Detailed information for compound 701145

Basic information

Technical information
  • TDR Targets ID: 701145
  • Name: N-(4-acetylphenyl)-2-[(2-oxo-5,6,7,8-tetrahyd ro-1H-quinazolin-4-yl)sulfanyl]acetamide
  • MW: 357.427 | Formula: C18H19N3O3S
  • H donors: 2 H acceptors: 5 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C(=O)C)CSc1nc(O)nc2c1CCCC2
  • InChi: 1S/C18H19N3O3S/c1-11(22)12-6-8-13(9-7-12)19-16(23)10-25-17-14-4-2-3-5-15(14)20-18(24)21-17/h6-9H,2-5,10H2,1H3,(H,19,23)(H,20,21,24)
  • InChiKey: XKBKDBCJOHWLJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-acetylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)thio]acetamide
  • N-(4-acetylphenyl)-2-[(2-keto-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)thio]acetamide
  • N-(4-ethanoylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]ethanamide
  • ZINC04317016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Doublecortin family protein 0.0198 0.1713 0.8311
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0058 0.0459 0.0459
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0174 0.064
Brugia malayi notch-like transmembrane receptor 0.0009 0.0012 0.0058
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0051 0.0391 0.0391
Toxoplasma gondii cell division protein CDC48AP 0.0084 0.0693 0.5767
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0033 0.0234 0.195
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0051 0.0391 0.0391
Onchocerca volvulus 0.0012 0.0043 0.0182
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0183 0.1581 0.5829
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0043 0.0251
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0043 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.1581 0.1581
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0043 0.0358
Echinococcus multilocularis lipoxygenase domain containing protein 0.0198 0.1713 0.1713
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0043 0.0358
Loa Loa (eye worm) notch protein 0.0009 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0083 0.0678 0.2497
Echinococcus multilocularis protein jagged 2 0.0009 0.0012 0.0012
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0163 0.1393 0.8119
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0129
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0174 0.0843
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0027 0.0086
Brugia malayi hypothetical protein 0.0051 0.0391 0.1897
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Trypanosoma brucei diacylglycerol kinase, putative 0.0012 0.0043 0.0379
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0012 0.0012
Schistosoma mansoni slit 0.0009 0.0012 0.0012
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0134 0.1136 1
Trypanosoma cruzi katanin, putative 0.0007 0 0.0000043848
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0052 0.0405 0.0405
Echinococcus granulosus fibropellin Ia 0.0009 0.0012 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0043 0.0043
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0027 0.0027
Brugia malayi Cadherin domain containing protein 0.0009 0.0012 0.0058
Onchocerca volvulus Peroxidase homolog 0.0027 0.0174 0.0951
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Schistosoma mansoni notch 0.0009 0.0012 0.0012
Schistosoma mansoni peroxidasin 0.0027 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Echinococcus multilocularis fat cadherin tumor suppressor 0.0009 0.0012 0.0012
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0043 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0129
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0174 0.0843
Brugia malayi hypothetical protein 0.0198 0.1713 0.8311
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Loa Loa (eye worm) ceramide kinase 0.0012 0.0043 0.0159
Plasmodium vivax multidomain scavenger receptor, putative 0.0198 0.1713 1
Plasmodium falciparum LCCL domain-containing protein 0.0198 0.1713 1
Trypanosoma brucei Sphingosine kinase 0.0012 0.0043 0.0379
Trypanosoma cruzi katanin, putative 0.0007 0 0.0000043848
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0043 0.0379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Entamoeba histolytica cdc48-like protein, putative 0.0134 0.1136 0.4186
Loa Loa (eye worm) hypothetical protein 0.031 0.2713 1
Echinococcus granulosus protein jagged 1 0.0009 0.0012 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0027 0.0098
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0012 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0098
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0391 0.3442
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0051 0.0391 0.1441
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0043 0.0159
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Brugia malayi Delta serrate ligand family protein 0.0009 0.0012 0.0058
Echinococcus granulosus protein jagged 2 0.0009 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.031 0.2713 1
Brugia malayi Ceramide kinase 0.0012 0.0043 0.0209
Loa Loa (eye worm) VCP protein 0.0058 0.0459 0.169
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0134 0.1136 0.663
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Brugia malayi Muscle positioning protein 4 0.0009 0.0012 0.0058
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0134 0.1136 0.1136
Onchocerca volvulus 0.0051 0.0391 0.2228
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0174 0.0951
Brugia malayi hypothetical protein 0.0012 0.0043 0.0209
Schistosoma mansoni notch 0.0009 0.0012 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.043 0.3575
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus granulosus RUN 0.0198 0.1713 0.1713
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0043 0.0379
Schistosoma mansoni polycystin 1-related 0.0198 0.1713 0.1713
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0043 0.0358
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Schistosoma mansoni coup transcription factor 0.001 0.0027 0.0027
Echinococcus granulosus Vam6:Vps39 protein 0.0051 0.0391 0.0391
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0043 0.0209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0043 0.0379
Brugia malayi vesicle-fusing ATPase 0.0083 0.0678 0.3286
Echinococcus multilocularis Polycystic kidney disease protein 0.0198 0.1713 0.1713
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0043 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0489 0.0489
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Loa Loa (eye worm) hypothetical protein 0.0198 0.1713 0.6314
Echinococcus multilocularis fibropellin Ia 0.0009 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0043 0.0043
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0043 0.0358
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0027 0.0129
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0027 0.0129
Schistosoma mansoni rab6-interacting 0.0198 0.1713 0.1713
Echinococcus granulosus protein jagged 2 0.0009 0.0012 0.0012
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0163 0.1393 0.1393
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0043 0.0379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Schistosoma mansoni notch 0.0009 0.0012 0.0012
Echinococcus granulosus sphingosine kinase 1 0.031 0.2713 0.2713
Schistosoma mansoni cpg binding protein 0.0029 0.0196 0.0196
Echinococcus multilocularis cpg binding protein 0.0031 0.0211 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0098
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0012 0.0012
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0051 0.0391 0.0391
Onchocerca volvulus 0.001 0.0027 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0129
Schistosoma mansoni lipoxygenase 0.1122 1 1
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0043 0.0379
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0174 0.064
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0027 0.0086
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0163 0.1393 0.5135
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0391 0.3442
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0027 0.0027
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0163 0.1393 0.5135
Trypanosoma cruzi metalloprotease, putative 0.0007 0 0.0000043848
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0174 0.0951
Brugia malayi hypothetical protein 0.0198 0.1713 0.8311
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0141 0.1201 0.1201
Brugia malayi hypothetical protein 0.0027 0.0174 0.0843
Leishmania major diacylglycerol kinase, putative 0.0012 0.0043 0.0379
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Schistosoma mansoni loxhd1 0.0198 0.1713 0.1713
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0027 0.0027
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0141 0.1201 0.6989
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0027 0.0027
Schistosoma mansoni lipoxygenase 0.0765 0.68 0.68
Trypanosoma cruzi katanin, putative 0.0007 0 0.0000043848
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0098
Schistosoma mansoni cpg binding protein 0.0031 0.0211 0.0211
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0163 0.1393 0.1393
Schistosoma mansoni hypothetical protein 0.0414 0.3652 0.3652
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0027 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0198 0.1713 0.1713
Brugia malayi ATPase, AAA family protein 0.0007 0 0.0000024162
Schistosoma mansoni protein kinase 0.0173 0.1491 0.1491
Echinococcus granulosus peroxidasin 0.0027 0.0174 0.0174
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0051 0.0391 0.1441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0098
Giardia lamblia High cysteine protein 0.0009 0.0012 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0027 0.0129
Mycobacterium tuberculosis Putative conserved ATPase 0.0084 0.0693 0.2433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0129
Trichomonas vaginalis bmru protein, putative 0.0012 0.0043 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0129
Brugia malayi Protein kinase domain containing protein 0.0163 0.1393 0.6759
Brugia malayi CXXC zinc finger family protein 0.0029 0.0196 0.095
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0183 0.1581 0.1581
Onchocerca volvulus 0.0027 0.0174 0.0951
Echinococcus granulosus protein kinase 0.0123 0.1035 0.1035
Brugia malayi diacylglycerol kinase 0.0012 0.0043 0.0209
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0174 0.064
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0174 0.0843
Echinococcus granulosus microtubule associated protein 2 0.0699 0.6206 0.6206
Onchocerca volvulus 0.0029 0.0196 0.1081
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0129
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0159
Echinococcus multilocularis neural cadherin 0.0009 0.0012 0.0012
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0012 0.0058
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Brugia malayi nuclear hormone receptor 0.001 0.0027 0.0129
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0043 0.0182
Schistosoma mansoni vam6/vps39 related 0.0051 0.0391 0.0391
Loa Loa (eye worm) Notch2 0.0009 0.0012 0.0044
Leishmania major hypothetical protein, conserved 0.0012 0.0043 0.0379
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0159
Echinococcus granulosus FTZ F1 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Echinococcus granulosus dnaJ subfamily B 0.0414 0.3652 0.3652
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0405 0.0405
Trypanosoma cruzi vesicular transport protein (CDC48 homologue), putative 0.0007 0 0.0000043848
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0027 0.0027
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0043 0.0159
Echinococcus multilocularis notch 0.0009 0.0012 0.0012
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0141 0.1201 0.1201
Trypanosoma cruzi katanin-like protein, putative 0.0007 0 0.0000043848
Giardia lamblia AAA family ATPase 0.0084 0.0693 1
Trichomonas vaginalis bmru protein, putative 0.0012 0.0043 0.0358
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0043 0.0358
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Onchocerca volvulus 0.0027 0.0174 0.0951
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0174 0.0951
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0129
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1122 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0027 0.0027
Brugia malayi probable protein kinase 0.0173 0.1491 0.7235
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0043 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Toxoplasma gondii cell division protein CDC48CY 0.0141 0.1201 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0129
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Schistosoma mansoni peroxidasin 0.0027 0.0174 0.0174
Brugia malayi GCC2 and GCC3 family protein 0.0009 0.0012 0.0058
Echinococcus multilocularis ceramide kinase 0.0012 0.0043 0.0043
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Loa Loa (eye worm) fidgetin protein 0.0007 0 0.0000018357
Schistosoma mansoni protein kinase 0.0052 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0129
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0141 0.1201 1
Schistosoma mansoni sphingosine kinase A B 0.031 0.2713 0.2713
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0058 0.0459 0.2224
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0174 0.064
Loa Loa (eye worm) hypothetical protein 0.0172 0.1477 0.5445
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Entamoeba histolytica hypothetical protein, conserved 0.031 0.2713 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0174 0.0843
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0183 0.1581 0.1581
Onchocerca volvulus 0.0027 0.0174 0.0951
Loa Loa (eye worm) hypothetical protein 0.0198 0.1713 0.6314
Echinococcus multilocularis neurogenic locus notch protein 4 0.0009 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0012 0.0043 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0098
Trypanosoma cruzi vacuolar transport protein 4A, putative 0.0007 0 0.0000043848
Brugia malayi follicle stimulating hormone receptor 0.0237 0.2061 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0405 0.0405
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0043 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0016 0.0057
Schistosoma mansoni protein kinase 0.0123 0.1035 0.1035
Schistosoma mansoni cpg binding protein 0.0031 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Loa Loa (eye worm) hypothetical protein 0.0051 0.0391 0.1441
Echinococcus granulosus protein jagged 1 0.0009 0.0012 0.0012
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0043 0.0379
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Schistosoma mansoni sphingoid long chain base kinase 0.031 0.2713 0.2713
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0027 0.0098
Toxoplasma gondii EGF family domain-containing protein 0.0009 0.0012 0.01
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus granulosus neural cadherin 0.0009 0.0012 0.0012
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0043 0.0043
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.3652 0.3652
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Schistosoma mansoni notch 0.0009 0.0012 0.0012
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0043 0.0358
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0043 0.0358
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.2061 0.7598
Schistosoma mansoni nuclear hormone receptor 0.001 0.0027 0.0027
Brugia malayi steroid hormone receptor 0.001 0.0027 0.0129
Brugia malayi EGF-like domain containing protein 0.0009 0.0012 0.0058
Brugia malayi valosin containing protein 0.0083 0.0678 0.3286
Echinococcus multilocularis lipoxygenase domain containing protein 0.0198 0.1713 0.1713
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0043 0.0159
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0012
Schistosoma mansoni rap gtpase-activating protein 0.0051 0.0391 0.0391
Schistosoma mansoni rab6-interacting 0.0198 0.1713 0.1713
Loa Loa (eye worm) vesicle-fusing ATPase 0.0083 0.0678 0.2497
Onchocerca volvulus 0.0198 0.1713 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0043 0.0379
Echinococcus multilocularis protein jagged 1 0.0009 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.031 0.2713 1
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0012 0.0012
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0043 0.0043
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0027 0.0027
Echinococcus granulosus ceramide kinase 0.0012 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0098
Echinococcus granulosus cpg binding protein 0.0031 0.0211 0.0211
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Brugia malayi Temporarily assigned gene name protein 59 0.0051 0.0391 0.1897
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0052 0.0405 0.0405
Brugia malayi Peroxidasin 0.0027 0.0174 0.0843
Schistosoma mansoni notch 0.0009 0.0012 0.0012
Schistosoma mansoni notch 0.0009 0.0012 0.0012
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0198 0.1713 0.1713
Schistosoma mansoni hypothetical protein 0.0051 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0012 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0027 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0198 0.1713 0.1713
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0159
Brugia malayi diacylglycerol kinase 0.0012 0.0043 0.0209
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0196 0.0722
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0405 0.0405
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0051 0.0391 0.0391
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0043 0.0358
Brugia malayi map kinase activated protein kinase protein 2 0.0183 0.1581 0.7672
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0043 0.0379
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0141 0.1201 0.1201
Trypanosoma cruzi katanin, putative 0.0007 0 0.0000043848
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0043 0.0379
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0172 0.1477 0.1477
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0084 0.0693 0.5767
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0033 0.0234 0.195
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0043 0.0379
Echinococcus multilocularis peroxidasin 0.0027 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0098
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0134 0.1136 0.4186
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Echinococcus multilocularis slit 2 protein 0.0009 0.0012 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0129
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0009 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0052 0.0405 0.1965
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0027 0.0086
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0123 0.1035 0.3815
Echinococcus granulosus neurogenic locus protein delta 0.0009 0.0012 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.6206 0.6206
Brugia malayi Cadherin domain containing protein 0.0009 0.0012 0.0058
Mycobacterium ulcerans ATPase 0.0084 0.0693 0.2433
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0043 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.1393 0.1393
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0405 0.0405
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0405 0.0405
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0134 0.1136 0.6543
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0391 0.3442
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0043 0.0358
Brugia malayi nuclear receptor NHR-88 0.001 0.0027 0.0129
Echinococcus granulosus Polycystic kidney disease protein 0.0198 0.1713 0.1713
Loa Loa (eye worm) ATPase 0.0007 0 0.0000018357
Schistosoma mansoni cell polarity protein 0.0009 0.0012 0.0012
Trypanosoma brucei Valosin-containing protein 0.0134 0.1136 1
Brugia malayi ecdysteroid receptor 0.001 0.0027 0.0129
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0027 0.0027
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0043 0.0379
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0015 0.0071
Onchocerca volvulus Peroxidase homolog 0.0027 0.0174 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0027 0.0129
Echinococcus granulosus notch 0.0009 0.0012 0.0012
Echinococcus granulosus neurogenic locus notch protein 4 0.0009 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0044
Schistosoma mansoni septate junction protein 0.0009 0.0012 0.0012
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0129
Echinococcus multilocularis 0.0123 0.1035 0.1035
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0174 0.0843
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0174 0.0951
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0009 0.0012 0.0058
Plasmodium vivax cell division cycle ATPase, putative 0.0051 0.0393 0.2097
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0163 0.1393 0.6759
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0174 0.064
Brugia malayi vps4b-prov protein 0.0007 0 0.0000024162
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.6206 0.6206
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0043 0.0379
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0043 0.0358
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Brugia malayi Blistered cuticle protein 3 0.0027 0.0174 0.0843
Trypanosoma cruzi katanin, putative 0.0007 0 0.0000043848
Echinococcus multilocularis sphingosine kinase 1 0.031 0.2713 0.2713
Echinococcus granulosus delta-like protein 1 0.0009 0.0012 0.0012
Loa Loa (eye worm) doublecortin family protein 0.0198 0.1713 0.6314
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.064
Schistosoma mansoni laminin gamma-3 chain 0.0009 0.0012 0.0012
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0058 0.0459 0.0459
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0043 0.0043
Echinococcus granulosus slit 2 protein 0.0009 0.0012 0.0012
Trypanosoma cruzi Valosin-containing protein, putative 0.0134 0.1136 1
Echinococcus multilocularis protein jagged 1 0.0009 0.0012 0.0012
Trypanosoma cruzi vacuolar protein sorting-associated protein 4, putative 0.0007 0 0.0000043848
Echinococcus multilocularis RUN 0.0198 0.1713 0.1713
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0052 0.0405 0.1493
Onchocerca volvulus 0.0198 0.1713 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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