Detailed information for compound 695341

Basic information

Technical information
  • TDR Targets ID: 695341
  • Name: 2-[(4-bromophenyl)methylsulfanyl]-3-(phenylme thyl)-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • MW: 445.396 | Formula: C20H17BrN2OS2
  • H donors: 0 H acceptors: 1 LogP: 4.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)CSc1nc2CCSc2c(=O)n1Cc1ccccc1
  • InChi: 1S/C20H17BrN2OS2/c21-16-8-6-15(7-9-16)13-26-20-22-17-10-11-25-18(17)19(24)23(20)12-14-4-2-1-3-5-14/h1-9H,10-13H2
  • InChiKey: YESTYACTMHRMPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-bromophenyl)methylthio]-3-(phenylmethyl)-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • 3-(benzyl)-2-[(4-bromobenzyl)thio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA helicase recq5 0.0022 0.0077 0.0075
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0617 0.1459
Plasmodium falciparum pyruvate kinase 0.0034 0.016 0.1735
Onchocerca volvulus 0.0085 0.0502 1
Echinococcus multilocularis dna polymerase eta 0.0129 0.0793 0.0765
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.016 0.1892
Toxoplasma gondii exonuclease III APE 0.0021 0.0069 0.0966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0113 0.0692 0.871
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0077 0.0446 0.6384
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Schistosoma mansoni hypothetical protein 0.0356 0.2317 0.2316
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.044 0.5112
Entamoeba histolytica protein kinase, putative 0.0091 0.0544 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0261 0.0258
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.016 0.1892
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.016 0.1892
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0792
Trypanosoma brucei pyruvate kinase 1 0.0034 0.016 0.125
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0435 0.0432
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1601 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.0103
Chlamydia trachomatis pyruvate kinase 0.0034 0.016 0.1142
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.1658
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Plasmodium vivax pyruvate kinase, putative 0.0034 0.016 0.2286
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0645 0.1555
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0435 0.0405
Chlamydia trachomatis cytosol aminopeptidase 0.0113 0.0692 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0502 0.3136
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0005 0.0052
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0077 0.0918
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0077 0.0046
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.008 0.0469
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.044 0.0985
Schistosoma mansoni pyruvate kinase 0.0018 0.0048 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0000000010134
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0113 0.0692 0.871
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.008 0.0147
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0311 0.0643
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.008 0.095
Echinococcus multilocularis dnaJ subfamily B 0.0859 0.5692 0.5679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0789 0.0787
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0449
Mycobacterium ulcerans hypothetical protein 0.0023 0.0087 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0261 0.0258
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.0544 1
Onchocerca volvulus 0.0076 0.044 0.8517
Echinococcus multilocularis dna polymerase kappa 0.0102 0.0617 0.0588
Mycobacterium ulcerans pyruvate kinase 0.0034 0.016 0.0241
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.008 0.0493
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0258 0.0256
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0435 0.0997
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0435 0.0405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Onchocerca volvulus 0.0049 0.0258 0.4228
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0304 0.0274
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0082 0.0514
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0544 0.0542
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.008 0.095
Loa Loa (eye worm) hypothetical protein 0.0056 0.0304 0.1872
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0243
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0056 0.0317
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.008 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.008 0.0147
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0082 0.008
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0617 0.1459
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0446 0.5591
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.008 0.0147
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1251 0.1223
Echinococcus granulosus pyruvate kinase 0.0034 0.016 0.0129
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1251 0.1223
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.008 0.0028
Schistosoma mansoni cpg binding protein 0.0064 0.0358 0.0356
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0258 0.0228
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0502 0.05
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0258 0.4228
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0792
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.008 0.0028
Toxoplasma gondii propionate-CoA ligase 0.0022 0.008 0.1119
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.008 0.0971
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.027 0.2768
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0067
Brugia malayi CXXC zinc finger family protein 0.006 0.0335 0.2093
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0113 0.0692 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0082 0.0514
Leishmania major DNA damage repair protein, putative 0.0023 0.0087 0.0243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0261 0.023
Echinococcus multilocularis leucine aminopeptidase protein 0.0113 0.0692 0.0663
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0324 0.351
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.1073
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0048 0.0662
Brugia malayi mbt repeat family protein 0.0049 0.0258 0.1615
Trypanosoma cruzi DNA polymerase eta, putative 0.0129 0.0793 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.044 0.2722
Loa Loa (eye worm) RecQ helicase 0.0022 0.0077 0.0449
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0113 0.0692 0.8595
Trypanosoma brucei DNA polymerase eta, putative 0.0129 0.0793 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0261 0.023
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.008 0.0055
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.091
Trypanosoma brucei unspecified product 0.0052 0.0278 0.2884
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0132 0.1872
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0106 0.0645 0.1532
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Echinococcus granulosus dnaJ subfamily B 0.0859 0.5692 0.5679
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Leishmania major DNA polymerase kappa, putative 0.0023 0.0087 0.0243
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0091 0.1628
Leishmania major pyruvate kinase 0.0034 0.016 0.125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0261 0.023
Loa Loa (eye worm) hypothetical protein 0.0091 0.0541 0.3357
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.044 0.5112
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.016 0.0267
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.0469
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0005 0.0003
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0077 0.048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0069 0.0815
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0091 0.1281
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0435 0.2691
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.0147
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.1073
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0091 0.0303
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0082 0.0178
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.008 0.0049
Schistosoma mansoni hypothetical protein 0.0859 0.5692 0.5691
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0091 0.0303
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0069 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.027 0.2768
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0069 0.1004
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0077 0.0046
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Brugia malayi Protein kinase domain containing protein 0.0091 0.0544 0.3398
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0091 0.0535
Loa Loa (eye worm) hypothetical protein 0.0085 0.0502 0.3114
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0087 0.0602
Trypanosoma brucei unspecified product 0.0096 0.0572 0.6942
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.044 0.096
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.008 0.1119
Entamoeba histolytica protein kinase, putative 0.0091 0.0544 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0258 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.008 0.0055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.044 0.807
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.048 0.567
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Treponema pallidum licC protein (licC) 0.0106 0.0645 1
Mycobacterium ulcerans hypothetical protein 0.0076 0.044 0.0985
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0311 0.4476
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0113 0.0692 0.8595
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.048 0.567
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Trichomonas vaginalis DNA polymerase eta, putative 0.0102 0.0617 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.044 0.096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0815
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.008 0.0028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0274
Brugia malayi AMP-binding enzyme family protein 0.0076 0.044 0.2745
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0091 0.1281
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0102 0.0617 1
Loa Loa (eye worm) oxidoreductase 0.0022 0.008 0.0469
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0087 0.0243
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.044 0.0985
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0258 0.0256
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0502 0.0472
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0645 0.1555
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0067
Leishmania major pyruvate kinase 0.0034 0.016 0.125
Schistosoma mansoni cpg binding protein 0.0064 0.0358 0.0356
Echinococcus granulosus bloom syndrome protein 0.0022 0.0077 0.0046
Schistosoma mansoni DNA polymerase eta 0.0129 0.0793 0.0791
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0617 0.7569
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0258 0.1587
Trypanosoma brucei unspecified product 0.0052 0.0278 0.2884
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.044 0.0985
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.095
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0435 0.2714
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Echinococcus multilocularis dual specificity 0.0091 0.0544 0.0515
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Entamoeba histolytica hypothetical protein 0.0024 0.0091 0.1643
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.0258 0.1587
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.016 0.0999
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0258 0.0228
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.0544 0.6837
Echinococcus granulosus dual specificity 0.0091 0.0544 0.0515
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0261 0.0258
Schistosoma mansoni cpg binding protein 0.006 0.0335 0.0333
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0311 0.4081
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0087 0.1039
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0077 0.0449
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.044 0.0985
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1601 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0077 0.0046
Toxoplasma gondii leucyl aminopeptidase LAP 0.0113 0.0692 0.9924
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0535
Echinococcus multilocularis pyruvate kinase 0.0034 0.016 0.0129
Schistosoma mansoni pyruvate kinase 0.0034 0.016 0.0158
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.016 0.125
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0077 0.0918
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0069 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Echinococcus multilocularis pyruvate kinase 0.0027 0.0112 0.0081
Brugia malayi polk-prov protein 0.0051 0.027 0.1685
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.016 0.1963
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0087 0.0085
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0435 0.0432
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.048
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0087 0.1039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0069 0.1238
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0087 0.1039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0261 0.1627
Echinococcus multilocularis pyruvate kinase 0.0034 0.016 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0087 0.1039
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0082 0.0483
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0258 0.0228
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0091 0.0544 0.6556
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0082 0.0051
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0091 0.0669
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.044 0.101
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.016 0.2268
Echinococcus multilocularis microtubule associated protein 2 0.1501 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0091 0.0544 0.3377
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.008 0.0055
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.008 0.0028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0000000010134
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0077 0.0918
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.008 0.0469
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.008 0.0028
Echinococcus granulosus leucine aminopeptidase protein 0.0113 0.0692 0.0663
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0077 0.0662
Echinococcus granulosus dna polymerase kappa 0.0102 0.0617 0.0588
Schistosoma mansoni hypothetical protein 0.0356 0.2317 0.2316
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0091 0.003
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.008 0.0028
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.008 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0274
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.008 0.05
Giardia lamblia DNA damage repair protein 0.0023 0.0087 0.0897
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0031 0.0029
Schistosoma mansoni DNA helicase recq1 0.0022 0.0077 0.0075
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0113 0.0692 0.1633
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0082 0.0051
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0082 0.0051
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0077 0.0046
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0077 0.0046
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.016 0.0999
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0581 0.3825 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Schistosoma mansoni pyruvate kinase 0.0034 0.016 0.0158
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.016 0.2313
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.008 0.1434
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0581 0.3825 1
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0087 0.0243
Loa Loa (eye worm) hypothetical protein 0.0129 0.0793 0.4939
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0324 0.351
Brugia malayi ImpB/MucB/SamB family protein 0.0129 0.0793 0.4956
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0091 0.0058
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0082 0.008
Leishmania major DNA polymerase kappa, putative 0.0082 0.048 0.567
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0091 0.1347
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Mycobacterium ulcerans leucyl aminopeptidase 0.0113 0.0692 0.1657
Leishmania major DNA polymerase eta, putative 0.0129 0.0793 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0069 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0077 0.0444
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0106 0.0645 0.9248
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.008 0.0078
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Leishmania major DNA polymerase eta, putative 0.0077 0.0446 0.5199
Brugia malayi AMP-binding enzyme family protein 0.0076 0.044 0.2745
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0581 0.3825 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Echinococcus multilocularis cpg binding protein 0.0064 0.0358 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0304 0.0274
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0973
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0113 0.0692 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0091 0.1291
Mycobacterium ulcerans hypothetical protein 0.0106 0.0645 0.1532
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.044 0.0985
Brugia malayi cytosol aminopeptidase 0.0023 0.0082 0.0514
Echinococcus multilocularis geminin 0.0356 0.2317 0.2293
Loa Loa (eye worm) pyruvate kinase 0.0034 0.016 0.097
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0979
Loa Loa (eye worm) hypothetical protein 0.0076 0.044 0.2722
Mycobacterium ulcerans hypothetical protein 0.0106 0.0645 0.1532
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0091 0.0544 0.6556
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.008 0.0055
Schistosoma mansoni microtubule-associated protein tau 0.1501 1 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.016 0.097
Schistosoma mansoni hypothetical protein 0.0301 0.1952 0.195
Loa Loa (eye worm) pyruvate kinase 0.0034 0.016 0.097
Onchocerca volvulus 0.006 0.0335 0.6044
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0581 0.3825 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0311 0.3657
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0572 0.6942
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0979
Echinococcus granulosus pyruvate kinase 0.0034 0.016 0.0129
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.044 0.807
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0261 0.16
Giardia lamblia Pyruvate kinase 0.0034 0.016 0.2586
Echinococcus granulosus dna polymerase eta 0.0129 0.0793 0.0765
Giardia lamblia DINP protein human, muc B family 0.0082 0.048 1
Entamoeba histolytica hypothetical protein 0.0091 0.0544 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0304 0.1898
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0087 0.1219
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.008 0.05
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0324 0.351
Plasmodium falciparum M17 leucyl aminopeptidase 0.0113 0.0692 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.044 0.807
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.016 0.0213
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.044 0.101
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.0147
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0082 0.0483
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.0544 0.6837
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0091 0.0058
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0048 0.0667
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0258 0.0228
Loa Loa (eye worm) hypothetical protein 0.0091 0.0541 0.3357
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.008 0.0055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0311 0.0668
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0113 0.0692 0.1657
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0054 0.0338
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.008 0.0971
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.00000000037791
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0069 0.0489
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0069 0.0434
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0082 0.0514
Echinococcus granulosus geminin 0.0356 0.2317 0.2293
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.044 0.0985
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0077 0.1376
Loa Loa (eye worm) hypothetical protein 0.0034 0.016 0.097
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0304 0.0302
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.008 0.1119
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.0469
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.095
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.016 0.2313
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0697 1
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0617 0.7569
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.016 0.1963
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.044 0.5112
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0005 0.0041
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.008 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0069 0.0038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.048 0.1117
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0328
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0335 0.2068
Loa Loa (eye worm) hypothetical protein 0.0076 0.044 0.2722
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0091 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0261 0.023
Brugia malayi mbt repeat family protein 0.0049 0.0258 0.1615
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.044 0.0985
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0087 0.1229
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.008 0.1127
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0077 0.0444
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0435 0.7979
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0502 0.0472
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Echinococcus granulosus cpg binding protein 0.0064 0.0358 0.0328
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0076 0.044 0.2745
Loa Loa (eye worm) MBCTL1 0.0056 0.0304 0.1872
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0091 0.0058
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0087 0.0243
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.008 0.0055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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