Detailed information for compound 695284

Basic information

Technical information
  • TDR Targets ID: 695284
  • Name: 3-butyl-1,7-dimethyl-9-(2-phenylethyl)-7,8-di hydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • MW: 395.498 | Formula: C22H29N5O2
  • H donors: 0 H acceptors: 3 LogP: 3.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(=O)n(C)c2c(c1=O)n1CC(C)CN(c1n2)CCc1ccccc1
  • InChi: 1S/C22H29N5O2/c1-4-5-12-26-20(28)18-19(24(3)22(26)29)23-21-25(14-16(2)15-27(18)21)13-11-17-9-7-6-8-10-17/h6-10,16H,4-5,11-15H2,1-3H3
  • InChiKey: VOCDEDWZKUBPRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-butyl-1,7-dimethyl-9-(2-phenylethyl)-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0066 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0085 0.0051
Leishmania major DNA polymerase eta, putative 0.0084 0.0487 0.5247
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0299 0.0299
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0188 0.0288
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0111 0.1474
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0111 0.0566
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0085 0.0954
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0459 0.4906
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.0085 0.0047
Loa Loa (eye worm) histone methyltransferase 0.002 0.0064 0.0376
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0084 0.0483 0.0447
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0085 0.0048
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0621 0.7141
Plasmodium falciparum pyruvate kinase 0.0039 0.0188 0.1945
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0968
Leishmania major DNA polymerase kappa, putative 0.0026 0.0102 0.045
Chlamydia trachomatis cytosol aminopeptidase 0.0118 0.0709 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0299 0.1812
Schistosoma mansoni hypothetical protein 0.0388 0.2493 0.2493
Echinococcus granulosus L aminoadipate semialdehyde 0.0098 0.0574 0.0538
Brugia malayi polk-prov protein 0.0057 0.0308 0.1836
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0188 0.25
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.0621 0.3778
Leishmania major DNA polymerase eta, putative 0.0142 0.0869 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0118 0.0709 0.801
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0085 0.0047
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0122 0.0734 0.9757
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.00000000089184
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0665 0.4318 1
Echinococcus granulosus leucine aminopeptidase protein 0.0118 0.0709 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0534 0.5839
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0111 0.1566
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0304 0.0565
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0085 0.0048
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0085 0.0864
Brugia malayi Protein kinase domain containing protein 0.0105 0.0621 0.3758
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0084 0.0483 0.0447
Chlamydia trachomatis pyruvate kinase 0.0039 0.0188 0.1292
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0459 0.0926
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1973
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0102 0.1142
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0085 0.0505
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0459 0.093
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0066 0.0563
Loa Loa (eye worm) MBCTL1 0.0064 0.035 0.2124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.1639 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0188 0.1133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.00000000089184
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.0483 0.2913
Echinococcus granulosus cpg binding protein 0.007 0.0389 0.0353
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0665 0.4318 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0474
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0085 0.0354
Brugia malayi cytosol aminopeptidase 0.0024 0.0085 0.0472
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.006 0.0326 0.359
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0085 0.0505
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0111 0.0111
Mycobacterium ulcerans DNA polymerase IV 0.0115 0.0689 0.1467
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0085 0.0864
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0111 0.0107
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0085 0.0244
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0267 0.1618
Loa Loa (eye worm) hypothetical protein 0.0057 0.0308 0.1863
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0066 0.0384
Leishmania major pyruvate kinase 0.0039 0.0188 0.1528
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0299 0.0262
Echinococcus multilocularis geminin 0.0388 0.2493 0.2464
Loa Loa (eye worm) oxidoreductase 0.0024 0.0085 0.0505
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0459 0.0926
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0085 0.0954
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.011 0.0656
Echinococcus granulosus dna polymerase eta 0.0142 0.0869 0.0834
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0066 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0364 0.2209
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0102 0.1351
Loa Loa (eye worm) hypothetical protein 0.0064 0.035 0.2124
Brugia malayi AMP-binding enzyme family protein 0.008 0.0459 0.2767
Echinococcus multilocularis dna polymerase kappa 0.0115 0.0689 0.0654
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0111 0.0566
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0299 0.0262
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0665 0.4318 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Mycobacterium ulcerans hypothetical protein 0.0122 0.0734 0.1573
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0064 0.035 0.0314
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0085 0.0247
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0092 0.0534 0.5839
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0085 0.0051
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0188 0.2106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0689 0.7929
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0085 0.0051
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0085 0.0051
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.0621 0.6917
Echinococcus multilocularis pyruvate kinase 0.002 0.0063 0.0025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0084 0.0483 0.0483
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0665 0.4318 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0073 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0085 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0111 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0363 0.37
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0102 0.1142
Schistosoma mansoni DNA helicase recq1 0.0022 0.0073 0.0073
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0299 0.0262
Echinococcus multilocularis pyruvate kinase 0.0031 0.0134 0.0096
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0188 0.1133
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0225 0.1413 0.138
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.0621 0.6917
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.011 0.1772
Echinococcus multilocularis pyruvate kinase 0.002 0.0063 0.0025
Echinococcus multilocularis dual specificity 0.0105 0.0621 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Trypanosoma brucei unspecified product 0.0058 0.0312 0.3063
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0066 0.0065
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0621 0.7141
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0483 0.0986
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0085 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0188 0.1104
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0638 0.713
Echinococcus multilocularis leucine aminopeptidase protein 0.0118 0.0709 0.0673
Leishmania major DNA polymerase kappa, putative 0.0092 0.0534 0.5839
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0689 0.7929
Mycobacterium ulcerans hypothetical protein 0.0026 0.0102 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0267 0.0231
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0118 0.0709 0.1513
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0118 0.0709 0.1473
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0098 0.0574 0.3468
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0188 0.2142
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0474
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0299 0.0299
Treponema pallidum licC protein (licC) 0.0122 0.0734 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0073 0.016
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.0085 0.0047
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0188 0.0243
Plasmodium falciparum DNA repair protein REV1, putative 0.0026 0.0102 0.0606
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0115 0.0689 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0085 0.0954
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0397
Entamoeba histolytica hypothetical protein 0.0027 0.0111 0.1787
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.0621 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0084 0.0483 0.2936
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0968
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0111 0.006
Leishmania major pyruvate kinase 0.0039 0.0188 0.1528
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0073 0.0219
Schistosoma mansoni pyruvate kinase 0.002 0.0063 0.0063
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0459 0.7399
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0085 0.1134
Loa Loa (eye worm) hypothetical protein 0.008 0.0459 0.2791
Mycobacterium ulcerans hypothetical protein 0.0122 0.0734 0.1573
Schistosoma mansoni hypothetical protein 0.0344 0.2203 0.2203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0689 0.7929
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.0689 0.7767
Entamoeba histolytica deoxycytidyl transferase, putative 0.0084 0.0483 0.7783
Mycobacterium ulcerans hypothetical protein 0.008 0.0459 0.0926
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0118 0.0709 0.1516
Loa Loa (eye worm) RecQ helicase 0.0022 0.0073 0.0428
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0064 0.0027
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0188 0.1528
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0085 0.0051
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0085 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0459 0.0926
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0459 0.4906
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036017
Brugia malayi mbt repeat family protein 0.0056 0.0299 0.1785
Echinococcus multilocularis pyruvate kinase 0.0039 0.0188 0.0151
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0188 0.1528
Echinococcus granulosus pyruvate kinase 0.0039 0.0188 0.0151
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Echinococcus granulosus bloom syndrome protein 0.0022 0.0073 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1973
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0304 0.0565
Onchocerca volvulus 0.0098 0.0574 1
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0085 0.0247
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0085 0.0247
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0102 0.1142
Onchocerca volvulus 0.0066 0.0364 0.571
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0045
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0063 0.0882
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.0085 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0363 0.37
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0459 0.4906
Trypanosoma brucei unspecified product 0.0058 0.0312 0.3063
Schistosoma mansoni myelin transcription factor 1 myt1 0.0064 0.035 0.035
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0066 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0111 0.075
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0111 0.1479
Brugia malayi mbt repeat family protein 0.0056 0.0299 0.1785
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0308 0.3014
Entamoeba histolytica protein kinase, putative 0.0105 0.0621 1
Entamoeba histolytica hypothetical protein 0.0105 0.0621 1
Echinococcus multilocularis microtubule associated protein 2 0.1526 1 1
Echinococcus granulosus pyruvate kinase 0.0039 0.0188 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0474
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0244
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0063 0.0334
Schistosoma mansoni microtubule-associated protein tau 0.1526 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0689 0.7929
Entamoeba histolytica protein kinase, putative 0.0105 0.0621 1
Schistosoma mansoni pyruvate kinase 0.0039 0.0188 0.0188
Toxoplasma gondii exonuclease III APE 0.0021 0.0066 0.0871
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0024 0.0085 0.0472
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0753 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0244
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0188 0.2656
Onchocerca volvulus 0.008 0.0459 0.766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0267 0.0267
Brugia malayi CXXC zinc finger family protein 0.0066 0.0364 0.2184
Echinococcus granulosus histone acetyltransferase MYST2 0.0064 0.035 0.0314
Loa Loa (eye worm) hypothetical protein 0.0142 0.0869 0.5291
Schistosoma mansoni ap endonuclease 0.0021 0.0066 0.0066
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0085 0.0085
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0299 0.0262
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0073 0.0397
Echinococcus granulosus geminin 0.0388 0.2493 0.2464
Schistosoma mansoni cpg binding protein 0.007 0.0389 0.0389
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0459 0.093
Echinococcus multilocularis pyruvate kinase 0.0039 0.0188 0.0151
Echinococcus granulosus dual specificity 0.0105 0.0621 0.0585
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0459 0.0926
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0085 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0308 0.3014
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0064 0.035 0.0314
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0459 0.0884
Mycobacterium ulcerans fatty-acid-CoA ligase 0.006 0.0326 0.0612
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0299 0.438
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0028 0.00000000089184
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0066 0.0858
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.0085 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0267 0.0267
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0188 0.1104
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0066 0.0028
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0066 0.1056
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0064 0.035 0.2099
Schistosoma mansoni ap endonuclease 0.0021 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.0066 0.0364 0.0364
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0244
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0073 0.0674
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0073 0.1173
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0621 0.0621
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0037
Giardia lamblia Pyruvate kinase 0.0039 0.0188 0.2664
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0028 0.00000000089184
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0085 0.0048
Brugia malayi AMP-binding enzyme family protein 0.008 0.0459 0.2767
Leishmania major DNA damage repair protein, putative 0.0026 0.0102 0.045
Schistosoma mansoni DNA polymerase eta 0.0142 0.0869 0.0869
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0066 0.0725
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0098 0.0574 0.0574
Schistosoma mansoni hypothetical protein 0.0388 0.2493 0.2493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.00000000089184
Echinococcus granulosus dna polymerase kappa 0.0115 0.0689 0.0654
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0459 0.0884
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0118 0.0709 0.801
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0085 0.0048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0064 0.0027
Echinococcus multilocularis pyruvate kinase 0.002 0.0063 0.0025
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0085 0.0051
Trypanosoma cruzi DNA polymerase eta, putative 0.0142 0.0869 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0073 0.0035
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0073 0.0428
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0188 0.242
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0073 0.0035
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0102 0.045
Echinococcus multilocularis histone acetyltransferase MYST2 0.0064 0.035 0.0314
Schistosoma mansoni DNA helicase recq5 0.0022 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0938 0.6116 0.6116
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0085 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0505
Plasmodium vivax acyl-CoA synthetase, putative 0.006 0.0326 0.4594
Echinococcus granulosus pyruvate kinase 0.002 0.0063 0.0025
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0487 0.6468
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0085 0.0247
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.0734 0.1577
Giardia lamblia DNA damage repair protein 0.0026 0.0102 0.083
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0066 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0267 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0102 0.1142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0085 0.0474
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0085 0.0051
Schistosoma mansoni pyruvate kinase 0.0039 0.0188 0.0188
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.00000000089184
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0428
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.0102 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0487 0.5592
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0951
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0066 0.0925
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0188 0.2106
Trypanosoma brucei unspecified product 0.0107 0.0638 0.713
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0459 0.0926
Echinococcus multilocularis cpg binding protein 0.007 0.0389 0.0353
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0118 0.0709 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0085 0.0051
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0085 0.1205
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0038 0.0038
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0118 0.0709 0.8154
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0085 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0505
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0102 0.045
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0188 0.2106
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0085 0.0048
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0459 0.0926
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0188 0.0293
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0092 0.0534 0.1106
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0073 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1973
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0085 0.1134
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0063 0.083
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0244
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0188 0.1133
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0085 0.0474
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0073 0.0674
Loa Loa (eye worm) hypothetical protein 0.008 0.0459 0.2791
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.0851 0.0851
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0111 0.1474
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0066 0.0725
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.0734 0.1577
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0085 0.0503
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0656
Echinococcus granulosus pyruvate kinase 0.002 0.0063 0.0025
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0085 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.00000000089184
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0073 0.016
Loa Loa (eye worm) hypothetical protein 0.0098 0.0574 0.3489
Plasmodium vivax DNA repair protein REV1, putative 0.0026 0.0102 0.1434
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0085 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0689 0.7767
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0122 0.0734 0.1573
Trichomonas vaginalis DNA polymerase eta, putative 0.0115 0.0689 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0111 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0304 0.0565
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0085 0.0954
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0073 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.00000000089184
Mycobacterium ulcerans DNA polymerase IV 0.0115 0.0689 0.1467
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0267 0.159
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0225 0.1413 0.138
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0188 0.2142
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0024 0.0085 0.0472
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0459 0.0926
Plasmodium falciparum acyl-CoA synthetase 0.006 0.0326 0.4071
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0066 0.0563
Trypanosoma brucei chrX additional, unordered contigs 0.0026 0.0102 0.045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0267 0.0267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0267 0.0231
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0073 0.0674
Schistosoma mansoni cpg binding protein 0.007 0.0389 0.0389
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0102 0.045
Echinococcus granulosus dnaJ subfamily B 0.0938 0.6116 0.6101
Echinococcus multilocularis dnaJ subfamily B 0.0938 0.6116 0.6101
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0085 0.0085
Brugia malayi AMP-binding enzyme family protein 0.008 0.0459 0.2767
Onchocerca volvulus 0.0056 0.0299 0.438
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0085 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0142 0.0869 0.5275
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0047
Giardia lamblia DINP protein human, muc B family 0.0092 0.0534 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0118 0.0709 0.9415
Mycobacterium ulcerans leucyl aminopeptidase 0.0118 0.0709 0.1513
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0085 0.1134
Trypanosoma brucei DNA polymerase eta, putative 0.0142 0.0869 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0084 0.0483 0.0483
Echinococcus granulosus pyruvate kinase 0.002 0.0063 0.0025
Brugia malayi follicle stimulating hormone receptor 0.0259 0.1639 1
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0188 0.242
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0459 0.7399
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0267 0.0231
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0085 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0363 0.37
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0034 0.0153 0.2029
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0188 0.1133
Echinococcus multilocularis dna polymerase eta 0.0142 0.0869 0.0834
Loa Loa (eye worm) hypothetical protein 0.008 0.0459 0.2791
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0102 0.045
Loa Loa (eye worm) hypothetical protein 0.0104 0.0617 0.3756
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0085 0.0951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0304 0.0565
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.006 0.0326 0.0615
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1973
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0474
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0809
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0118 0.0709 0.8154
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0085 0.0503
Plasmodium falciparum M17 leucyl aminopeptidase 0.0118 0.0709 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0085 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0098 0.0574 0.0538
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0085 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.0689 0.7767
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0299 0.0299
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0299 0.1812
Loa Loa (eye worm) hypothetical protein 0.006 0.0326 0.1973
Loa Loa (eye worm) hypothetical protein 0.0104 0.0617 0.3756
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0085 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0459 0.7399
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0085 0.1375

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.