Detailed information for compound 695506

Basic information

Technical information
  • TDR Targets ID: 695506
  • Name: 1-(9-bromo-2-thiophen-2-ylspiro[1,10b-dihydro pyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidi ne]-1'-yl)ethanone
  • MW: 446.361 | Formula: C20H20BrN3O2S
  • H donors: 0 H acceptors: 1 LogP: 3.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)C1CC(=NN1C1(O2)CCN(CC1)C(=O)C)c1cccs1
  • InChi: 1S/C20H20BrN3O2S/c1-13(25)23-8-6-20(7-9-23)24-17(12-16(22-24)19-3-2-10-27-19)15-11-14(21)4-5-18(15)26-20/h2-5,10-11,17H,6-9,12H2,1H3
  • InChiKey: DCJREUJXFBEADT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[9-bromo-2-(2-thienyl)spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]-1'-yl]ethanone
  • 1-[9-bromo-2-(2-thienyl)-1'-spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]yl]ethanone
  • 1-(9-bromo-2-thiophen-2-yl-spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]-1'-yl)ethanone
  • STOCK3S-91295

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0268 0.1627
Loa Loa (eye worm) hypothetical protein 0.0051 0.0278 0.1678
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Loa Loa (eye worm) oxidoreductase 0.0022 0.0081 0.0475
Echinococcus multilocularis microtubule associated protein 2 0.1481 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0081 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.1481 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0556 0.3375
Entamoeba histolytica protein kinase, putative 0.0092 0.0559 1
Echinococcus granulosus pyruvate kinase 0.0035 0.0165 0.0133
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0095 0.0076
Onchocerca volvulus 0.0061 0.0345 0.6063
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0475
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0065 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0313 0.0657
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.009 0.1263
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.1018
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0085 0.0514
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0443 0.7926
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0333 0.3569
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0443 0.5042
Trypanosoma brucei DNA polymerase eta, putative 0.013 0.0814 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0266 0.0266
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0313 0.19
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0333 0.3569
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0165 0.022
Toxoplasma gondii exonuclease III APE 0.002 0.0065 0.0915
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0559 0.6854
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0475
Echinococcus multilocularis pyruvate kinase 0.0035 0.0165 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.071 0.8602
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0095 0.1325
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.0336
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.071 0.8602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0268 0.0268
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0081 0.0039
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0085 0.0053
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0165 0.2314
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0427
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0085 0.0504
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0165 0.2307
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0443 0.5042
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0051 0.0714
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0081 0.0485
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0443 0.7926
Entamoeba histolytica hypothetical protein 0.0024 0.0095 0.1696
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0559 0.659
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0095 0.0076
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1302
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0078 0.0458 0.6402
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0083 0.0493 0.1122
Trypanosoma brucei DNA polymerase IV, putative 0.0097 0.0587 0.6971
Treponema pallidum licC protein (licC) 0.0108 0.0662 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.0447 0.0447
Echinococcus multilocularis dual specificity 0.0092 0.0559 0.0528
Schistosoma mansoni pyruvate kinase 0.0035 0.0165 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0634 0.7592
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.1018
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0165 0.0991
Loa Loa (eye worm) hypothetical protein 0.0086 0.0516 0.3132
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0094 0.0557
Brugia malayi mbt repeat family protein 0.0049 0.0266 0.1616
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0715 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.071 0.1637
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0165 0.133
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0165 0.2
Trypanosoma brucei unspecified product 0.0052 0.0286 0.2948
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0081 0.0081
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0516 0.0485
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.0447 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Schistosoma mansoni hypothetical protein 0.0305 0.2001 0.2001
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.071 0.0679
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0443 0.5042
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0443 0.2695
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0081 0.0039
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0165 0.133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0268 0.0236
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.071 1
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0443 0.2695
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0437
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0165 0.0991
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0085 0.0053
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0051 0.0708
Schistosoma mansoni DNA polymerase eta 0.013 0.0814 0.0814
Brugia malayi CXXC zinc finger family protein 0.0061 0.0345 0.2094
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0095 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0065 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0443 0.0979
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0081 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0095 0.067
Giardia lamblia DNA damage repair protein 0.0024 0.009 0.0897
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0268 0.0236
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0587 0.3923 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0443 0.0979
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0081 0.0039
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0587 0.3923 1
Echinococcus granulosus cpg binding protein 0.0064 0.0368 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Leishmania major DNA polymerase eta, putative 0.0078 0.0458 0.5242
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0081 0.1136
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0065 0.0383
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0959
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0266 0.0234
Trypanosoma brucei unspecified product 0.0052 0.0286 0.2948
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0095 0.1336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0268 0.0236
Schistosoma mansoni hypothetical protein 0.036 0.2376 0.2376
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0165 0.1
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0475
Echinococcus multilocularis pyruvate kinase 0.0027 0.0116 0.0083
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0266 0.0234
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1282 0.1253
Schistosoma mansoni pyruvate kinase 0.0035 0.0165 0.0165
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0104 0.0634 1
Schistosoma mansoni cpg binding protein 0.0061 0.0345 0.0345
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0332
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0391
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0065 0.0773
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0634 0.1474
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0064
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0559 0.659
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Brugia malayi Protein kinase domain containing protein 0.0092 0.0559 0.3401
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0493 0.571
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0081 0.1127
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0165 0.0991
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000035938
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0313 0.4415
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.071 0.0679
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0559 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0057 0.0338
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0447 0.2716
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0081 0.0039
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0587 0.3923 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0801
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0959
Trypanosoma cruzi DNA polymerase kappa, putative 0.0104 0.0634 0.7778
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0662 0.1559
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0268 0.0236
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0081 0.0485
Trypanosoma cruzi DNA polymerase eta, putative 0.013 0.0814 1
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0165 0.2314
Entamoeba histolytica hypothetical protein 0.0092 0.0559 1
Onchocerca volvulus 0.0086 0.0516 1
Schistosoma mansoni hypothetical protein 0.036 0.2376 0.2376
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1079
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0268 0.1618
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0065 0.1172
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0959
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.0447 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0094 0.1681
Leishmania major pyruvate kinase 0.0035 0.0165 0.133
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0165 0.1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0559 0.6854
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0081 0.1127
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0085 0.0504
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0443 0.0992
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0447 0.1001
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0339
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Onchocerca volvulus 0.0075 0.0443 0.8326
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0165 0.2326
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0065 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0443 0.7926
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.1641 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0313 0.0313
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000096512
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0587 0.3923 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0081 0.0039
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.071 0.8711
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.071 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.0447 0.0415
Plasmodium falciparum pyruvate kinase 0.0035 0.0165 0.1736
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.009 0.0602
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.093
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0085 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0278 0.2834
Trypanosoma brucei DNA polymerase IV, putative 0.0104 0.0634 0.7592
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0083 0.0493 0.571
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0108 0.0662 0.9256
Echinococcus granulosus dual specificity 0.0092 0.0559 0.0528
Loa Loa (eye worm) hypothetical protein 0.0075 0.0443 0.2687
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0165 0.0258
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0801
Brugia malayi follicle stimulating hormone receptor 0.0252 0.1641 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0165 0.2
Echinococcus multilocularis dna polymerase eta 0.013 0.0814 0.0784
Brugia malayi cytosol aminopeptidase 0.0023 0.0085 0.0514
Onchocerca volvulus 0.0049 0.0266 0.4262
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0333 0.3569
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0137 0.1912
Echinococcus multilocularis dnaJ subfamily B 0.0868 0.5834 0.5821
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Schistosoma mansoni cpg binding protein 0.0064 0.0368 0.0368
Echinococcus granulosus dnaJ subfamily B 0.0868 0.5834 0.5821
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0332
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.0447 0.2709
Echinococcus granulosus dna polymerase eta 0.013 0.0814 0.0784
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0081 0.0039
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0266 0.0234
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0443 0.0979
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.071 0.167
Leishmania major DNA polymerase kappa, putative 0.0083 0.0493 0.571
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Loa Loa (eye worm) hypothetical protein 0.013 0.0814 0.4953
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0662 0.1559
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0266 0.0266
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0266 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Mycobacterium ulcerans hypothetical protein 0.0108 0.0662 0.1547
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0085 0.0053
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0516 0.0485
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0081 0.0054
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Mycobacterium ulcerans hypothetical protein 0.0075 0.0443 0.0979
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0313 0.3555
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0092 0.0556 0.3375
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0557
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0081 0.1127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0443 0.0943
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0081 0.0054
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1892
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0085 0.0085
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.071 0.1682
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0292 0.0602
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0313 0.0281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0809 0.0809
Loa Loa (eye worm) hypothetical protein 0.0075 0.0443 0.2687
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0165 0.0273
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0081 0.0054
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.009 0.009
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.0336
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0085 0.0514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.009 0.1273
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0065 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.071 0.8711
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0427
Giardia lamblia DINP protein human, muc B family 0.0083 0.0493 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0313 0.0642
Loa Loa (eye worm) hypothetical protein 0.0075 0.0443 0.2687
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0165 0.194
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.093
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0959
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1282 0.1253
Loa Loa (eye worm) hypothetical protein 0.0049 0.0266 0.1608
Echinococcus granulosus dna polymerase kappa 0.0104 0.0634 0.0603
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0443 0.0979
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0054
Echinococcus granulosus pyruvate kinase 0.0035 0.0165 0.0133
Brugia malayi mbt repeat family protein 0.0049 0.0266 0.1616
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0266 0.1608
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0313 0.0281
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1079
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0863
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0065 0.0033
Trichomonas vaginalis DNA polymerase eta, putative 0.0104 0.0634 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.071 0.9919
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0095 0.1325
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0516 0.0516
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Echinococcus multilocularis dna polymerase kappa 0.0104 0.0634 0.0603
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0278 0.2834
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0095 0.0091
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.071 1
Leishmania major DNA damage repair protein, putative 0.0024 0.009 0.0332
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0081 0.0455
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0065 0.0773
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0475
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.004
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Schistosoma mansoni hypothetical protein 0.0868 0.5834 0.5834
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0458 0.561
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0081 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0313 0.3986
Echinococcus multilocularis cpg binding protein 0.0064 0.0368 0.0336
Mycobacterium ulcerans hypothetical protein 0.0108 0.0662 0.1547
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0081 0.0048
Schistosoma mansoni ap endonuclease 0.002 0.0065 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.0447 0.799
Trypanosoma brucei unspecified product 0.0097 0.0587 0.6971
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0443 0.0943
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0165 0.194
Leishmania major pyruvate kinase 0.0035 0.0165 0.133
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0085 0.0085
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0108 0.0662 0.1547
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0085 0.0266
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0033 0.0033
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0095 0.1395
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0081 0.0054
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0085 0.0053
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0266 0.0266
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0095 0.0391
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.009 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0313 0.0281
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0443 0.2695
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0081 0.0054
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0085 0.0514
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0313 0.0281
Brugia malayi polk-prov protein 0.0051 0.0278 0.1687
Chlamydia trachomatis pyruvate kinase 0.0035 0.0165 0.1143
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0266 0.4262
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0085 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0268 0.0268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0065 0.0951
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0268 0.0268
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0065 0.0923
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0443 0.0979
Echinococcus multilocularis pyruvate kinase 0.0035 0.0165 0.0133
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0443 0.0979
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0559 0.3395
Echinococcus multilocularis geminin 0.036 0.2376 0.2351
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Schistosoma mansoni cpg binding protein 0.0064 0.0368 0.0368
Mycobacterium ulcerans DNA polymerase IV 0.0104 0.0634 0.1474
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0443 0.0979
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.071 0.167
Brugia malayi ImpB/MucB/SamB family protein 0.013 0.0814 0.4958
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0095 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0443 0.0992
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0085 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096512
Echinococcus granulosus geminin 0.036 0.2376 0.2351
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0065 0.0392
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0516 0.3139
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0165 0.194
Loa Loa (eye worm) MBCTL1 0.0056 0.0313 0.1892
Leishmania major DNA polymerase kappa, putative 0.0024 0.009 0.0332
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0427
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Schistosoma mansoni pyruvate kinase 0.0018 0.0051 0.0051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.05
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0081 0.0054
Leishmania major DNA polymerase eta, putative 0.013 0.0814 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0065 0.0681
Loa Loa (eye worm) hypothetical protein 0.0056 0.0313 0.1896
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0345 0.2086
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0065 0.0681
Schistosoma mansoni ap endonuclease 0.002 0.0065 0.0065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000096512
Giardia lamblia Pyruvate kinase 0.0035 0.0165 0.2586
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.0634 0.7592
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.004
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0081 0.1442
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Entamoeba histolytica protein kinase, putative 0.0092 0.0559 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0801

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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