Detailed information for compound 695274

Basic information

Technical information
  • TDR Targets ID: 695274
  • Name: ethyl 2-[9-(furan-2-ylmethyl)-1-methyl-2,4-di oxo-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-y l]acetate
  • MW: 387.39 | Formula: C18H21N5O5
  • H donors: 0 H acceptors: 4 LogP: 0.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cn1c(=O)n(C)c2c(c1=O)n1CCCN(c1n2)Cc1ccco1
  • InChi: 1S/C18H21N5O5/c1-3-27-13(24)11-23-16(25)14-15(20(2)18(23)26)19-17-21(7-5-8-22(14)17)10-12-6-4-9-28-12/h4,6,9H,3,5,7-8,10-11H2,1-2H3
  • InChiKey: SQWYDZDSCUTEBD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[9-(2-furylmethyl)-1-methyl-2,4-dioxo-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetate
  • 2-[9-(2-furylmethyl)-1-methyl-2,4-dioxo-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetic acid ethyl ester
  • 2-[9-(2-furylmethyl)-2,4-diketo-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetic acid ethyl ester
  • ethyl 2-[9-(furan-2-ylmethyl)-1-methyl-2,4-dioxo-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]ethanoate
  • ZINC04249260

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0259 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0259 0.0229
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0503 0.0473
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.008 0.0029
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0055
Treponema pallidum licC protein (licC) 0.0113 0.0646 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0081 0.044 0.5109
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.008 0.1433
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0082 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0545 0.0543
Loa Loa (eye worm) hypothetical protein 0.006 0.0311 0.1917
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0978
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0545 0.6562
Leishmania major DNA polymerase kappa, putative 0.0025 0.0087 0.0247
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0081 0.044 0.0984
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0082 0.0484
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0077 0.0908
Echinococcus multilocularis leucine aminopeptidase protein 0.012 0.0692 0.0663
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.05
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0304 0.1901
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0304 0.0274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.029 0.0612
Leishmania major pyruvate kinase 0.0036 0.016 0.1255
Leishmania major 4-coumarate:coa ligase-like protein 0.0081 0.044 0.5109
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0077 0.0103
Brugia malayi follicle stimulating hormone receptor 0.0264 0.1602 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0137 0.0794 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.016 0.1966
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0133 0.1875
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0259 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0324 0.3513
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0082 0.008
Echinococcus granulosus dnaJ subfamily B 0.0912 0.5698 0.5685
Echinococcus granulosus cpg binding protein 0.0068 0.0359 0.0328
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0092 0.0308
Schistosoma mansoni hypothetical protein 0.0912 0.5698 0.5698
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0056 0.0025
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.2723
Trypanosoma brucei DNA polymerase eta, putative 0.0137 0.0794 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.008 0.1119
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.012 0.0692 0.1654
Echinococcus multilocularis dna polymerase eta 0.0137 0.0794 0.0766
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0082 0.0051
Mycobacterium ulcerans hypothetical protein 0.0113 0.0646 0.1533
Giardia lamblia DINP protein human, muc B family 0.0087 0.0481 1
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0082 0.0051
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.2723
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0259 0.1591
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0081 0.044 0.0984
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0024 0.0082 0.0513
Echinococcus multilocularis pyruvate kinase 0.0036 0.016 0.013
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0259 0.0229
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1253 0.1226
Mycobacterium ulcerans DNA polymerase IV 0.0109 0.0618 0.1459
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0077 0.0913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0261 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0261 0.0258
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0092 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0069 0.0788
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0077 0.0103
Loa Loa (eye worm) hypothetical protein 0.0059 0.0304 0.1876
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.012 0.0692 0.8586
Echinococcus granulosus dna polymerase kappa 0.0109 0.0618 0.0589
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0055
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0087 0.0247
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0503 0.0501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.0000000010113
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0077 0.0046
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.095
Brugia malayi polk-prov protein 0.0054 0.027 0.1688
Entamoeba histolytica hypothetical protein 0.0025 0.0092 0.1646
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0618 0.7769
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.079 0.0788
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0081 0.044 0.1008
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0077 0.0913
Loa Loa (eye worm) pyruvate kinase 0.0036 0.016 0.0972
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.008 0.05
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0077 0.044
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.008 0.047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.0000000010113
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0087 0.104
Echinococcus granulosus pyruvate kinase 0.0019 0.0048 0.0017
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0082 0.0484
Echinococcus granulosus leucine aminopeptidase protein 0.012 0.0692 0.0663
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0069 0.0813
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0087 0.104
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0304 0.0302
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0077 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0481 0.5673
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.016 0.1966
Schistosoma mansoni terminal deoxycytidyl transferase 0.008 0.0435 0.0433
Echinococcus granulosus pyruvate kinase 0.0019 0.0048 0.0017
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0179
Toxoplasma gondii propionate-CoA ligase 0.0024 0.008 0.1119
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.008 0.0055
Mycobacterium ulcerans hypothetical protein 0.0113 0.0646 0.1533
Echinococcus multilocularis cpg binding protein 0.0068 0.0359 0.0328
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0005 0.0003
Trypanosoma brucei unspecified product 0.0102 0.0573 0.6945
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0081 0.044 0.0984
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.016 0.1896
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0978
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0069 0.0972
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.044 0.0984
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.008 0.0049
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.016 0.0268
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.0059
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0082 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0646 0.1555
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.008 0.1128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0031 0.0029
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.008 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.008 0.05
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0091 0.1631
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0259 0.0257
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0092 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0449
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.0000000010113
Mycobacterium ulcerans pyruvate kinase 0.0036 0.016 0.0242
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0087 0.0247
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.012 0.0692 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0069 0.0324
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0077 0.0479
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.008 0.0055
Echinococcus multilocularis dnaJ subfamily B 0.0912 0.5698 0.5685
Schistosoma mansoni DNA helicase recq5 0.0023 0.0077 0.0075
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.008 0.0149
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.0446 0.5591
Echinococcus granulosus pyruvate kinase 0.0019 0.0048 0.0017
Loa Loa (eye worm) hypothetical protein 0.006 0.0311 0.1917
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.047
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.012 0.0692 0.1677
Echinococcus multilocularis dna polymerase kappa 0.0109 0.0618 0.0589
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0081 0.044 0.0959
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.0000000010113
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0069 0.0813
Loa Loa (eye worm) hypothetical protein 0.0091 0.0503 0.312
Schistosoma mansoni hypothetical protein 0.0378 0.232 0.2318
Schistosoma mansoni DNA polymerase eta 0.0137 0.0794 0.0792
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0092 0.1285
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.008 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0081 0.044 0.2746
Loa Loa (eye worm) hypothetical protein 0.006 0.0311 0.1917
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0077 0.0046
Leishmania major DNA damage repair protein, putative 0.0025 0.0087 0.0247
Schistosoma mansoni pyruvate kinase 0.0036 0.016 0.0158
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0077 0.0449
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0077 0.0046
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.008 0.0055
Brugia malayi ImpB/MucB/SamB family protein 0.0137 0.0794 0.4961
Echinococcus multilocularis pyruvate kinase 0.0019 0.0048 0.0017
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0082 0.0051
Echinococcus multilocularis pyruvate kinase 0.0019 0.0048 0.0017
Schistosoma mansoni ap endonuclease 0.0022 0.0069 0.0067
Onchocerca volvulus 0.0064 0.0335 0.6039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0069 0.1235
Loa Loa (eye worm) hypothetical protein 0.006 0.0311 0.1917
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0069 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.0000000010113
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Giardia lamblia Pyruvate kinase 0.0036 0.016 0.2587
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.0545 0.3383
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0005 0.0041
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0077 0.1372
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0077 0.0913
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0179
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0304 0.0274
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.044 0.0984
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.008 0.0029
Plasmodium falciparum acyl-CoA synthetase 0.006 0.0311 0.4081
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.027 0.2772
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0261 0.0258
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.016 0.2315
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0069 0.1002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.0000000010113
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0259 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0261 0.023
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.008 0.0078
Schistosoma mansoni ap endonuclease 0.0022 0.0069 0.0067
Entamoeba histolytica hypothetical protein 0.0097 0.0545 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0081 0.044 0.0959
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0435 0.0996
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.016 0.0214
Schistosoma mansoni cpg binding protein 0.0068 0.0359 0.0356
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0077 0.0479
Echinococcus multilocularis geminin 0.0378 0.232 0.2296
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.008 0.0435 0.0405
Echinococcus granulosus dna polymerase eta 0.0137 0.0794 0.0766
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.006 0.0311 0.3655
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0324 0.3513
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0261 0.1627
Toxoplasma gondii exonuclease III APE 0.0022 0.0069 0.0964
Echinococcus granulosus pyruvate kinase 0.0036 0.016 0.013
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.0545 0.6562
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Schistosoma mansoni pyruvate kinase 0.0036 0.016 0.0158
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0179
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0698 1
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0024 0.0082 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.027 0.2772
Loa Loa (eye worm) hypothetical protein 0.0052 0.0259 0.1591
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.0059
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0082 0.0179
Loa Loa (eye worm) histone methyltransferase 0.002 0.0056 0.0318
Echinococcus multilocularis microtubule associated protein 2 0.1593 1 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.05
Leishmania major pyruvate kinase 0.0036 0.016 0.1255
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0545 0.6842
Schistosoma mansoni microtubule-associated protein tau 0.1593 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0545 1
Schistosoma mansoni cpg binding protein 0.0064 0.0335 0.0333
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0092 0.1285
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.008 0.0149
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.008 0.0029
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0092 0.135
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0069 0.0432
Loa Loa (eye worm) hypothetical protein 0.006 0.0311 0.1917
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.029 0.0612
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.0435 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0324 0.3513
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.047
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0048 0.067
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0005 0.0052
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.008 0.0029
Loa Loa (eye worm) pyruvate kinase 0.0036 0.016 0.0972
Loa Loa (eye worm) hypothetical protein 0.0036 0.016 0.0972
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.008 0.0149
Onchocerca volvulus 0.0091 0.0503 1
Trypanosoma brucei unspecified product 0.0055 0.0279 0.2887
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0304 0.0274
Echinococcus granulosus bloom syndrome protein 0.0023 0.0077 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0081 0.044 0.2746
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Schistosoma mansoni hypothetical protein 0.032 0.1956 0.1954
Mycobacterium ulcerans leucyl aminopeptidase 0.012 0.0692 0.1654
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.00000000037761
Trypanosoma brucei pyruvate kinase 1 0.0036 0.016 0.1255
Onchocerca volvulus 0.0052 0.0259 0.4231
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.008 0.0435 0.2695
Leishmania major 4-coumarate:coa ligase-like protein 0.0081 0.044 0.5109
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.008 0.0055
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0082 0.0051
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.016 0.1896
Schistosoma mansoni pyruvate kinase 0.0019 0.0048 0.0046
Chlamydia trachomatis cytosol aminopeptidase 0.012 0.0692 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0081 0.044 0.8058
Loa Loa (eye worm) RecQ helicase 0.0023 0.0077 0.0449
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0077 0.0479
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.095
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0087 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0077 0.044
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0082 0.0051
Chlamydia trachomatis pyruvate kinase 0.0036 0.016 0.1144
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0259 0.4231
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.012 0.0692 0.8701
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.05
Onchocerca volvulus 0.0081 0.044 0.8502
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0048 0.0665
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.008 0.1119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0081 0.044 0.1008
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0077 0.0654
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.016 0.1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0077 0.1071
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0092 0.0031
Leishmania major DNA polymerase eta, putative 0.0082 0.0446 0.52
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0087 0.1222
Entamoeba histolytica protein kinase, putative 0.0097 0.0545 1
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0113 0.0646 0.1533
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0087 0.0481 0.5673
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0573 0.6945
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.016 0.2315
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.008 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.044 0.8058
Brugia malayi Protein kinase domain containing protein 0.0097 0.0545 0.3404
Echinococcus multilocularis pyruvate kinase 0.0036 0.016 0.013
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0503 0.0473
Plasmodium falciparum M17 leucyl aminopeptidase 0.012 0.0692 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.012 0.0692 0.9915
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0087 0.0247
Brugia malayi mbt repeat family protein 0.0052 0.0259 0.1617
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0618 0.7769
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1253 0.1226
Plasmodium vivax pyruvate kinase, putative 0.0036 0.016 0.2292
Echinococcus multilocularis pyruvate kinase 0.0029 0.0112 0.0081
Brugia malayi mbt repeat family protein 0.0052 0.0259 0.1617
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0092 0.067
Schistosoma mansoni DNA helicase recq1 0.0023 0.0077 0.0075
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0087 0.1232
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0335 0.207
Trypanosoma brucei DNA polymerase IV, putative 0.0109 0.0618 0.7572
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0082 0.0513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.029 0.0612
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0069 0.0482
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0109 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0542 0.3363
Echinococcus multilocularis pyruvate kinase 0.0019 0.0048 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0087 0.104
Echinococcus multilocularis dual specificity 0.0097 0.0545 0.0516
Plasmodium falciparum pyruvate kinase 0.0036 0.016 0.1738
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0087 0.0481 0.1117
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0055
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.0149
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.006 0.0311 0.0667
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.012 0.0692 0.8586
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0005 0.0041
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0617 0.3833 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0077 0.0046
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.008 0.0055
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0054 0.0338
Entamoeba histolytica protein kinase, putative 0.0097 0.0545 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.044 0.0984
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.008 0.0055
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.008 0.0055
Trichomonas vaginalis DNA polymerase eta, putative 0.0109 0.0618 1
Brugia malayi CXXC zinc finger family protein 0.0064 0.0335 0.2095
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0087 0.0085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0618 0.7769
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0069 0.0027
Leishmania major DNA polymerase eta, putative 0.0137 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0537
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.008 0.095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.044 0.8058
Loa Loa (eye worm) oxidoreductase 0.0024 0.008 0.047
Giardia lamblia DNA damage repair protein 0.0025 0.0087 0.0896
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0261 0.0258
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.3833 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0618 0.7769
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0435 0.2718
Plasmodium vivax acyl-CoA synthetase, putative 0.006 0.0311 0.4477
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Loa Loa (eye worm) MBCTL1 0.0059 0.0304 0.1876
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.008 0.0491
Brugia malayi cytosol aminopeptidase 0.0024 0.0082 0.0513
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.05
Schistosoma mansoni cpg binding protein 0.0068 0.0359 0.0356
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0617 0.3833 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0082 0.0446 0.6386
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.0000000010113
Schistosoma mansoni hypothetical protein 0.0378 0.232 0.2318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0261 0.023
Echinococcus granulosus pyruvate kinase 0.0036 0.016 0.013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0069 0.0402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0261 0.023
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0082 0.0179
Trypanosoma brucei unspecified product 0.0055 0.0279 0.2887
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0092 0.1296
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.008 0.0969
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0087 0.0602
Mycobacterium ulcerans DNA polymerase IV 0.0109 0.0618 0.1459
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0304 0.0274
Mycobacterium ulcerans hypothetical protein 0.0025 0.0087 0.0048
Mycobacterium ulcerans hypothetical protein 0.0081 0.044 0.0984
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.016 0.2272
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.1602 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.006 0.0311 0.0642
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0069 0.0788
Trypanosoma brucei DNA polymerase IV, putative 0.0109 0.0618 0.7572
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.008 0.0435 0.0405
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.3833 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.0000000010113
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.008 0.0029
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.012 0.0692 0.8701
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.008 0.0029
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.012 0.0692 0.163
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.016 0.1896
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0081 0.044 0.0984
Loa Loa (eye worm) hypothetical protein 0.0097 0.0542 0.3363
Leishmania major DNA polymerase kappa, putative 0.0087 0.0481 0.5673
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.008 0.0969
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0091 0.0537
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.027 0.1662
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0113 0.0646 0.9256
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0261 0.16
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0087 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0646 0.1555
Loa Loa (eye worm) hypothetical protein 0.0137 0.0794 0.4945
Echinococcus granulosus dual specificity 0.0097 0.0545 0.0516
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.016 0.1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.029 0.0612
Echinococcus granulosus geminin 0.0378 0.232 0.2296
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0503 0.3141
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.008 0.095
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0092 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0618 0.7572
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0087 0.104
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.016 0.1255
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0259 0.0229
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0069 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0081 0.044 0.2746
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0077 0.1071
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0545 0.6842
Loa Loa (eye worm) pyruvate kinase 0.0036 0.016 0.0972
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0081 0.044 0.2723
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0056 0.0025
Entamoeba histolytica deoxycytidyl transferase, putative 0.008 0.0435 0.7976
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.008 0.047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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