0257
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0018 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0155 0.0271 0.285
Loa Loa (eye worm) glutathione reductase 0.0196 0.0349 0.3675
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0271 0.2816
Mycobacterium ulcerans dehydrogenase 0.0018 0.0006 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Schistosoma mansoni hypothetical protein 0.0041 0.005 0.0045
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0056 0.0078 0.0173
Schistosoma mansoni hypothetical protein 0.0041 0.005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0099 0.0162 0.1702
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0018 0.0006 0.0014
Brugia malayi hypothetical protein 0.0018 0.0006 0.0013
Echinococcus multilocularis musashi 0.0032 0.0033 0.0032
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.0102 0.1889
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0017 0.0028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0162 0.0283 0.8058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.012 0.0203 0.0202
Brugia malayi Pre-SET motif family protein 0.0249 0.0451 0.4719
Onchocerca volvulus 0.0104 0.0171 0.3227
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.004 0.0034
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0131 0.6347
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0447 0.0834 0.1971
Schistosoma mansoni cellular tumor antigen P53 0.016 0.028 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.006 0.1057
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0018 0.0006 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0066 0.0065
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0162 0.0161
Echinococcus multilocularis ferritin 0.0018 0.0006 0.0004
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0471 0.4934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.0421
Loa Loa (eye worm) thioredoxin reductase 0.0196 0.0349 0.3675
Loa Loa (eye worm) hypothetical protein 0.0508 0.0951 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0162 0.0283 0.0659
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0025 0.0544
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.016 0.028 0.2946
Leishmania major hypothetical protein, conserved 0.0018 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0111 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.042
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0006 0.0008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0075 0.2005
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0006 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0018 0.0006 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0075 0.1353
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0102 0.2804
Brugia malayi intermediate filament protein 0.0032 0.0033 0.0305
Schistosoma mansoni hypothetical protein 0.0049 0.0066 0.006
Loa Loa (eye worm) hypothetical protein 0.0073 0.0111 0.1172
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0018 0.0006 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.012 0.0203 0.0202
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0018 0.0006 0.0062
Echinococcus multilocularis tar DNA binding protein 0.007 0.0105 0.0104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0066 0.0065
Onchocerca volvulus 0.0032 0.0033 0.0536
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0106 0.0175 0.0409
Onchocerca volvulus 0.0036 0.004 0.0666
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0018 0.0006 0.0006
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0131 0.6347
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0078 0.2122
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0078 0.2122
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0017 0.0028
Brugia malayi beta-lactamase 0.0073 0.0111 0.1131
Echinococcus granulosus tar DNA binding protein 0.007 0.0105 0.0104
Schistosoma mansoni tar DNA-binding protein 0.007 0.0105 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0111 0.3082
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.0951 0.095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.004 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0075 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0526
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0006 0.0005
Treponema pallidum NADH oxidase 0.0068 0.0102 0.3489
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2197 0.4208 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0033 0.0538
Leishmania major NADH dehydrogenase, putative 0.0018 0.0006 0.0001
Onchocerca volvulus 0.016 0.028 0.536
Schistosoma mansoni lamin 0.0032 0.0033 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0111 0.0257
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0171 0.1759
Echinococcus multilocularis GPCR, family 2 0.0049 0.0066 0.0065
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0066 0.065
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0018 0.0006 0.0005
Mycobacterium ulcerans glutamate synthase subunit beta 0.0018 0.0006 0.0001
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.0102 0.2803
Echinococcus granulosus expressed protein 0.0018 0.0006 0.0004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0102 0.2804
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0006 0.0005
Loa Loa (eye worm) beta-lactamase 0.0073 0.0111 0.1172
Leishmania major hypothetical protein, conserved 0.0073 0.0111 0.3073
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0017 0.0564
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0018 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.9101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0179
Trypanosoma cruzi NADH dehydrogenase, putative 0.0018 0.0006 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.9101
Brugia malayi beta-lactamase family protein 0.0073 0.0111 0.1131
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0111 0.0252
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0006 0.0062
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0017 0.0032
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0053 0.0052
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0111 0.0257
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0006 0.0001
Echinococcus granulosus expressed conserved protein 0.0093 0.015 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0111 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0006 0.0001
Echinococcus granulosus lamin dm0 0.0032 0.0033 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0209 0.2195
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.0102 0.0101
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Schistosoma mansoni transcription factor LCR-F1 0.012 0.0203 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0111 0.0252
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0018 0.0006 0.0001
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0018 0.0006 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0038 0.0642
Brugia malayi glutamate synthase 0.0018 0.0006 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0025 0.0557
Onchocerca volvulus 0.0073 0.0111 0.2063
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0006 0.0008
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0006 0.0001
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0018 0.0006 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0111 0.3073
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0054 0.139
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0299 0.5737
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0006 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.002 0.0415
Schistosoma mansoni hypothetical protein 0.0104 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0032 0.0032 0.0338
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0018 0.0006 0.0006
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0471 0.4957
Leishmania major hypothetical protein, conserved 0.0018 0.0006 0.0001
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0018 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0006 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0006 0.0007
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2197 0.4208 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.0102 0.1033
Mycobacterium ulcerans ferredoxin reductase 0.0018 0.0006 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0025 0.0557
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.0102 0.0097
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0017 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Mycobacterium ulcerans transcriptional regulator 0.2197 0.4208 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0131 0.1379
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0018 0.0006 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0025 0.0544
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0111 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0033 0.0538
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.1542 0.1541
Echinococcus multilocularis expressed protein 0.0018 0.0006 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.004 0.0034
Trypanosoma brucei NADH dehydrogenase 0.0018 0.0006 0.0001
Echinococcus granulosus thioredoxin glutathione reductase 0.0197 0.0351 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.042
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.004 0.0039
Plasmodium vivax SET domain protein, putative 0.0036 0.004 0.1004
Plasmodium falciparum ferrodoxin reductase-like protein 0.0018 0.0006 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.0421
Loa Loa (eye worm) RNA binding protein 0.007 0.0105 0.1109
Loa Loa (eye worm) hypothetical protein 0.0073 0.0111 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.0421
Brugia malayi hypothetical protein 0.0028 0.0025 0.0213
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0067 0.0665
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.0102 0.1889
Chlamydia trachomatis thioredoxin reductase 0.0018 0.0006 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0447 0.0834 0.1979
Loa Loa (eye worm) hypothetical protein 0.0073 0.0111 0.1172
Mycobacterium ulcerans lipase LipD 0.0073 0.0111 0.0252
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0057
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.0102 0.2804
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0053 0.0927
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0447 0.0834 0.1979
Echinococcus granulosus peptidase Clp S14 family 0.0106 0.0175 0.0174
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0106 0.0175 0.0409
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.0867 0.2059
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0048 0.0834
Entamoeba histolytica hypothetical protein 0.012 0.0203 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0075 0.2005
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0017 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0299 0.574
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0259
Mycobacterium ulcerans hypothetical protein 0.0018 0.0006 0.0001
Toxoplasma gondii ABC1 family protein 0.0073 0.0111 0.3072
Mycobacterium tuberculosis Conserved protein 0.0073 0.0111 0.0257
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0018 0.0006 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0006 0.0007
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 1
Trichomonas vaginalis glutamate synthase, putative 0.0018 0.0006 0.0008
Echinococcus multilocularis protein patched 0.0042 0.0053 0.0052
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0447 0.0834 0.1979
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0053 0.0557
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0162 0.0283 0.8055
Onchocerca volvulus 0.0283 0.0517 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0075 0.349
Echinococcus multilocularis protein dispatched 1 0.0048 0.0065 0.0063
Brugia malayi beta-lactamase family protein 0.0073 0.0111 0.1131
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0497 0.093 0.2209
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0018 0.0006 0.0005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.0102 0.0235
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0075 0.0074
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0018 0.0006 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0283 0.8058
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0017 0.0564
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0111 0.3073
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0068 0.0102 0.3492
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0062
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0073 0.0111 0.1172
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.0259 0.0258
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0111 0.0252
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.0102 1
Schistosoma mansoni hypothetical protein 0.0049 0.0066 0.006
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0162 0.0283 0.0281
Echinococcus granulosus intermediate filament protein 0.0032 0.0033 0.0032
Mycobacterium ulcerans hypothetical protein 0.0024 0.0017 0.0028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.0102 0.2813
Treponema pallidum oxidoreductase 0.0018 0.0006 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0102 0.3489
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0066 0.065
Mycobacterium ulcerans monoxygenase 0.0018 0.0006 0.0001
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0018 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0006 0.0015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0196 0.0349 0.0824
Echinococcus granulosus GPCR family 2 0.0049 0.0066 0.0065
Mycobacterium tuberculosis Conserved protein 0.0073 0.0111 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0317 0.6085
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0017 0.0028
Schistosoma mansoni hypothetical protein 0.0049 0.0066 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.042
Trypanosoma cruzi trypanothione reductase, putative 0.0196 0.0349 1
Loa Loa (eye worm) programmed cell death 8 0.0018 0.0006 0.0062
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0111 0.2069
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.9101

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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