Detailed information for compound 695452

Basic information

Technical information
  • TDR Targets ID: 695452
  • Name: 9-(3-chloro-2-methylphenyl)-1,3-dimethyl-7,8- dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • MW: 359.81 | Formula: C17H18ClN5O2
  • H donors: 0 H acceptors: 3 LogP: 2.64 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1C)N1CCCn2c1nc1c2c(=O)n(c(=O)n1C)C
  • InChi: 1S/C17H18ClN5O2/c1-10-11(18)6-4-7-12(10)22-8-5-9-23-13-14(19-16(22)23)20(2)17(25)21(3)15(13)24/h4,6-7H,5,8-9H2,1-3H3
  • InChiKey: ANCUYFWKXRYESX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-(3-chloro-2-methyl-phenyl)-1,3-dimethyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • 9-(3-chloro-2-methyl-phenyl)-1,3-dimethyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone
  • STOCK5S-84773
  • BAS 12521552

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0336 0.3579
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.009 0.0309
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0272 0.1685
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0118 0.069 0.8436
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.011 0.0642 0.7657
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0067 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0282 0.2862
Echinococcus multilocularis leucine aminopeptidase protein 0.0118 0.069 0.0661
Schistosoma mansoni cpg binding protein 0.0064 0.0343 0.0343
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0075 0.0358
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0075 0.0512
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.008 0.0049
Toxoplasma gondii exonuclease III APE 0.0021 0.0067 0.094
Echinococcus multilocularis pyruvate kinase 0.0019 0.0052 0.0021
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0527 0.0498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0258 0.161
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0272 0.0242
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.1311 0.1283
Schistosoma mansoni pyruvate kinase 0.0037 0.0169 0.0169
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.1311 0.1283
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0075 0.0358
Schistosoma mansoni cpg binding protein 0.0068 0.0366 0.0366
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1123
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1123
Leishmania major DNA polymerase eta, putative 0.0082 0.0458 0.5205
Mycobacterium ulcerans DNA polymerase IV 0.011 0.0642 0.1457
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.008 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Loa Loa (eye worm) histone methyltransferase 0.002 0.0056 0.0336
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0075 0.0449
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0494
Loa Loa (eye worm) hypothetical protein 0.006 0.0315 0.1951
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Loa Loa (eye worm) hypothetical protein 0.0099 0.0568 0.3539
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0258 0.0228
Loa Loa (eye worm) hypothetical protein 0.006 0.0315 0.1951
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0445 0.5039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0445 0.0977
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000097321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0258 0.0258
Plasmodium falciparum acyl-CoA synthetase 0.006 0.0315 0.4117
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0445 0.0959
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0169 0.1981
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0099 0.0571 0.6721
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0258 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.009 0.1073
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0293 0.0593
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0174
Schistosoma mansoni hypothetical protein 0.0913 0.5828 0.5828
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0484
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.006 0.0315 0.367
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Mycobacterium ulcerans leucyl aminopeptidase 0.0118 0.069 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0075 0.088
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0052 0.0749
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0174
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.1045
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0445 0.7791
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000097321
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0003 0.0003
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0174
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0118 0.069 0.1552
Echinococcus multilocularis pyruvate kinase 0.0019 0.0052 0.0021
Loa Loa (eye worm) hypothetical protein 0.0093 0.0527 0.3284
Onchocerca volvulus 0.008 0.0445 0.8162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0677 0.1564
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0169 0.1354
Schistosoma mansoni pyruvate kinase 0.0019 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0282 0.2862
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.1038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0494
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0067 0.1174
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.16 1
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0445 0.5039
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0169 0.0278
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0169 0.0225
Chlamydia trachomatis pyruvate kinase 0.0037 0.0169 0.1211
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.0571 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0258 0.0228
Echinococcus granulosus pyruvate kinase 0.0019 0.0052 0.0021
Schistosoma mansoni hypothetical protein 0.0378 0.2372 0.2372
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0118 0.069 0.158
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.0458 0.5583
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0445 0.0959
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0293 0.0593
Plasmodium falciparum pyruvate kinase 0.0037 0.0169 0.1833
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0067 0.0413
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.1045
Brugia malayi ImpB/MucB/SamB family protein 0.0138 0.0817 0.5105
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0527 0.0527
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0169 0.2365
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0075 0.0845
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0173
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0097 0.1358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0293 0.0593
Entamoeba histolytica protein kinase, putative 0.0099 0.0571 1
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0445 0.0977
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0258 0.0258
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0445 0.0959
Trypanosoma brucei unspecified product 0.0056 0.0288 0.2946
Echinococcus granulosus dna polymerase eta 0.0138 0.0817 0.0789
Echinococcus granulosus cpg binding protein 0.0068 0.0366 0.0336
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Echinococcus granulosus pyruvate kinase 0.0037 0.0169 0.0138
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0067 0.0953
Onchocerca volvulus 0.0093 0.0527 1
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0116 0.0677 0.1546
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0445 0.7791
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0272 0.4291
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0484
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0935
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0097 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.009 0.009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0445 0.0929
Loa Loa (eye worm) hypothetical protein 0.006 0.0315 0.1951
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.045 0.0989
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0067 0.0241
Mycobacterium ulcerans DNA polymerase IV 0.011 0.0642 0.1457
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0056 0.0025
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.032 0.0289
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0118 0.069 0.8303
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0088 0.0498 0.111
Brugia malayi AMP-binding enzyme family protein 0.008 0.0445 0.2777
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.009 0.1265
Loa Loa (eye worm) hypothetical protein 0.0061 0.032 0.1983
Mycobacterium ulcerans hypothetical protein 0.0116 0.0677 0.1546
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.0498 0.5737
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Schistosoma mansoni DNA helicase recq5 0.0023 0.0075 0.0075
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0081 0.045 0.28
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0272 0.0272
Echinococcus multilocularis dual specificity 0.0099 0.0571 0.0542
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0445 0.7791
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.008 0.0049
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0075 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.0594 0.7023
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0484
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.008 0.0033
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0075 0.01
Mycobacterium ulcerans hypothetical protein 0.0025 0.009 0.0059
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0527 0.0498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0583
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0099 0.0571 0.3559
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0935
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.032 0.1992
Loa Loa (eye worm) hypothetical protein 0.0055 0.0282 0.1747
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0067 0.0036
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0097 0.0096
Echinococcus granulosus dnaJ subfamily B 0.0913 0.5828 0.5815
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0067 0.0036
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.009 0.1308
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0075 0.0459
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0097 0.0397
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.008 0.008
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0949
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0445 0.5039
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0097 0.0397
Schistosoma mansoni pyruvate kinase 0.0037 0.0169 0.0169
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.0445 0.2769
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0003 0.005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0067 0.0972
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0075 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0571 0.0571
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0097 0.0075
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0169 0.2036
Brugia malayi mbt repeat family protein 0.0053 0.0272 0.1694
Echinococcus multilocularis dnaJ subfamily B 0.0913 0.5828 0.5815
Leishmania major DNA damage repair protein, putative 0.0025 0.009 0.0309
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0075 0.0043
Trichomonas vaginalis DNA polymerase eta, putative 0.011 0.0642 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0003 0.004
Mycobacterium ulcerans hypothetical protein 0.0116 0.0677 0.1546
Trypanosoma brucei unspecified product 0.0056 0.0288 0.2946
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0138 0.1932
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0075 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0258 0.1601
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0174
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0118 0.069 0.1597
Trypanosoma brucei DNA polymerase eta, putative 0.0138 0.0817 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0081 0.045 0.042
Brugia malayi mbt repeat family protein 0.0053 0.0272 0.1694
Trypanosoma cruzi DNA polymerase eta, putative 0.0138 0.0817 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0052 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0081 0.045 0.045
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0632 0.4011 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.008 0.0495
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0082 0.0458 0.6418
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0677 0.1564
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0053
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0948
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000097321
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.008 0.0033
Leishmania major DNA polymerase eta, putative 0.0138 0.0817 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0067 0.0788
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0096 0.1679
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1401
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0075 0.0043
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0088 0.0498 0.5737
Echinococcus granulosus leucine aminopeptidase protein 0.0118 0.069 0.0661
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0097 0.0075
Loa Loa (eye worm) hypothetical protein 0.0138 0.0817 0.51
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0948
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0336 0.3579
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0642 0.7657
Echinococcus multilocularis dna polymerase eta 0.0138 0.0817 0.0789
Loa Loa (eye worm) RecQ helicase 0.0023 0.0075 0.0449
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0169 0.1038
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0445
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0632 0.4011 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0169 0.2036
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0169 0.1981
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0632 0.4011 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000097321
Leishmania major DNA polymerase kappa, putative 0.0025 0.009 0.0309
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0053
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0118 0.069 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.009 0.1073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000097321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0031 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0642 0.7842
Loa Loa (eye worm) hypothetical protein 0.006 0.0315 0.1951
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0097 0.1403
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0484
Echinococcus granulosus geminin 0.0378 0.2372 0.2348
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0642 0.7842
Echinococcus granulosus dna polymerase kappa 0.011 0.0642 0.0612
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0118 0.069 0.8436
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0075 0.0845
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0484
Echinococcus granulosus bloom syndrome protein 0.0023 0.0075 0.0043
Schistosoma mansoni DNA helicase recq1 0.0023 0.0075 0.0075
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.00000000097321
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0169 0.1354
Schistosoma mansoni microtubule-associated protein tau 0.1558 1 1
Entamoeba histolytica hypothetical protein 0.0099 0.0571 1
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0445 0.0959
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.009 0.0309
Loa Loa (eye worm) hypothetical protein 0.0053 0.0272 0.1685
Giardia lamblia DNA damage repair protein 0.0025 0.009 0.0865
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0097 0.1358
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0099 0.0571 0.6979
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0272 0.0242
Echinococcus granulosus pyruvate kinase 0.0037 0.0169 0.0138
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000097321
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Schistosoma mansoni ap endonuclease 0.0021 0.0067 0.0067
Echinococcus multilocularis pyruvate kinase 0.0037 0.0169 0.0138
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0174
Brugia malayi AMP-binding enzyme family protein 0.008 0.0445 0.2777
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.009 0.1073
Brugia malayi polk-prov protein 0.0055 0.0282 0.1756
Echinococcus multilocularis pyruvate kinase 0.0029 0.0118 0.0087
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0067 0.0788
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.008 0.0484
Giardia lamblia Pyruvate kinase 0.0037 0.0169 0.2624
Leishmania major pyruvate kinase 0.0037 0.0169 0.1354
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0169 0.1048
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0097 0.1394
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.0459
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0118 0.069 0.8303
Brugia malayi follicle stimulating hormone receptor 0.0259 0.16 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0445 0.2769
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0075 0.0043
Brugia malayi CXXC zinc finger family protein 0.0064 0.0343 0.2136
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0272 0.0242
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.032 0.032
Brugia malayi cytosol aminopeptidase 0.0023 0.008 0.0495
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Entamoeba histolytica protein kinase, putative 0.0099 0.0571 1
Brugia malayi Protein kinase domain containing protein 0.0099 0.0571 0.3567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0258 0.0228
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0169 0.1981
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0272 0.0272
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0075 0.0459
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.008 0.0484
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.009 0.0309
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.116
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0096 0.0583
Schistosoma mansoni terminal deoxycytidyl transferase 0.0081 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.006 0.0315 0.1951
Schistosoma mansoni cpg binding protein 0.0068 0.0366 0.0366
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0033
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0527 0.3291
Echinococcus multilocularis pyruvate kinase 0.0019 0.0052 0.0021
Schistosoma mansoni leucine aminopeptidase 0.0023 0.008 0.008
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.008 0.0495
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0445 0.0959
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.008 0.0033
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0445 0.0959
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0055 0.0336
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0052 0.0725
Onchocerca volvulus 0.0053 0.0272 0.4291
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0272 0.0272
Brugia malayi AMP-binding enzyme family protein 0.008 0.0445 0.2777
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0097 0.0707
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0343 0.2127
Giardia lamblia DINP protein human, muc B family 0.0088 0.0498 1
Schistosoma mansoni ap endonuclease 0.0021 0.0067 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0067 0.0725
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0049
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0445 0.0959
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.00000000037742
Echinococcus multilocularis pyruvate kinase 0.0037 0.0169 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.009 0.0309
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0642 0.7842
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.032 0.0289
Echinococcus multilocularis dna polymerase kappa 0.011 0.0642 0.0612
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.008 0.0049
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0713 1
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0169 0.0258
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0169 0.2365
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0075 0.0845
Plasmodium vivax acyl-CoA synthetase, putative 0.006 0.0315 0.4558
Mycobacterium ulcerans hypothetical protein 0.008 0.0445 0.0959
Echinococcus multilocularis geminin 0.0378 0.2372 0.2348
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.008 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0067 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0067 0.0725
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0003 0.0041
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1123
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0056 0.0025
Toxoplasma gondii leucyl aminopeptidase LAP 0.0118 0.069 0.9677
Trypanosoma brucei aminopeptidase, putative 0.0023 0.008 0.0174
Loa Loa (eye worm) MBCTL1 0.0061 0.032 0.1983
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0272 0.0242
Echinococcus granulosus pyruvate kinase 0.0019 0.0052 0.0021
Echinococcus granulosus dual specificity 0.0099 0.0571 0.0542
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0097 0.0043
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0099 0.0571 0.6979
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.009 0.1073
Chlamydia trachomatis cytosol aminopeptidase 0.0118 0.069 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0081 0.045 0.7876
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0169 0.1048
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0445 0.0929
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0336 0.3579
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0075 0.1304
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0173
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.009 0.0604
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.009 0.0309
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.006 0.0315 0.0647
Leishmania major DNA polymerase kappa, putative 0.0088 0.0498 0.5737
Schistosoma mansoni DNA polymerase eta 0.0138 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0099 0.0568 0.3539
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0169 0.1038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0258 0.0258
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.011 0.0642 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0081 0.045 0.042
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0169 0.2365
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.032 0.0289
Trypanosoma brucei unspecified product 0.0103 0.0594 0.7023
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.032 0.0289
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0449
Onchocerca volvulus 0.0064 0.0343 0.5868
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0632 0.4011 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0169 0.1038
Schistosoma mansoni hypothetical protein 0.0328 0.2046 0.2046
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0169 0.2444
Echinococcus multilocularis microtubule associated protein 2 0.1558 1 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0099 0.0571 0.6721
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.008 0.0495
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.045 0.2808
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0116 0.0677 0.9493
Leishmania major pyruvate kinase 0.0037 0.0169 0.1354
Schistosoma mansoni hypothetical protein 0.0378 0.2372 0.2372
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Loa Loa (eye worm) hypothetical protein 0.008 0.0445 0.2769
Treponema pallidum licC protein (licC) 0.0116 0.0677 1
Entamoeba histolytica hypothetical protein 0.0026 0.0097 0.1694
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0642 0.7842
Mycobacterium ulcerans fatty-acid-CoA ligase 0.006 0.0315 0.0627
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.008 0.0033
Plasmodium falciparum M17 leucyl aminopeptidase 0.0118 0.069 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0067 0.0345
Echinococcus multilocularis cpg binding protein 0.0068 0.0366 0.0336
Trypanosoma brucei DNA polymerase IV, putative 0.011 0.0642 0.7657
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.00000000097321
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0293 0.0593

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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