Detailed information for compound 659056

Basic information

Technical information
  • TDR Targets ID: 659056
  • Name: 1-[(2-bromophenyl)methyl]-4-[(4,5-dimethoxy-2 -nitrophenyl)methyl]piperazine
  • MW: 450.326 | Formula: C20H24BrN3O4
  • H donors: 0 H acceptors: 2 LogP: 3.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CN2CCN(CC2)Cc2ccccc2Br)c(cc1OC)[N+](=O)[O-]
  • InChi: 1S/C20H24BrN3O4/c1-27-19-11-16(18(24(25)26)12-20(19)28-2)14-23-9-7-22(8-10-23)13-15-5-3-4-6-17(15)21/h3-6,11-12H,7-10,13-14H2,1-2H3
  • InChiKey: XRJFHGAEGJNNNE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-bromophenyl)methyl]-4-[(4,5-dimethoxy-2-nitro-phenyl)methyl]piperazine
  • 1-(2-bromobenzyl)-4-(4,5-dimethoxy-2-nitro-benzyl)piperazine
  • BAS 01840688
  • Oprea1_378418
  • Oprea1_565437
  • 1-(2-Bromo-benzyl)-4-(4,5-dimethoxy-2-nitro-benzyl)-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.008 0.0233
Brugia malayi Thioredoxin reductase 0.0041 0.0051 0.0147
Leishmania major GTP-binding protein, putative 0.0022 0.0013 0.0217
Onchocerca volvulus 0.1679 0.3319 1
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0122 0.2081
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1399 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0071 0.0111 0.0331
Brugia malayi hypothetical protein 0.0025 0.002 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.008 0.0201
Brugia malayi RNA, U transporter 1 0.0083 0.0136 0.0402
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0068 0.0106 0.1808
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0219 0.0623
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.0206 0.0586
Trypanosoma brucei unspecified product 0.0027 0.0024 0.0408
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0122 0.4143
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0561 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.01 0.0169 0.0157
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0122 0.4143
Onchocerca volvulus 0.1679 0.3319 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0057 0.0964
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0057 0.0964
Onchocerca volvulus 0.0963 0.189 0.5688
Loa Loa (eye worm) hypothetical protein 0.0076 0.0122 0.0331
Echinococcus multilocularis dnaJ subfamily B 0.169 0.334 0.3332
Trypanosoma brucei trypanothione reductase 0.0041 0.0051 0.0869
Loa Loa (eye worm) hypothetical protein 0.0076 0.0122 0.0331
Echinococcus multilocularis cpg binding protein 0.0133 0.0236 0.0223
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0013 0.0217
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0062 0.0181
Brugia malayi Bromodomain containing protein 0.0158 0.0286 0.0855
Loa Loa (eye worm) hypothetical protein 0.0963 0.189 0.5677
Loa Loa (eye worm) hypothetical protein 0.0717 0.1399 0.4193
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0259 1
Onchocerca volvulus 0.0717 0.1399 0.4208
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0017 0.0291
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0023 0.009
Trichomonas vaginalis ran, putative 0.0022 0.0013 0.0013
Mycobacterium tuberculosis Conserved protein 0.0076 0.0122 0.0825
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.1973
Echinococcus granulosus zinc finger protein 0.0088 0.0145 0.0397
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.1679 0.3319 1
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0048 0.0823
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0028 0.0479
Brugia malayi PHD-finger family protein 0.011 0.0189 0.0562
Brugia malayi beta-lactamase family protein 0.0076 0.0122 0.0361
Echinococcus multilocularis snurportin 1 0.0312 0.0592 0.058
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0029 0.0048
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0592 0.1753
Schistosoma mansoni transient receptor potential channel 0.0133 0.0235 0.0702
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0122 0.0802
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0122 0.0825
Loa Loa (eye worm) hypothetical protein 0.0076 0.0122 0.0331
Mycobacterium tuberculosis Probable reductase 0.0093 0.0155 0.1192
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0024 0.0408
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0043 0.0091
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0122 0.0825
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.0587 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0176 0.1423
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0587 1
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0068 0.0106 0.1808
Plasmodium falciparum thioredoxin reductase 0.0041 0.0051 1
Brugia malayi glutathione reductase 0.0041 0.0051 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Loa Loa (eye worm) hypothetical protein 0.088 0.1725 0.5179
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0176 0.3922
Schistosoma mansoni DNA polymerase eta 0.0039 0.0048 0.0145
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0066 0.0054
Mycobacterium ulcerans hypothetical protein 0.0076 0.0122 0.4143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0062 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0062 0.0149
Echinococcus granulosus TRP transient receptor potential channel 0.0075 0.012 0.0322
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0122 1
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0122 0.0802
Mycobacterium tuberculosis Conserved protein 0.0076 0.0122 0.0825
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0122 0.2081
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0028 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0029 0.0027 0.0014
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0963 0.189 0.5691
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0048 0.0138
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0048 0.0823
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0013 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Echinococcus granulosus short transient receptor potential channel 6 0.0133 0.0235 0.0667
Entamoeba histolytica hypothetical protein 0.0024 0.0017 0.008
Schistosoma mansoni hypothetical protein 0.0063 0.0096 0.0287
Loa Loa (eye worm) hypothetical protein 0.0076 0.0122 0.0331
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0048 0.0107
Loa Loa (eye worm) MBCTL1 0.0055 0.008 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0043 0.003
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0048 0.0823
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0259 0.8771
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0262 0.4462
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0122 0.0331
Leishmania major DNA polymerase eta, putative 0.0039 0.0048 0.0823
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0066 0.0054
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0029 0.0027 0.0074
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0048 0.0823
Echinococcus granulosus cpg binding protein 0.0133 0.0236 0.067
Loa Loa (eye worm) PHD-finger family protein 0.0085 0.014 0.0385
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0029 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0062 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Schistosoma mansoni hypothetical protein 0.0278 0.0525 0.1572
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0254 0.0476 0.0464
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0122 0.0366
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0048 0.0036
Brugia malayi hypothetical protein 0.0717 0.1399 0.4211
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0259 0.235
Schistosoma mansoni myst-related protein 0.0022 0.0013 0.004
Loa Loa (eye worm) hypothetical protein 0.0717 0.1399 0.4193
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0963 0.189 0.5691
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0043 0.0092
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0048 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0073 0.0116 0.0346
Plasmodium falciparum zinc finger protein, putative 0.0022 0.0013 0.0197
Echinococcus granulosus transient receptor potential ion channel A 0.0192 0.0353 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Loa Loa (eye worm) hypothetical protein 0.0963 0.189 0.5677
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0029 0.0027 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0073 0.0116 0.0346
Plasmodium vivax importin-beta 2, putative 0.0029 0.0028 0.1407
Brugia malayi Latrophilin receptor protein 2 0.0278 0.0525 0.1576
Schistosoma mansoni hypothetical protein 0.0038 0.0046 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0023 0.009
Schistosoma mansoni cpg binding protein 0.0119 0.0206 0.0618
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0029 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0122 0.0825
Onchocerca volvulus 0.0156 0.0282 0.0837
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0963 0.189 0.5691
Onchocerca volvulus 0.1679 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.0963 0.189 0.5677
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0013 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0024 0.0408
Onchocerca volvulus 0.0963 0.189 0.5688
Onchocerca volvulus 0.0048 0.0066 0.0187
Echinococcus granulosus importin subunit beta 1 0.0029 0.0028 0.0046
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0155 0.2407
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.035 0.0338
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.002 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.1679 0.3319 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0048 0.0036
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0066 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0155 0.1192
Brugia malayi hypothetical protein 0.0038 0.0046 0.0133
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.0587 1
Loa Loa (eye worm) bromodomain containing protein 0.0073 0.0116 0.0311
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0278 0.0525 0.0513
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0048 0.0649
Schistosoma mansoni transient receptor potential channel 0.0133 0.0235 0.0702
Loa Loa (eye worm) hypothetical protein 0.02 0.0369 0.1076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0062 0.005
Echinococcus granulosus transient receptor potential gamma protein 0.02 0.0369 0.107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0278 0.0525 0.154
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.1679 0.3319 1
Mycobacterium ulcerans hypothetical protein 0.0163 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0306 0.0887
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0048 0.0269
Trypanosoma brucei unspecified product 0.0039 0.0048 0.0823
Brugia malayi beta-lactamase 0.0076 0.0122 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0052 0.0118
Brugia malayi LBP/BPI 0.0717 0.1399 0.4211
Schistosoma mansoni hypothetical protein 0.169 0.334 1
Brugia malayi hypothetical protein 0.0156 0.0282 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Brugia malayi mbt repeat family protein 0.0048 0.0066 0.0193
Brugia malayi latrophilin 2 splice variant baaae 0.0602 0.117 0.3519
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0062 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0278 0.0525 0.154
Echinococcus multilocularis short transient receptor potential channel 6 0.0133 0.0235 0.0222
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0068 0.0106 0.0318
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0013 0.0217
Loa Loa (eye worm) hypothetical protein 0.0067 0.0104 0.0276
Onchocerca volvulus 0.0119 0.0206 0.061
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0122 0.011
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0155 0.1192
Brugia malayi MH2 domain containing protein 0.0125 0.0219 0.0652
Schistosoma mansoni SET domain protein 0.0017 0.0004 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0046 0.0139
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0051 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0122 0.2081
Brugia malayi Calcitonin receptor-like protein seb-1 0.088 0.1725 0.5194
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0155 0.1192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Loa Loa (eye worm) hypothetical protein 0.0156 0.0282 0.0814
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0602 0.117 0.3499
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0068 0.0106 0.0283
Schistosoma mansoni hypothetical protein 0.0085 0.014 0.0419
Echinococcus granulosus snurportin 1 0.0312 0.0592 0.1742
Echinococcus multilocularis transient receptor potential gamma protein 0.02 0.0369 0.0356
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0031 0.0093
Onchocerca volvulus 0.1679 0.3319 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0023 0.009
Schistosoma mansoni hypothetical protein 0.0602 0.117 0.3502
Onchocerca volvulus 0.1679 0.3319 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0073 0.0116 0.0103
Schistosoma mansoni transient receptor potential channel 4 0.02 0.0369 0.1104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Schistosoma mansoni bromodomain containing protein 0.0024 0.0019 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Toxoplasma gondii thioredoxin reductase 0.0041 0.0051 0.1165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Echinococcus granulosus methyl CpG binding domain protein 2 0.0071 0.0111 0.0294
Schistosoma mansoni transient receptor potential channel 0.02 0.0369 0.1104
Entamoeba histolytica hypothetical protein 0.0038 0.0046 0.0614
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0071 0.0111 0.0098
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0066 0.0162
Onchocerca volvulus 0.1679 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0108
Loa Loa (eye worm) hypothetical protein 0.0963 0.189 0.5677
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0048 0.0108
Echinococcus granulosus short transient receptor potential channel 6 0.0133 0.0235 0.0667
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.008 0.0067
Toxoplasma gondii ABC1 family protein 0.0076 0.0122 0.2791
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0176 0.1423
Schistosoma mansoni cpg binding protein 0.0133 0.0236 0.0706
Brugia malayi SET domain containing protein 0.0017 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0278 0.0525 0.155
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0963 0.189 0.5677
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0026
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.008 0.0067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0023 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Loa Loa (eye worm) hypothetical protein 0.0293 0.0553 0.1635
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Brugia malayi mbt repeat family protein 0.0048 0.0066 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0024 0.0408
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0017 0.0045
Toxoplasma gondii hypothetical protein 0.005 0.0069 0.1584
Leishmania major importin beta-1 subunit, putative 0.0024 0.0017 0.0291
Echinococcus multilocularis dna polymerase eta 0.0039 0.0048 0.0036
Schistosoma mansoni hypothetical protein 0.0278 0.0525 0.1572
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.035 0.1014
Echinococcus granulosus dna polymerase eta 0.0039 0.0048 0.0107
Echinococcus granulosus GPCR family 2 0.0278 0.0525 0.154
Echinococcus granulosus dna polymerase kappa 0.0039 0.0048 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0587 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0149 0.0266 0.0762
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0048 0.1638
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0149 0.0266 0.0254
Loa Loa (eye worm) hypothetical protein 0.0055 0.008 0.0202
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0122 0.0825
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0295 0.2755
Plasmodium vivax glutathione reductase, putative 0.0041 0.0051 0.3497
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Trypanosoma cruzi ISWI complex protein 0.0063 0.0096 0.1636
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.1679 0.3319 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0028 0.0479
Schistosoma mansoni zinc finger protein 0.0088 0.0145 0.0434
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0345
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0004 0.0011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0029 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0122 0.0329
Echinococcus multilocularis GPCR, family 2 0.0278 0.0525 0.0513
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0058 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0252 0.0472 0.1412
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0122 0.0825
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0122 0.0825
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0052 0.0039
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.1679 0.3319 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0029 0.0027 0.0043
Brugia malayi Importin beta-1 subunit 0.0029 0.0028 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0235 0.0438 1
Brugia malayi beta-lactamase family protein 0.0076 0.0122 0.0361
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0013 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0018
Brugia malayi Transient-receptor-potential like protein 0.0075 0.012 0.0354
Loa Loa (eye worm) hypothetical protein 0.0717 0.1399 0.4193
Giardia lamblia DINP protein human, muc B family 0.0039 0.0048 0.0649
Leishmania major hypothetical protein, conserved 0.0063 0.0096 0.1636
Leishmania major hypothetical protein, conserved 0.0025 0.002 0.0345
Loa Loa (eye worm) hypothetical protein 0.0183 0.0335 0.0975
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0066 0.0187
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.088 0.1725 0.5194
Brugia malayi diacylglycerol acyltransferase family protein 0.0068 0.0106 0.0313
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0028 0.0015
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0122 0.0825
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0048 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0046 0.0101
Schistosoma mansoni hypothetical protein 0.0294 0.0556 0.1666
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0155 0.1192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0062 0.0187
Trichomonas vaginalis esterase, putative 0.0076 0.0122 0.0802
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0122 0.0802
Brugia malayi hypothetical protein 0.0963 0.189 0.5691
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0254 0.0476 0.1392
Loa Loa (eye worm) hypothetical protein 0.0075 0.012 0.0324
Loa Loa (eye worm) hypothetical protein 0.0159 0.0286 0.0828
Schistosoma mansoni zinc finger protein 0.0063 0.0096 0.0287
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0017 0.0045
Schistosoma mansoni hypothetical protein 0.0278 0.0525 0.1572
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0963 0.189 0.5677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0023 0.009
Mycobacterium ulcerans lipase LipD 0.0076 0.0122 0.4143
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0051 0.003
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0066 0.0161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0023 0.009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.01 0.0169 0.0507
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0488 0.0943 1
Trypanosoma brucei ISWI complex protein 0.0063 0.0096 0.1636
Leishmania major DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Echinococcus multilocularis zinc finger protein 0.0088 0.0145 0.0132
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.002 0.069
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0048 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.1973
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0262 0.4462
Loa Loa (eye worm) latrophilin receptor protein 2 0.0278 0.0525 0.155
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0066 0.0198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0046 0.0034
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.0561 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0073 0.0116 0.0309
Brugia malayi Bromodomain containing protein 0.0317 0.0602 0.1808
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0023 0.009
Schistosoma mansoni myst-related protein 0.0022 0.0013 0.004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0155 0.1192
Loa Loa (eye worm) beta-lactamase 0.0076 0.0122 0.0331
Echinococcus granulosus geminin 0.0891 0.1746 0.5208
Leishmania major trypanothione reductase 0.0041 0.0051 0.0869
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0017 0.0045
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.002 0.0345
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0278 0.0525 0.0513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0262 0.4462
Trypanosoma cruzi ISWI complex protein 0.0063 0.0096 0.1636
Trypanosoma brucei unspecified product 0.0027 0.0024 0.0408
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0023 0.009
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.008 0.0238
Leishmania major diacylglycerol acyltransferase, putative 0.0068 0.0106 0.1808
Loa Loa (eye worm) glutathione reductase 0.0041 0.0051 0.0116
Toxoplasma gondii dgat2l1-prov protein 0.0068 0.0106 0.2425
Schistosoma mansoni hypothetical protein 0.0891 0.1746 0.5226
Schistosoma mansoni ran 0.0022 0.0013 0.0038
Echinococcus granulosus dnaJ subfamily B 0.169 0.334 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0116 0.0311
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0048 0.0269
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0963 0.189 0.5677
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0122 0.0366
Mycobacterium tuberculosis Conserved protein 0.0076 0.0122 0.0825
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0051 0.3497
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0057 0.0964
Loa Loa (eye worm) hypothetical protein 0.0076 0.0122 0.0331
Onchocerca volvulus 0.0076 0.0122 0.0356
Schistosoma mansoni methyl-cpg binding protein mbd 0.0071 0.0111 0.0331
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0219 0.0623
Onchocerca volvulus 0.1679 0.3319 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0057 0.0964
Entamoeba histolytica hypothetical protein 0.0022 0.0013 0.0014
Entamoeba histolytica hypothetical protein 0.0038 0.0046 0.0614
Entamoeba histolytica hypothetical protein 0.0038 0.0046 0.0614
Trichomonas vaginalis helicase, putative 0.0027 0.0023 0.009
Loa Loa (eye worm) hypothetical protein 0.0717 0.1399 0.4193
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.0561 1
Plasmodium falciparum importin beta, putative 0.0029 0.0028 0.4025
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0176 0.1423
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0048 0.0823
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.008 0.0201
Entamoeba histolytica hypothetical protein 0.0038 0.0046 0.0614
Plasmodium falciparum glutathione reductase 0.0041 0.0051 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0062 0.0187
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0075 0.012 0.0107
Echinococcus multilocularis geminin 0.0891 0.1746 0.1735
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0048 0.1638
Loa Loa (eye worm) hypothetical protein 0.0076 0.0122 0.0331
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0031 0.0093
Schistosoma mansoni hypothetical protein 0.0891 0.1746 0.5226
Onchocerca volvulus 0.1679 0.3319 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0062 0.005
Brugia malayi CXXC zinc finger family protein 0.0119 0.0206 0.0615
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0122 0.0361
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0068 0.0106 0.1808
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0278 0.0525 0.1576
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0561 0.3963
Loa Loa (eye worm) hypothetical protein 0.0125 0.0218 0.0622
Onchocerca volvulus 0.0068 0.0106 0.0307
Leishmania major hypothetical protein, conserved 0.0076 0.0122 0.2081
Echinococcus multilocularis transient receptor potential ion channel A 0.0192 0.0353 0.034
Onchocerca volvulus 0.0076 0.0122 0.0356
Schistosoma mansoni hypothetical protein 0.0312 0.0592 0.1774
Schistosoma mansoni bromodomain containing protein 0.0269 0.0505 0.1513
Schistosoma mansoni ran 0.0022 0.0013 0.0038
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0066 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0122 0.0802
Loa Loa (eye worm) pigment dispersing factor receptor c 0.088 0.1725 0.5179
Echinococcus multilocularis short transient receptor potential channel 6 0.0133 0.0235 0.0222
Mycobacterium ulcerans beta-lactamase 0.0076 0.0122 0.4143
Schistosoma mansoni cpg binding protein 0.0133 0.0236 0.0706
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0076 0.1287
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0048 0.0823
Onchocerca volvulus 0.0076 0.0122 0.0356
Schistosoma mansoni importin beta-1 0.0029 0.0028 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0122 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0048 0.0823
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0051 0.0869
Echinococcus granulosus fetal alzheimer antigen falz 0.01 0.0169 0.0471
Schistosoma mansoni hypothetical protein 0.0278 0.0525 0.1572
Brugia malayi hypothetical protein 0.0963 0.189 0.5691
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0066 0.0161

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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