Detailed information for compound 664379

Basic information

Technical information
  • TDR Targets ID: 664379
  • Name: N-[[5-[2-[(2-methoxyphenyl)amino]-2-oxoethyl] sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]- 4-methylbenzamide
  • MW: 425.504 | Formula: C21H23N5O3S
  • H donors: 2 H acceptors: 4 LogP: 2.32 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)CSc1nnc(n1C)CNC(=O)c1ccc(cc1)C
  • InChi: 1S/C21H23N5O3S/c1-14-8-10-15(11-9-14)20(28)22-12-18-24-25-21(26(18)2)30-13-19(27)23-16-6-4-5-7-17(16)29-3/h4-11H,12-13H2,1-3H3,(H,22,28)(H,23,27)
  • InChiKey: RHHAFGXGAFHXKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[5-[2-[(2-methoxyphenyl)amino]-2-oxo-ethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]-4-methyl-benzamide
  • N-[[5-[[2-[(2-methoxyphenyl)amino]-2-oxoethyl]thio]-4-methyl-1,2,4-triazol-3-yl]methyl]-4-methylbenzamide
  • N-[[5-[[2-keto-2-[(2-methoxyphenyl)amino]ethyl]thio]-4-methyl-1,2,4-triazol-3-yl]methyl]-4-methyl-benzamide
  • ZINC02841132
  • STK143725

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Doublecortin family protein 0.004 0.0445 0.1263
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0387 0.0387
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.2643 0.3755
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0387 0.0303
Schistosoma mansoni loxhd1 0.004 0.0445 0.0621
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0384 0.0793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0166 0.0223
Trichomonas vaginalis set domain proteins, putative 0.0241 0.3971 0.3971
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0166 0.0454
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0338 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0166 0.0454
Leishmania major hypothetical protein, conserved 0.0037 0.0384 0.1469
Mycobacterium ulcerans hypothetical protein 0.0037 0.0384 0.1353
Schistosoma mansoni rotamase 0.0034 0.0338 0.0468
Schistosoma mansoni alpha glucosidase 0.0037 0.0387 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0166 0.0454
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0087 0.0224
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0387 0.0387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0087 0.0087
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0491 0.0855
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0268 0.2033
Trichomonas vaginalis rotamase, putative 0.0034 0.0338 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0166 0.0454
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0384 0.0384
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0087 0.0573
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0166 0.0223
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0197 0.3199 0.8298
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0166 0.0223
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0197 0.3199 0.8795
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0774 0.5103
Echinococcus granulosus chromobox protein 1 0.0071 0.0983 0.1389
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0166 0.0454
Echinococcus multilocularis expressed protein 0.0034 0.0338 0.0468
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0268 0.0826
Schistosoma mansoni zinc finger protein 0.0022 0.0121 0.0159
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0268 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0439 0.0439
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0129 0.0346
Schistosoma mansoni coup transcription factor 0.0024 0.0166 0.0223
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0166 0.0223
Brugia malayi beta-lactamase family protein 0.0037 0.0384 0.1086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0166 0.0223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0087 0.0224
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.4946 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0847 0.1194
Brugia malayi hypothetical protein 0.004 0.0445 0.1263
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0445 0.0621
Echinococcus granulosus ng dimethylarginine dimethylaminohydrolase 0.0159 0.2525 0.3586
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0384 0.0534
Schistosoma mansoni chromobox protein 0.0071 0.0983 0.1389
Echinococcus granulosus geminin 0.0172 0.276 0.3921
Toxoplasma gondii thioredoxin reductase 0.0086 0.1258 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0166 0.0223
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0166 0.0223
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0166 0.0223
Echinococcus multilocularis ng dimethylarginine dimethylaminohydrolase 0.0159 0.2525 0.3586
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0047 0.0053
Onchocerca volvulus 0.0037 0.0384 0.0573
Echinococcus granulosus dna polymerase eta 0.002 0.0087 0.011
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0384 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0166 0.0454
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0835 0.1177
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0087 0.011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0166 0.0454
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0111 0.0293
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0384 0.0793
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0197 0.3199 0.8298
Plasmodium vivax SET domain protein, putative 0.0031 0.0286 0.0177
Trypanosoma brucei trypanothione reductase 0.0086 0.1258 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0219 0.3585 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0166 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0387 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0166 0.0223
Brugia malayi ecdysteroid receptor 0.0024 0.0166 0.0454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0589 0.0827
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0062 0.0062
Onchocerca volvulus 0.0043 0.0489 0.0848
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0384 0.2966
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0268 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0062 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0166 0.0223
Brugia malayi chromobox protein homolog 3 0.004 0.0439 0.1244
Mycobacterium tuberculosis Conserved protein 0.0037 0.0384 0.0793
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0387 0.0387
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0445 0.0621
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0835 0.1177
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.1258 1
Onchocerca volvulus 0.0029 0.0255 0.0232
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0159 0.2525 0.3586
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0166 0.0454
Brugia malayi hypothetical protein 0.004 0.0445 0.1263
Plasmodium falciparum thioredoxin reductase 0.0086 0.1258 1
Brugia malayi Pre-SET motif family protein 0.0212 0.3459 1
Onchocerca volvulus 0.0031 0.0288 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0166 0.0454
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0087 0.0573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0062 0.0062
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0445 0.0621
Schistosoma mansoni DNA polymerase eta 0.002 0.0087 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0384 0.2966
Schistosoma mansoni hypothetical protein 0.004 0.0445 0.0621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0268 0.0484
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0387 0.0538
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.1267 0.1793
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0129 0.0346
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0047 0.0053
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0445 0.0621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Schistosoma mansoni alpha-glucosidase 0.0143 0.224 0.3179
Loa Loa (eye worm) glutathione reductase 0.0086 0.1258 0.362
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0384 0.0793
Leishmania major hypothetical protein, unknown function 0.0159 0.2525 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0384 0.1353
Loa Loa (eye worm) hypothetical protein 0.0072 0.1002 0.2878
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0445 0.1787
Mycobacterium tuberculosis Probable reductase 0.0197 0.3199 0.8298
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.3459 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0589 0.0827
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0087 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0166 0.0223
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0219 0.3585 0.9326
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0983 0.2824
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0268 0.0369
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0058 0.014
Brugia malayi nuclear hormone receptor 0.0024 0.0166 0.0454
Brugia malayi steroid hormone receptor 0.0024 0.0166 0.0454
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0268 0.1007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.1007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0384 0.1086
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0166 0.0454
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0166 0.0223
Onchocerca volvulus 0.004 0.0445 0.0734
Schistosoma mansoni cpg binding protein 0.0033 0.0318 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0439 0.0439
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.1258 0.3123
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0445 0.0621
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0286 0.0394
Onchocerca volvulus 0.004 0.0445 0.0734
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0268 0.0826
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0268 0.2033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0445 0.0621
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0983 0.0983
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0166 0.0223
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0491 0.0491
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0384 0.2966
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0384 0.1086
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0166 0.0223
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.2033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0047 0.0053
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0268 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0166 0.0454
Loa Loa (eye worm) hypothetical protein 0.0048 0.0589 0.1681
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0166 0.0223
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0268 0.0826
Leishmania major hypothetical protein, unknown function 0.0159 0.2525 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0387 0.2987
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Schistosoma mansoni hypothetical protein 0.0416 0.7024 1
Trichomonas vaginalis esterase, putative 0.0037 0.0384 0.0384
Brugia malayi NG,NG-dimethylarginine dimethylaminohydrolase 1, putative 0.0159 0.2525 0.7292
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0384 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0268 0.2033
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0197 0.3199 0.8298
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0338 0.0338
Echinococcus multilocularis dna polymerase kappa 0.002 0.0087 0.011
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0387 0.0387
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0384 0.1086
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0197 0.3199 0.8298
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.3838 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0383 0.0532
Onchocerca volvulus 0.0096 0.1421 0.3297
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0983 0.0983
Plasmodium vivax glutathione reductase, putative 0.0086 0.1258 1
Brugia malayi Heterochromatin protein 1 0.0071 0.0983 0.2824
Schistosoma mansoni zinc finger protein 0.0016 0.0016 0.0009
Echinococcus granulosus chromobox protein 1 0.0071 0.0983 0.1389
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0439 0.0716
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0384 0.0384
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0062 0.0062
Echinococcus granulosus cpg binding protein 0.0033 0.0318 0.0439
Echinococcus multilocularis geminin 0.0172 0.276 0.3921
Schistosoma mansoni hypothetical protein 0.0021 0.0111 0.0144
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0387 0.0387
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0087 0.0087
Brugia malayi PHD-finger family protein 0.0027 0.0216 0.0598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0166 0.0454
Schistosoma mansoni cpg binding protein 0.0033 0.0318 0.0439
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0087 0.011
Trypanosoma brucei glucosidase, putative 0.0037 0.0387 0.2987
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0166 0.0454
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0087 0.0284
Schistosoma mansoni hypothetical protein 0.0172 0.276 0.3921
Loa Loa (eye worm) hypothetical protein 0.0037 0.0384 0.1086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0384 0.0534
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.7024 1
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.1258 0.362
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.4946 0.4901
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0166 0.0223
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0384 0.0384
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0324 0.248
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0166 0.0223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0166 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0268 0.2033
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0087 0.0573
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0324 0.0239
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.1258 1
Trypanosoma brucei unspecified product 0.002 0.0087 0.0573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0062 0.0062
Onchocerca volvulus 0.0159 0.2525 0.6199
Mycobacterium tuberculosis Conserved protein 0.0037 0.0384 0.0793
Mycobacterium ulcerans beta-lactamase 0.0037 0.0384 0.1353
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0387 0.0387
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0387 0.0538
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0384 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0166 0.0454
Mycobacterium tuberculosis Probable dehydrogenase 0.0197 0.3199 0.8298
Plasmodium falciparum glutathione reductase 0.0086 0.1258 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.2033
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0491 0.0491
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0166 0.0223
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0255 0.071
Echinococcus multilocularis zinc finger protein 0.0022 0.0121 0.0159
Schistosoma mansoni lipoxygenase 0.0176 0.2825 0.4014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0062 0.0062
Toxoplasma gondii ABC1 family protein 0.0037 0.0384 0.1171
Brugia malayi Bromodomain containing protein 0.0078 0.1107 0.3183
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.1267 0.1793
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0324 0.248
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0268 0.0268
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0174 0.0234
Brugia malayi Thioredoxin reductase 0.0086 0.1258 0.362
Loa Loa (eye worm) hypothetical protein 0.0045 0.0532 0.1514
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.2033
Leishmania major DNA polymerase kappa, putative 0.002 0.0087 0.0284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4946 0.4946
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Loa Loa (eye worm) hypothetical protein 0.004 0.0439 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0166 0.0454
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.2643 0.3755
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0087 0.0573
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0087 0.011
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.4946 1
Brugia malayi beta-lactamase family protein 0.0037 0.0384 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Trichomonas vaginalis rotamase, putative 0.0033 0.0324 0.0324
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0268 0.2033
Brugia malayi glutathione reductase 0.0086 0.1258 0.362
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.2033
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0087 0.0224
Loa Loa (eye worm) hypothetical protein 0.0031 0.0288 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0236 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0489 0.0683
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0387 0.1094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0384 0.1086
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0268 0.2033
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0087 0.0573
Loa Loa (eye worm) hypothetical protein 0.0037 0.0384 0.1086
Schistosoma mansoni chromobox protein 0.0071 0.0983 0.1389
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0176 0.2825 0.4014
Loa Loa (eye worm) hypothetical protein 0.0159 0.2525 0.7292
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0384 0.0793
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0387 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0324 0.248
Echinococcus granulosus RUN 0.004 0.0445 0.0621
Loa Loa (eye worm) hypothetical protein 0.0039 0.0426 0.1208
Loa Loa (eye worm) beta-lactamase 0.0037 0.0384 0.1086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0166 0.0454
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0166 0.0223
Leishmania major trypanothione reductase 0.0086 0.1258 0.4953
Echinococcus multilocularis RUN 0.004 0.0445 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0166 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0062 0.0062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.1007
Mycobacterium tuberculosis Conserved protein 0.0037 0.0384 0.0793
Brugia malayi nuclear receptor NHR-88 0.0024 0.0166 0.0454
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0268 0.0268
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0166 0.0223
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0087 0.0573
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0268 0.0369
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0445 0.1787
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0087 0.0573
Echinococcus multilocularis chromobox protein 1 0.0071 0.0983 0.1389
Loa Loa (eye worm) hypothetical protein 0.0024 0.0166 0.0454
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0387 0.1479
Loa Loa (eye worm) hypothetical protein 0.0041 0.0468 0.1331
Schistosoma mansoni rab6-interacting 0.004 0.0445 0.0621
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0174 0.0234
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0166 0.0223
Echinococcus granulosus zinc finger protein 0.0022 0.0121 0.0159
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0268 0.075
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0384 0.1171
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0383 0.0532
Onchocerca volvulus 0.0241 0.3971 1
Onchocerca volvulus 0.0037 0.0384 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0166 0.0454
Leishmania major DNA polymerase eta, putative 0.002 0.0087 0.0284
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0268 0.2033
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0338 0.0952
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.2033
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0176 0.2825 0.4014
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0387 0.1094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0166 0.0223
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0166 0.0223
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0166 0.0223
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.4946 0.4901
Brugia malayi CXXC zinc finger family protein 0.0029 0.0255 0.071
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.3585 0.9326
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0589 0.0827
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0268 0.1007
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0166 0.0223
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0384 0.0534
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0387 0.1197
Echinococcus granulosus expressed protein 0.0034 0.0338 0.0468
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0387 0.0387
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.2643 0.3755
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0166 0.0454
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0286 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0268 0.2033
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0087 0.0573
Echinococcus multilocularis chromobox protein 1 0.0071 0.0983 0.1389
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0166 0.0223
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.2643 0.7635
Loa Loa (eye worm) hypothetical protein 0.004 0.0445 0.1263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0166 0.0454
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0324 0.0561
Brugia malayi Pre-SET motif family protein 0.0031 0.0286 0.0801
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0087 0.0573
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.2285 0.5938
Echinococcus granulosus dna polymerase kappa 0.002 0.0087 0.011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0255 0.035
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0384 0.0793
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0166 0.0223
Schistosoma mansoni hypothetical protein 0.0172 0.276 0.3921
Onchocerca volvulus 0.0037 0.0384 0.0573
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0047 0.0053
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0349
Schistosoma mansoni rab6-interacting 0.004 0.0445 0.0621
Brugia malayi Bromodomain containing protein 0.0039 0.0425 0.1205
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.2285 0.586
Loa Loa (eye worm) doublecortin family protein 0.004 0.0445 0.1263
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0268 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0286 0.0394
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.2285 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0087 0.0573
Brugia malayi beta-lactamase 0.0037 0.0384 0.1086
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0166 0.0223
Loa Loa (eye worm) hypothetical protein 0.004 0.0445 0.1263
Loa Loa (eye worm) hypothetical protein 0.0037 0.0384 0.1086
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0387 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0384 0.1086
Schistosoma mansoni lipoxygenase 0.0104 0.1562 0.2213
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0268 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0166 0.0454
Schistosoma mansoni polycystin 1-related 0.004 0.0445 0.0621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0166 0.0454
Echinococcus multilocularis cpg binding protein 0.0033 0.0318 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0384 0.0384
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.2643 0.7635
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0589 0.0827
Echinococcus granulosus dnaJ subfamily B 0.0416 0.7024 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0384 0.1353
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0159 0.2525 0.3586
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0384 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0166 0.0454
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0387 0.2987
Schistosoma mansoni bromodomain containing protein 0.0066 0.0899 0.1268
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0219 0.3585 0.9326
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0586 1 1
Schistosoma mansoni alpha-glucosidase 0.0143 0.224 0.3179
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0384 0.1353
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0166 0.0223
Echinococcus multilocularis dna polymerase eta 0.002 0.0087 0.011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0174 0.0234
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0324 0.1228

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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