TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 433.496 | Formula: C26H27NO5
H donors: 1 H acceptors: 2 LogP: 3.28 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCOC(=C1C(=NC2=C(C1c1cccc(c1)Oc1ccccc1)C(=O)CCC2)C)O
InChi: 1S/C26H27NO5/c1-17-23(26(29)31-15-14-30-2)24(25-21(27-17)12-7-13-22(25)28)18-8-6-11-20(16-18)32-19-9-4-3-5-10-19/h3-6,8-11,16,24,29H,7,12-15H2,1-2H3
InChiKey: LUTCFMKNPJISKW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0035	0.003	0.0463
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0129	0.0113
Brugia malayi	Cathepsin L-like precursor	0.005	0.0055	0.0371
Plasmodium vivax	vivapain-1	0.0026	0.0016	0.0433
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.0055	0.1924
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0035	0.003	0.0014
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.017	0.1128
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0035	0.003	0.0203
Mycobacterium tuberculosis	Conserved protein	0.0145	0.0208	0.0423
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.003	0.0611
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0041	0.0265
Onchocerca volvulus	Cathepsin L homolog	0.005	0.0055	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0208	0.1384
Toxoplasma gondii	propionate-CoA ligase	0.0035	0.003	0.0494
Plasmodium falciparum	cysteine proteinase falcipain 3	0.005	0.0055	0.1249
Echinococcus multilocularis	expressed conserved protein	0.009	0.012	0.0104
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0041	0.0025
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.005	0.0055	0.0039
Brugia malayi	Cathepsin L-like precursor	0.0034	0.0029	0.0192
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0088	0.0116	0.0197
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0145	0.0208	0.0423
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0151	0.0218	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0021	0.0134
Mycobacterium tuberculosis	Conserved protein	0.0145	0.0208	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0183
Echinococcus multilocularis	survival motor neuron protein 1	0.0943	0.1494	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Schistosoma mansoni	transcription factor LCR-F1	0.0215	0.032	0.0319
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0145	0.0208	0.0207
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0039	0.0754
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0039	0.1339
Mycobacterium ulcerans	lipase LipD	0.0145	0.0208	0.0406
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	0.0721
Brugia malayi	MH2 domain containing protein	0.0121	0.017	0.1136
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0035	0.003	0.0018
Leishmania major	cathepsin L-like protease	0.005	0.0055	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0208	0.1384
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0215	0.032	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0208	0.1384
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0151	0.0218	0.0429
Onchocerca volvulus		0.005	0.0055	0.1049
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0016	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0194
Trichomonas vaginalis	D-aminoacylase, putative	0.0145	0.0208	0.582
Brugia malayi	Cathepsin L-like precursor	0.005	0.0055	0.0371
Onchocerca volvulus		0.0035	0.003	0.0276
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0035	0.003	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0208	0.1384
Leishmania major	acetyl-CoA synthetase, putative	0.0035	0.003	0.0611
Brugia malayi	Pre-SET motif family protein	0.0202	0.0301	0.2013
Trichomonas vaginalis	penicillin-binding protein, putative	0.0145	0.0208	0.582
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0083	0.0109	0.0196
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0145	0.0208	0.0423
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0118	0.0164	0.0323
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.003	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Trypanosoma brucei	hypothetical protein, conserved	0.0145	0.0208	0.7228
Entamoeba histolytica	cysteine protease, putative	0.005	0.0055	0.1288
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0035	0.003	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0116	0.0771
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0021	0.002
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.003	0.0194
Trypanosoma cruzi	cysteine peptidase, putative	0.0191	0.0282	1
Mycobacterium ulcerans	hypothetical protein	0.0118	0.0164	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Plasmodium vivax	hypothetical protein, conserved	0.0145	0.0208	0.5996
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0035	0.003	0.0841
Onchocerca volvulus		0.005	0.0055	0.1049
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0145	0.0208	0.0192
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0035	0.003	0.0494
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0129	0.0113
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.0195	0.0179
Brugia malayi	AMP-binding enzyme family protein	0.0118	0.0164	0.11
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0014	0.0448
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0032	0.0022
Plasmodium falciparum	acyl-CoA synthetase	0.0088	0.0116	0.3085
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0088	0.0116	0.0214
Onchocerca volvulus		0.023	0.0346	1
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0016	0.0109
Schistosoma mansoni	peptidase Clp (S14 family)	0.023	0.0346	0.0345
Trypanosoma cruzi	cysteine proteinase, putative	0.0026	0.0016	0.053
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0116	0.0771
Echinococcus granulosus	expressed conserved protein	0.009	0.012	0.0104
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0055	0.0371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.005	0.0055	0.1189
Echinococcus multilocularis	protein patched	0.0041	0.0041	0.0025
Mycobacterium ulcerans	beta-lactamase	0.0145	0.0208	0.0406
Echinococcus multilocularis	protein dispatched 1	0.0047	0.005	0.0034
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0079	0.0103	0.0165
Echinococcus granulosus	cathepsin l1	0.0034	0.0029	0.0012
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0145	0.0208	0.0423
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.003	0.0018
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2751	0.4407	1
Loa Loa (eye worm)	fibroinase	0.005	0.0055	0.0362
Trichomonas vaginalis	antibiotic synthetase, putative	0.0035	0.003	0.0428
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0055	0.1288
Onchocerca volvulus		0.0035	0.003	0.0276
Brugia malayi	hypothetical protein	0.0943	0.1494	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0118	0.0164	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.0021	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0014	0.0365
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	1
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.003	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0208	0.1384
Leishmania major	hypothetical protein, conserved	0.0145	0.0208	0.7228
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	1
Loa Loa (eye worm)	beta-lactamase	0.0145	0.0208	0.1384
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0039	0.069
Loa Loa (eye worm)	hypothetical protein	0.005	0.0055	0.0362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0083	0.0109	0.0196
Mycobacterium ulcerans	acyl-CoA synthetase	0.0118	0.0164	0.0306
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.023	0.0346	1
Loa Loa (eye worm)	ctsf protein	0.005	0.0055	0.0362
Leishmania major	cathepsin L-like protease	0.005	0.0055	0.1545
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0021	0.0225
Onchocerca volvulus		0.0034	0.0029	0.0225
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0132	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0183
Brugia malayi	cathepsin F-like cysteine proteinase	0.0017	0.0001	0.0009
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0035	0.003	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0194
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0034	0.0029	0.0192
Entamoeba histolytica	hypothetical protein	0.0215	0.032	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0035	0.003	0.0428
Echinococcus granulosus	tumor protein p63	0.1325	0.2109	0.2096
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0118	0.0164	0.4869
Brugia malayi	Cathepsin L-like precursor	0.0034	0.0029	0.0192
Entamoeba histolytica	cysteine proteinase, putative	0.0034	0.0029	0.041
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.017	0.1128
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0021	0.002
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2751	0.4407	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0016	0.0086
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0035	0.003	0.1032
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.005	0.0055	0.1249
Echinococcus granulosus	cathepsin l cysteine peptidase	0.005	0.0055	0.0039
Mycobacterium ulcerans	transcriptional regulator	0.2751	0.4407	1
Schistosoma mansoni	hypothetical protein	0.0215	0.032	0.0319
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0035	0.003	0.0018
Brugia malayi	beta-lactamase family protein	0.0145	0.0208	0.1392
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0021	0.0005
Trypanosoma cruzi	cruzipain precursor, putative	0.0191	0.0282	1
Brugia malayi	AMP-binding enzyme family protein	0.0118	0.0164	0.11
Schistosoma mansoni	hypothetical protein	0.004	0.0039	0.0037
Mycobacterium ulcerans	acyl-CoA synthetase	0.0118	0.0164	0.0306
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.023	0.0346	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0035	0.003	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0287	0.1914
Schistosoma mansoni	patched 1	0.0041	0.0041	0.004
Plasmodium vivax	vivapain-3	0.0026	0.0016	0.0433
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0041	0.0025
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0118	0.0164	0.0306
Schistosoma mansoni	hypothetical protein	0.0192	0.0285	0.0283
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0039	0.0933
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.005	0.0055	0.1189
Echinococcus multilocularis	cysteine protease	0.005	0.0055	0.0039
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0035	0.003	0.0018
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0021	0.0005
Echinococcus granulosus	cathepsin l1	0.005	0.0055	0.0039
Mycobacterium ulcerans	acyl-CoA synthetase	0.0118	0.0164	0.0306
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0041	0.0749
Trichomonas vaginalis	D-aminoacylase, putative	0.0145	0.0208	0.582
Onchocerca volvulus		0.0118	0.0164	0.4408
Loa Loa (eye worm)	hypothetical protein	0.005	0.0056	0.0365
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0129	0.0864
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0016	0.053
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0145	0.0208	0.1392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Echinococcus multilocularis	cathepsin L cysteine protease	0.005	0.0055	0.0039
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0129	0.3711
Brugia malayi	Inositol-1	0.004	0.0039	0.0261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Trichomonas vaginalis	set domain proteins, putative	0.023	0.0346	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0151	0.0218	0.0446
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0039	0.069
Schistosoma mansoni	inositol monophosphatase	0.004	0.0039	0.0038
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	1
Leishmania major	cathepsin L-like protease	0.0191	0.0282	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0118	0.0164	0.0323
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0118	0.0164	0.0306
Onchocerca volvulus		0.005	0.0055	0.1049
Trypanosoma cruzi	cysteine peptidase, putative	0.0191	0.0282	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Brugia malayi	CHE-14 protein	0.0041	0.0041	0.0274
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0026	0.0016	0.007
Trypanosoma cruzi	hypothetical protein, conserved	0.0145	0.0208	0.7353
Loa Loa (eye worm)	hypothetical protein	0.023	0.0346	0.2309
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0145	0.0208	0.0207
Mycobacterium tuberculosis	Conserved protein	0.0145	0.0208	0.0423
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0055	0.1288
Schistosoma mansoni	cellular tumor antigen P53	0.0194	0.0287	0.0286
Brugia malayi	AMP-binding enzyme family protein	0.0118	0.0164	0.11
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0925	0.1466	0.3291
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.003	0.0611
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0145	0.0208	0.0406
Mycobacterium tuberculosis	Probable hydrolase	0.0145	0.0208	0.0423
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0118	0.0164	0.4869
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0016	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0029	0.0378
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0088	0.0116	0.3338
Onchocerca volvulus		0.0035	0.003	0.0276
Loa Loa (eye worm)	oxidoreductase	0.0035	0.003	0.0194
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0174	0.0256	0.905
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0039	0.002
Leishmania major	cathepsin L-like protease	0.005	0.0055	0.1545
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.003	0.1032
Echinococcus multilocularis	microtubule associated protein 2	0.6222	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0026	0.0016	0.053
Onchocerca volvulus		0.0192	0.0285	0.8113
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.005	0.0055	0.0039
Onchocerca volvulus	Cathepsin L homolog	0.005	0.0055	0.1049
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0151	0.0218	0.0446
Onchocerca volvulus		0.0145	0.0208	0.5753
Toxoplasma gondii	cathepsin CPL	0.005	0.0055	0.1249
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.003	0.0194
Brugia malayi	cathepsin L-like precursor	0.0034	0.0029	0.0192
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.2751	0.4407	1
Loa Loa (eye worm)	hypothetical protein	0.0943	0.1494	1
Brugia malayi	Cathepsin L-like precursor	0.005	0.0055	0.0371
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0083	0.0109	0.0196
Schistosoma mansoni	hypothetical protein	0.004	0.0039	0.0037
Onchocerca volvulus		0.005	0.0055	0.1049
Plasmodium vivax	SET domain protein, putative	0.0029	0.0021	0.0582
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0103	0.267
Onchocerca volvulus		0.0035	0.003	0.0276
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.0195	0.0179
Trichomonas vaginalis	D-aminoacylase, putative	0.0145	0.0208	0.582
Mycobacterium tuberculosis	Probable esterase LipL	0.0145	0.0208	0.0423
Leishmania major	4-coumarate:coa ligase-like protein	0.0118	0.0164	0.5603
Toxoplasma gondii	ABC1 family protein	0.0145	0.0208	0.5844
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0035	0.003	0.0203
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.0301	0.2005
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.003	0.0203
Brugia malayi	Probable ClpP-like protease	0.023	0.0346	0.2316
Echinococcus granulosus	survival motor neuron protein 1	0.0943	0.1494	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Leishmania major	cathepsin L-like protease	0.0191	0.0282	1
Loa Loa (eye worm)	cysteine protease	0.005	0.0055	0.0362
Brugia malayi	beta-lactamase family protein	0.0145	0.0208	0.1392
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0026	0.0016	0.0015
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0017	0.0001	0.0009
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0001	0.0009
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.003	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Mycobacterium leprae	conserved hypothetical protein	0.0145	0.0208	0.0406
Schistosoma mansoni	hypothetical protein	0.004	0.0039	0.0037
Trichomonas vaginalis	penicillin-binding protein, putative	0.0145	0.0208	0.582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.0055	0.0362
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0035	0.003	0.0494
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0021	0.002
Onchocerca volvulus		0.005	0.0055	0.1049
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0035	0.003	0.0611
Plasmodium vivax	vivapain-2	0.005	0.0055	0.1569
Schistosoma mansoni	survival motor neuron protein	0.0192	0.0285	0.0283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0016	0.0086
Loa Loa (eye worm)	inositol-1	0.004	0.0039	0.0252
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0215	0.032	0.0305
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0039	0.1339
Brugia malayi	hypothetical protein	0.0024	0.0014	0.0093
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0039	0.069
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0039	0.0023
Trypanosoma cruzi	cysteine peptidase, putative	0.0191	0.0282	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0034	0.0029	0.0027
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	0.0721
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.005	0.0055	0.0362
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2751	0.4407	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0021	0.002
Schistosoma mansoni	hypothetical protein	0.004	0.0039	0.0037
Leishmania major	4-coumarate:coa ligase-like protein	0.0118	0.0164	0.5603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0183
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.0055	0.0054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.003	0.0018
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0039	0.0023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Schistosoma mansoni	inositol monophosphatase	0.004	0.0039	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0145	0.0208	0.7353
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0034	0.0029	0.0378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium ulcerans	esterase/lipase LipP	0.0145	0.0208	0.0406
Brugia malayi	hypothetical protein	0.0215	0.032	0.2145
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1574	0.2511	0.2499
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0039	0.0933
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0041	0.0025
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0035	0.003	0.0018
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.003	0.1032
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.023	0.0346	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0164	0.1092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0129	0.0856
Schistosoma mansoni	microtubule-associated protein tau	0.6222	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0192	0.0285	0.1905
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Brugia malayi	beta-lactamase	0.0145	0.0208	0.1392
Onchocerca volvulus		0.005	0.0055	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0164	0.1092
Trypanosoma cruzi	major cysteine proteinase, putative	0.015	0.0217	0.7656
Onchocerca volvulus		0.0194	0.0287	0.819
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.002	0.0003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium tuberculosis	Probable lipase LipD	0.0145	0.0208	0.0423
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0039	0.0748
Leishmania major	cathepsin L-like protease	0.005	0.0055	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0041	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0164	0.1092
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.023	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0208	0.1384
Plasmodium vivax	unspecified product	0.0026	0.0016	0.0433
Leishmania major	4-coumarate:coa ligase-like protein	0.0118	0.0164	0.5603
Leishmania major	cathepsin L-like protease	0.005	0.0055	0.1545
Leishmania major	cysteine peptidase A (CPA)	0.005	0.0055	0.1545
Brugia malayi	Cathepsin L-like precursor	0.005	0.0055	0.0371
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0014	0.0448
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0118	0.0164	0.0306
Echinococcus multilocularis	cathepsin L cysteine protease	0.005	0.0055	0.0039
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.003	0.0018
Echinococcus multilocularis	cysteine protease	0.005	0.0055	0.0039
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0145	0.0208	0.1384
Toxoplasma gondii	hypothetical protein	0.0079	0.0103	0.267
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.023	0.0346	1
Echinococcus multilocularis	tumor protein p63	0.1325	0.2109	0.2096
Mycobacterium tuberculosis	Probable lipase LipE	0.0145	0.0208	0.0423
Onchocerca volvulus		0.0145	0.0208	0.5753
Onchocerca volvulus		0.0145	0.0208	0.5753
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0116	0.0771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium ulcerans	hypothetical protein	0.0145	0.0208	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.0032	0.0004
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.003	0.0018
Leishmania major	acetyl-CoA synthetase, putative	0.0035	0.003	0.0611
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.0055	0.0054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Entamoeba histolytica	hypothetical protein	0.0215	0.032	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0118	0.0164	0.4869
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0014	0.0084
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0016	0.0109
Trypanosoma cruzi	cysteine proteinase, putative	0.0026	0.0016	0.053
Echinococcus granulosus	beta LACTamase domain containing family member	0.0145	0.0208	0.0192
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.023	0.0346	0.033
Entamoeba histolytica	hypothetical protein	0.0215	0.032	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0035	0.003	0.1032
Echinococcus granulosus	cathepsin L cysteine proteinase	0.005	0.0055	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0116	0.0771
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0083	0.0109	0.0196
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0021	0.0005
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0079	0.0103	0.2937
Trichomonas vaginalis	esterase, putative	0.0145	0.0208	0.582
Brugia malayi	Cathepsin L-like precursor	0.005	0.0055	0.0371
Entamoeba histolytica	hypothetical protein	0.0215	0.032	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0118	0.0164	0.0306
Leishmania major	cathepsin L-like protease	0.0191	0.0282	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.005	0.0055	0.1249
Echinococcus granulosus	peptidase Clp S14 family	0.0151	0.0218	0.0202
Mycobacterium leprae	Probable lipase LipE	0.0145	0.0208	0.0406
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0035	0.003	0.0014
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0118	0.0164	0.0306
Brugia malayi	Cathepsin L-like precursor	0.005	0.0055	0.0371
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0035	0.003	0.0494
Plasmodium vivax	vivapain-2	0.005	0.0055	0.1569
Onchocerca volvulus		0.005	0.0055	0.1049
Onchocerca volvulus	Cathepsin F homolog	0.005	0.0055	0.1049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0055	0.1189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.0055	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0116	0.0771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0191	0.0282	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.023	0.0346	0.033
Trypanosoma cruzi	cysteine protease, putative	0.0026	0.0016	0.053

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 657473