Detailed information for compound 695417

Basic information

Technical information
  • TDR Targets ID: 695417
  • Name: 1,7-dimethyl-9-(2-methylphenyl)-3-pentyl-7,8- dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • MW: 395.498 | Formula: C22H29N5O2
  • H donors: 0 H acceptors: 3 LogP: 4.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCn1c(=O)n(C)c2c(c1=O)n1CC(C)CN(c1n2)c1ccccc1C
  • InChi: 1S/C22H29N5O2/c1-5-6-9-12-25-20(28)18-19(24(4)22(25)29)23-21-26(13-15(2)14-27(18)21)17-11-8-7-10-16(17)3/h7-8,10-11,15H,5-6,9,12-14H2,1-4H3
  • InChiKey: PLGQDTCGLXFTMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-amyl-1,7-dimethyl-9-(2-methylphenyl)-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.0019 0.0065 0.0914
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0108 0.071 1
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0085 0.0266
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0081 0.0048
Leishmania major DNA polymerase eta, putative 0.0073 0.0459 0.5243
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0081 0.0484
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0081 0.1441
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0313 0.0313
Echinococcus granulosus pyruvate kinase 0.0017 0.0051 0.0018
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0081 0.0928
Schistosoma mansoni DNA helicase recq1 0.002 0.0073 0.0073
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0073 0.004
Schistosoma mansoni hypothetical protein 0.0821 0.5841 0.5841
Giardia lamblia Pyruvate kinase 0.0033 0.0166 0.2588
Plasmodium falciparum DNA repair protein REV1, putative 0.0022 0.0091 0.0602
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0085 0.0513
Mycobacterium ulcerans hypothetical protein 0.0102 0.0664 0.1547
Leishmania major DNA damage repair protein, putative 0.0022 0.0091 0.0335
Mycobacterium ulcerans hypothetical protein 0.0102 0.0664 0.1547
Schistosoma mansoni cpg binding protein 0.0061 0.0369 0.0369
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0081 0.0959
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0072 0.0447 0.0416
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0065 0.0221
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0081 0.0039
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0166 0.1944
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0443 0.2695
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.00000000035922
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0589 0.6974
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0085 0.0504
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0073 0.0436
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0166 0.022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.00000000096324
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0081 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0091 0.108
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0085 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0268 0.0268
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0091 0.108
Chlamydia trachomatis pyruvate kinase 0.0033 0.0166 0.1146
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0267 0.0267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0268 0.0236
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0065 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.00000000096324
Loa Loa (eye worm) hypothetical protein 0.0071 0.0443 0.2689
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0314 0.3987
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0081 0.0959
Loa Loa (eye worm) hypothetical protein 0.0053 0.0314 0.1897
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0278 0.2838
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.0266
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0166 0.1335
Onchocerca volvulus 0.0071 0.0443 0.831
Entamoeba histolytica protein kinase, putative 0.0088 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0443 0.2689
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0073 0.0097
Schistosoma mansoni hypothetical protein 0.034 0.2379 0.2379
Schistosoma mansoni cpg binding protein 0.0061 0.0369 0.0369
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0081 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0268 0.0236
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0065 0.0678
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0166 0.2003
Entamoeba histolytica recQ family helicase, putative 0.002 0.0073 0.1299
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.0266
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0313 0.0281
Echinococcus multilocularis pyruvate kinase 0.0017 0.0051 0.0018
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0081 0.0039
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0051 0.0717
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0081 0.0959
Leishmania major DNA polymerase eta, putative 0.0123 0.0815 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0073 0.1016
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0073 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0635 0.7781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0443 0.0942
Toxoplasma gondii leucyl aminopeptidase LAP 0.0108 0.071 0.991
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0443 0.0978
Plasmodium vivax DNA repair protein REV1, putative 0.0022 0.0091 0.1276
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0085 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0123 0.0815 0.4964
Echinococcus granulosus geminin 0.034 0.2379 0.2353
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0065 0.0678
Loa Loa (eye worm) hypothetical protein 0.0082 0.0517 0.3139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.00000000096324
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0166 0.1335
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.00000000096324
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0073 0.0427
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0081 0.0081
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0073 0.0097
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0003 0.0039
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.056 0.6597
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0314 0.3554
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0065 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0065 0.0772
Schistosoma mansoni cpg binding protein 0.0058 0.0345 0.0345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0065 0.0772
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0166 0.2316
Echinococcus multilocularis dna polymerase eta 0.0123 0.0815 0.0785
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0333 0.3572
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0268 0.0268
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0091 0.0335
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0137 0.1915
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0166 0.1002
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0073 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0443 0.0978
Brugia malayi follicle stimulating hormone receptor 0.0238 0.1641 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0081 0.0204
Trypanosoma cruzi DNA polymerase eta, putative 0.0123 0.0815 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0058 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0447 0.272
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0443 0.7914
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0267 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Giardia lamblia DNA damage repair protein 0.0022 0.0091 0.0895
Loa Loa (eye worm) hypothetical protein 0.0123 0.0815 0.496
Leishmania major DNA polymerase kappa, putative 0.0078 0.0494 0.5713
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0102 0.0664 0.9266
Chlamydia trachomatis cytosol aminopeptidase 0.0108 0.071 1
Echinococcus multilocularis dnaJ subfamily B 0.0821 0.5841 0.5827
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0081 0.0204
Echinococcus multilocularis cpg binding protein 0.0061 0.0369 0.0337
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0085 0.0513
Echinococcus granulosus dnaJ subfamily B 0.0821 0.5841 0.5827
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0081 0.0054
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0081 0.0039
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0443 0.0978
Loa Loa (eye worm) hypothetical protein 0.0053 0.0314 0.1897
Loa Loa (eye worm) hypothetical protein 0.0087 0.0557 0.3382
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0267 0.1611
Echinococcus granulosus dna polymerase kappa 0.0098 0.0635 0.0604
Brugia malayi mbt repeat family protein 0.0047 0.0267 0.1619
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0664 0.156
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0081 0.0204
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0091 0.0335
Onchocerca volvulus 0.0082 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0314 0.1897
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0081 0.0054
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0073 0.0797
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0108 0.071 0.87
Schistosoma mansoni DNA polymerase IV / kappa 0.0022 0.0091 0.0091
Trypanosoma brucei unspecified product 0.005 0.0287 0.2951
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0313 0.0281
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.1017
Loa Loa (eye worm) hypothetical protein 0.0087 0.0557 0.3382
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0081 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0443 0.2695
Echinococcus multilocularis pyruvate kinase 0.0017 0.0051 0.0018
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0095 0.0077
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0085 0.0513
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.00000000096324
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0073 0.004
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0095 0.1397
Schistosoma mansoni ap endonuclease 0.0019 0.0065 0.0065
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0108 0.071 0.1667
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0476
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0443 0.5039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.081 0.081
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0166 0.0273
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0081 0.0054
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0073 0.1016
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0081 0.0928
Echinococcus multilocularis pyruvate kinase 0.0017 0.0051 0.0018
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0081 0.0054
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0073 0.0436
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0078 0.0494 0.5713
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0313 0.0281
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0443 0.0978
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0166 0.1944
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.1611
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0427
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0313 0.1903
Echinococcus multilocularis bloom syndrome protein 0.002 0.0073 0.004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0065 0.1169
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0085 0.0052
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0635 0.1474
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.1285 0.1256
Onchocerca volvulus 0.0047 0.0267 0.4265
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0081 0.0054
Loa Loa (eye worm) hypothetical protein 0.0071 0.0443 0.2689
Leishmania major pyruvate kinase 0.0033 0.0166 0.1335
Schistosoma mansoni DNA helicase recq5 0.002 0.0073 0.0073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0024 0.00000000096324
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0635 0.7781
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0095 0.0395
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0278 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Echinococcus multilocularis leucine aminopeptidase protein 0.0108 0.071 0.0679
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.0266
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0517 0.0517
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0081 0.0204
Brugia malayi mbt repeat family protein 0.0047 0.0267 0.1619
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0556 0.3931 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0095 0.0077
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0314 0.0656
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0443 0.0978
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Echinococcus granulosus dna polymerase eta 0.0123 0.0815 0.0785
Schistosoma mansoni ap endonuclease 0.0019 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0085 0.0052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0345 0.2089
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0081 0.0048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0443 0.0942
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0081 0.0484
Entamoeba histolytica hypothetical protein 0.0023 0.0095 0.1698
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0267 0.0235
Trypanosoma brucei unspecified product 0.005 0.0287 0.2951
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0095 0.134
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0065 0.0922
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0166 0.0993
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0268 0.0268
Echinococcus multilocularis geminin 0.034 0.2379 0.2353
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0098 0.0635 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0095 0.1328
Loa Loa (eye worm) oxidoreductase 0.0021 0.0081 0.0476
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0081 0.0476
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0081 0.0204
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0314 0.0642
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.0266
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0024 0.00000000096324
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0073 0.0459 0.6404
Echinococcus granulosus cpg binding protein 0.0061 0.0369 0.0337
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0556 0.3931 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0081 0.0054
Echinococcus multilocularis dna polymerase kappa 0.0098 0.0635 0.0604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0293 0.0601
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0065 0.0329
Entamoeba histolytica hypothetical protein 0.0088 0.056 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0094 0.1683
Schistosoma mansoni pyruvate kinase 0.0017 0.0051 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.056 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0268 0.0236
Echinococcus multilocularis pyruvate kinase 0.0026 0.0116 0.0083
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0166 0.0259
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.1285 0.1256
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0081 0.0039
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0095 0.0091
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0073 0.0861
Leishmania major DNA polymerase kappa, putative 0.0022 0.0091 0.0335
Brugia malayi CXXC zinc finger family protein 0.0058 0.0345 0.2096
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0081 0.1137
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0072 0.0447 0.0447
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0057 0.0338
Entamoeba histolytica protein kinase, putative 0.0088 0.056 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0556 0.3931 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0073 0.0797
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0635 0.7781
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0081 0.0959
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0081 0.1127
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0081 0.0054
Giardia lamblia DINP protein human, muc B family 0.0078 0.0494 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0166 0.2003
Entamoeba histolytica recQ family DNA helicase 0.001 0.0003 0.0049
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0108 0.071 0.8591
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0313 0.0281
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0081 0.0484
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0088 0.056 0.3402
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0166 0.2333
Schistosoma mansoni DNA polymerase eta 0.0123 0.0815 0.0815
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0517 0.0486
Schistosoma mansoni hypothetical protein 0.034 0.2379 0.2379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0293 0.0601
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0085 0.0052
Treponema pallidum licC protein (licC) 0.0102 0.0664 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0268 0.1619
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0166 0.0993
Echinococcus granulosus dual specificity 0.0088 0.056 0.0529
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0073 0.0436
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0443 0.5039
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0091 0.0335
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0058 0.0025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0072 0.0447 0.0416
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0095 0.1328
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0081 0.0054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0447 0.1001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0065 0.0949
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0268 0.0236
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0166 0.1002
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0095 0.0037
Schistosoma mansoni pyruvate kinase 0.0033 0.0166 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0443 0.0978
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0065 0.0383
Loa Loa (eye worm) hypothetical protein 0.0053 0.0313 0.1896
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.1641 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0314 0.1897
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0085 0.0085
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0081 0.0039
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0443 0.7914
Schistosoma mansoni terminal deoxycytidyl transferase 0.0072 0.0447 0.0447
Schistosoma mansoni pyruvate kinase 0.0033 0.0166 0.0166
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0664 0.156
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.1017
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0095 0.0671
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0081 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0494 0.5713
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0278 0.2838
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0088 0.056 0.6597
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0085 0.0504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0024 0.00000000096324
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0556 0.3931 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0108 0.071 0.1679
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0081 0.0484
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0108 0.071 0.8591
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0081 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.1399 1 1
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0081 0.1127
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0058 0.034
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.056 0.6859
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.056 0.056
Echinococcus multilocularis microtubule associated protein 2 0.1399 1 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0166 0.0133
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0267 0.0235
Brugia malayi polk-prov protein 0.0048 0.0278 0.1689
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0094 0.0559
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0293 0.0601
Loa Loa (eye worm) hypothetical protein 0.0053 0.0314 0.1897
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0065 0.0032
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0095 0.0395
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0091 0.0335
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0003 0.0003
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0051 0.0711
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0091 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0333 0.3572
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0443 0.0991
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0085 0.0052
Onchocerca volvulus 0.0058 0.0345 0.6056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0476
Trypanosoma brucei DNA polymerase eta, putative 0.0123 0.0815 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0267 0.4265
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0333 0.3572
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0314 0.4418
Mycobacterium ulcerans hypothetical protein 0.0071 0.0443 0.0978
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0081 0.0484
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0166 0.1944
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0081 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0716 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0166 0.0133
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0065 0.0391
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0635 0.7596
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.056 0.6859
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0073 0.0332
Leishmania major pyruvate kinase 0.0033 0.0166 0.1335
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0081 0.0039
Echinococcus granulosus pyruvate kinase 0.0017 0.0051 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0443 0.5039
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0443 0.0978
Brugia malayi Protein kinase domain containing protein 0.0088 0.056 0.3408
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0095 0.0077
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0073 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0559
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.0459 0.561
Mycobacterium ulcerans hypothetical protein 0.0022 0.0091 0.0065
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0635 0.7596
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0081 0.0484
Echinococcus granulosus bloom syndrome protein 0.002 0.0073 0.004
Brugia malayi cytosol aminopeptidase 0.0022 0.0085 0.0513
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0081 0.0054
Mycobacterium ulcerans leucyl aminopeptidase 0.0108 0.071 0.1667
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0267 0.0235
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0073 0.0797
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0166 0.2312
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0091 0.108
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0517 0.3145
Plasmodium falciparum pyruvate kinase 0.0033 0.0166 0.174
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.0635 0.1474
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0267 0.0267
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0085 0.0266
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0108 0.071 0.87
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0108 0.071 0.1634
Trypanosoma brucei unspecified product 0.0091 0.0589 0.6974
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0078 0.0494 0.1121
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0102 0.0664 0.1547
Echinococcus multilocularis dual specificity 0.0088 0.056 0.0529
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0072 0.0447 0.2713
Trypanosoma brucei chrX additional, unordered contigs 0.0022 0.0091 0.0335
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0635 0.7596
Echinococcus multilocularis pyruvate kinase 0.0033 0.0166 0.0133
Loa Loa (eye worm) MBCTL1 0.0053 0.0313 0.1896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0293 0.0601
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0517 0.0486
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0081 0.0476
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0073 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0091 0.108
Echinococcus multilocularis pyruvate kinase 0.0033 0.0166 0.0133
Loa Loa (eye worm) hypothetical protein 0.0033 0.0166 0.0993
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0081 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0443 0.2695
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0443 0.0991
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0166 0.0993
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0268 0.1626
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0003 0.0039
Plasmodium falciparum M17 leucyl aminopeptidase 0.0108 0.071 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0443 0.7914
Loa Loa (eye worm) RecQ helicase 0.002 0.0073 0.0427
Echinococcus granulosus pyruvate kinase 0.0017 0.0051 0.0018
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0085 0.0085
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0166 0.2316
Trichomonas vaginalis DNA polymerase eta, putative 0.0098 0.0635 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0072 0.0447 0.7986
Echinococcus granulosus leucine aminopeptidase protein 0.0108 0.071 0.0679
Schistosoma mansoni hypothetical protein 0.0288 0.2005 0.2005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.0635 0.7781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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