Detailed information for compound 665742

Basic information

Technical information
  • TDR Targets ID: 665742
  • Name: ZINC01145373
  • MW: 352.341 | Formula: C19H16N2O5
  • H donors: 1 H acceptors: 3 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)c1ccc(o1)c1ccccc1[N+](=O)[O-]
  • InChi: 1S/C19H16N2O5/c1-2-25-14-9-7-13(8-10-14)20-19(22)18-12-11-17(26-18)15-5-3-4-6-16(15)21(23)24/h3-12H,2H2,1H3,(H,20,22)
  • InChiKey: UNWCHFYXLBHKIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_221100

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acetyl-CoA synthetase 0.0009 0.0035 0.0089
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0007 0.0008 0.0023
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 0.1342
Trypanosoma brucei NADH-dependent fumarate reductase 0.0028 0.0273 0.088
Brugia malayi N-terminal motif family protein 0.0084 0.0987 0.2779
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Echinococcus multilocularis protein kinase c epsilon type 0.0015 0.0112 0.0112
Trypanosoma brucei rac serine-threonine kinase, putative 0.0009 0.0033 0.0082
Mycobacterium ulcerans electron transfer protein FdxB 0.0028 0.0273 0.088
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0041 0.0442 0.3026
Brugia malayi RNA, U transporter 1 0.008 0.0944 0.2657
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Entamoeba histolytica protein kinase, putative 0.0009 0.0033 0.0297
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0117
Plasmodium vivax flavodoxin domain containing protein 0.0216 0.2669 0.883
Entamoeba histolytica type A flavoprotein, putative 0.0093 0.1107 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0028 0.0283 0.0752
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0009 0.0033 0.0033
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0031 0.0314 0.2834
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Leishmania major nitrate reductase, putative 0.0028 0.0273 0.088
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0243 0.3022 0.3443
Giardia lamblia Hypothetical protein 0.0216 0.2669 1
Entamoeba histolytica type A flavoprotein, putative 0.0093 0.1107 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0023 0.0211 0.0593
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0093 0.1107 0.273
Echinococcus granulosus geminin 0.0695 0.8777 1
Trypanosoma brucei trypanothione reductase 0.002 0.0173 0.0547
Leishmania major GTP-binding protein, putative 0.0021 0.0186 0.0589
Brugia malayi Pre-SET motif family protein 0.0041 0.0442 0.1243
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.031 0.5239
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0028 0.0273 0.2413
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0295 0.1245
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0035 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0112 0.0128
Plasmodium falciparum importin beta, putative 0.0028 0.0281 0.0904
Loa Loa (eye worm) hypothetical protein 0.0036 0.0382 0.1016
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0295 0.0295
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0009 0.0033 0.0087
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0035 0.0093
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0295 0.0831
Brugia malayi diaphorase 0.0028 0.0273 0.0769
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0047 0.0115
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0039 0.0423 0.0481
Toxoplasma gondii NADPH-glutathione reductase 0.0007 0.0008 0.0056
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0009 0.0035 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.031 0.2804
Brugia malayi RasGEF domain containing protein 0.0009 0.0032 0.0089
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0031 0.0314 0.0314
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0006 0.0002 0.0007
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0243 0.3022 0.3022
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.0089
Plasmodium vivax importin-beta 2, putative 0.0028 0.0281 0.0904
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.0145
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0281 0.1922
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0009 0.0035 0.0318
Plasmodium falciparum thioredoxin reductase 0.002 0.0173 0.0547
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0009 0.0035 0.0035
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0112 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0025 0.0245 0.0279
Leishmania major hypothetical protein, conserved 0.0093 0.1107 0.3646
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0009 0.0035 0.0089
Brugia malayi beta-lactamase family protein 0.0029 0.0295 0.0831
Leishmania major cytochrome-b5 reductase, putative 0.0028 0.0273 0.088
Entamoeba histolytica protein kinase, putative 0.0009 0.0033 0.0297
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0023 0.0211 0.024
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0009 0.0035 0.0089
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0281 0.0746
Schistosoma mansoni aldehyde dehydrogenase 0.0025 0.0245 0.0279
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0035 0.0086
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0007 0.0008 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0281 0.0904
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0033 0.0033
Echinococcus granulosus NDR protein kinase 0.0009 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.031 0.0825
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0667
Brugia malayi protein kinase C II. 0.0015 0.0112 0.0315
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0025 0.0245 0.0786
Brugia malayi beta-lactamase 0.0029 0.0295 0.0831
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0295 0.0728
Trypanosoma brucei nitrate reductase, putative 0.0028 0.0273 0.088
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0028 0.0273 0.115
Loa Loa (eye worm) diaphorase 0.0028 0.0273 0.0727
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0188 0.2314 1
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0028 0.0273 0.0996
Echinococcus granulosus GPCR family 2 0.0023 0.0211 0.024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0295 0.0785
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0124
Brugia malayi hypothetical protein 0.0084 0.0987 0.2777
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.002 0.0173 0.0715
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 0.3681
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0009 0.0035 0.0089
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0009 0.0033 0.0087
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0006 0.0002 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0186 0.0589
Schistosoma mansoni importin beta-1 0.0028 0.0281 0.032
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0117
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0009 0.0033 0.0037
Trichomonas vaginalis glutathione reductase, putative 0.0007 0.0008 0.002
Brugia malayi FAD binding domain containing protein 0.0243 0.3022 0.8506
Echinococcus multilocularis thioredoxin glutathione reductase 0.002 0.0173 0.0173
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0025 0.0243 0.1019
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0522
Brugia malayi Protein kinase domain containing protein 0.0009 0.0033 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0025 0.0245 0.0786
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1725 0.1965
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0035 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0023 0.0211 0.0593
Loa Loa (eye worm) hypothetical protein 0.0023 0.0211 0.056
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0009 0.0035 0.0089
Mycobacterium tuberculosis Probable reductase 0.0045 0.0496 0.2117
Schistosoma mansoni gabp alpha 0.0028 0.0283 0.0322
Trypanosoma cruzi reductase, putative 0.0028 0.0273 0.088
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0243 0.3022 1
Onchocerca volvulus 0.0031 0.031 0.0765
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0295 0.0728
Mycobacterium tuberculosis Probable monooxygenase 0.0028 0.0273 0.115
Loa Loa (eye worm) MH2 domain-containing protein 0.0059 0.0679 0.1806
Echinococcus granulosus transcription factor Dp 1 0.0018 0.0148 0.0169
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0093 0.1107 0.3646
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0285 0.3552 0.9445
Entamoeba histolytica hypothetical protein 0.0084 0.0987 0.8913
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0216 0.2669 0.6584
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0045 0.0496 0.2117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.005 0.056 0.2395
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0295 0.1245
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0013 0.009 0.0747
Echinococcus granulosus Protein kinase C brain isozyme 0.0015 0.0112 0.0128
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0028 0.0273 0.088
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0047 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0031 0.031 0.0874
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0009 0.0035 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0196 0.0814
Schistosoma mansoni hypothetical protein 0.0023 0.0211 0.024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0031 0.0314 0.1014
Toxoplasma gondii ABC1 family protein 0.0029 0.0295 0.2023
Toxoplasma gondii thioredoxin reductase 0.002 0.0173 0.1186
Leishmania major NADH-dependent fumarate reductase-like protein 0.0028 0.0273 0.088
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 0.1342
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0442 0.0503
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Brugia malayi Probable ClpP-like protease 0.0039 0.0413 0.1162
Trichomonas vaginalis sulfite reductase, putative 0.0243 0.3022 0.7453
Brugia malayi Ets-domain containing protein 0.0028 0.0283 0.0796
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0009 0.0033 0.0033
Mycobacterium ulcerans beta-lactamase 0.0029 0.0295 0.0953
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0442 0.1174
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0243 0.3022 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0007 0.0008 0.0056
Brugia malayi MH2 domain containing protein 0.0059 0.0679 0.1913
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0009 0.0035 0.0117
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0212 0.0524
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0442 0.0503
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0295 0.0728
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0295 0.0953
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0045 0.0496 0.2117
Schistosoma mansoni hypothetical protein 0.0695 0.8777 1
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0295 0.1245
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Echinococcus multilocularis geminin 0.0695 0.8777 0.8777
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0028 0.0273 0.0273
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0019 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0033 0.0037
Mycobacterium ulcerans hypothetical protein 0.0029 0.0295 0.0953
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0009 0.0033 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.0036 0.0382 0.1241
Schistosoma mansoni ran 0.0021 0.0186 0.0211
Echinococcus multilocularis peptidase Clp (S14 family) 0.0025 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0029 0.0295 0.0785
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.005 0.056 0.2395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0072 0.0837 0.2356
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0186 0.0589
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0295 0.0728
Loa Loa (eye worm) FAD binding domain-containing protein 0.0243 0.3022 0.8034
Leishmania major p450 reductase, putative 0.0243 0.3022 1
Schistosoma mansoni serine/threonine kinase 0.0009 0.0033 0.0037
Entamoeba histolytica G protein alpha subunit, putative 0.0006 0 0.0002
Loa Loa (eye worm) fli-1 protein 0.0086 0.102 0.2711
Echinococcus multilocularis transcription factor Dp 1 0.0018 0.0148 0.0148
Onchocerca volvulus 0.0009 0.0035 0.0087
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 0.2213
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0093 0.1107 0.273
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0295 0.0336
Onchocerca volvulus 0.0029 0.0295 0.0728
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Brugia malayi Protein kinase domain containing protein 0.0009 0.0033 0.0092
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0031 0.0314 0.0357
Trichomonas vaginalis esterase, putative 0.0029 0.0295 0.0728
Brugia malayi glutaminase DH11.1 0.0234 0.29 0.8164
Plasmodium vivax hypothetical protein, conserved 0.0093 0.1107 0.3646
Loa Loa (eye worm) TAR-binding protein 0.0141 0.1725 0.4585
Echinococcus granulosus tar DNA binding protein 0.0141 0.1725 0.1965
Entamoeba histolytica type A flavoprotein, putative 0.0093 0.1107 1
Leishmania major cytochrome P450 reductase, putative 0.0216 0.2669 0.883
Brugia malayi DIX domain containing protein 0.001 0.0047 0.0132
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0009 0.0035 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0072 0.0837 0.2225
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0212 0.0676
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0281 0.0904
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.0089
Loa Loa (eye worm) AGC/PKN protein kinase 0.0009 0.0033 0.0087
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0031 0.031 0.1311
Echinococcus granulosus importin subunit beta 1 0.0028 0.0281 0.032
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Onchocerca volvulus 0.0009 0.0035 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.1725 0.4855
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0002 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0023 0.0211 0.056
Loa Loa (eye worm) hypothetical protein 0.0122 0.148 0.3935
Trypanosoma cruzi nitrate reductase, putative 0.0028 0.0273 0.088
Brugia malayi C1-like domain containing protein 0.0006 0.0002 0.0007
Echinococcus granulosus cytochrome b5 reductase 4 0.0028 0.0273 0.0311
Onchocerca volvulus 0.0324 0.4054 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0025 0.0245 0.1027
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0186 0.0211
Loa Loa (eye worm) oxidoreductase 0.0009 0.0035 0.0093
Echinococcus granulosus histone lysine methyltransferase setb 0.0041 0.0442 0.0503
Plasmodium falciparum nitric oxide synthase, putative 0.0243 0.3022 1
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.0099
Brugia malayi Importin beta-1 subunit 0.0028 0.0281 0.079
Brugia malayi glutathione reductase 0.002 0.0173 0.0487
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0295 0.4953
Entamoeba histolytica hypothetical protein 0.0023 0.0212 0.192
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0112 0.0128
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0212 0.0524
Chlamydia trachomatis sulfite reductase 0.015 0.1836 1
Brugia malayi TAR-binding protein 0.0141 0.1725 0.4855
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0295 0.1245
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0025 0.0245 0.0279
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0295 0.0728
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0009 0.0033 0.0037
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0295 0.1245
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0028 0.0273 0.088
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0031 0.0314 0.0357
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0039 0.0413 0.1342
Leishmania major hypothetical protein, conserved 0.0036 0.0382 0.1241
Onchocerca volvulus 0.0029 0.0295 0.0728
Echinococcus multilocularis snurportin 1 0.0301 0.3761 0.3761
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0196 0.0814
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Trypanosoma cruzi p450 reductase, putative 0.0028 0.0273 0.088
Leishmania major NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Brugia malayi Protein kinase c protein 2 0.0006 0.0002 0.0007
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0039 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0547 0.1455
Mycobacterium tuberculosis Conserved protein 0.0029 0.0295 0.1245
Schistosoma mansoni hypothetical protein 0.0301 0.3761 0.4285
Schistosoma mansoni cytochrome B5 0.0028 0.0273 0.0311
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.0987 0.1124
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.0273 0.088
Brugia malayi Protein kinase domain containing protein 0.0006 0.0002 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0045 0.0496 0.2117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0023 0.0211 0.0211
Loa Loa (eye worm) RNA binding protein 0.0141 0.1725 0.4585
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0028 0.0273 0.0769
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0295 0.0336
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0035 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0033 0.0037
Loa Loa (eye worm) glutaminase 2 0.0234 0.29 0.771
Leishmania major cytochrome-b5 reductase, putative 0.0028 0.0273 0.088
Echinococcus granulosus serine:threonine protein kinase N2 0.0009 0.0033 0.0037
Loa Loa (eye worm) RasGEF domain-containing protein 0.0009 0.0032 0.0084
Onchocerca volvulus 0.0041 0.0442 0.1089
Entamoeba histolytica protein kinase, putative 0.0009 0.0033 0.0297
Schistosoma mansoni hypothetical protein 0.0084 0.0987 0.1124
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Brugia malayi beta-lactamase family protein 0.0029 0.0295 0.0831
Echinococcus multilocularis cytochrome b5 reductase 4 0.0028 0.0273 0.0273
Mycobacterium ulcerans oxygenase 0.0028 0.0273 0.088
Brugia malayi Fli-1 protein 0.0086 0.102 0.287
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0031 0.0314 0.0834
Loa Loa (eye worm) glutathione reductase 0.002 0.0173 0.046
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0028 0.0273 0.0727
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.0089
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0025 0.0243 0.3961
Trypanosoma cruzi PAB1-binding protein , putative 0.0036 0.0382 0.1241
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0212 0.0524
Entamoeba histolytica hypothetical protein 0.0084 0.0987 0.8913
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0295 0.1245
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 0.1342
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0013 0.009 0.0272
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0028 0.0273 0.088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0093
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0243 0.3022 1
Mycobacterium ulcerans lipase LipD 0.0029 0.0295 0.0953
Trypanosoma cruzi PAB1-binding protein , putative 0.0036 0.0382 0.1241
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0039 0.0413 0.2827
Plasmodium vivax thioredoxin reductase, putative 0.002 0.0173 0.0547
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0039 0.0413 0.2827
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0028 0.0273 0.0311
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0047 0.0124
Echinococcus multilocularis GA binding protein alpha chain 0.0028 0.0283 0.0283
Loa Loa (eye worm) glutaminase 0.0234 0.29 0.771
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0093 0.1107 0.3646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0295 0.0785
Leishmania major trypanothione reductase 0.002 0.0173 0.0547
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0093 0.1107 0.3646
Entamoeba histolytica protein kinase, putative 0.0009 0.0033 0.0297
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0028 0.0273 0.088
Leishmania major reductase, putative 0.0028 0.0273 0.088
Brugia malayi AMP-binding enzyme family protein 0.0031 0.031 0.0874
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0015 0.0112 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1769 0.2016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0031 0.0314 0.0883
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.0987 0.0987
Schistosoma mansoni glutaminase 0.0234 0.29 0.3304
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0028 0.0273 0.1451
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0028 0.0273 0.1873
Echinococcus granulosus protein kinase c epsilon type 0.0015 0.0112 0.0128
Brugia malayi flavodoxin family protein 0.0243 0.3022 0.8506
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0589
Loa Loa (eye worm) hypothetical protein 0.0029 0.0295 0.0785
Mycobacterium tuberculosis Probable dehydrogenase 0.0045 0.0496 0.2117
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Trichomonas vaginalis set domain proteins, putative 0.0324 0.4054 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.031 0.1003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0016 0.0128 0.0128
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0243 0.3022 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0243 0.3022 1
Brugia malayi AMP-binding enzyme family protein 0.0031 0.031 0.0874
Loa Loa (eye worm) hypothetical protein 0.0072 0.0837 0.2225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1769 0.1769
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0028 0.0273 0.088
Schistosoma mansoni atypical protein kinase C 0.0015 0.0112 0.0128
Echinococcus multilocularis GPCR, family 2 0.0023 0.0211 0.0211
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0093 0.1107 0.3646
Plasmodium falciparum glutathione reductase 0.002 0.0173 0.0547
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1725 0.1965
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0243 0.3022 0.3443
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0009 0.0035 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0295 0.0785
Mycobacterium tuberculosis Possible oxygenase 0.0028 0.0273 0.115
Schistosoma mansoni hypothetical protein 0.0023 0.0211 0.024
Echinococcus multilocularis serine:threonine protein kinase 38 0.0009 0.0033 0.0033
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0013 0.009 0.0272
Toxoplasma gondii aldehyde dehydrogenase 0.0025 0.0245 0.1679
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0002 0.0003
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0031 0.0314 0.1014
Brugia malayi FAD binding domain containing protein 0.015 0.1836 0.5167
Mycobacterium tuberculosis Conserved protein 0.0029 0.0295 0.1245
Entamoeba histolytica hypothetical protein 0.0084 0.0987 0.8913
Loa Loa (eye worm) hypothetical protein 0.0023 0.0212 0.0563
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.005 0.056 1
Mycobacterium ulcerans hypothetical protein 0.0031 0.031 0.1003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 0.2213
Schistosoma mansoni hypothetical protein 0.0023 0.0211 0.024
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0243 0.3022 1
Mycobacterium tuberculosis Conserved protein 0.0029 0.0295 0.1245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0196 0.0814
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0047 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.031 0.1003
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0243 0.3022 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0072 0.0837 0.2356
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0033 0.0037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0031 0.0314 0.1014
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0009 0.0035 0.004
Leishmania major NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Brugia malayi p70 ribosomal S6 kinase beta 0.0009 0.0033 0.0092
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0031 0.031 0.1003
Echinococcus granulosus cytochrome b5 reductase 4 0.0028 0.0273 0.0311
Schistosoma mansoni dishevelled 0.001 0.0047 0.0053
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0212 0.0678
Leishmania major oxidoreductase-like protein 0.0028 0.0273 0.088
Schistosoma mansoni ets-related 0.0086 0.102 0.1162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.1725 0.4585
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0186 0.0589
Entamoeba histolytica Ran family GTPase 0.0021 0.0186 0.1676
Loa Loa (eye worm) hypothetical protein 0.0031 0.031 0.0825
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0045 0.0496 0.2117
Giardia lamblia Nitric oxide synthase, inducible 0.0216 0.2669 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Leishmania major importin beta-1 subunit, putative 0.0023 0.0212 0.0678
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0093 0.1107 0.3646
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0025 0.0243 0.1019
Schistosoma mansoni hypothetical protein 0.0695 0.8777 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0009 0.0035 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0212 0.0563
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0009 0.0035 0.0117
Trypanosoma brucei oxidoreductase-protein, putative 0.0028 0.0273 0.088
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0009 0.0035 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0295 0.0785
Loa Loa (eye worm) hypothetical protein 0.0113 0.1368 0.3637
Schistosoma mansoni ran 0.0021 0.0186 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.031 0.1003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0035 0.0093
Plasmodium vivax SET domain protein, putative 0.0041 0.0442 0.1438
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0013 0.0033
Plasmodium falciparum acyl-CoA synthetase 0.0023 0.0212 0.0676
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0023 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0023 0.0212 0.0563
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0028 0.0273 0.1873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0025 0.0245 0.0245
Echinococcus granulosus thioredoxin glutathione reductase 0.002 0.0173 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0442 0.0503
Plasmodium falciparum ferredoxin--NADP reductase 0.0028 0.0273 0.088
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0295 0.0953
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0243 0.3022 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0023 0.0212 0.0676
Echinococcus granulosus peptidase Clp S14 family 0.0025 0.0243 0.0277
Echinococcus granulosus methionine synthase reductase 0.015 0.1836 0.2091
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0243 0.3022 0.8034
Trypanosoma brucei NADH-dependent fumarate reductase 0.0028 0.0273 0.088
Toxoplasma gondii flavodoxin domain-containing protein 0.0121 0.1459 1
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.0987 0.1124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0212 0.0563
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0035 0.0099
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0186 0.1271
Plasmodium vivax glutathione reductase, putative 0.002 0.0173 0.0547
Toxoplasma gondii propionate-CoA ligase 0.0009 0.0035 0.0241
Brugia malayi hypothetical protein 0.0036 0.0382 0.1075
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0009 0.0033 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.031 0.2804
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0028 0.0273 0.0311
Loa Loa (eye worm) hypothetical protein 0.0084 0.0987 0.2625
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0031 0.031 0.1003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1769 0.4704
Loa Loa (eye worm) thioredoxin reductase 0.002 0.0173 0.046
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0009 0.0035 0.0089
Brugia malayi Protein kinase domain containing protein 0.0009 0.0033 0.0092
Loa Loa (eye worm) hypothetical protein 0.012 0.1447 0.3847
Loa Loa (eye worm) hypothetical protein 0.0023 0.0212 0.0563
Entamoeba histolytica acyl-coA synthetase, putative 0.0031 0.031 0.2804
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0442 0.0503
Brugia malayi protein kinase C3,putative 0.0006 0.0002 0.0007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0186 0.0186
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0047 0.0047
Echinococcus granulosus GA binding protein alpha chain 0.0028 0.0283 0.0322
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0186 0.0493
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.005 0.056 0.2395
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0041 0.0442 0.0442
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0009 0.0035 0.0241
Brugia malayi hypothetical protein 0.0023 0.0219 0.0615
Schistosoma mansoni peptidase Clp (S14 family) 0.0039 0.0413 0.047
Mycobacterium ulcerans oxidoreductase 0.0028 0.0273 0.088
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0117
Echinococcus multilocularis protein kinase c iota type 0.0015 0.0112 0.0112
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0007 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0113 0.1368 0.3637
Loa Loa (eye worm) AGC/NDR protein kinase 0.0009 0.0033 0.0087
Schistosoma mansoni NADPH flavin oxidoreductase 0.0123 0.1483 0.169
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0023 0.0211 0.024
Plasmodium falciparum ataxin-2 like protein, putative 0.0036 0.0382 0.1241
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0047 0.0053
Mycobacterium ulcerans glutaminase 0.0234 0.29 0.9596
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0084 0.0987 0.2435
Loa Loa (eye worm) hypothetical protein 0.0031 0.031 0.0825
Schistosoma mansoni hypothetical protein 0.0023 0.0211 0.024
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0009 0.0033 0.0037
Mycobacterium ulcerans monooxygenase 0.0028 0.0273 0.088
Echinococcus granulosus protein kinase C gamma type 0.0009 0.0033 0.0037
Trypanosoma brucei PAB1-binding protein , putative 0.0036 0.0382 0.1241
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0033 0.0037
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0035 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1769 0.1769
Brugia malayi RNA binding protein 0.0141 0.1725 0.4855
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0047 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0025 0.0245 0.0786
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0039 0.0413 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Toxoplasma gondii AGC kinase 0.0009 0.0033 0.0225
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0007 0.0008 0.0008
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0013 0.009 0.1049
Trichomonas vaginalis mercuric reductase, putative 0.0007 0.0008 0.002
Loa Loa (eye worm) FAD binding domain-containing protein 0.015 0.1836 0.488
Brugia malayi Hr1 repeat family protein 0.0009 0.0033 0.0092
Trichomonas vaginalis glutaminase, putative 0.0234 0.29 0.7153
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0031 0.0314 0.1014
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0093 0.1107 0.273
Echinococcus multilocularis tar DNA binding protein 0.0141 0.1725 0.1725
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.031 0.1003
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0273 0.115
Schistosoma mansoni diflavin oxidoreductase 0.0121 0.1459 0.1663
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0295 0.0953
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0295 0.1245
Entamoeba histolytica type A flavoprotein, putative 0.0093 0.1107 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0028 0.0273 0.115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0025 0.0245 0.0786
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0295 0.0336
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0186 0.0589
Plasmodium vivax acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0281 0.0281
Entamoeba histolytica hypothetical protein 0.0084 0.0987 0.8913
Toxoplasma gondii LsmAD domain-containing protein 0.0036 0.0382 0.2618
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0243 0.3022 1
Brugia malayi Ets-domain containing protein 0.0028 0.0283 0.0796
Toxoplasma gondii hypothetical protein 0.0013 0.009 0.0618
Loa Loa (eye worm) beta-lactamase 0.0029 0.0295 0.0785
Onchocerca volvulus 0.0009 0.0035 0.0087
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Loa Loa (eye worm) AGC/AKT protein kinase 0.0009 0.0033 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1769 0.2016
Brugia malayi flavodoxin family protein 0.0093 0.1107 0.3116
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0016 0.0128 0.0145
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0015 0.0112 0.0112
Schistosoma mansoni dishevelled 0.001 0.0047 0.0053
Treponema pallidum flavodoxin 0.0093 0.1107 1
Trypanosoma cruzi oxidoreductase-protein, putative 0.0028 0.0273 0.088
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0009 0.0033 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.031 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1725 0.1965
Toxoplasma gondii flavodoxin domain-containing protein 0.0121 0.1459 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0039 0.0413 0.7187
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Leishmania major NADH-dependent fumarate reductase, putative 0.0028 0.0273 0.088
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0045 0.0496 0.8778
Onchocerca volvulus 0.0029 0.0295 0.0728
Trichomonas vaginalis ran, putative 0.0021 0.0186 0.0457
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.031 0.5239
Trypanosoma cruzi p450 reductase, putative 0.0243 0.3022 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.031 0.1003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1769 0.498
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0035 0.0089
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0009 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0612
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0295 0.0785
Echinococcus granulosus snurportin 1 0.0301 0.3761 0.4285
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0033 0.0081
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0009 0.003 0.0075
Schistosoma mansoni hypothetical protein 0.0049 0.0547 0.0623
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0093 0.1107 0.273
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0028 0.0273 0.088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0041 0.0442 0.0442
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1769 0.2016
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0006 0.0002 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0035 0.0117
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0033 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0036 0.0382 0.1241
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0295 0.0953
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0243 0.3022 0.3022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0093
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0006 0.0002 0.0006
Mycobacterium leprae Probable lipase LipE 0.0029 0.0295 0.4953
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0295 0.0953
Loa Loa (eye worm) hypothetical protein 0.0039 0.0413 0.1097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1769 0.2016
Entamoeba histolytica type A flavoprotein, putative 0.0093 0.1107 1
Brugia malayi Thioredoxin reductase 0.002 0.0173 0.0487
Echinococcus multilocularis methionine synthase reductase 0.015 0.1836 0.1836
Loa Loa (eye worm) hypothetical protein 0.0113 0.1368 0.3637
Loa Loa (eye worm) flavodoxin family protein 0.0093 0.1107 0.2943
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.031 0.1003
Echinococcus multilocularis serine threonine protein kinase 0.0009 0.0033 0.0033
Onchocerca volvulus 0.0028 0.0273 0.0674
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0243 0.3022 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0196 0.0814
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0173 0.0547
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3761 1
Schistosoma mansoni acetyl-CoA synthetase 0.0009 0.0035 0.004
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0023 0.0212 0.1115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1769 0.2016
Loa Loa (eye worm) transcription factor SMAD2 0.0059 0.0679 0.1806
Schistosoma mansoni cytochrome P450 reductase 0.0243 0.3022 0.3443
Onchocerca volvulus 0.0009 0.0035 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.031 0.1311
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0039 0.0413 0.047
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0009 0.0035 0.0117
Brugia malayi latrophilin 2 splice variant baaae 0.0049 0.0547 0.154
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0009 0.0035 0.0089
Echinococcus granulosus protein kinase c iota type 0.0015 0.0112 0.0128
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0212 0.0883
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1725 0.1965
Schistosoma mansoni protein kinase C mu 0.0006 0.0002 0.0003
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0028 0.0273 0.088
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1725 0.1965
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0295 0.0953
Leishmania major hypothetical protein, conserved 0.0029 0.0295 0.0953
Leishmania major NADH-cytochrome b5 reductase, putative 0.0028 0.0273 0.088
Brugia malayi Pre-SET motif family protein 0.0285 0.3552 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0093 0.1107 0.3646
Onchocerca volvulus 0.0113 0.1368 0.3374
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.031 0.1003
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.015 0.1836 0.2091
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0009 0.0035 0.0117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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