Detailed information for compound 700190

Basic information

Technical information
  • TDR Targets ID: 700190
  • Name: 2-[[5,7-bis(ethylamino)-[1,2,4]triazolo[5,4-f ][1,3,5]triazin-3-yl]sulfanyl]-N-(3-chlorophe nyl)acetamide
  • MW: 406.893 | Formula: C16H19ClN8OS
  • H donors: 3 H acceptors: 5 LogP: 4.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc(NCC)nc2n1c(SCC(=O)Nc1cccc(c1)Cl)nn2
  • InChi: 1S/C16H19ClN8OS/c1-3-18-13-21-14(19-4-2)25-15(22-13)23-24-16(25)27-9-12(26)20-11-7-5-6-10(17)8-11/h5-8H,3-4,9H2,1-2H3,(H,20,26)(H2,18,19,21,22,23)
  • InChiKey: XWHZXZTYFCAYRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5,7-bis(ethylamino)-[1,2,4]triazolo[5,4-f][1,3,5]triazin-3-yl]thio]-N-(3-chlorophenyl)acetamide
  • 2-[[5,7-bis(ethylamino)-[1,2,4]triazolo[5,4-f][1,3,5]triazin-3-yl]sulfanyl]-N-(3-chlorophenyl)ethanamide
  • ZINC04570507

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.016 0.0298
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Leishmania major DNA polymerase kappa, putative 0.0023 0.016 0.2104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.016 0.2104
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0124 0.1685 0.1685
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Echinococcus granulosus peregrin 0.0029 0.0238 0.0238
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0086 0.5
Onchocerca volvulus 0.0026 0.0206 0.0706
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Giardia lamblia DINP protein human, muc B family 0.0023 0.016 0.0524
Schistosoma mansoni ran 0.0026 0.0195 0.0169
Echinococcus multilocularis dna polymerase eta 0.0054 0.0624 0.0624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0542 0.0542
Giardia lamblia PHD finger protein 15 0.0029 0.0238 0.0833
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.038
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0014 0.0026 0.0026
Onchocerca volvulus 0.0183 0.257 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.005 0.0379
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0086 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0329 0.0303
Echinococcus granulosus snurportin 1 0.0372 0.5421 0.5421
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0014 0.0026 0.0026
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0014 0.0026 0.0026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.5365
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.016 0.0543
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1645 0.3034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.016 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Brugia malayi Bromodomain containing protein 0.0029 0.0238 0.0852
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.016 0.016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0933
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0014 0.0026 0.0026
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.172
Brugia malayi Protein-tyrosine phosphatase 1 0.0014 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0329 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Leishmania major importin beta-1 subunit, putative 0.0028 0.0234 0.328
Echinococcus granulosus lamin dm0 0.0026 0.0206 0.0206
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0014 0.0026 0.0049
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0071
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.016 0.0295
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.016 0.2104
Brugia malayi Importin beta-1 subunit 0.0035 0.0334 0.1225
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Echinococcus granulosus lamin 0.0026 0.0206 0.0206
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0014 0.0026 0.0049
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0659 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0195 0.0202
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0933
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Plasmodium vivax importin-beta 2, putative 0.0035 0.0334 1
Schistosoma mansoni importin beta-1 0.0035 0.0334 0.0308
Entamoeba histolytica hypothetical protein 0.0075 0.0939 0.1094
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Brugia malayi hypothetical protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0334 0.8621
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0195 0.0195
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0124 0.1685 0.1685
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0939 0.0939
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0238 0.0238
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0381 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0014 0.0026 0.0026
Trichomonas vaginalis dullard protein, putative 0.0015 0.0034 0.0009
Leishmania major GTP-binding protein, putative 0.0026 0.0195 0.2658
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0329 0.0329
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0381 0.5609
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.257 0.3049
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1218 0.1218
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0659 1
Onchocerca volvulus 0.0026 0.0206 0.0706
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0014 0.0026 0.0026
Trichomonas vaginalis ran, putative 0.0026 0.0195 0.0202
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0329 0.0607
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0058
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.016 0.016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0086 0.0232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0542 0.1
Brugia malayi hypothetical protein 0.0014 0.0026 0.0021
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0195 0.2658
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.0034 0.0009
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0014 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0075 0.0939 0.0915
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0014 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Brugia malayi MH2 domain containing protein 0.0122 0.1645 0.6368
Schistosoma mansoni ran 0.0026 0.0195 0.0169
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.016 0.016
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0659 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0624 0.9443
Loa Loa (eye worm) hypothetical protein 0.0049 0.0546 0.1007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0195 0.4625
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0542 0.0542
Echinococcus multilocularis 0.0014 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0124 0.1685 0.1685
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0124 0.1685 0.6527
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Leishmania major hypothetical protein, conserved 0.0015 0.0034 0.0119
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.016 0.0298
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.257 0.3049
Echinococcus granulosus importin subunit beta 1 0.0035 0.0334 0.0334
Entamoeba histolytica hypothetical protein 0.0075 0.0939 0.1094
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.016 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0014 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) protein tyrosine phosphatase 0.0014 0.0026 0.0049
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0542 0.0517
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0234 0.328
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0238 0.5881
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0127 0.1719 1
Trypanosoma brucei unspecified product 0.0016 0.005 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.005 0.0379
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.016 0.2104
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.0681
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0124 0.1685 0.1663
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Echinococcus granulosus dna polymerase eta 0.0054 0.0624 0.0624
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0014 0.0026 0.0026
Echinococcus multilocularis peregrin 0.0029 0.0238 0.0238
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.257 0.3049
Schistosoma mansoni DNA polymerase eta 0.0054 0.0624 0.0599
Brugia malayi hypothetical protein 0.0014 0.0026 0.0021
Echinococcus multilocularis lamin dm0 0.0026 0.0206 0.0206
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Echinococcus multilocularis dna polymerase kappa 0.0023 0.016 0.016
Brugia malayi jmjC domain containing protein 0.0093 0.1218 0.4695
Echinococcus multilocularis snurportin 1 0.0372 0.5421 0.5421
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0034 0.003
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0034 0.0034
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0567 0.837 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0195 0.2658
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0183 0.257 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0206 0.038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0542 0.0517
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0014 0.0026 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.005 0.0379
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0238 0.0212
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1645 0.3034
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0183 0.257 1
Brugia malayi hypothetical protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0039
Entamoeba histolytica hypothetical protein 0.0075 0.0939 0.1094
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0034 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0542 0.0542
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0195 0.0195
Trypanosoma brucei unspecified product 0.0023 0.016 0.2104
Plasmodium falciparum importin beta, putative 0.0035 0.0334 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0334 0.0334
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0234 0.0249
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase 0.0014 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0054 0.0624 0.1151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Brugia malayi RNA, U transporter 1 0.0099 0.1303 0.5028
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0567 0.837 1
Trypanosoma brucei unspecified product 0.0016 0.005 0.0379
Trichomonas vaginalis dullard protein, putative 0.0015 0.0034 0.0009
Echinococcus granulosus protein tyrosine phosphatase n9 0.0014 0.0026 0.0026
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0014 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0056 0.0659 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1218 0.1218
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0014 0.0026 0.0021
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0334 0.4852
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0034 0.0008
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Schistosoma mansoni hypothetical protein 0.0029 0.0238 0.0212
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0014 0.0026 0.0049
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0014 0.0026 0.0021
Echinococcus granulosus dna polymerase kappa 0.0023 0.016 0.016
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Leishmania major DNA polymerase eta, putative 0.0054 0.0624 0.9443
Brugia malayi PHD-finger family protein 0.0029 0.0238 0.0852
Schistosoma mansoni lamin 0.0026 0.0206 0.018
Echinococcus granulosus intermediate filament protein 0.0026 0.0206 0.0206
Plasmodium falciparum phd finger protein, putative 0.0029 0.0238 0.6822
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0928 0.0904
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0183 0.257 0.4742
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0014 0.0026 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0206 0.0725
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0014 0.0026 0.0026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0086 0.0933
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0624 0.2365
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0624 0.9443
Echinococcus multilocularis musashi 0.0026 0.0206 0.0206
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0234 0.0249
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.257 0.3049
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.016 0.2104
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.016 0.2104
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0034 0.0008
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.257 0.3049
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0034 0.0009
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0334 0.0615
Trichomonas vaginalis dullard protein, putative 0.0015 0.0034 0.0009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Schistosoma mansoni hypothetical protein 0.0372 0.5421 0.5408
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0659 0.0759
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0407 0.0407
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0086 0.0933
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0542 0.0517
Brugia malayi Protein-tyrosine phosphatase 0.0014 0.0026 0.0021
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0014 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0238 0.5881
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0183 0.257 0.3049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0939 0.0939
Brugia malayi intermediate filament protein 0.0026 0.0206 0.0725
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.016 0.2104
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0195 0.2658
Toxoplasma gondii exonuclease III APE 0.0018 0.0086 0.1483
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0034 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Brugia malayi hypothetical protein 0.0075 0.0939 0.36
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.016 0.0454
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Brugia malayi jmjC domain containing protein 0.0035 0.0329 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0086 0.0071
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0238 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0238 0.044
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0183 0.257 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.257 0.3049
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0329 0.0329
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Echinococcus multilocularis 0.0015 0.0034 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0238 0.6822
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.016 0.0454
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0183 0.257 0.3049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0542 0.2044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0034 0.0119
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0939 0.0915
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.0661
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Echinococcus granulosus jumonji domain containing protein 0.004 0.0407 0.0407
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0234 0.0249
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.016 0.0134
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.2104
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0124 0.1685 0.3109
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Schistosoma mansoni intermediate filament proteins 0.0026 0.0206 0.018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Entamoeba histolytica hypothetical protein 0.0075 0.0939 0.1094
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5421 1
Brugia malayi hypothetical protein 0.0014 0.0026 0.0021
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0034 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0334 0.4852
Echinococcus multilocularis hypothetical protein 0.0014 0.0026 0.0026
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0014 0.0026 0.0026
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0086 0.0086
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0086 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0238 0.044
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.0367
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0034 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Schistosoma mansoni lamin 0.0026 0.0206 0.018
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0195 0.5365
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0034 0.0009
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0014 0.0026 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0049
Entamoeba histolytica hypothetical protein 0.0028 0.0234 0.0249
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0014 0.0026 0.0049
Onchocerca volvulus Alhambra homolog 0.0029 0.0238 0.0833
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0026 0.0026
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0124 0.1685 0.1685
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.0359
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0697 0.1286
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0034 0.0051
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0659 0.0759
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.016 0.016
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0034 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0381 0.5609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.172
Echinococcus multilocularis lamin 0.0026 0.0206 0.0206
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0086 0.0253
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0206 0.038

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 16.21 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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