Detailed information for compound 669056

Basic information

Technical information
  • TDR Targets ID: 669056
  • Name: 2-methylsulfanyl-4-phenylquinazoline
  • MW: 252.334 | Formula: C15H12N2S
  • H donors: 0 H acceptors: 2 LogP: 4.05 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc2ccccc2c(n1)c1ccccc1
  • InChi: 1S/C15H12N2S/c1-18-15-16-13-10-6-5-9-12(13)14(17-15)11-7-3-2-4-8-11/h2-10H,1H3
  • InChiKey: DRBQMOFGKVCOTA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methylsulfanyl-4-phenyl-quinazoline
  • 2-(methylthio)-4-phenylquinazoline
  • 2-(methylthio)-4-phenyl-quinazoline
  • ZINC02852018
  • STK043896
  • AJ-292/40762739

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0476 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0303 0.2492 0.3425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0392 0.0538
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0284 0.1018
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0611 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0433 0.0598
Plasmodium falciparum ornithine aminotransferase 0.0047 0.0313 0.147
Onchocerca volvulus 0.0186 0.1495 0.181
Leishmania major protein kinase, putative 0.0014 0.0034 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0049 0.0078
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0031 0.0005
Giardia lamblia Pyruvate kinase 0.0035 0.0218 0.3226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.015 0.0182
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.2528 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0242 0.0333
Trypanosoma brucei protein kinase, putative 0.0052 0.036 0.1317
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0047 0.0313 0.1056
Loa Loa (eye worm) hypothetical protein 0.0155 0.1238 0.1709
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0149 0.0763
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0122 0.0474
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0052 0.007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0546 0.0661
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0047 0.0313 0.0429
Echinococcus multilocularis pyruvate kinase 0.0018 0.0071 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.1051 0.1444
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0392 0.1354
Schistosoma mansoni smad 0.0016 0.0052 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0231 0.028
Mycobacterium tuberculosis Conserved protein 0.0186 0.1495 0.1469
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.1901 0.2624
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1495 0.5866
Toxoplasma gondii exonuclease III APE 0.0038 0.0242 0.124
Loa Loa (eye worm) hypothetical protein 0.0239 0.1949 0.269
Mycobacterium tuberculosis Conserved protein 0.0186 0.1495 0.1469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0182 0.022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0041
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0157 0.1249 0.1222
Toxoplasma gondii thioredoxin reductase 0.0039 0.0246 0.126
Loa Loa (eye worm) hypothetical protein 0.0186 0.1495 0.2064
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.036 0.0497
Onchocerca volvulus 0.0013 0.003 0.0035
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0047 0.0313 0.1056
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0218 0.0264
Onchocerca volvulus 0.0125 0.0977 0.1183
Brugia malayi hypoxia-induced factor 1 0.0158 0.1261 0.1739
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0186 0.1495 0.2063
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.003 0.0041
Mycobacterium ulcerans esterase/lipase LipP 0.0186 0.1495 0.5482
Onchocerca volvulus 0.0981 0.8255 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.015 0.0182
Loa Loa (eye worm) hypothetical protein 0.0186 0.1495 0.2064
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0149 0.0619
Brugia malayi RNA, U transporter 1 0.0093 0.0708 0.0977
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0084 0.0114
Leishmania major trypanothione reductase 0.0039 0.0246 0.0864
Brugia malayi beta-lactamase 0.0186 0.1495 0.2063
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1495 0.1811
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0303 0.2492 0.3425
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0392 0.1452
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.036 0.1845
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0476 0.0654
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0218 0.0701
Trichomonas vaginalis helicase, putative 0.0014 0.0034 0.0041
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0482 0.0452
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0312 0.0377
Leishmania major hypothetical protein, conserved 0.0027 0.0149 0.0476
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0031 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0242 0.11
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0312 0.1125
Giardia lamblia Pyruvate kinase 0.0018 0.0071 0.0701
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.036 0.1321
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0195 0.1001
Brugia malayi MH1 domain containing protein 0.0016 0.0052 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0242 0.0849
Echinococcus multilocularis pyruvate kinase 0.0035 0.0218 0.0298
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0482 0.2471
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0546 0.0749
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0312 0.0427
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0031 0.0041
Schistosoma mansoni cpg binding protein 0.0064 0.0463 0.0635
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1292 0.1265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Echinococcus multilocularis peptidase Clp (S14 family) 0.0157 0.1249 0.1715
Echinococcus granulosus importin subunit beta 1 0.0033 0.0195 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0977 0.1343
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1215 0.1669
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0157 0.1249 0.1222
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0218 0.03
Schistosoma mansoni bromodomain containing protein 0.0011 0.0009 0.0012
Echinococcus granulosus smad 0.0016 0.0052 0.007
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0667 0.0638
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0546 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0312 0.3882
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0218 0.0263
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0186 0.1495 0.1469
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0218 0.03
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.1261 0.174
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0312 0.1129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0242 0.2454
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0218 0.0301
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0149 0.0472
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0218 0.0301
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0142 0.0452
Brugia malayi steroid hormone receptor 0.001 0.0001 0.0001
Schistosoma mansoni transient receptor potential channel 0.0066 0.0476 0.0654
Schistosoma mansoni smad1 5 8 and 0.0016 0.0052 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1074 0.1476
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0031 0.0158
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.025 0.0342
Mycobacterium ulcerans hypothetical protein 0.0328 0.2702 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0034 0.0016
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0231 0.0319
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.2528 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0242 0.0212
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0392 0.0538
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0195 0.0658
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.003 0.0036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0546 0.2066
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.0735 0.1009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0011 0.0009 0.0012
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 0.7181
Onchocerca volvulus 0.0061 0.0433 0.0524
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0611 0.3026
Echinococcus granulosus single minded 2 0.0038 0.0238 0.0326
Mycobacterium ulcerans lipase LipD 0.0186 0.1495 0.5482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0231 0.028
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0392 0.0538
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0674 0.3358
Loa Loa (eye worm) beta-lactamase 0.0186 0.1495 0.2064
Plasmodium vivax SET domain protein, putative 0.0125 0.0977 0.4938
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0047 0.0313 0.1059
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0041
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.036 0.5667
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0313 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0482 0.1809
Brugia malayi Pre-SET motif family protein 0.0862 0.7244 1
Schistosoma mansoni Smad4 0.0016 0.0052 0.007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.035 0.2888 0.3987
Schistosoma mansoni pyruvate kinase 0.0018 0.0071 0.0097
Echinococcus multilocularis muscleblind protein 0.0153 0.1215 0.1669
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0242 0.0293
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1152 0.4495
Leishmania major pyruvate kinase 0.0035 0.0218 0.0754
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.036 0.0436
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0284 0.1018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0153 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.0735 0.1009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.075 0.0722
Brugia malayi Muscleblind-like protein 0.0153 0.1215 0.1677
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0763 0.1047
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1152 0.4492
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0052 0.0072
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0546 0.8873
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.3791 0.521
Mycobacterium ulcerans acetylornithine aminotransferase 0.0047 0.0313 0.1056
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0034 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0312 0.0377
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0127 0.0106
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0218 0.1118
Loa Loa (eye worm) hypothetical protein 0.0186 0.1495 0.2064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0149 0.0476
Loa Loa (eye worm) hypothetical protein 0.0035 0.0218 0.0301
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1495 0.1811
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0284 0.1018
Loa Loa (eye worm) hypothetical protein 0.0186 0.1495 0.2064
Brugia malayi beta-lactamase family protein 0.0186 0.1495 0.2063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0312 0.1129
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0127 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.036 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0001
Brugia malayi Probable ClpP-like protease 0.0239 0.1949 0.269
Echinococcus multilocularis dnaJ subfamily B 0.0866 0.7275 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0218 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1495 0.5866
Schistosoma mansoni cpg binding protein 0.0061 0.0433 0.0595
Mycobacterium ulcerans hypothetical protein 0.0162 0.1292 0.4722
Schistosoma mansoni hypothetical protein 0.0866 0.7275 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0674 0.0817
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0977 0.1343
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0122 0.0368
Loa Loa (eye worm) hypothetical protein 0.0063 0.0448 0.0619
Schistosoma mansoni pyruvate kinase 0.0035 0.0218 0.0298
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0928 0.1274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0231 0.028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0218 0.098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0001
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.003 0.0036
Brugia malayi nuclear receptor NHR-88 0.001 0.0001 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0031 0.0004
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0218 0.0188
Mycobacterium tuberculosis Probable esterase LipL 0.0186 0.1495 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1074 0.1476
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0049 0.0066
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0546 0.0753
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0312 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0977 0.1343
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0667 0.2384
Echinococcus granulosus geminin 0.0173 0.1389 0.1909
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.036 0.0436
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 1
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0113 0.0156
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0351 0.0481
Schistosoma mansoni single-minded 0.0051 0.0351 0.0481
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0674 0.3459
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0071 0.0366
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Brugia malayi hypothetical protein 0.0027 0.0149 0.0205
Schistosoma mansoni ap endonuclease 0.0038 0.0242 0.0331
Echinococcus multilocularis zinc finger protein 0.0011 0.0009 0.0012
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0312 0.1129
Brugia malayi Pre-SET motif family protein 0.0125 0.0977 0.1349
Echinococcus granulosus muscleblind protein 0.0153 0.1215 0.1669
Plasmodium falciparum importin beta, putative 0.0033 0.0195 0.0857
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0049 0.0078
Echinococcus granulosus Aminotransferase class III 0.0047 0.0313 0.0429
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0312 0.3882
Schistosoma mansoni zinc finger protein 0.0011 0.0009 0.0012
Onchocerca volvulus 0.0186 0.1495 0.181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.036 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0312 0.0377
Brugia malayi MAP kinase sur-1 0.0052 0.036 0.0496
Echinococcus granulosus histone lysine methyltransferase setb 0.0125 0.0977 0.1343
Leishmania major GTP-binding protein, putative 0.0024 0.0122 0.0368
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0205
Toxoplasma gondii histone lysine methyltransferase SET1 0.0127 0.0997 0.5118
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0218 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Toxoplasma gondii ABC1 family protein 0.0186 0.1495 0.7671
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1152 0.4495
Leishmania major hypothetical protein, conserved 0.0186 0.1495 0.5866
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0186 0.1495 0.2064
Loa Loa (eye worm) hypothetical protein 0.0186 0.1495 0.2064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0031 0.0004
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0546 0.2062
Mycobacterium tuberculosis Probable reductase 0.0088 0.0667 0.0638
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.0269
Echinococcus multilocularis cpg binding protein 0.0064 0.0463 0.0635
Loa Loa (eye worm) Smad1 0.0016 0.0052 0.0072
Toxoplasma gondii hypothetical protein 0.005 0.0338 0.1734
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0047 0.0313 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0049 0.006
Echinococcus granulosus pyruvate kinase 0.0018 0.0071 0.0097
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.003 0.0036
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0246 0.0339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0049 0.0067
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0218 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0173 0.021
Brugia malayi Smad1 0.0016 0.0052 0.0071
Brugia malayi MH2 domain containing protein 0.0016 0.0052 0.0071
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0031 0.0158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Plasmodium vivax importin-beta 2, putative 0.0033 0.0195 0.0862
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0239 0.1949 0.2678
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.1074 0.1483
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0031 0.0041
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0312 0.0427
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0328 0.2702 1
Mycobacterium tuberculosis Probable hydrolase 0.0186 0.1495 0.1469
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0546 0.8664
Brugia malayi Importin beta-1 subunit 0.0033 0.0195 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0001 0.0001
Echinococcus multilocularis smad 0.0016 0.0052 0.007
Mycobacterium tuberculosis Probable lipase LipD 0.0186 0.1495 0.1469
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0476 0.0654
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0195 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Echinococcus multilocularis geminin 0.0173 0.1389 0.1909
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1074 0.1476
Echinococcus granulosus ornithine aminotransferase 0.0047 0.0313 0.0429
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.036 0.0496
Loa Loa (eye worm) hypothetical protein 0.01 0.0763 0.1053
Echinococcus multilocularis pyruvate kinase 0.0018 0.0071 0.0097
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0047 0.0313 0.0283
Leishmania major protein kinase, putative 0.0014 0.0034 0.0016
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0047 0.0313 0.0283
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0239 0.1949 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0127 0.0175
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0328 0.2702 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0218 0.0705
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.003 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0667 0.0638
Echinococcus multilocularis pyruvate kinase 0.0018 0.0071 0.0097
Loa Loa (eye worm) hypothetical protein 0.0171 0.1373 0.1896
Brugia malayi follicle stimulating hormone receptor 0.0699 0.5859 0.8087
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.0084 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0001
Brugia malayi MH1 domain containing protein 0.0016 0.0052 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0186 0.1495 0.5864
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.075 0.0722
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0052 0.007
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0047 0.0313 0.1605
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2528 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0071 0.0097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0186 0.1495 0.1469
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0186 0.1495 0.5482
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0242 0.0293
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0231 0.0807
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0242 0.0849
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0104 0.0292
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0242 0.0331
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0021 0.0027
Brugia malayi acetyltransferase, GNAT family protein 0.0303 0.2492 0.344
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0239 0.1949 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.036 0.0493
Chlamydia trachomatis pyruvate kinase 0.0035 0.0218 0.0981
Schistosoma mansoni pyruvate kinase 0.0035 0.0218 0.0298
Trichomonas vaginalis esterase, putative 0.0186 0.1495 0.1811
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0049 0.0066
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0862 0.7244 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0142 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0546 0.0753
Brugia malayi PAS domain containing protein 0.0051 0.0351 0.0484
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0546 0.0749
Brugia malayi hypothetical protein 0.0155 0.1238 0.1708
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0041
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0546 0.0749
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0482 0.1688
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.075 0.0722
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0115 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.036 0.0436
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0699 0.5859 0.8087
Entamoeba histolytica hypothetical protein 0.0027 0.0142 0.0426
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0977 0.5015
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0149 0.0476
Brugia malayi Thioredoxin reductase 0.0039 0.0246 0.0338
Brugia malayi MH2 domain containing protein 0.0016 0.0052 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0034 0.0016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.003 0.0036
Schistosoma mansoni hypothetical protein 0.035 0.2888 0.3969
Loa Loa (eye worm) hypothetical protein 0.0034 0.0203 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1074 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0546 0.0661
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0115 0.0157
Brugia malayi hypothetical protein 0.0171 0.1373 0.1895
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0674 0.3459
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0246 0.0215
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0049 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0041
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0313 0.0429
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0674 0.0817
Brugia malayi Bromodomain containing protein 0.0011 0.0009 0.0012
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.003 0.004
Echinococcus granulosus pyruvate kinase 0.0035 0.0218 0.0298
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0242 0.0845
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0238 0.0326
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.003 0.004
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0049 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0029 0.0039
Mycobacterium leprae Probable lipase LipE 0.0186 0.1495 0.5484
Mycobacterium tuberculosis Conserved protein 0.0186 0.1495 0.1469
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.3791 0.521
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0328 0.2702 0.2679
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0047 0.0313 0.1059
Brugia malayi PHD-finger family protein 0.0011 0.0009 0.0012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0242 0.3636
Echinococcus granulosus histone acetyltransferase KAT2B 0.0294 0.242 0.3326
Loa Loa (eye worm) hypothetical protein 0.0125 0.0977 0.1349
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0122 0.0364
Echinococcus granulosus dnaJ subfamily B 0.0866 0.7275 1
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0238 0.0328
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0052 0.0072
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0052 0.007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0122 0.0168
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 1
Trichomonas vaginalis ran, putative 0.0024 0.0122 0.0147
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0122 0.0166
Brugia malayi hypothetical protein 0.0018 0.0066 0.0091
Plasmodium falciparum glutathione reductase 0.0039 0.0246 0.112
Schistosoma mansoni ap endonuclease 0.0038 0.0242 0.0331
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0231 0.028
Plasmodium vivax glutathione reductase, putative 0.0039 0.0246 0.1124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0142 0.0173
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0031 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0186 0.1495 0.1469
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0254 0.0308
Echinococcus multilocularis Smad4 0.0016 0.0052 0.007
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0157 0.1249 0.4562
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0115 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0312 0.043
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0122 0.0624
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.003 0.0036
Onchocerca volvulus 0.0186 0.1495 0.181
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.3791 0.521
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0546 0.2066
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0231 0.0317
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0476 0.0654
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0001 0.0001
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0218 0.075
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0047 0.0313 0.147
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0242 0.1104
Loa Loa (eye worm) acetyltransferase 0.0303 0.2492 0.344
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1495 0.1811
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0328 0.2702 0.3273
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0084 0.0114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0122 0.0368
Schistosoma mansoni smad1 5 8 and 0.0016 0.0052 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0482 0.0661
Echinococcus multilocularis snurportin 1 0.035 0.2888 0.3969
Echinococcus multilocularis pyruvate kinase 0.0028 0.0155 0.0211
Schistosoma mansoni transient receptor potential channel 0.0066 0.0476 0.0654
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0482 0.0661
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1495 0.2054
Onchocerca volvulus 0.0038 0.0238 0.0287
Brugia malayi nuclear hormone receptor 0.001 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0977 0.1343
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.036 0.1321
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.036 0.1317
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0081 0.0201
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0546 0.2066
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0047 0.0313 0.1059
Loa Loa (eye worm) hypothetical protein 0.0186 0.1495 0.2064
Brugia malayi CXXC zinc finger family protein 0.0061 0.0433 0.0598
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0364 0.1339
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0218 0.075
Schistosoma mansoni smad1 5 8 and 0.0016 0.0052 0.007
Trypanosoma brucei trypanothione reductase 0.0039 0.0246 0.086
Mycobacterium ulcerans beta-lactamase 0.0186 0.1495 0.5482
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0617 0.3059
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0242 0.079
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0122 0.1567
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0392 0.1354
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0071 0.0217
Loa Loa (eye worm) glutathione reductase 0.0039 0.0246 0.0339
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0008 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1495 0.1811
Echinococcus granulosus neuropeptide s receptor 0.0456 0.3791 0.521
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0031 0.0037
Brugia malayi beta-lactamase family protein 0.0186 0.1495 0.2063
Loa Loa (eye worm) hypothetical protein 0.0153 0.1215 0.1677
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0031 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0001 0.0001
Mycobacterium ulcerans L-lysine aminotransferase 0.0047 0.0313 0.1056
Mycobacterium tuberculosis Probable aminotransferase 0.0328 0.2702 0.2679
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0617 0.3056
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis pyruvate kinase 0.0035 0.0218 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0036
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0186 0.1495 0.2054
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.003 0.004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0011 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0064 0.0463 0.0635
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0071 0.0212
Echinococcus granulosus Smad4 0.0016 0.0052 0.007
Giardia lamblia GTOR 0.0046 0.0312 0.484
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.036 0.0493
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0242 0.0331
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0284 0.1014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1074 0.1476
Brugia malayi ecdysteroid receptor 0.001 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0049 0.006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0041
Echinococcus granulosus peptidase Clp S14 family 0.0157 0.1249 0.1715
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0031 0.0037
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0313 0.0429
Plasmodium vivax ornithine aminotransferase, putative 0.0047 0.0313 0.1474
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0034 0.0016
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0122 0.0167
Schistosoma mansoni importin beta-1 0.0033 0.0195 0.0267
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0239 0.1949 0.2678
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0482 0.0661
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0047 0.0313 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Schistosoma mansoni transient receptor potential channel 0.01 0.0763 0.1047
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0242 0.11
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0041
Schistosoma mansoni bromodomain containing protein 0.0011 0.0009 0.0012
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.036 0.1321
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0031 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0981 0.8255 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0122 0.0166
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0047 0.0313 0.0283
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0195 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Toxoplasma gondii hypothetical protein 0.0082 0.0617 0.3165
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0142 0.0173
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0231 0.0317
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0238 0.0776
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0122 0.0479
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.036 0.0493
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Mycobacterium ulcerans hypothetical protein 0.0186 0.1495 0.5482
Schistosoma mansoni ran 0.0024 0.0122 0.0166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0153 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0031 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0013
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0546 0.0749
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0674 0.0926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0312 0.043
Schistosoma mansoni hypothetical protein 0.0173 0.1389 0.1909
Echinococcus granulosus pyruvate kinase 0.0018 0.0071 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0001
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0611 1
Echinococcus granulosus cpg binding protein 0.0064 0.0463 0.0635
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0617 0.3056
Schistosoma mansoni peptidase Clp (S14 family) 0.0239 0.1949 0.2678
Leishmania major importin beta-1 subunit, putative 0.0027 0.0142 0.0452
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.0084 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0482 0.1688
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0667 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Loa Loa (eye worm) hypothetical protein 0.0037 0.0231 0.0319
Schistosoma mansoni ran 0.0024 0.0122 0.0166
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0313 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0052 0.007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0049 0.006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0242 0.0334
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0049 0.0066
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0763 0.1047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0186 0.1495 0.1469
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0239 0.1949 0.7181
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0392 0.0541
Plasmodium vivax hypothetical protein, conserved 0.0186 0.1495 0.7635
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Brugia malayi MH2 domain containing protein 0.0233 0.1901 0.2623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.013 0.0157
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0546 0.0749
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0546 0.0749
Schistosoma mansoni hypothetical protein 0.0173 0.1389 0.1909
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0149 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0153 0.0185
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.036 0.1321
Echinococcus granulosus zinc finger protein 0.0011 0.0009 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0977 0.1343
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0149 0.0615
Plasmodium falciparum thioredoxin reductase 0.0039 0.0246 0.112
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0312 0.1125
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0239 0.1949 0.7182
Mycobacterium leprae conserved hypothetical protein 0.0186 0.1495 0.5484
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0392 0.0363
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0246 0.1124
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.025 0.0342
Echinococcus granulosus snurportin 1 0.035 0.2888 0.3969
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.036 0.0493
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0239 0.1949 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0047 0.0313 0.0283
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0049 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.1074 0.1483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0049 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1495 0.2054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0312 0.1129
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0218 0.0263
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.1901 0.2624
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0242 0.11
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0482 0.1688
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0031 0.0004
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0231 0.0807
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0667 0.0638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1074 0.1476
Brugia malayi glutathione reductase 0.0039 0.0246 0.0338
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0021 0.0027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.075 0.2697
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0242 0.0849
Echinococcus granulosus pyruvate kinase 0.0035 0.0218 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0049 0.006
Echinococcus multilocularis Aminotransferase class III 0.0047 0.0313 0.0429
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.003 0.0036
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2528 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0231 0.028
Loa Loa (eye worm) hypothetical protein 0.0153 0.1215 0.1677
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1074 0.1476
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0231 0.0803
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.003 0.0036
Onchocerca volvulus 0.0155 0.1238 0.1499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.021 0.0255
Echinococcus multilocularis beta LACTamase domain containing family member 0.0186 0.1495 0.2054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0001
Leishmania major pyruvate kinase 0.0035 0.0218 0.0754
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0763 0.1047
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0218 0.0264
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.036 0.1321
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0082 0.0617 0.2198
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0482 0.0661
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0218 0.0754
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0546 0.0749
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0013
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0049 0.0078
Plasmodium falciparum pyruvate kinase 0.0035 0.0218 0.0976
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0246 0.0864
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0125 0.0977 0.1343
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0667 0.0638
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.021 0.108
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.036 0.1321
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0546 0.0661
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0031 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1495 0.1811

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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