Detailed information for compound 686694

Basic information

Technical information
  • TDR Targets ID: 686694
  • Name: 2-[[1-(3-hydroxypropyl)-2-oxo-6,7-dihydro-5H- cyclopenta[e]pyrimidin-4-yl]sulfanyl]-N-(2-me thoxyphenyl)acetamide
  • MW: 389.469 | Formula: C19H23N3O4S
  • H donors: 2 H acceptors: 3 LogP: 1.62 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCn1c(=O)nc(c2c1CCC2)SCC(=O)Nc1ccccc1OC
  • InChi: 1S/C19H23N3O4S/c1-26-16-9-3-2-7-14(16)20-17(24)12-27-18-13-6-4-8-15(13)22(10-5-11-23)19(25)21-18/h2-3,7,9,23H,4-6,8,10-12H2,1H3,(H,20,24)
  • InChiKey: ZIQQDKWZUWDVIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[1-(3-hydroxypropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]-N-(2-methoxyphenyl)acetamide
  • 2-[[1-(3-hydroxypropyl)-2-keto-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]-N-(2-methoxyphenyl)acetamide
  • 2-[[1-(3-hydroxypropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]sulfanyl]-N-(2-methoxyphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0103 0.0154
Brugia malayi Protein kinase domain containing protein 0.0242 0.2161 0.3432
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0063 1
Trypanosoma cruzi tubulin gamma chain 0.0028 0.0156 0.0248
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0239 0.037
Brugia malayi Hr1 repeat family protein 0.0083 0.0668 0.1054
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0014 0.0019 0.0012
Schistosoma mansoni tyrosine kinase 0.0157 0.1361 0.1355
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0156 0.0237
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0181 0.1586 1
Brugia malayi protein kinase C II. 0.009 0.0739 0.1167
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Giardia lamblia Beta tubulin 0.0028 0.0156 0.0237
Giardia lamblia Kinase, PLK 0.0683 0.6283 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0063 0.046
Echinococcus granulosus neuroglian 0.0014 0.0019 0.002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Schistosoma mansoni tubulin subunit beta 0.0028 0.0156 0.0149
Loa Loa (eye worm) AGC/PKN protein kinase 0.0083 0.0668 0.1054
Schistosoma mansoni titin 0.0014 0.0019 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Schistosoma mansoni tyrosine kinase 0.0098 0.0805 0.0799
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0156 0.0237
Trichomonas vaginalis tubulin epsilon chain, putative 0.0012 0.0007 0.0011
Brugia malayi MH2 domain containing protein 0.0118 0.0998 0.158
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0755
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Echinococcus granulosus geminin 0.0168 0.1462 0.2319
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0021
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.0103 0.0165
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0063 0.009
Echinococcus multilocularis tubulin gamma 1 chain 0.0028 0.0156 0.0237
Entamoeba histolytica hypothetical protein 0.0036 0.0226 0.0359
Brugia malayi hypothetical protein 0.0036 0.0226 0.0349
Schistosoma mansoni alpha tubulin 0.0028 0.0156 0.0149
Echinococcus multilocularis epidermal growth factor receptor 0.0298 0.2685 0.4267
Leishmania major hypothetical protein, conserved 0.0023 0.0103 0.0165
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.0103 0.0154
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0063 0.01
Trypanosoma brucei tubulin gamma chain 0.0028 0.0156 0.0248
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Trypanosoma brucei epsilon tubulin 0.0028 0.0156 0.0248
Plasmodium falciparum tubulin beta chain 0.0028 0.0156 0.1136
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0156 0.0237
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Loa Loa (eye worm) AGC/NDR protein kinase 0.0083 0.0668 0.1054
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0014 0.0019 0.002
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0491 0.0781
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0185 0.0284
Entamoeba histolytica serine/threonine protein kinase, putative 0.0683 0.6283 1
Schistosoma mansoni ap endonuclease 0.0018 0.0063 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0051
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0023 0.0103 0.0097
Entamoeba histolytica protein kinase, putative 0.0242 0.2161 0.3439
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0668 0.0662
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0063 0.0356
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0668 0.1064
Trypanosoma brucei tubulin delta chain 0.0012 0.0007 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0063 0.009
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0069 0.054 0.2574
Entamoeba histolytica hypothetical protein 0.0036 0.0226 0.0359
Loa Loa (eye worm) alpha-tubulin 0.0028 0.0156 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0158 0.1369 0.2171
Trypanosoma brucei zeta tubulin 0.0012 0.0007 0.0011
Echinococcus granulosus tubulin alpha chain 0.0028 0.0156 0.0237
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0012 0.001 0.0004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus tubulin subunit TubB 0.0028 0.0156 0.0237
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0039 0.0185
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0103 0.0165
Toxoplasma gondii alpha tubulin TUBA1 0.0028 0.0156 0.0741
Plasmodium falciparum tubulin gamma chain 0.0028 0.0156 0.1136
Trypanosoma cruzi polo-like protein kinase, putative 0.0683 0.6283 1
Brugia malayi alpha-tubulin 0.0028 0.0156 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0103 0.0165
Echinococcus granulosus tubulin alpha 1C chain 0.0028 0.0156 0.0237
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0039 0.0051
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0103 0.0755
Entamoeba histolytica tubulin family protein 0.0028 0.0156 0.0248
Trypanosoma cruzi beta tubulin, putative 0.0028 0.0156 0.0248
Entamoeba histolytica hypothetical protein 0.0036 0.0226 0.0359
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0156 0.0248
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus beta tubulin 0.0028 0.0156 0.0237
Trypanosoma brucei alpha tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0156 0.0237
Schistosoma mansoni dihydrofolate reductase 0.0181 0.1586 0.1581
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0019 0.002
Echinococcus multilocularis hemicentin 1 0.0014 0.0019 0.002
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0083 0.0668 0.1054
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0039 0.0051
Toxoplasma gondii AGC kinase 0.0236 0.2099 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0098 0.0805 0.1272
Echinococcus multilocularis protein kinase c iota type 0.009 0.0739 0.1167
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0683 0.6283 1
Echinococcus multilocularis rac serine:threonine kinase 0.0164 0.1431 0.2269
Toxoplasma gondii exonuclease III APE 0.0018 0.0063 0.03
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Schistosoma mansoni hypothetical protein 0.0036 0.0226 0.0219
Echinococcus multilocularis tubulin alpha 3 chain 0.0028 0.0156 0.0237
Echinococcus granulosus tubulin alpha 3 chain 0.0028 0.0156 0.0237
Schistosoma mansoni tyrosine kinase 0.0298 0.2685 0.268
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0063 0.0356
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0156 0.0248
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0103 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0066 0.0514 0.0808
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0127 0.1081 0.1712
Echinococcus multilocularis hemicentin 1 0.0014 0.0019 0.002
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0039 0.0051
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0739 0.0733
Schistosoma mansoni tyrosine kinase 0.0162 0.1407 0.1401
Echinococcus granulosus tubulin beta 1 chain 0.0028 0.0156 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0683 0.6283 0.6281
Echinococcus granulosus tubulin beta 4A class IVa 0.0028 0.0156 0.0237
Brugia malayi tubulin alpha-2 chain 0.0028 0.0156 0.0237
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0078 0.0622 0.0991
Trypanosoma brucei alpha tubulin 0.0028 0.0156 0.0248
Loa Loa (eye worm) tubulin beta-1 chain 0.0028 0.0156 0.0237
Toxoplasma gondii beta tubulin 0.0028 0.0156 0.0741
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0028 0.0156 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0011
Echinococcus granulosus peroxisome assembly protein 26 0.0028 0.0156 0.0237
Toxoplasma gondii beta-1 tubulin, putative 0.0028 0.0156 0.0741
Echinococcus granulosus beta tubulin 0.0028 0.0156 0.0237
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0083 0.0668 0.1054
Brugia malayi Peroxidasin 0.0014 0.002 0.0021
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0083 0.0668 0.1054
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0156 0.0237
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Brugia malayi C1-like domain containing protein 0.0012 0.001 0.0004
Schistosoma mansoni tubulin subunit beta 0.0028 0.0156 0.0149
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0051
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0185 0.1624 0.2577
Schistosoma mansoni cell adhesion molecule 0.0014 0.0019 0.0012
Echinococcus granulosus alpha tubulin 0.0028 0.0156 0.0237
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0163 0.1413 0.2241
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0164 0.1431 0.2277
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0103 0.0154
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0156 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0739 0.0733
Loa Loa (eye worm) beta-tubulin 0.0028 0.0156 0.0237
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0041 0.0066
Onchocerca volvulus 0.0299 0.2692 0.4267
Echinococcus multilocularis hypothetical protein 0.0028 0.0156 0.0237
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0668 0.1064
Echinococcus multilocularis nervana 2 0.0153 0.1323 0.2098
Trypanosoma brucei beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0163 0.1413 0.2241
Echinococcus multilocularis dihydrofolate reductase 0.0181 0.1586 0.2517
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0153 0.1323 0.2098
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0023 0.0103 0.0154
Schistosoma mansoni tubulin subunit beta 0.0028 0.0156 0.0149
Echinococcus granulosus peroxidasin 0.0014 0.002 0.0021
Echinococcus multilocularis serine:threonine protein kinase 38 0.0083 0.0668 0.1054
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0083 0.0668 0.1054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0609 0.559 0.8896
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Echinococcus granulosus roundabout 2 0.0014 0.0019 0.002
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0023 0.0103 0.0154
Schistosoma mansoni tubulin subunit gamma 0.0028 0.0156 0.0149
Brugia malayi Tubulin alpha-2 chain 0.0028 0.0156 0.0237
Schistosoma mansoni tyrosine kinase 0.0018 0.0064 0.0058
Trypanosoma brucei polo-like protein kinase 0.0683 0.6283 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0016 0.0041 0.0055
Echinococcus granulosus nervana 2 0.0153 0.1323 0.2098
Onchocerca volvulus Serine\/threonine kinase homolog 0.0683 0.6283 1
Entamoeba histolytica tubulin family protein 0.0028 0.0156 0.0248
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni alpha tubulin 0.0028 0.0156 0.0149
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0103 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0012 0.0007 0.0032
Trypanosoma brucei alpha tubulin 0.0028 0.0156 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0668 0.0662
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Brugia malayi Protein kinase c protein 2 0.0012 0.001 0.0004
Giardia lamblia Kinase, AGC PKA 0.0158 0.1369 0.2171
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0491 0.0781
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0156 0.0248
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0098 0.0805 0.1272
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0041 0.0066
Brugia malayi Tubulin beta-1 chain 0.0028 0.0156 0.0237
Schistosoma mansoni serine/threonine-protein kinase 0.0164 0.1431 0.1425
Loa Loa (eye worm) tubulin alpha 2 0.0016 0.0041 0.0055
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Entamoeba histolytica protein kinase, putative 0.0236 0.2099 0.3341
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Loa Loa (eye worm) tubulin alpha-2 chain 0.0028 0.0156 0.0237
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0039 0.0204
Loa Loa (eye worm) tubulin beta chain 0.0028 0.0156 0.0237
Schistosoma mansoni septate junction protein 0.0014 0.0019 0.0012
Plasmodium falciparum phosphodiesterase delta, putative 0.0023 0.0103 0.0755
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Plasmodium vivax phosphodiesterase gamma, putative 0.0023 0.0103 0.0755
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0156 0.0237
Onchocerca volvulus 0.0014 0.0025 0.0009
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Entamoeba histolytica PH domain containing protein kinase, putative 0.0164 0.1431 0.2277
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0039 0.0284
Trichomonas vaginalis tubulin, putative 0.0012 0.0007 0.0011
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0156 0.0237
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0083 0.0668 0.1054
Schistosoma mansoni septate junction protein 0.0014 0.0019 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0103 0.0165
Schistosoma mansoni hypothetical protein 0.0168 0.1462 0.1456
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0185 0.1624 0.2577
Loa Loa (eye worm) dihydrofolate reductase 0.0181 0.1586 0.2517
Echinococcus granulosus Glutaredoxin protein 5 0.0153 0.1323 0.2098
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Schistosoma mansoni protein kinase C mu 0.0012 0.001 0.0003
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0019 0.002
Brugia malayi Tubulin gamma chain 0.0028 0.0156 0.0237
Schistosoma mansoni serine/threonine kinase 0.0083 0.0668 0.0662
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0069 0.054 0.086
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0023 0.0103 0.0154
Schistosoma mansoni cell adhesion molecule 0.0014 0.0019 0.0012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0039 0.0062
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Echinococcus granulosus serine:threonine protein kinase N2 0.0083 0.0668 0.1054
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0239 0.037
Giardia lamblia Hypothetical protein 0.0023 0.0103 0.0154
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0039 0.0051
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0236 0.2099 0.3334
Trichomonas vaginalis tubulin gamma chain, putative 0.0012 0.0007 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.1962 0.1956
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0063 0.009
Echinococcus multilocularis GPCR, family 2 0.0031 0.0185 0.0284
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0158 0.1369 0.2171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0029
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.0103 0.0097
Loa Loa (eye worm) hypothetical protein 0.0099 0.0816 0.1289
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Brugia malayi isocitrate dehydrogenase 0.0016 0.0039 0.0051
Onchocerca volvulus Tyrosine kinase homolog 0.0356 0.3222 0.5113
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0609 0.559 0.8896
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0185 0.1624 0.2577
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0012 0.001 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0051
Brugia malayi tubulin alpha chain - mouse 0.0028 0.0156 0.0237
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0089 0.073 0.1162
Toxoplasma gondii beta-tubulin, putative 0.0028 0.0156 0.0741
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0158 0.1369 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0185 0.0284
Schistosoma mansoni tyrosine kinase 0.0162 0.1407 0.1401
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0023 0.0103 0.0154
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0524 0.0824
Entamoeba histolytica protein kinase 2, putative 0.0158 0.1369 0.2179
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0083 0.0668 0.1054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0816 0.1289
Loa Loa (eye worm) tubulin alpha chain 0.0028 0.0156 0.0237
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0156 0.0248
Trypanosoma brucei epsilon tubulin 0.0028 0.0156 0.0248
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.0065 0.0093
Echinococcus multilocularis roundabout 2 0.0014 0.0019 0.002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0039 0.0062
Echinococcus granulosus epidermal growth factor receptor 0.0298 0.2685 0.4267
Entamoeba histolytica hypothetical protein 0.0036 0.0226 0.0359
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Loa Loa (eye worm) hypothetical protein 0.0067 0.0524 0.0824
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Loa Loa (eye worm) blistered cuticle protein 3 0.0034 0.0208 0.0321
Echinococcus granulosus NDR protein kinase 0.0083 0.0668 0.1054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Echinococcus granulosus roundabout 2 0.0014 0.0019 0.002
Echinococcus multilocularis roundabout 2 0.0014 0.0019 0.002
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0103 0.0154
Trypanosoma cruzi Protein kinase B 0.0164 0.1431 0.2277
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.1873 0.2981
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0023 0.0103 0.0165
Loa Loa (eye worm) hypothetical protein 0.0185 0.1624 0.2577
Schistosoma mansoni tyrosine kinase 0.0098 0.0805 0.0799
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0156 0.0237
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0103 0.0755
Echinococcus granulosus tubulin alpha 0.0028 0.0156 0.0237
Echinococcus granulosus roundabout 2 0.0014 0.0019 0.002
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0156 0.0237
Echinococcus granulosus GPCR family 2 0.0031 0.0185 0.0284
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0063 1
Trypanosoma brucei alpha tubulin 0.0028 0.0156 0.0248
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni hypothetical protein 0.0067 0.0524 0.0517
Loa Loa (eye worm) tubulin beta-2A chain 0.0028 0.0156 0.0237
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Trypanosoma brucei beta tubulin 0.0028 0.0156 0.0248
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Trypanosoma brucei beta tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0683 0.6283 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0755
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0028 0.0156 0.0741
Brugia malayi serine/threonine-protein kinase plk-2 0.0683 0.6283 1
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0357 0.3237 0.5147
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Trypanosoma cruzi polo-like protein kinase, putative 0.0683 0.6283 1
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Echinococcus granulosus tubulin alpha 3 chain 0.0028 0.0156 0.0237
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0156 0.0237
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0103 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0103 0.0165
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0063 0.009
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0014 0.0019 0.002
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0069 0.054 0.3945
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0668 0.1064
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.1873 0.2981
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0039 0.0062
Brugia malayi protein kinase C3,putative 0.0012 0.001 0.0004
Echinococcus multilocularis Protein kinase C, brain isozyme 0.009 0.0739 0.1167
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Brugia malayi Protein kinase domain containing protein 0.0066 0.0514 0.0808
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0158 0.1369 0.2179
Echinococcus granulosus tubulin alpha 1C chain 0.0028 0.0156 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0668 0.0662
Loa Loa (eye worm) tubulin beta-4 chain 0.0028 0.0156 0.0237
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Plasmodium vivax tubulin alpha chain, putative 0.0028 0.0156 0.1136
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0023 0.0103 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Echinococcus granulosus lachesin 0.0014 0.0019 0.002
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0226 0.0219
Brugia malayi Raf kinase 0.0214 0.1891 0.3002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0298 0.2685 0.4267
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0156 0.0237
Brugia malayi beta-tubulin, identical 0.0028 0.0156 0.0237
Loa Loa (eye worm) AGC/AKT protein kinase 0.0242 0.2161 0.3432
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0103 0.0165
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Schistosoma mansoni hypothetical protein 0.0031 0.0185 0.0178
Brugia malayi Tubulin alpha chain 0.0028 0.0156 0.0237
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0083 0.0668 0.1054
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus hemicentin 1 0.0014 0.0019 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0103 0.0165
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Giardia lamblia Beta tubulin 0.0028 0.0156 0.0237
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus tubulin alpha chain 0.0028 0.0156 0.0237
Echinococcus granulosus protein kinase c iota type 0.009 0.0739 0.1167
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis serine:threonine protein kinase N2 0.0083 0.0668 0.1054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0208 0.0332
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0063 0.01
Echinococcus multilocularis peroxisome assembly protein 26 0.0028 0.0156 0.0237
Echinococcus granulosus raf serine:threonine protein kinase 0.0221 0.1962 0.3115
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0103 0.0097
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0491 0.0771
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0103 0.0154
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus insulin receptor 0.0098 0.0805 0.1272
Entamoeba histolytica protein kinase, putative 0.0083 0.0668 0.1064
Trypanosoma cruzi alpha tubulin, putative 0.0028 0.0156 0.0248
Trypanosoma brucei alpha tubulin, putative 0.0016 0.0041 0.0066
Echinococcus granulosus protein kinase C gamma type 0.0083 0.0668 0.1054
Schistosoma mansoni hypothetical protein 0.0168 0.1462 0.1456
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0103 0.0165
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0023 0.0103 0.0154
Brugia malayi Tubulin alpha-2 chain 0.0028 0.0156 0.0237
Leishmania major delta tubulin, putative 0.0012 0.0007 0.0011
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0051
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0023 0.0103 0.0165
Trypanosoma cruzi zeta tubulin, putative 0.0012 0.0007 0.0011
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0491 0.0771
Echinococcus multilocularis Glutaredoxin protein 5 0.0153 0.1323 0.2098
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0012 0.001 0.0004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0491 0.0781
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0185 0.1624 0.1619
Trypanosoma cruzi epsilon tubulin, putative 0.0028 0.0156 0.0248
Echinococcus granulosus protein kinase c epsilon type 0.009 0.0739 0.1167
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Entamoeba histolytica tubulin alpha-1 chain 0.0028 0.0156 0.0248
Echinococcus multilocularis epidermal growth factor receptor 0.0162 0.1407 0.223
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0156 0.0149
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Trypanosoma cruzi tubulin delta chain 0.0012 0.0007 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0063 0.009
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0019 0.002
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0039 0.0062
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trypanosoma brucei beta tubulin 0.0028 0.0156 0.0248
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni vav2 0.0014 0.0025 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0185 0.0284
Schistosoma mansoni ap endonuclease 0.0018 0.0063 0.0056
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0998 0.158
Echinococcus granulosus epidermal growth factor receptor 0.0162 0.1407 0.223
Trypanosoma cruzi tubulin delta chain 0.0012 0.0007 0.0011
Plasmodium vivax tubulin epsilon chain, putative 0.0028 0.0156 0.1136
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.0103 0.0154
Trypanosoma brucei epsilon tubulin 0.0028 0.0156 0.0248
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0491 0.0484
Plasmodium falciparum tubulin epsilon chain, putative 0.0028 0.0156 0.1136
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0156 0.0237
Loa Loa (eye worm) hypothetical protein 0.0299 0.2692 0.4278
Onchocerca volvulus Dual oxidase homolog 0.0034 0.0208 0.0302
Echinococcus multilocularis tubulin alpha 1C chain 0.0028 0.0156 0.0237
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0185 0.1624 0.7737
Echinococcus granulosus tubulin alpha chain 0.0028 0.0156 0.0237
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus tubulin gamma 1 chain 0.0028 0.0156 0.0237
Giardia lamblia Gamma tubulin 0.0028 0.0156 0.0237
Leishmania major hypothetical protein, conserved 0.0023 0.0103 0.0165
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0012 0.001 0.0004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus serine/threonine protein kinase 0.0164 0.1431 0.2269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0063 0.01
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0028 0.0156 0.0248
Entamoeba histolytica protein kinase, putative 0.0242 0.2161 0.3439
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0041 0.0066
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Loa Loa (eye worm) tubulin alpha 2 0.0016 0.0041 0.0055
Echinococcus granulosus tubulin alpha chain 0.0028 0.0156 0.0237
Brugia malayi Immunoglobulin I-set domain containing protein 0.0357 0.3237 0.5147
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0063 0.01
Schistosoma mansoni tyrosine kinase 0.0157 0.1361 0.1355
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0041 0.0066
Plasmodium vivax tubulin gamma chain, putative 0.0028 0.0156 0.1136
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Plasmodium vivax delta tubulin, putative 0.0012 0.0007 0.0049
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0083 0.0668 0.1054
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Brugia malayi dihydrofolate reductase family protein 0.0181 0.1586 0.2517
Toxoplasma gondii alpha-tubulin I, putative 0.0028 0.0156 0.0741
Loa Loa (eye worm) hypothetical protein 0.0083 0.0668 0.1054
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0034 0.0208 0.0332
Plasmodium falciparum phosphodiesterase gamma, putative 0.0023 0.0103 0.0755
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0069 0.054 0.086
Trypanosoma brucei zeta tubulin, putative 0.0012 0.0007 0.0011
Schistosoma mansoni hypothetical protein 0.0031 0.0185 0.0178
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0103 0.0154
Echinococcus multilocularis tubulin beta 1 chain 0.0028 0.0156 0.0237
Echinococcus multilocularis neuroglian 0.0014 0.0019 0.002
Schistosoma mansoni cell adhesion molecule 0.0014 0.0019 0.0012
Schistosoma mansoni tyrosine kinase 0.0157 0.1361 0.1355
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0041 0.0066
Loa Loa (eye worm) tubulin alpha chain 0.0028 0.0156 0.0237
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0083 0.0668 0.1054
Schistosoma mansoni hypothetical protein 0.0031 0.0185 0.0178
Leishmania major zeta tubulin, putative 0.0012 0.0007 0.0011
Echinococcus multilocularis insulin receptor 0.0098 0.0805 0.1272
Brugia malayi Protein kinase domain containing protein 0.0083 0.0668 0.1054
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0156 0.0237
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0683 0.6283 1
Brugia malayi Protein kinase domain containing protein 0.0012 0.001 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0816 0.1289
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0185 0.0284
Echinococcus multilocularis serine threonine protein kinase 0.0083 0.0668 0.1054
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0067 0.0518 0.0814
Plasmodium vivax tubulin alpha chain, putative 0.0028 0.0156 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.001 0.0003
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0181 0.1586 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Schistosoma mansoni alpha tubulin 0.0028 0.0156 0.0149
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0103 0.0165
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0012 0.001 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0039 0.0185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0226 0.0349
Brugia malayi p70 ribosomal S6 kinase beta 0.0236 0.2099 0.3334
Leishmania major ferric reductase, putative 0.0034 0.0208 0.0332
Echinococcus granulosus tubulin epsilon chain 0.0028 0.0156 0.0237
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0491 0.0771
Loa Loa (eye worm) raf kinase 0.0216 0.1916 0.3043
Plasmodium falciparum alpha tubulin 1 0.0028 0.0156 0.1136
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0012 0.0007 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0103 0.0165
Entamoeba histolytica tubulin gamma chain 0.0028 0.0156 0.0248
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0103 0.0165
Leishmania major gamma-tubulin 0.0028 0.0156 0.0248
Loa Loa (eye worm) tubulin gamma chain 0.0028 0.0156 0.0237
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0185 0.1624 0.2577
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis protein kinase c epsilon type 0.009 0.0739 0.1167
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0153 0.1323 0.2098
Schistosoma mansoni atypical protein kinase C 0.009 0.0739 0.0733
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0998 0.158
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0103 0.0165
Echinococcus multilocularis tyrosine protein kinase otk 0.0014 0.0019 0.002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0683 0.6283 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0755
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0156 0.0237
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0039 0.0032
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0162 0.1407 0.223
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0156 0.0237
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Loa Loa (eye worm) alpha-tubulin 0.0028 0.0156 0.0237
Onchocerca volvulus 0.0016 0.0041 0.0036
Echinococcus granulosus serine threonine protein kinase nrc 0.0158 0.1369 0.2171
Giardia lamblia Alpha-tubulin 0.0028 0.0156 0.0237
Echinococcus multilocularis tubulin subunit TubB 0.0028 0.0156 0.0237
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0156 0.0237
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0185 0.0284
Schistosoma mansoni neuroglian 0.0014 0.0019 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0668 0.0662
Schistosoma mansoni roundabout 0.0014 0.0019 0.0012
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0019 0.002
Echinococcus multilocularis nervana 2 0.0153 0.1323 0.2098
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0755
Loa Loa (eye worm) hypothetical protein 0.0031 0.0185 0.0284
Echinococcus multilocularis raf serine:threonine protein kinase 0.0221 0.1962 0.3115
Trichomonas vaginalis tubulin, putative 0.0016 0.0041 0.0066
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0491 0.0771
Echinococcus granulosus dihydrofolate reductase 0.0181 0.1586 0.2517
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0055
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0041 0.0066
Plasmodium falciparum tubulin delta chain, putative 0.0012 0.0007 0.0049
Giardia lamblia hypothetical protein 0.0023 0.0103 0.0154
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0012 0.0007 0.0011
Schistosoma mansoni nephrin 0.0014 0.0019 0.0012
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis tubulin alpha 3 chain 0.0028 0.0156 0.0237
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0156 0.0237
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0063 0.046
Echinococcus multilocularis beta tubulin 0.0028 0.0156 0.0237
Echinococcus granulosus tyrosine protein kinase otk 0.0014 0.0019 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Chlamydia trachomatis dihydrofolate reductase 0.0181 0.1586 0.5
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0739 0.0733
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0156 0.0248
Brugia malayi hypothetical protein 0.0299 0.2692 0.4278
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0156 0.0237
Echinococcus granulosus myotubularin protein 13 0.0014 0.0025 0.0029
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0156 0.0248
Brugia malayi Protein kinase domain containing protein 0.0098 0.0805 0.1272
Echinococcus multilocularis myotubularin protein 13 0.0014 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0237
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0185 0.0284
Schistosoma mansoni tubulin subunit beta 0.0028 0.0156 0.0149
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0156 0.0248
Echinococcus multilocularis tubulin alpha 0.0028 0.0156 0.0237
Echinococcus multilocularis geminin 0.0168 0.1462 0.2319
Trichomonas vaginalis tubulin, putative 0.0016 0.0041 0.0066
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0163 0.1413 0.2241
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0103 0.0755
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0491 0.0781
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0156 0.0237
Echinococcus multilocularis peroxidasin 0.0014 0.002 0.0021
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0208 0.0332
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.009 0.0739 0.1167
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0103 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0007 0.0011
Echinococcus granulosus nervana 2 0.0153 0.1323 0.2098
Trypanosoma brucei beta tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus tubulin alpha chain 0.0028 0.0156 0.0237
Brugia malayi Tubulin beta chain 0.0016 0.0041 0.0055
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0019 0.002
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0156 0.0149
Leishmania major epsilon tubulin, putative 0.0028 0.0156 0.0248
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0014 0.0019 0.0012
Echinococcus multilocularis tubulin epsilon chain 0.0028 0.0156 0.0237
Brugia malayi Dihydrofolate reductase 0.0181 0.1586 0.2517
Brugia malayi Protein kinase domain containing protein 0.0083 0.0668 0.1054
Echinococcus multilocularis roundabout 2 0.0014 0.0019 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0063 0.01
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0023 0.0103 0.0097
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0098 0.0805 0.1272
Schistosoma mansoni tubulin subunit epsilon 0.0028 0.0156 0.0149
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0103 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Schistosoma mansoni hypothetical protein 0.0031 0.0185 0.0178
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0156 0.0237
Trypanosoma cruzi zeta tubulin, putative 0.0012 0.0007 0.0011
Giardia lamblia Alpha-tubulin 0.0028 0.0156 0.0237
Onchocerca volvulus 0.0345 0.3121 0.4952
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0185 0.0284
Plasmodium falciparum alpha tubulin 2 0.0028 0.0156 0.1136
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0039 0.0062
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0156 0.0237
Schistosoma mansoni serine/threonine-protein kinase 0.0164 0.1431 0.1425
Plasmodium vivax tubulin beta chain, putative 0.0028 0.0156 0.1136
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0066 0.0514 0.0808
Echinococcus multilocularis serine:threonine protein kinase N2 0.0083 0.0668 0.1054
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0163 0.1413 0.2241
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0023 0.0103 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.001 0.0003
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0156 0.0237
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0069 0.054 0.3945
Echinococcus multilocularis tubulin subunit beta 0.0028 0.0156 0.0237
Echinococcus multilocularis lachesin 0.0014 0.0019 0.002
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0156 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0683 0.6283 1
Echinococcus granulosus Protein kinase C brain isozyme 0.009 0.0739 0.1167
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0156 0.0149
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0023 0.0103 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Echinococcus multilocularis tubulin alpha 1C chain 0.0028 0.0156 0.0237
Trypanosoma brucei rac serine-threonine kinase, putative 0.0242 0.2161 0.3439
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Echinococcus multilocularis 0.0091 0.0748 0.1181
Brugia malayi Pleckstrin Homology Domain 0.0014 0.0025 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0103 0.0492
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Entamoeba histolytica PH domain containing protein kinase, putative 0.0164 0.1431 0.2277
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Schistosoma mansoni tubulin subunit beta 0.0028 0.0156 0.0149
Echinococcus granulosus tubulin subunit beta 0.0028 0.0156 0.0237
Echinococcus multilocularis beta tubulin 0.0028 0.0156 0.0237
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0023 0.0103 0.0154
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0158 0.1369 1
Leishmania major alpha tubulin 0.0028 0.0156 0.0248
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0103 0.0165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.002
Trichomonas vaginalis AGC family protein kinase 0.0242 0.2161 0.3439
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0039 0.0284
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0226 0.0349
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0063 0.01
Trypanosoma cruzi epsilon tubulin, putative 0.0028 0.0156 0.0248
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0103 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0154
Echinococcus granulosus contactin 0.0014 0.0019 0.002
Brugia malayi Furin-like cysteine rich region family protein 0.0298 0.2685 0.4267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0063 0.01
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0019 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0816 0.1289
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0019 0.002
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0156 0.0248
Loa Loa (eye worm) PDE1B protein 0.0023 0.0103 0.0154
Schistosoma mansoni tubulin subunit beta 0.0028 0.0156 0.0149
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0491 0.0781
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0069 0.054 0.086
Leishmania major beta tubulin 0.0028 0.0156 0.0248
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0012 0.0007 0.0011
Trichomonas vaginalis tubulin, putative 0.0028 0.0156 0.0248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0185 0.1624 0.2577
Brugia malayi Prion-like- 0.0014 0.0019 0.002
Giardia lamblia Beta tubulin 0.0028 0.0156 0.0237
Entamoeba histolytica tubulin alpha chain, putative 0.0028 0.0156 0.0248
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0023 0.0103 0.0165
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0156 0.0237
Brugia malayi Blistered cuticle protein 3 0.0034 0.0208 0.0321
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0181 0.1586 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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