Detailed information for compound 695395

Basic information

Technical information
  • TDR Targets ID: 695395
  • Name: 9-(4-chlorophenyl)-3-[(2-fluorophenyl)methyl] -1,7-dimethyl-7,8-dihydro-6H-purino[8,7-b]pyr imidine-2,4-dione
  • MW: 453.897 | Formula: C23H21ClFN5O2
  • H donors: 0 H acceptors: 3 LogP: 4.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CN(c2ccc(cc2)Cl)c2n(C1)c1c(n2)n(C)c(=O)n(c1=O)Cc1ccccc1F
  • InChi: 1S/C23H21ClFN5O2/c1-14-11-28(17-9-7-16(24)8-10-17)22-26-20-19(29(22)12-14)21(31)30(23(32)27(20)2)13-15-5-3-4-6-18(15)25/h3-10,14H,11-13H2,1-2H3
  • InChiKey: MPZJKLSOHJDZBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-(4-chlorophenyl)-3-(2-fluorobenzyl)-1,7-dimethyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone
  • PB246151952

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni leucine aminopeptidase 0.0024 0.008 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0454 0.0931
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0083 0.1367
Loa Loa (eye worm) hypothetical protein 0.0061 0.0321 0.1993
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.0605 0.377
Trichomonas vaginalis DNA polymerase eta, putative 0.0116 0.0672 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.029 0.4355
Onchocerca volvulus 0.0056 0.029 0.4355
Toxoplasma gondii leucyl aminopeptidase LAP 0.0119 0.069 0.9407
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0083 0.0052
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0098 0.0559 0.3472
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0061 0.0321 0.1993
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0083 0.0488
Echinococcus multilocularis leucine aminopeptidase protein 0.0119 0.069 0.0658
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0075 0.0849
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.008 0.0484
Trypanosoma brucei unspecified product 0.0058 0.0302 0.3011
Loa Loa (eye worm) hypothetical protein 0.0061 0.0321 0.1993
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0096 0.0376
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0605 0.0605
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0916
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0454 0.0931
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0181 0.1117
Schistosoma mansoni DNA polymerase eta 0.0143 0.0847 0.0847
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0083 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0258 0.0225
Schistosoma mansoni cpg binding protein 0.0066 0.0353 0.0353
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0034 0.0146 0.1996
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0454 0.0931
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0075 0.0096
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0181 0.2421
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.16 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0083 0.1127
Trypanosoma brucei DNA polymerase eta, putative 0.0143 0.0847 1
Echinococcus granulosus pyruvate kinase 0.002 0.0058 0.0024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0084 0.047 0.047
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.029 0.029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0454 0.0897
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.008 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Echinococcus granulosus leucine aminopeptidase protein 0.0119 0.069 0.0658
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0092 0.052 0.1102
Echinococcus multilocularis dna polymerase eta 0.0143 0.0847 0.0816
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0119 0.069 0.8141
Echinococcus granulosus dnaJ subfamily B 0.0943 0.5981 0.5968
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.008 0.008
Echinococcus granulosus cpg binding protein 0.007 0.0378 0.0345
Schistosoma mansoni hypothetical protein 0.0943 0.5981 0.5981
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0096 0.0376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0258 0.0258
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0258 0.16
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0075 0.0772
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0061 0.0321 0.0611
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0075 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0067 0.0656
Plasmodium falciparum DNA repair protein REV1, putative 0.0026 0.0096 0.0606
Trypanosoma brucei DNA polymerase IV, putative 0.0116 0.0672 0.7751
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0258 0.159
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0226 0.1381 0.1352
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0181 0.2113
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0454 0.0931
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0024 0.008 0.0472
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0075 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0025 0.00000000093192
Mycobacterium ulcerans DNA polymerase IV 0.0116 0.0672 0.1454
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0106 0.153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.03 0.0573
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0083 0.0946
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0672 0.7922
Mycobacterium ulcerans hypothetical protein 0.0123 0.0716 0.1561
Plasmodium vivax DNA repair protein REV1, putative 0.0026 0.0096 0.1397
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0098 0.0559 0.0559
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0083 0.0052
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0106 0.0055
Echinococcus granulosus pyruvate kinase 0.002 0.0058 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0025 0.00000000093192
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.008 0.0046
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0075 0.026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0067 0.0761
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0105 0.0638
Mycobacterium ulcerans hypothetical protein 0.0123 0.0716 0.1561
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.008 0.0484
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0454 0.7506
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.083 0.083
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0083 0.0488
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0181 0.1117
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0075 0.0772
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0167
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0058 0.0792
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0083 0.1127
Giardia lamblia DINP protein human, muc B family 0.0092 0.052 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0075 0.0041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0061 0.0321 0.0624
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0454 0.0944
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0181 0.0288
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0181 0.207
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.008 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0034 0.0034
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0083 0.1198
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0119 0.069 0.7988
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.05
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0096 0.0376
Echinococcus multilocularis cpg binding protein 0.007 0.0378 0.0345
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0119 0.069 0.8141
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0083 0.0052
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0084 0.047 0.0438
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0067 0.0972
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0916
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0181 0.207
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0454 0.0897
Trypanosoma brucei unspecified product 0.0108 0.0622 0.711
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0449
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.0096 0.0096
Schistosoma mansoni pyruvate kinase 0.0039 0.0181 0.0181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0025 0.00000000093192
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0083 0.0488
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0083 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0258 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0096 0.1109
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0067 0.0141
Treponema pallidum licC protein (licC) 0.0123 0.0716 1
Giardia lamblia DNA damage repair protein 0.0026 0.0096 0.0829
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0167
Leishmania major DNA polymerase eta, putative 0.0085 0.0473 0.521
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0083 0.02
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.05
Plasmodium vivax acyl-CoA synthetase, putative 0.0061 0.0321 0.4655
Echinococcus granulosus pyruvate kinase 0.002 0.0058 0.0024
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0083 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.0437
Schistosoma mansoni DNA helicase recq5 0.0023 0.0075 0.0075
Echinococcus multilocularis dnaJ subfamily B 0.0943 0.5981 0.5968
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0181 0.2421
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0075 0.0041
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0096 0.0376
Loa Loa (eye worm) hypothetical protein 0.0064 0.034 0.2111
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.008 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.006 0.0026
Echinococcus multilocularis pyruvate kinase 0.002 0.0058 0.0024
Echinococcus granulosus dna polymerase eta 0.0143 0.0847 0.0816
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0083 0.0052
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0075 0.0041
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0075 0.0449
Mycobacterium ulcerans hypothetical protein 0.0082 0.0454 0.0931
Trypanosoma brucei DNA polymerase IV, putative 0.0116 0.0672 0.7751
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0119 0.069 0.7988
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0083 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0454 0.2816
Leishmania major DNA damage repair protein, putative 0.0026 0.0096 0.0376
Trypanosoma cruzi DNA polymerase eta, putative 0.0143 0.0847 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0559 0.348
Echinococcus granulosus geminin 0.0391 0.2436 0.241
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0067 0.0761
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0025 0.00000000093192
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Giardia lamblia Pyruvate kinase 0.0039 0.0181 0.2665
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0025 0.00000000093192
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0167
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0075 0.0772
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0075 0.1232
Loa Loa (eye worm) hypothetical protein 0.0105 0.0601 0.3748
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0003 0.0039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0067 0.1109
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0064 0.034 0.2101
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0352 0.3652
Schistosoma mansoni ap endonuclease 0.0022 0.0067 0.0067
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0067 0.0033
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.0083 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0258 0.0225
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0181 0.1106
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.029 0.0257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0025 0.00000000093192
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0067 0.09
Loa Loa (eye worm) hypothetical protein 0.0082 0.0454 0.2825
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0061 0.0321 0.3689
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0083 0.02
Schistosoma mansoni myelin transcription factor 1 myt1 0.0064 0.034 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.03 0.0573
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0454 0.4963
Echinococcus multilocularis pyruvate kinase 0.0039 0.0181 0.0148
Echinococcus granulosus dual specificity 0.0105 0.0605 0.0573
Loa Loa (eye worm) hypothetical protein 0.0082 0.0454 0.2825
Echinococcus multilocularis geminin 0.0391 0.2436 0.241
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0075 0.0437
Schistosoma mansoni cpg binding protein 0.007 0.0378 0.0378
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0083 0.0083
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.029 0.0257
Schistosoma mansoni ap endonuclease 0.0022 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0143 0.0847 0.5285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0258 0.0258
Brugia malayi CXXC zinc finger family protein 0.0066 0.0353 0.2185
Loa Loa (eye worm) MBCTL1 0.0064 0.034 0.2111
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0454 0.2816
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0167
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0181 0.2626
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0734 1
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0024 0.008 0.0472
Schistosoma mansoni pyruvate kinase 0.0039 0.0181 0.0181
Toxoplasma gondii exonuclease III APE 0.0022 0.0067 0.0914
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0672 0.7922
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.0605 0.6897
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0083 0.0488
Echinococcus multilocularis microtubule associated protein 2 0.157 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.008 0.0167
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0058 0.0334
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0605 0.7133
Entamoeba histolytica hypothetical protein 0.0105 0.0605 1
Schistosoma mansoni microtubule-associated protein tau 0.157 1 1
Echinococcus granulosus pyruvate kinase 0.0039 0.0181 0.0148
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.029 0.1798
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0298 0.2961
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0106 0.144
Echinococcus granulosus histone acetyltransferase MYST2 0.0064 0.034 0.0307
Brugia malayi polk-prov protein 0.0058 0.0298 0.1838
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0067 0.039
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0105 0.1731
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0003 0.0047
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0058 0.0842
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.0083 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0352 0.3652
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0454 0.0931
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0096 0.1109
Onchocerca volvulus 0.0066 0.0353 0.5686
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0083 0.02
Plasmodium falciparum acyl-CoA synthetase 0.0061 0.0321 0.4163
Loa Loa (eye worm) hypothetical protein 0.0058 0.0298 0.1848
Echinococcus granulosus L aminoadipate semialdehyde 0.0098 0.0559 0.0527
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0083 0.02
Echinococcus granulosus bloom syndrome protein 0.0023 0.0075 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0181 0.1464
Echinococcus granulosus pyruvate kinase 0.0039 0.0181 0.0148
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0083 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0454 0.0931
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0454 0.4963
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.00000000037748
Echinococcus multilocularis pyruvate kinase 0.0039 0.0181 0.0148
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.029 0.029
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0454 0.0931
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0119 0.069 0.1466
Loa Loa (eye worm) RecQ helicase 0.0023 0.0075 0.0449
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.006 0.0026
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0083 0.0052
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0181 0.1464
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0672 0.7922
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0084 0.047 0.2925
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.0716 0.1573
Schistosoma mansoni hypothetical protein 0.0347 0.2155 0.2155
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Leishmania major pyruvate kinase 0.0039 0.0181 0.1464
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0075 0.0355
Schistosoma mansoni pyruvate kinase 0.002 0.0058 0.0058
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0083 0.1127
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0454 0.7506
Loa Loa (eye worm) hypothetical protein 0.0082 0.0454 0.2825
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0106 0.0093
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.0605 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.1016
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0106 0.1441
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0085 0.0473 0.6454
Trypanosoma brucei chrX additional, unordered contigs 0.0026 0.0096 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0083 0.0946
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.0437
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0083 0.0488
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0056 0.029 0.1798
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0123 0.0716 0.1561
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0181 0.0238
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0075 0.026
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.0083 0.0038
Onchocerca volvulus 0.0098 0.0559 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0181 0.2113
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0119 0.069 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0258 0.0258
Mycobacterium ulcerans hypothetical protein 0.0026 0.0096 0.0071
Chlamydia trachomatis cytosol aminopeptidase 0.0119 0.069 1
Mycobacterium ulcerans leucyl aminopeptidase 0.0119 0.069 0.1499
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.0622 0.711
Leishmania major DNA polymerase kappa, putative 0.0092 0.052 0.5807
Echinococcus multilocularis dual specificity 0.0105 0.0605 0.0573
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.047 0.0982
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0083 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0181 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.03 0.0573
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0067 0.0194
Brugia malayi Protein kinase domain containing protein 0.0105 0.0605 0.3762
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0638
Entamoeba histolytica protein kinase, putative 0.0105 0.0605 1
Echinococcus multilocularis pyruvate kinase 0.002 0.0058 0.0024
Brugia malayi mbt repeat family protein 0.0056 0.029 0.1787
Echinococcus multilocularis pyruvate kinase 0.0031 0.0128 0.0094
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0181 0.1117
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0226 0.1381 0.1352
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0116 0.0672 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.008 0.0472
Schistosoma mansoni DNA helicase recq1 0.0023 0.0075 0.0075
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0106 0.0107
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0096 0.1109
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0353 0.2194
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0083 0.0052
Entamoeba histolytica protein kinase, putative 0.0105 0.0605 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0084 0.047 0.047
Echinococcus multilocularis pyruvate kinase 0.002 0.0058 0.0024
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0669 0.4224 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0075 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0116 0.0672 0.7922
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0083 0.0052
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0083 0.02
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0083 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.052 0.5807
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0181 0.207
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0003 0.0041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.0716 0.1573
Echinococcus multilocularis histone acetyltransferase MYST2 0.0064 0.034 0.0307
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0106 0.0093
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.029 0.0257
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0669 0.4224 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0064 0.034 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0454 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Leishmania major DNA polymerase eta, putative 0.0143 0.0847 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0067 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0352 0.3652
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0096 0.1314
Loa Loa (eye worm) oxidoreductase 0.0024 0.0083 0.05
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0083 0.0946
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0454 0.7506
Entamoeba histolytica hypothetical protein 0.0028 0.0106 0.1746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0258 0.0225
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0106 0.0751
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0298 0.2961
Trypanosoma brucei aminopeptidase, putative 0.0024 0.008 0.0167
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0067 0.0402
Leishmania major pyruvate kinase 0.0039 0.0181 0.1464
Brugia malayi mbt repeat family protein 0.0056 0.029 0.1787
Schistosoma mansoni hypothetical protein 0.0391 0.2436 0.2436
Echinococcus granulosus dna polymerase kappa 0.0116 0.0672 0.064
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0106 0.0093
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0083 0.0898
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0083 0.0389
Brugia malayi cytosol aminopeptidase 0.0024 0.008 0.0472
Loa Loa (eye worm) hypothetical protein 0.0061 0.0321 0.1993
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0083 0.05
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0473 0.5575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0025 0.00000000093192
Schistosoma mansoni cpg binding protein 0.007 0.0378 0.0378
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0669 0.4224 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0083 0.0488
Loa Loa (eye worm) hypothetical protein 0.0039 0.0181 0.1117
Echinococcus multilocularis dna polymerase kappa 0.0116 0.0672 0.064
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0454 0.4963
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0067 0.0656
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0064 0.034 0.0307
Brugia malayi follicle stimulating hormone receptor 0.0261 0.16 1
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0096 0.1109
Loa Loa (eye worm) hypothetical protein 0.0061 0.0321 0.1993
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0083 0.05
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0454 0.2816
Entamoeba histolytica deoxycytidyl transferase, putative 0.0084 0.047 0.7769
Chlamydia trachomatis pyruvate kinase 0.0039 0.0181 0.1294
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0119 0.069 0.1499
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0672 0.7751
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0083 0.0898
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.03 0.0573
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0092 0.052 0.5807
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0106 0.144
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.008 0.0046
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.0605 0.6897
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0025 0.00000000093192
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0669 0.4224 1
Plasmodium falciparum M17 leucyl aminopeptidase 0.0119 0.069 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0083 0.0038
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0123 0.0716 0.9761
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0083 0.0038
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0181 0.247
Loa Loa (eye worm) hypothetical protein 0.0105 0.0601 0.3748
Brugia malayi ImpB/MucB/SamB family protein 0.0143 0.0847 0.5279
Echinococcus multilocularis L aminoadipate semialdehyde 0.0098 0.0559 0.0527
Schistosoma mansoni hypothetical protein 0.0391 0.2436 0.2436
Trypanosoma brucei unspecified product 0.0058 0.0302 0.3011
Leishmania major DNA polymerase kappa, putative 0.0026 0.0096 0.0376
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0119 0.069 0.151
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.029 0.0257
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0083 0.0049
Plasmodium falciparum pyruvate kinase 0.0039 0.0181 0.1948
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.0605 0.7133
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.1016
Onchocerca volvulus 0.0082 0.0454 0.7803
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.0083 0.0038
Loa Loa (eye worm) histone methyltransferase 0.002 0.006 0.0357
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0084 0.047 0.0438
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0106 0.0494
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0083 0.0946
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0067 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0083 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.047 0.2916
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.029 0.029
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0181 0.0275
Mycobacterium ulcerans DNA polymerase IV 0.0116 0.0672 0.1454
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0106 0.0494

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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