Detailed information for compound 679076

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.175 | Formula: C15H12Cl2N2O
  • H donors: 2 H acceptors: 1 LogP: 4.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)C1=NNC(C1)c1ccccc1Cl)O
  • InChi: 1S/C15H12Cl2N2O/c16-9-5-6-15(20)11(7-9)14-8-13(18-19-14)10-3-1-2-4-12(10)17/h1-7,13,18,20H,8H2
  • InChiKey: OZDAJKLNBBLWEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis expressed protein 0.0008 0.005 0.0035
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0053 0.1187 0.1494
Leishmania major hypothetical protein, conserved 0.0053 0.1187 0.1494
Toxoplasma gondii hypothetical protein 0.0048 0.1049 0.2673
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0149 0.363 1
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0578
Entamoeba histolytica hypothetical protein 0.0023 0.0414 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0314 0.0299
Echinococcus multilocularis ferritin 0.0008 0.005 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0328 0.0306
Onchocerca volvulus 0.0053 0.1187 0.2602
Loa Loa (eye worm) hypothetical protein 0.0049 0.1072 0.1375
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.1187 0.1494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.102 0.1006
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0053 0.1187 0.1173
Schistosoma mansoni loxhd1 0.0019 0.0328 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.102 0.1006
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0107 0.0151
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3389 0.4537
Mycobacterium leprae putative cytochrome p450 0.0011 0.0107 1
Schistosoma mansoni ran 0.0021 0.0361 0.0346
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0107 0.0151
Schistosoma mansoni importin beta-1 0.0028 0.0549 0.0534
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0314 0.0865
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.7423 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0414 0.0425
Schistosoma mansoni cpg binding protein 0.0028 0.0552 0.0537
Echinococcus granulosus ferritin 0.0008 0.005 0.0035
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0053 0.1187 0.3067
Schistosoma mansoni hypothetical protein 0.0053 0.1187 0.1173
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.7341 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0361 0.0352
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0107 0.0151
Echinococcus granulosus Zinc finger RanBP2 type 0.0053 0.1187 0.1173
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0107 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0361 0.0352
Chlamydia trachomatis SWIB complex protein 0.0149 0.363 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0107 0.0151
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0107 0.0151
Plasmodium vivax importin-beta 2, putative 0.0028 0.0549 0.0708
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0549 0.0534
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0361 0.0346
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0549 0.1255
Schistosoma mansoni hypothetical protein 0.0149 0.363 0.362
Onchocerca volvulus 0.0049 0.1072 0.2253
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0107 0.0151
Onchocerca volvulus 0.0053 0.1187 0.2602
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0149 0.363 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0552 0.0669
Brugia malayi Cytochrome P450 family protein 0.0011 0.0107 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1124 0.1406
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0053 0.1187 0.1494
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0314 1
Schistosoma mansoni ferritin 0.0008 0.005 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.1187 0.1494
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0053 0.1187 0.3164
Loa Loa (eye worm) hypothetical protein 0.0053 0.1187 0.1532
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0107 0.0151
Leishmania major importin beta-1 subunit, putative 0.0023 0.0414 0.0425
Echinococcus multilocularis SWI:SNF matrix associated 0.0149 0.363 0.362
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0893 0.1087
Schistosoma mansoni lipoxygenase 0.0081 0.1887 0.1874
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0549 0.0611
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0053 0.1187 0.1494
Toxoplasma gondii ran binding protein 0.0053 0.1187 0.3067
Schistosoma mansoni apoferritin-2 0.0008 0.005 0.0035
Loa Loa (eye worm) hypothetical protein 0.0053 0.1187 0.1532
Trichomonas vaginalis ferritin, putative 0.0008 0.005 0.0138
Echinococcus multilocularis SWI:SNF matrix associated 0.0149 0.363 0.362
Echinococcus granulosus snurportin 1 0.0298 0.7423 0.7419
Leishmania major hypothetical protein, conserved 0.0053 0.1187 0.1494
Loa Loa (eye worm) hypothetical protein 0.0053 0.1187 0.1532
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0328 0.0313
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0149 0.363 0.362
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0107 0.0151
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0107 0.0151
Brugia malayi YY1-associated factor 2 0.0053 0.1187 0.3164
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0107 0.0151
Schistosoma mansoni RNA binding protein 0.0053 0.1187 0.1173
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0107 0.0151
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0107 0.0151
Echinococcus multilocularis tumor protein p63 0.0332 0.8267 0.8264
Schistosoma mansoni brg-1 associated factor 0.0149 0.363 0.362
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1352 0.1338
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0107 0.0151
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0053 0.1187 0.2602
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0053 0.1187 0.3164
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0107 0.0151
Schistosoma mansoni TRABID protein (C64 family) 0.0053 0.1187 0.1173
Loa Loa (eye worm) cytochrome P450 0.0011 0.0107 0.0065
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0107 0.0151
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0414 0.1142
Schistosoma mansoni ferritin 0.0008 0.005 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0549 0.0611
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0001
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0107 0.0151
Echinococcus multilocularis SWI:SNF matrix associated 0.0149 0.363 0.362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.102 0.1006
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0053 0.1187 0.1173
Echinococcus granulosus RUN 0.0019 0.0328 0.0313
Schistosoma mansoni ferritin light chain 0.0008 0.005 0.0035
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0314 0.0287
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0328 0.0313
Brugia malayi brahma associated protein 60 kDa 0.0149 0.363 1
Schistosoma mansoni ferritin 0.0008 0.005 0.0035
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0893 0.1087
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0361 0.0352
Brugia malayi cytochrome P450 0.0011 0.0107 0.0141
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0053 0.1187 0.1494
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0053 0.1187 0.1494
Brugia malayi Importin beta-1 subunit 0.0028 0.0549 0.1378
Chlamydia trachomatis DNA topoisomerase I 0.0149 0.363 0.5
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0361 1
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.1187 0.1494
Schistosoma mansoni ap endonuclease 0.0019 0.0314 0.0299
Brugia malayi Cytochrome P450 family protein 0.0048 0.1071 0.2839
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0314 0.0705
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0314 0.0287
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0107 0.0151
Echinococcus multilocularis snurportin 1 0.0298 0.7423 0.7419
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0107 0.0151
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0314 0.0299
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0053 0.1187 0.2633
Loa Loa (eye worm) brahma associated protein 0.0149 0.363 0.4849
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.1187 0.1494
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0107 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.363 1
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0107 0.0091
Brugia malayi hypothetical protein 0.0019 0.0328 0.0761
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0107 0.0151
Leishmania major hypothetical protein, conserved 0.0053 0.1187 0.1494
Onchocerca volvulus 0.0053 0.1187 0.2602
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0107 0.0151
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0361 0.0346
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0328 0.0365
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0361 0.0853
Loa Loa (eye worm) hypothetical protein 0.0028 0.0549 0.0665
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0328 0.0043
Schistosoma mansoni hypothetical protein 0.0149 0.363 0.362
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0314 0.0705
Echinococcus granulosus SWI:SNF matrix associated 0.0149 0.363 0.362
Schistosoma mansoni polycystin 1-related 0.0019 0.0328 0.0313
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0107 0.0151
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0053 0.1187 0.1494
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.379 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0328 0.0313
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0328 0.0313
Echinococcus multilocularis RUN 0.0019 0.0328 0.0313
Echinococcus granulosus tumor protein p63 0.0332 0.8267 0.8264
Leishmania major hypothetical protein, conserved 0.0053 0.1187 0.1494
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0314 0.0287
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.119 0.3075
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0107 0.0151
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0361 0.0142
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0328 0.0365
Schistosoma mansoni hypothetical protein 0.0019 0.0328 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0107 0.0151
Entamoeba histolytica Ran family GTPase 0.0021 0.0361 0.4702
Brugia malayi Cytochrome P450 family protein 0.0019 0.0328 0.076
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0053 0.1187 0.3164
Schistosoma mansoni hypothetical protein 0.0298 0.7423 0.7419
Plasmodium falciparum importin beta, putative 0.0028 0.0549 0.0708
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0107 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0328 0.0313
Schistosoma mansoni ran 0.0021 0.0361 0.0346
Trichomonas vaginalis ran, putative 0.0021 0.0361 0.0995
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.102 0.1006
Schistosoma mansoni lipoxygenase 0.0115 0.2768 0.2757
Leishmania major GTP-binding protein, putative 0.0021 0.0361 0.0352
Onchocerca volvulus 0.0053 0.1187 0.2602
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.7341 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0149 0.363 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0149 0.363 0.4849
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0053 0.1187 0.1494
Echinococcus multilocularis zinc finger protein Ran binding 0.0053 0.1187 0.1173
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.1187 0.1494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.102 0.1006
Schistosoma mansoni hypothetical protein 0.0011 0.0107 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0107 0.0151
Brugia malayi Doublecortin family protein 0.0019 0.0328 0.0761
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0053 0.1187 0.1173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0314 0.0287
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3389 0.4537
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0328 0.0306
Plasmodium vivax hypothetical protein, conserved 0.0149 0.363 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0107 0.0151
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0361 0.0142
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0328 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0107 0.0151
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0107 0.0151
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0314 0.0721
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.102 0.1006
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.1071 0.1374
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0107 0.0151
Brugia malayi brahma associated protein 60 kDa 0.0149 0.363 1
Schistosoma mansoni ap endonuclease 0.0019 0.0314 0.0299
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0328 0.0743
Brugia malayi SWIB/MDM2 domain containing protein 0.0149 0.363 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0549 0.0534
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0328 0.0365
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0414 0.1142
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0107 0.0151
Brugia malayi RNA, U transporter 1 0.0079 0.1859 0.5043
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Brugia malayi CXXC zinc finger family protein 0.0028 0.0552 0.1387
Schistosoma mansoni hypothetical protein 0.04 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0314 0.0865
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.7341 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1187 0.1532
Schistosoma mansoni cytochrome P450 0.0011 0.0107 0.0091
Echinococcus multilocularis ring and YY1 binding protein 0.0053 0.1187 0.1173
Schistosoma mansoni fusion 0.0053 0.1187 0.1173
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0107 0.0151
Schistosoma mansoni rab6-interacting 0.0019 0.0328 0.0313
Brugia malayi Cytochrome P450 family protein 0.0019 0.0328 0.076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0314 0.0346
Trypanosoma cruzi WLM domain containing protein, putative 0.0053 0.1187 0.1494
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0149 0.363 0.362
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0328 0.0365
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.3389 0.4537
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0107 0.0151
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0107 0.0151
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.7341 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0328 0.0313
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0053 0.1187 0.1532
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.1072 0.1058
Brugia malayi hypothetical protein 0.0019 0.0328 0.0761
Schistosoma mansoni ferritin light chain 0.0008 0.005 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0328 0.0306
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0053 0.1187 0.3164
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0893 0.1087
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0149 0.363 1
Echinococcus multilocularis 0.0011 0.0107 0.0091
Echinococcus granulosus expressed protein 0.0008 0.005 0.0035
Echinococcus granulosus ring and YY1 binding protein 0.0053 0.1187 0.1173
Schistosoma mansoni ferritin 0.0008 0.005 0.0035
Toxoplasma gondii exonuclease III APE 0.0019 0.0314 0.0589
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.102 0.2698
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0361 0.0723
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0414 0.1142
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0578
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0107 0.0151
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0107 0.0151
Trypanosoma cruzi WLM domain containing protein, putative 0.0053 0.1187 0.1494
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.102 0.1305
Echinococcus multilocularis dnaJ subfamily B 0.04 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.0328 0.0313
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0893 0.1087
Schistosoma mansoni apoferritin-2 0.0008 0.005 0.0035
Schistosoma mansoni hypothetical protein 0.0149 0.363 0.362
Onchocerca volvulus 0.0028 0.0552 0.0677
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2768 0.2757
Leishmania major cytochrome p450-like protein 0.0019 0.0328 0.0306
Leishmania major hypothetical protein, conserved 0.0053 0.1187 0.1494
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0107 0.0151
Mycobacterium ulcerans hypothetical protein 0.0155 0.379 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0107 0.0151
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0328 0.0365
Schistosoma mansoni zinc finger protein 0.0053 0.1187 0.1173
Onchocerca volvulus 0.0149 0.363 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2768 0.2757
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0361 0.041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.102 0.1006
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0149 0.363 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0107 0.0151
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0107 0.0151
Loa Loa (eye worm) hypothetical protein 0.0019 0.0328 0.0365
Echinococcus granulosus zinc finger protein Ran binding 0.0053 0.1187 0.1173

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.