Detailed information for compound 652476

Basic information

Technical information
  • TDR Targets ID: 652476
  • Name: 4-amino-N-(6-amino-4-methyl-1,3-benzothiazol- 2-yl)benzamide
  • MW: 298.363 | Formula: C15H14N4OS
  • H donors: 3 H acceptors: 2 LogP: 2.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)C(=O)Nc1nc2c(s1)cc(cc2C)N
  • InChi: 1S/C15H14N4OS/c1-8-6-11(17)7-12-13(8)18-15(21-12)19-14(20)9-2-4-10(16)5-3-9/h2-7H,16-17H2,1H3,(H,18,19,20)
  • InChiKey: AJLSUSIARKZBGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00191810
  • 4-Amino-N-(6-amino-4-methyl-benzothiazol-2-yl)-benzamide
  • Oprea1_840982
  • Oprea1_015237
  • BAS 03421545

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0034 0.0012 0.0065
Loa Loa (eye worm) lipase 0.1206 0.8343 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.1419 0.1698
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0006 0.0006
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1419 0.1419
Echinococcus granulosus potassium voltage gated channel protein 0.0089 0.0402 0.0402
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0108 0.0125
Onchocerca volvulus Matrilysin homolog 0.022 0.1336 0.1598
Onchocerca volvulus Matrilysin homolog 0.0099 0.0477 0.0568
Loa Loa (eye worm) hypothetical protein 0.0154 0.0864 0.1032
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0012 0.0007
Mycobacterium leprae PROBABLE HYDROLASE 0.0121 0.0631 1
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.006 0.0199 0.0195
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0069 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0009 0.0006
Loa Loa (eye worm) DPY-31 protein 0.0089 0.0403 0.048
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0094 0.0091
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0296 0.0351
Loa Loa (eye worm) hypothetical protein 0.0154 0.0864 0.1032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0235 0.0278
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0973 0.6689 1
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0078 0.0086
Plasmodium vivax SET domain protein, putative 0.0033 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0403 0.048
Brugia malayi Lectin C-type domain containing protein 0.006 0.0199 0.0234
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0078 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Onchocerca volvulus 0.0141 0.0772 0.0922
Brugia malayi beta-lactamase family protein 0.0033 0.0006 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0078 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0749 0.0895
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.028 0.0333
Onchocerca volvulus 0.0033 0.0009 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0402 0.0399
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0211 0.127 0.1923
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0052 0.0052
Brugia malayi CUB domain containing protein 0.006 0.0199 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0009 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0078 0.0108
Mycobacterium ulcerans hydrolase 0.0121 0.0631 0.0935
Echinococcus granulosus Tolloid protein 1 0.0708 0.4806 0.4806
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.1206 0.8343 0.8342
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.053 0.053
Onchocerca volvulus 0.006 0.0199 0.0234
Loa Loa (eye worm) matrix metalloproteinase 0.0099 0.0477 0.0568
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0078 0.0086
Brugia malayi Matrixin family protein 0.024 0.1477 0.1768
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0235 0.0278
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0749 0.0746
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0089 0.0402 0.0402
Trypanosoma brucei lipase domain protein, putative 0.1206 0.8343 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0009 0.0007
Schistosoma mansoni egf-like domain protein 0.0205 0.1232 0.1229
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.006 0.0199 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Onchocerca volvulus 0.0047 0.0108 0.0125
Mycobacterium tuberculosis 4,9-DHSA hydrolase 0.0958 0.6578 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0004
Brugia malayi Muscleblind-like protein 0.0154 0.0864 0.1032
Echinococcus granulosus dna polymerase eta 0.0072 0.028 0.028
Brugia malayi jmjC domain containing protein 0.0039 0.0052 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0078 0.0108
Loa Loa (eye worm) hypothetical protein 0.0205 0.1232 0.1473
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0749 0.0746
Echinococcus granulosus dna polymerase kappa 0.0043 0.0078 0.0078
Schistosoma mansoni lipoxygenase 0.0132 0.0708 0.0705
Brugia malayi beta-lactamase 0.0033 0.0006 0.0004
Loa Loa (eye worm) CUB domain-containing protein 0.006 0.0199 0.0234
Onchocerca volvulus 0.0033 0.0006 0.0004
Brugia malayi Matrixin family protein 0.0099 0.0477 0.0568
Onchocerca volvulus 0.1206 0.8343 1
Echinococcus multilocularis dna polymerase eta 0.0072 0.028 0.0277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0009 0.0006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0078 0.009
Brugia malayi Suppressor of lurcher protein 1 precursor 0.006 0.0199 0.0234
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.006 0.0199 0.0231
Trichomonas vaginalis lipase containing protein, putative 0.1206 0.8343 1
Echinococcus granulosus geminin 0.0166 0.0949 0.0949
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.0679 0.4601 0.5514
Echinococcus multilocularis muscleblind protein 0.0154 0.0864 0.0861
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0075 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.025 0.0296
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.0007
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0089 0.0403 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.1206 0.8343 1
Onchocerca volvulus 0.006 0.0199 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0235 0.0232
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0296 0.0348
Echinococcus multilocularis geminin 0.0166 0.0949 0.0946
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0141 0.0771 0.0768
Loa Loa (eye worm) hypothetical protein 0.0089 0.0402 0.0479
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1419 0.1416
Trypanosoma brucei lipase domain protein, putative 0.1206 0.8343 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.1232 0.1473
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0009 0.0009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0296 0.0348
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0296 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.006 0.0199 0.0231
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0078 0.011
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0089 0.0402 0.0479
Toxoplasma gondii calcium binding egf domain-containing protein 0.0228 0.1395 1
Echinococcus granulosus cubilin 0.006 0.0199 0.0199
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0012 0.0007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0012 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Echinococcus multilocularis CUB 0.006 0.0199 0.0195
Echinococcus granulosus neuropilin nrp and tolloid tll 0.006 0.0199 0.0199
Brugia malayi Matrixin family protein 0.0099 0.0477 0.0568
Onchocerca volvulus 0.0099 0.0477 0.0568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0749 0.0895
Echinococcus granulosus laminin 0.0228 0.1395 0.1395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0749 0.0746
Schistosoma mansoni lipoxygenase 0.0092 0.0426 0.0423
Brugia malayi Inositol-1 0.0034 0.0012 0.0011
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0864 0.0861
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0099 0.0477 0.0568
Loa Loa (eye worm) hypothetical protein 0.0056 0.0169 0.0198
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0205 0.1232 0.1473
Echinococcus multilocularis fibrillin 1 0.0228 0.1395 0.1393
Brugia malayi CUB domain containing protein 0.006 0.0199 0.0234
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0019
Echinococcus multilocularis laminin 0.0228 0.1395 0.1393
Schistosoma mansoni hypothetical protein 0.0141 0.0772 0.0769
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0078 0.2324
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0034 0.0012 0.0009
Loa Loa (eye worm) matrixin family protein 0.024 0.1477 0.1768
Schistosoma mansoni hypothetical protein 0.006 0.0199 0.0195
Echinococcus multilocularis inositol monophosphatase 1 0.0034 0.0012 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0078 0.009
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0075 0.0072
Brugia malayi Calcium binding EGF domain containing protein 0.0083 0.0362 0.043
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0374 0.0371
Plasmodium falciparum phd finger protein, putative 0.0033 0.0003 0.5
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0078 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0749 0.0749
Trypanosoma brucei unspecified product 0.0043 0.0078 0.0086
Loa Loa (eye worm) hypothetical protein 0.0099 0.0477 0.0568
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Schistosoma mansoni hypothetical protein 0.0166 0.0949 0.0946
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.0708 0.0705
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0134 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0009 0.0006
Onchocerca volvulus 0.0265 0.1653 0.1978
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0296 0.0348
Echinococcus multilocularis Tolloid protein 1 0.0708 0.4806 0.4805
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.006 0.0199 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0235 0.0232
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0235 0.0278
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0052 0.0049
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.028 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0235 0.0232
Echinococcus multilocularis cubilin 0.006 0.0199 0.0195
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0078 0.0078
Onchocerca volvulus 0.0033 0.0006 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0006 0.0004
Echinococcus granulosus tar DNA binding protein 0.0065 0.0235 0.0235
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0296 0.0351
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.006 0.0199 0.0195
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0078 0.0086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0006 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.1439 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0749 0.0749
Schistosoma mansoni microtubule-associated protein tau 0.1439 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0631 0.0753
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0235 0.0232
Leishmania major DNA polymerase eta, putative 0.0072 0.028 0.0329
Brugia malayi Hemopexin family protein 0.0141 0.0772 0.0922
Schistosoma mansoni hypothetical protein 0.0047 0.0108 0.0105
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0121 0.0631 0.095
Onchocerca volvulus Arrow homolog 0.0205 0.1232 0.1473
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0089 0.0403 0.048
Loa Loa (eye worm) hypothetical protein 0.0228 0.1395 0.1669
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0296 0.0296
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0012 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0078 0.0086
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0361 0.2336 0.2336
Brugia malayi jmjC domain containing protein 0.0107 0.053 0.0632
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.1206 0.8343 0.8343
Leishmania major DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Schistosoma mansoni hypothetical protein 0.0035 0.0019 0.0016
Loa Loa (eye worm) RNA binding protein 0.0065 0.0235 0.0278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0004
Loa Loa (eye worm) AStacin protease 0.0443 0.2919 0.3497
Schistosoma mansoni hypothetical protein 0.006 0.0199 0.0195
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0296 0.0293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.0708 0.0708
Brugia malayi astacin protease protein 30 0.0089 0.0403 0.048
Trichomonas vaginalis lipase containing protein, putative 0.1206 0.8343 1
Schistosoma mansoni DNA polymerase eta 0.0072 0.028 0.0277
Brugia malayi Nematode astacin protease protein 30 0.0089 0.0403 0.048
Echinococcus multilocularis cubilin 0.006 0.0199 0.0195
Brugia malayi RNA binding protein 0.0065 0.0235 0.0278
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Onchocerca volvulus 0.0033 0.0006 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0012 0.0007
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.006 0.0199 0.0195
Echinococcus granulosus CUB 0.006 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.006 0.0199 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0006 0.0003
Schistosoma mansoni inositol monophosphatase 0.0034 0.0012 0.0009
Echinococcus granulosus cubilin 0.006 0.0199 0.0199
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0019 0.0019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0069 0.0473
Loa Loa (eye worm) hypothetical protein 0.0051 0.0134 0.0157
Loa Loa (eye worm) hypothetical protein 0.0072 0.028 0.0333
Brugia malayi Fibulin-1 precursor 0.0228 0.1395 0.1669
Echinococcus multilocularis potassium voltage gated channel protein 0.0089 0.0402 0.0399
Loa Loa (eye worm) beta-lactamase 0.0033 0.0006 0.0004
Loa Loa (eye worm) kelch domain-containing protein family protein 0.006 0.0199 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0749 0.0746
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0089 0.0403 0.048
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.006 0.0199 0.0231
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0006 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0006 0.5458
Onchocerca volvulus Matrix metalloproteinase homolog 0.022 0.1336 0.1598
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0009 0.0006
Schistosoma mansoni inositol monophosphatase 0.0034 0.0012 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0052 0.0049
Leishmania major hypothetical protein, conserved 0.1206 0.8343 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0099 0.0477 0.0474
Brugia malayi TAR-binding protein 0.0065 0.0235 0.0278
Brugia malayi hypothetical protein 0.0232 0.1419 0.1698
Leishmania major DNA polymerase eta, putative 0.0042 0.0069 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0749 0.0746
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.1425 0.1704
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.053 0.0527
Echinococcus granulosus inositol monophosphatase 1 0.0034 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0166 0.0949 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Loa Loa (eye worm) CUB domain-containing protein 0.006 0.0199 0.0234
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0009 0.004
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0205 0.1232 0.1473
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0708 0.4806 0.4805
Schistosoma mansoni hypothetical protein 0.006 0.0199 0.0195
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0085 0.0375 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Toxoplasma gondii ABC1 family protein 0.0033 0.0006 0.0022
Schistosoma mansoni hypothetical protein 0.006 0.0199 0.0195
Brugia malayi Kelch motif family protein 0.006 0.0199 0.0234
Loa Loa (eye worm) lectin C-type domain-containing protein 0.006 0.0199 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Loa Loa (eye worm) hypothetical protein 0.0099 0.0477 0.0568
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0296 0.0293
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0134 0.0157
Brugia malayi beta-lactamase family protein 0.0033 0.0006 0.0004
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0296 0.0348
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1653 0.1975
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0134 0.0157
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0078 0.0075
Echinococcus granulosus peregrin 0.0033 0.0003 0.0003
Giardia lamblia DINP protein human, muc B family 0.0043 0.0078 1
Brugia malayi Pre-SET motif family protein 0.0233 0.1425 0.1704
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0052 0.0058
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0121 0.0631 0.0753
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0004
Onchocerca volvulus 0.0089 0.0403 0.048
Loa Loa (eye worm) hypothetical protein 0.006 0.0199 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0009 0.0006
Toxoplasma gondii calcium binding egf domain-containing protein 0.0228 0.1395 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0034 0.0012 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0199 0.0231
Onchocerca volvulus 0.006 0.0199 0.0234
Echinococcus granulosus muscleblind protein 0.0154 0.0864 0.0864
Brugia malayi CUB domain containing protein 0.006 0.0199 0.0234
Brugia malayi CUB domain containing protein 0.006 0.0199 0.0234
Loa Loa (eye worm) matrixin family protein 0.022 0.1336 0.1598
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0012 0.0007
Brugia malayi Matrixin family protein 0.0099 0.0477 0.0568
Loa Loa (eye worm) hypothetical protein 0.0083 0.0362 0.043
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0235 0.0232
Schistosoma mansoni polycystin 1-related 0.0115 0.0588 0.0585
Trypanosoma cruzi hypothetical protein, conserved 0.1206 0.8343 1
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.028 0.0329
Brugia malayi Lipase family protein 0.1206 0.8343 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0052 0.0049
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0708 0.4806 0.5759
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0402 0.0399
Brugia malayi Nematode astacin protease protein 30 0.0089 0.0403 0.048
Brugia malayi hypothetical protein 0.006 0.0199 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0006 0.0003
Loa Loa (eye worm) inositol-1 0.0034 0.0012 0.0011
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0228 0.1395 0.1669
Brugia malayi Matrixin family protein 0.0099 0.0477 0.0568
Loa Loa (eye worm) hypothetical protein 0.0288 0.1822 0.2181
Brugia malayi Calcium binding EGF domain containing protein 0.0228 0.1395 0.1669
Onchocerca volvulus Putative cubilin 0.0083 0.0362 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0078 0.0086
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1056 0.7277 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0108 0.0105
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0361 0.2336 0.2334
Brugia malayi CUB domain containing protein 0.006 0.0199 0.0234
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0235 0.0232
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0078 0.011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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