Detailed information for compound 695506

Basic information

Technical information
  • TDR Targets ID: 695506
  • Name: 1-(9-bromo-2-thiophen-2-ylspiro[1,10b-dihydro pyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidi ne]-1'-yl)ethanone
  • MW: 446.361 | Formula: C20H20BrN3O2S
  • H donors: 0 H acceptors: 1 LogP: 3.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)C1CC(=NN1C1(O2)CCN(CC1)C(=O)C)c1cccs1
  • InChi: 1S/C20H20BrN3O2S/c1-13(25)23-8-6-20(7-9-23)24-17(12-16(22-24)19-3-2-10-27-19)15-11-14(21)4-5-18(15)26-20/h2-5,10-11,17H,6-9,12H2,1H3
  • InChiKey: DCJREUJXFBEADT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[9-bromo-2-(2-thienyl)spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]-1'-yl]ethanone
  • 1-[9-bromo-2-(2-thienyl)-1'-spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]yl]ethanone
  • 1-(9-bromo-2-thiophen-2-yl-spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]-1'-yl)ethanone
  • STOCK3S-91295

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Echinococcus granulosus dnaJ subfamily B 0.0868 0.5834 0.5821
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0557
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0268 0.0268
Echinococcus granulosus pyruvate kinase 0.0035 0.0165 0.0133
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0095 0.067
Onchocerca volvulus 0.0049 0.0266 0.4262
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0081 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trypanosoma brucei unspecified product 0.0052 0.0286 0.2948
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0137 0.1912
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0108 0.0662 0.1547
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0081 0.0048
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.071 0.167
Leishmania major DNA polymerase eta, putative 0.013 0.0814 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.013 0.0814 0.4958
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0266 0.0234
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.0447 0.799
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1079
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0095 0.0091
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0516 0.0485
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0081 0.1127
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.1018
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0587 0.6971
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0081 0.0039
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.05
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0427
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0313 0.0281
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0559 0.6854
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0095 0.0076
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0095 0.0037
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Schistosoma mansoni hypothetical protein 0.0868 0.5834 0.5834
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1079
Schistosoma mansoni ap endonuclease 0.002 0.0065 0.0065
Brugia malayi polk-prov protein 0.0051 0.0278 0.1687
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0065 0.0383
Echinococcus granulosus dual specificity 0.0092 0.0559 0.0528
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0443 0.5042
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.093
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0165 0.2
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0065 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0443 0.2695
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.009 0.009
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0801
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0959
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.0447 0.0447
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0065 0.0033
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.071 0.0679
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0083 0.0493 0.571
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0313 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.0447 0.0415
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0081 0.0054
Leishmania major DNA polymerase kappa, putative 0.0083 0.0493 0.571
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0662 0.1559
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Onchocerca volvulus 0.0075 0.0443 0.8326
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.009 0.0332
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0313 0.19
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0443 0.0943
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0268 0.1618
Entamoeba histolytica hypothetical protein 0.0092 0.0559 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0443 0.0979
Trichomonas vaginalis DNA polymerase eta, putative 0.0104 0.0634 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Entamoeba histolytica protein kinase, putative 0.0092 0.0559 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Entamoeba histolytica hypothetical protein 0.0024 0.0095 0.1696
Schistosoma mansoni ap endonuclease 0.002 0.0065 0.0065
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0165 0.194
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0863
Schistosoma mansoni cpg binding protein 0.0064 0.0368 0.0368
Trypanosoma brucei DNA polymerase eta, putative 0.013 0.0814 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0266 0.0266
Trypanosoma brucei unspecified product 0.0052 0.0286 0.2948
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0443 0.0979
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0085 0.0053
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0443 0.7926
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0266 0.0266
Onchocerca volvulus 0.0086 0.0516 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0662 0.1559
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0443 0.2695
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0095 0.0076
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0095 0.1336
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0081 0.1442
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0959
Leishmania major pyruvate kinase 0.0035 0.0165 0.133
Loa Loa (eye worm) hypothetical protein 0.0051 0.0278 0.1678
Schistosoma mansoni pyruvate kinase 0.0018 0.0051 0.0051
Brugia malayi mbt repeat family protein 0.0049 0.0266 0.1616
Echinococcus multilocularis dual specificity 0.0092 0.0559 0.0528
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0165 0.0991
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0165 0.194
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0065 0.0033
Schistosoma mansoni pyruvate kinase 0.0035 0.0165 0.0165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.1641 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0443 0.0992
Echinococcus multilocularis dna polymerase eta 0.013 0.0814 0.0784
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0165 0.0273
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0065 0.0923
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0458 0.561
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0051 0.0714
Echinococcus multilocularis geminin 0.036 0.2376 0.2351
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0715 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0443 0.0992
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0475
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0634 0.7592
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0991
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0516 0.3139
Loa Loa (eye worm) hypothetical protein 0.0049 0.0266 0.1608
Echinococcus multilocularis dnaJ subfamily B 0.0868 0.5834 0.5821
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0809 0.0809
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0475
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Leishmania major DNA damage repair protein, putative 0.0024 0.009 0.0332
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0443 0.0979
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.071 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0081 0.0485
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0313 0.3555
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0108 0.0662 0.9256
Echinococcus multilocularis pyruvate kinase 0.0035 0.0165 0.0133
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0443 0.7926
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.071 0.9919
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0516 0.0516
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Loa Loa (eye worm) oxidoreductase 0.0022 0.0081 0.0475
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0959
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0085 0.0504
Leishmania major DNA polymerase eta, putative 0.0078 0.0458 0.5242
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0634 0.1474
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0559 0.659
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0085 0.0514
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0313 0.0281
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0959
Brugia malayi cytosol aminopeptidase 0.0023 0.0085 0.0514
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0057 0.0338
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0081 0.0039
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0081 0.0054
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0313 0.3986
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0075 0.0443 0.2687
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0443 0.0979
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0313 0.0642
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0266 0.4262
Entamoeba histolytica protein kinase, putative 0.0092 0.0559 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0443 0.5042
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0165 0.2
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0095 0.1395
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0266 0.0234
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.071 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0333 0.3569
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0801
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.0336
Toxoplasma gondii exonuclease III APE 0.002 0.0065 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0278 0.2834
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.071 0.1637
Schistosoma mansoni cpg binding protein 0.0061 0.0345 0.0345
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0085 0.0504
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0065 0.0681
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1282 0.1253
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1282 0.1253
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0165 0.022
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Echinococcus multilocularis cpg binding protein 0.0064 0.0368 0.0336
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0268 0.1627
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0516 0.0485
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0266 0.1608
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0559 0.0559
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0081 0.1136
Echinococcus multilocularis microtubule associated protein 2 0.1481 1 1
Echinococcus granulosus pyruvate kinase 0.0035 0.0165 0.0133
Loa Loa (eye worm) hypothetical protein 0.0075 0.0443 0.2687
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.1018
Schistosoma mansoni hypothetical protein 0.036 0.2376 0.2376
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0165 0.2314
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.0447 0.0415
Mycobacterium ulcerans hypothetical protein 0.0108 0.0662 0.1547
Echinococcus granulosus cpg binding protein 0.0064 0.0368 0.0336
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1892
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0085 0.0514
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.071 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0065 0.0335
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0094 0.1681
Mycobacterium ulcerans hypothetical protein 0.0108 0.0662 0.1547
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0634 0.7592
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000096512
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0332
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0095 0.1325
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0333 0.3569
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.0447 0.2709
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.071 0.0679
Mycobacterium ulcerans hypothetical protein 0.0075 0.0443 0.0979
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Leishmania major pyruvate kinase 0.0035 0.0165 0.133
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0083 0.0493 0.1122
Echinococcus granulosus dna polymerase eta 0.013 0.0814 0.0784
Brugia malayi Protein kinase domain containing protein 0.0092 0.0559 0.3401
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0085 0.0085
Trypanosoma brucei unspecified product 0.0097 0.0587 0.6971
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0165 0.1
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0313 0.4415
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.0447 0.0447
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0165 0.194
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0266 0.0234
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0104 0.0634 1
Schistosoma mansoni hypothetical protein 0.0305 0.2001 0.2001
Plasmodium falciparum pyruvate kinase 0.0035 0.0165 0.1736
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0345 0.2086
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0587 0.3923 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0081 0.0054
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0081 0.0081
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.004
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.071 0.8602
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0165 0.0991
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0634 0.1474
Loa Loa (eye worm) MBCTL1 0.0056 0.0313 0.1892
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0332
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0165 0.0991
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0065 0.1172
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0065 0.0773
Schistosoma mansoni hypothetical protein 0.036 0.2376 0.2376
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0075 0.0443 0.2687
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0165 0.2326
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0081 0.0054
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.004
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0339
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.071 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0559 0.659
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0095 0.0076
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0064
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0051 0.0708
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0092 0.0556 0.3375
Schistosoma mansoni cpg binding protein 0.0064 0.0368 0.0368
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0447 0.1001
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0313 0.0281
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.009 0.1273
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0391
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0085 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0443 0.0979
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0081 0.0039
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0081 0.0455
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0443 0.5042
Loa Loa (eye worm) hypothetical protein 0.0086 0.0516 0.3132
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Brugia malayi CXXC zinc finger family protein 0.0061 0.0345 0.2094
Giardia lamblia DNA damage repair protein 0.0024 0.009 0.0897
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0443 0.0943
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0268 0.0236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0268 0.0236
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0443 0.0979
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000035938
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0065 0.0773
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0081 0.1127
Giardia lamblia DINP protein human, muc B family 0.0083 0.0493 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0065 0.0225
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0065 0.0392
Echinococcus multilocularis pyruvate kinase 0.0027 0.0116 0.0083
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.071 0.8711
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0081 0.0048
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.009 0.1263
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0165 0.133
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0165 0.2314
Echinococcus multilocularis pyruvate kinase 0.0035 0.0165 0.0133
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0313 0.0657
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0268 0.0236
Onchocerca volvulus 0.0061 0.0345 0.6063
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0085 0.0514
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1302
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0443 0.2695
Brugia malayi follicle stimulating hormone receptor 0.0252 0.1641 1
Schistosoma mansoni pyruvate kinase 0.0035 0.0165 0.0165
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0266 0.0234
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0085 0.0053
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Brugia malayi mbt repeat family protein 0.0049 0.0266 0.1616
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0559 0.3395
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0559 0.6854
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0081 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0475
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0085 0.0053
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0095 0.1325
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0268 0.0236
Leishmania major DNA polymerase kappa, putative 0.0024 0.009 0.0332
Loa Loa (eye worm) hypothetical protein 0.0092 0.0556 0.3375
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0443 0.0979
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0165 0.1
Schistosoma mansoni microtubule-associated protein tau 0.1481 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0559 1
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0085 0.0266
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0065 0.0681
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0165 0.0258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0268 0.0268
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000096512
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0278 0.2834
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0165 0.133
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0443 0.7926
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0332
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0165 0.2307
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0801
Chlamydia trachomatis pyruvate kinase 0.0035 0.0165 0.1143
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0587 0.3923 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.071 0.8602
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0475
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0095 0.0391
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0094 0.0557
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0427
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0587 0.3923 1
Giardia lamblia Pyruvate kinase 0.0035 0.0165 0.2586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0039
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0313 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0081 0.0039
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0085 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0033 0.0033
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0081 0.0485
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.093
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.071 0.8711
Echinococcus granulosus dna polymerase kappa 0.0104 0.0634 0.0603
Echinococcus multilocularis dna polymerase kappa 0.0104 0.0634 0.0603
Echinococcus granulosus geminin 0.036 0.2376 0.2351
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.0336
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1079
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Treponema pallidum licC protein (licC) 0.0108 0.0662 1
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0081 0.1127
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0078 0.0458 0.6402
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0447 0.2716
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0587 0.3923 1
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0085 0.0053
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0493 0.571
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1079
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.071 0.167
Trypanosoma cruzi DNA polymerase eta, putative 0.013 0.0814 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0065 0.0951
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0081 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Schistosoma mansoni DNA polymerase eta 0.013 0.0814 0.0814
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0081 0.0039
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.009 0.0602
Loa Loa (eye worm) hypothetical protein 0.013 0.0814 0.4953
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0333 0.3569
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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