Detailed information for compound 695341

Basic information

Technical information
  • TDR Targets ID: 695341
  • Name: 2-[(4-bromophenyl)methylsulfanyl]-3-(phenylme thyl)-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • MW: 445.396 | Formula: C20H17BrN2OS2
  • H donors: 0 H acceptors: 1 LogP: 4.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)CSc1nc2CCSc2c(=O)n1Cc1ccccc1
  • InChi: 1S/C20H17BrN2OS2/c21-16-8-6-15(7-9-16)13-26-20-22-17-10-11-25-18(17)19(24)23(20)12-14-4-2-1-3-5-14/h1-9H,10-13H2
  • InChiKey: YESTYACTMHRMPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-bromophenyl)methylthio]-3-(phenylmethyl)-6,7-dihydrothieno[2,3-e]pyrimidin-4-one
  • 3-(benzyl)-2-[(4-bromobenzyl)thio]-6,7-dihydrothieno[2,3-e]pyrimidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0261 0.023
Echinococcus multilocularis pyruvate kinase 0.0027 0.0112 0.0081
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.016 0.0999
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1251 0.1223
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0087 0.0243
Brugia malayi CXXC zinc finger family protein 0.006 0.0335 0.2093
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.048
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0091 0.0669
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0617 0.1459
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0069 0.0489
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.0544 0.6837
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0091 0.0058
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Entamoeba histolytica hypothetical protein 0.0091 0.0544 1
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.008 0.0078
Leishmania major DNA polymerase kappa, putative 0.0082 0.048 0.567
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.008 0.0049
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.016 0.1963
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0005 0.0041
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0113 0.0692 0.8595
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.095
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0056 0.0317
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0091 0.0544 0.3377
Brugia malayi AMP-binding enzyme family protein 0.0076 0.044 0.2745
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0581 0.3825 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.008 0.05
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.1073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.0103
Brugia malayi ImpB/MucB/SamB family protein 0.0129 0.0793 0.4956
Trichomonas vaginalis DNA polymerase eta, putative 0.0102 0.0617 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0328
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0082 0.0483
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0335 0.2068
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0077 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.044 0.5112
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0091 0.1628
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0091 0.0085
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0258 0.0228
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0581 0.3825 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0311 0.0668
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0435 0.0405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.008 0.0147
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.008 0.1127
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0304 0.1898
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0243
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0446 0.5591
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0000000010134
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0581 0.3825 1
Echinococcus multilocularis cpg binding protein 0.0064 0.0358 0.0328
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.008 0.0055
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0091 0.1281
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0261 0.16
Trypanosoma brucei unspecified product 0.0052 0.0278 0.2884
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.008 0.0147
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0069 0.1004
Echinococcus granulosus pyruvate kinase 0.0034 0.016 0.0129
Echinococcus granulosus geminin 0.0356 0.2317 0.2293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0261 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0091 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0449
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0087 0.0085
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0304 0.0302
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.008 0.0028
Mycobacterium ulcerans hypothetical protein 0.0076 0.044 0.0985
Loa Loa (eye worm) hypothetical protein 0.0034 0.016 0.097
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0435 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0069 0.0815
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1601 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0581 0.3825 1
Echinococcus granulosus leucine aminopeptidase protein 0.0113 0.0692 0.0663
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0113 0.0692 0.1657
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.044 0.807
Loa Loa (eye worm) pyruvate kinase 0.0034 0.016 0.097
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0645 0.1555
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.008 0.0469
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0091 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.027 0.2768
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.048 0.567
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.0617 0.1459
Loa Loa (eye worm) hypothetical protein 0.0091 0.0541 0.3357
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0087 0.1219
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0645 0.1555
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0261 0.023
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.008 0.0028
Loa Loa (eye worm) pyruvate kinase 0.0034 0.016 0.097
Entamoeba histolytica protein kinase, putative 0.0091 0.0544 1
Leishmania major DNA polymerase eta, putative 0.0129 0.0793 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0502 0.0472
Echinococcus multilocularis geminin 0.0356 0.2317 0.2293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0091 0.1347
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.008 0.095
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.044 0.096
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0069 0.0434
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0258 0.0256
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.016 0.0213
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0617 0.7569
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0091 0.1291
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.008 0.0028
Echinococcus granulosus dual specificity 0.0091 0.0544 0.0515
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.016 0.2268
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0435 0.0432
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0082 0.0514
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0054 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0076 0.044 0.2745
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0435 0.7979
Schistosoma mansoni DNA polymerase eta 0.0129 0.0793 0.0791
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0258 0.1587
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0324 0.351
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0311 0.4476
Echinococcus granulosus pyruvate kinase 0.0034 0.016 0.0129
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Brugia malayi Protein kinase domain containing protein 0.0091 0.0544 0.3398
Schistosoma mansoni DNA helicase recq1 0.0022 0.0077 0.0075
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.016 0.125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0697 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0258 0.0228
Loa Loa (eye worm) hypothetical protein 0.0051 0.027 0.1658
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0091 0.0303
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.008 0.0028
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0077 0.0918
Schistosoma mansoni microtubule-associated protein tau 0.1501 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Echinococcus multilocularis dual specificity 0.0091 0.0544 0.0515
Echinococcus multilocularis microtubule associated protein 2 0.1501 1 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0541 0.3357
Leishmania major pyruvate kinase 0.0034 0.016 0.125
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Schistosoma mansoni cpg binding protein 0.006 0.0335 0.0333
Schistosoma mansoni DNA helicase recq5 0.0022 0.0077 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0311 0.4081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0815
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0535
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0087 0.0602
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0005 0.0052
Schistosoma mansoni pyruvate kinase 0.0018 0.0048 0.0046
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0324 0.351
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0435 0.0405
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0979
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.016 0.1963
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.016 0.0267
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0274
Trypanosoma brucei unspecified product 0.0052 0.0278 0.2884
Loa Loa (eye worm) hypothetical protein 0.0085 0.0502 0.3114
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.0469
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0077 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Loa Loa (eye worm) hypothetical protein 0.0076 0.044 0.2722
Plasmodium falciparum M17 leucyl aminopeptidase 0.0113 0.0692 1
Schistosoma mansoni hypothetical protein 0.0301 0.1952 0.195
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0617 0.7569
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.008 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0435 0.2691
Onchocerca volvulus 0.0076 0.044 0.8517
Schistosoma mansoni pyruvate kinase 0.0034 0.016 0.0158
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0041
Brugia malayi mbt repeat family protein 0.0049 0.0258 0.1615
Brugia malayi AMP-binding enzyme family protein 0.0076 0.044 0.2745
Echinococcus multilocularis leucine aminopeptidase protein 0.0113 0.0692 0.0663
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.008 0.0469
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0048 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0087 0.1039
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.016 0.2313
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0077 0.0444
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.008 0.0971
Giardia lamblia DNA damage repair protein 0.0023 0.0087 0.0897
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0077 0.0046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0261 0.1627
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0113 0.0692 0.1633
Echinococcus multilocularis pyruvate kinase 0.0034 0.016 0.0129
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0077 0.0046
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0082 0.008
Schistosoma mansoni pyruvate kinase 0.0034 0.016 0.0158
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.008 0.1119
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.044 0.0985
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.008 0.095
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.044 0.5112
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0544 0.0542
Entamoeba histolytica hypothetical protein 0.0024 0.0091 0.1643
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0077 0.0449
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0091 0.0303
Leishmania major DNA polymerase eta, putative 0.0077 0.0446 0.5199
Trypanosoma brucei unspecified product 0.0096 0.0572 0.6942
Giardia lamblia DINP protein human, muc B family 0.0082 0.048 1
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0106 0.0645 0.9248
Entamoeba histolytica protein kinase, putative 0.0091 0.0544 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.044 0.807
Brugia malayi cytosol aminopeptidase 0.0023 0.0082 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Trypanosoma brucei pyruvate kinase 1 0.0034 0.016 0.125
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0502 0.0472
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.016 0.1892
Echinococcus multilocularis dna polymerase kappa 0.0102 0.0617 0.0588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0261 0.0258
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0113 0.0692 0.871
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0082 0.0051
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0113 0.0692 0.1679
Mycobacterium ulcerans hypothetical protein 0.0106 0.0645 0.1532
Schistosoma mansoni cpg binding protein 0.0064 0.0358 0.0356
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0077 0.0046
Loa Loa (eye worm) hypothetical protein 0.0076 0.044 0.2722
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Giardia lamblia Pyruvate kinase 0.0034 0.016 0.2586
Loa Loa (eye worm) hypothetical protein 0.0076 0.044 0.2722
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0005 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0572 0.6942
Chlamydia trachomatis pyruvate kinase 0.0034 0.016 0.1142
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0082 0.0514
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.008 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0031 0.0029
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0087 0.1039
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0106 0.0645 0.1532
Leishmania major DNA damage repair protein, putative 0.0023 0.0087 0.0243
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.008 0.0055
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0082 0.008
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0258 0.0256
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0082 0.0051
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.008 0.0028
Plasmodium falciparum pyruvate kinase 0.0034 0.016 0.1735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0113 0.0692 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0087 0.0047
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0077 0.0444
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0069 0.0038
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.008 0.0028
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.008 0.0971
Toxoplasma gondii propionate-CoA ligase 0.0022 0.008 0.1119
Schistosoma mansoni hypothetical protein 0.0859 0.5692 0.5691
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0077 0.0446 0.6384
Loa Loa (eye worm) RecQ helicase 0.0022 0.0077 0.0449
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.008 0.0147
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.044 0.0985
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.0617 0.7767
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0113 0.0692 0.8595
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.044 0.5112
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0087 0.1229
Trypanosoma cruzi DNA polymerase eta, putative 0.0129 0.0793 1
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0082 0.0178
Schistosoma mansoni hypothetical protein 0.0356 0.2317 0.2316
Onchocerca volvulus 0.0085 0.0502 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0069 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Leishmania major pyruvate kinase 0.0034 0.016 0.125
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0082 0.0051
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0077 0.0046
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0048 0.0662
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.095
Trypanosoma brucei DNA polymerase eta, putative 0.0129 0.0793 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.008 0.0049
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.048
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0311 0.3657
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0069 0.1238
Onchocerca volvulus 0.006 0.0335 0.6044
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0792
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0069 0.0403
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.016 0.0999
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.008 0.1119
Loa Loa (eye worm) oxidoreductase 0.0022 0.008 0.0469
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.1073
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.0544 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.00000000037791
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.044 0.0985
Loa Loa (eye worm) MBCTL1 0.0056 0.0304 0.1872
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.027 0.2768
Loa Loa (eye worm) hypothetical protein 0.0057 0.0311 0.1916
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0082 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0087 0.1039
Onchocerca volvulus 0.0049 0.0258 0.4228
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.016 0.2313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0261 0.023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0069 0.0027
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0258 0.0228
Toxoplasma gondii exonuclease III APE 0.0021 0.0069 0.0966
Plasmodium vivax pyruvate kinase, putative 0.0034 0.016 0.2286
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0435 0.2714
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.0544 0.6837
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.044 0.0985
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0077 0.0918
Schistosoma mansoni hypothetical protein 0.0356 0.2317 0.2316
Echinococcus granulosus cpg binding protein 0.0064 0.0358 0.0328
Loa Loa (eye worm) hypothetical protein 0.0049 0.0258 0.1587
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0102 0.0617 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0258 0.0256
Mycobacterium ulcerans hypothetical protein 0.0106 0.0645 0.1532
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.0147
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0502 0.05
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0087 0.0243
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.008 0.0055
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.044 0.101
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.0103
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0311 0.0643
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0091 0.0544 0.6556
Leishmania major DNA polymerase kappa, putative 0.0023 0.0087 0.0243
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0091 0.0544 0.6556
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.044 0.096
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0304 0.0274
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.008 0.0055
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0113 0.0692 0.871
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0077 0.1376
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0979
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.029 0.0613
Loa Loa (eye worm) hypothetical protein 0.0056 0.0304 0.1872
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.044 0.0985
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.008 0.1434
Echinococcus multilocularis pyruvate kinase 0.0034 0.016 0.0129
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1601 1
Mycobacterium ulcerans pyruvate kinase 0.0034 0.016 0.0241
Echinococcus multilocularis dna polymerase eta 0.0129 0.0793 0.0765
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0324 0.351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0261 0.023
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0132 0.1872
Echinococcus multilocularis dnaJ subfamily B 0.0859 0.5692 0.5679
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Echinococcus granulosus dnaJ subfamily B 0.0859 0.5692 0.5679
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Schistosoma mansoni cpg binding protein 0.0064 0.0358 0.0356
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.008 0.0055
Echinococcus granulosus dna polymerase eta 0.0129 0.0793 0.0765
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.044 0.807
Brugia malayi mbt repeat family protein 0.0049 0.0258 0.1615
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.044 0.0985
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0087 0.0243
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.048 0.567
Treponema pallidum licC protein (licC) 0.0106 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0793 0.4939
Mycobacterium ulcerans leucyl aminopeptidase 0.0113 0.0692 0.1657
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1251 0.1223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0261 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.044 0.101
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.008 0.0055
Loa Loa (eye worm) pyruvate kinase 0.0034 0.016 0.097
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0258 0.4228
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0258 0.0228
Brugia malayi AMP-binding enzyme family protein 0.0022 0.008 0.05
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0274
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0792
Echinococcus granulosus bloom syndrome protein 0.0022 0.0077 0.0046
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.0617 0.7569
Chlamydia trachomatis cytosol aminopeptidase 0.0113 0.0692 1
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0082 0.0483
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0502 0.3136
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.008 0.0055
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0077 0.0918
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Echinococcus granulosus dna polymerase kappa 0.0102 0.0617 0.0588
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0091 0.0535
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.008 0.0028
Brugia malayi polk-prov protein 0.0051 0.027 0.1685
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.044 0.0985
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0789 0.0787
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.008 0.0055
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.016 0.1892
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.008 0.0028
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0091 0.1281
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0087 0.1039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0000000010134
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0077 0.0662
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0973
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0091 0.0058
Toxoplasma gondii leucyl aminopeptidase LAP 0.0113 0.0692 0.9924
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.008 0.0493
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.008 0.05
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.048 0.1117
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0304 0.0274
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0435 0.0997
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.016 0.1892
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.008 0.0469
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.008 0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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