Detailed information for compound 70157

Basic information

Technical information
  • TDR Targets ID: 70157
  • Name: 3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol
  • MW: 226.234 | Formula: C12H10N4O
  • H donors: 3 H acceptors: 3 LogP: 1.29 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nccc(n1)c1c[nH]c2c1c(O)ccc2
  • InChi: 1S/C12H10N4O/c13-12-14-5-4-8(16-12)7-6-15-9-2-1-3-10(17)11(7)9/h1-6,15,17H,(H2,13,14,16)
  • InChiKey: SZOKTSDFOPVLFD-UHFFFAOYSA-N  


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Synonyms

  • 3-(2-amino-4-pyrimidinyl)-1H-indol-4-ol
  • 3-(2-azanylpyrimidin-4-yl)-1H-indol-4-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, cAMP-dependent, catalytic, beta References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 9 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 5 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens 3-phosphoinositide dependent protein kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens cyclin B1 References
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha References
Homo sapiens dopamine receptor D5 Starlite/ChEMBL References
Homo sapiens cyclin T1 References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Homo sapiens cyclin A2 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133074 All targets in OG5_133074
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131337 All targets in OG5_131337
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Dopamine receptor protein 1 Get druggable targets OG5_134111 All targets in OG5_134111
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_128785 All targets in OG5_128785
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cyclin-dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi phosphoinositide-dependent protein kinase I Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni kinase Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K06276 3-phosphoinositide dependent protein kinase-1, putative Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar ot C terminus of S. cerevisiae SGV1 (YPR161C) Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans CDC2-related protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134111 All targets in OG5_134111
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase, cAMP-dependent, catalytic, beta 358 aa 320 aa 27.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 9 372 aa 313 aa 31.6 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/PKA protein kinase 0.0147032 0.0798289 0.184956
Trichomonas vaginalis cyclins, putative 0.0138317 0.0690389 0.419257
Echinococcus granulosus cyclins 0.0112119 0.0366004 0.0366004
Loa Loa (eye worm) hypothetical protein 0.0160505 0.0965107 0.223606
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0147032 0.0798289 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0147032 0.0798289 0.36667
Trichomonas vaginalis cyclins, putative 0.0215553 0.164669 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.085876
Brugia malayi Protein kinase domain containing protein 0.0107361 0.0307098 0.0468091
Trypanosoma cruzi cyclin 6, putative 0.0215553 0.164669 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0171834 0.110538 0.595915
Brugia malayi Cyclin, N-terminal domain containing protein 0.0215553 0.164669 0.250995
Leishmania major protein kinase A catalytic subunit isoform 2 0.0147032 0.0798289 0.36667
Loa Loa (eye worm) hypothetical protein 0.0215553 0.164669 0.381524
Schistosoma mansoni cyclin B 0.0215553 0.164669 0.317798
Schistosoma mansoni serine/threonine protein kinase 0.0147032 0.0798289 0.154063
Echinococcus granulosus cyclins 0.0112119 0.0366004 0.0366004
Entamoeba histolytica PH domain containing protein kinase, putative 0.0147032 0.0798289 0.484782
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0142764 0.074544 0.0801909
Trichomonas vaginalis cyclin B, putative 0.0215553 0.164669 1
Entamoeba histolytica cyclin, putative 0.0112119 0.0366004 0.222266
Trichomonas vaginalis cyclins, putative 0.0112119 0.0366004 0.222266
Leishmania major protein kinase A catalytic subunit isoform 1 0.0147032 0.0798289 0.36667
Loa Loa (eye worm) hypothetical protein 0.0334897 0.312437 0.723887
Trypanosoma cruzi cyclin, putative 0.0215553 0.164669 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171834 0.110538 0.595915
Loa Loa (eye worm) AGC/PKA protein kinase 0.0147032 0.0798289 0.184956
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0215553 0.164669 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0147032 0.0798289 0.484782
Giardia lamblia Hypothetical protein 0.0112119 0.0366004 0.0439731
Echinococcus granulosus cyclin B 0.0215553 0.164669 0.164669
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171834 0.110538 0.213329
Echinococcus granulosus cyclin B3 1 0.0112119 0.0366004 0.0366004
Trichomonas vaginalis cyclin B, putative 0.0112119 0.0366004 0.222266
Schistosoma mansoni cyclin B3 0.0289946 0.25678 0.495563
Loa Loa (eye worm) carbonic anhydrase 3 0.0171834 0.110538 0.256107
Echinococcus multilocularis cyclin b3 0.0112119 0.0366004 0.039373
Brugia malayi cell division control protein 2 homolog 0.0107361 0.0307098 0.0468091
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107361 0.0307098 0.0711518
Echinococcus multilocularis cyclin dependent kinase 9 0.00901494 0.00939899 0.010111
Toxoplasma gondii AGC kinase 0.0147032 0.0798289 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0109496 0.0333538 0.5
Brugia malayi Serotonin receptor 0.0612428 0.656066 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0501048 0.518158 1
Loa Loa (eye worm) serotonin transporter b 0.0109496 0.0333538 0.0772776
Echinococcus granulosus cyclins 0.0112119 0.0366004 0.0366004
Trichomonas vaginalis conserved hypothetical protein 0.0112119 0.0366004 0.222266
Onchocerca volvulus 0.0215553 0.164669 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.0798289
Echinococcus granulosus cyclin dependent kinase 0.0107361 0.0307098 0.0307098
Loa Loa (eye worm) hypothetical protein 0.0215553 0.164669 0.381524
Echinococcus multilocularis cyclin B 0.0215553 0.164669 0.177143
Loa Loa (eye worm) hypothetical protein 0.0103435 0.0258482 0.059888
Entamoeba histolytica cell division protein kinase 2, putative 0.0107361 0.0307098 0.186494
Trichomonas vaginalis cyclin D, putative 0.0112119 0.0366004 0.222266
Trypanosoma brucei mitotic cyclin 6 0.0215553 0.164669 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0289946 0.25678 0.594935
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Echinococcus granulosus serotonin transporter 0.0109496 0.0333538 0.0333538
Leishmania major protein kinase A catalytic subunit 0.0147032 0.0798289 0.36667
Echinococcus granulosus hypothetical protein 0.0890206 1 1
Trichomonas vaginalis AGC family protein kinase 0.0147032 0.0798289 0.484782
Echinococcus multilocularis conserved hypothetical protein 0.0833333 0.929583 1
Trichomonas vaginalis cyclins, putative 0.0215553 0.164669 1
Plasmodium falciparum cyclin 0.0112119 0.0366004 0.119925
Echinococcus granulosus carbonic anhydrase II 0.0171834 0.110538 0.110538
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0147032 0.0798289 0.36667
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0147032 0.0798289 0.36667
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00959904 0.0166311 0.0385328
Entamoeba histolytica cyclin, putative 0.0215553 0.164669 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0107361 0.0307098 0.0711518
Echinococcus multilocularis cyclin dependent kinase 1 0.0107361 0.0307098 0.0330361
Trichomonas vaginalis cyclins, putative 0.0215553 0.164669 1
Brugia malayi hypothetical protein 0.0196415 0.140973 0.214877
Toxoplasma gondii AGC kinase 0.0147032 0.0798289 1
Echinococcus granulosus cyclins 0.0112119 0.0366004 0.0366004
Echinococcus multilocularis serotonin receptor 0.0160505 0.0965107 0.103822
Echinococcus granulosus cyclin dependent kinase 1 0.0107361 0.0307098 0.0307098
Schistosoma mansoni serine/threonine protein kinase 0.0107361 0.0307098 0.0592672
Loa Loa (eye worm) hypothetical protein 0.0109496 0.0333538 0.0772776
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0147032 0.0798289 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0289946 0.25678 0.391394
Entamoeba histolytica cyclin family protein 0.0112119 0.0366004 0.222266
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.085876
Brugia malayi Dopamine receptor protein 1 0.0357437 0.340345 0.518767
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109496 0.0333538 0.0508391
Echinococcus multilocularis cyclin B3 1 0.0112119 0.0366004 0.039373
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109496 0.0333538 0.0643699
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.085876
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.0798289
Giardia lamblia Cyclin A 0.0112119 0.0366004 0.0439731
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0171834 0.110538 0.168487
Trichomonas vaginalis CMGC family protein kinase 0.0107361 0.0307098 0.186494
Echinococcus multilocularis cyclin dependent kinase 5 0.0107361 0.0307098 0.0330361
Entamoeba histolytica cyclin family protein 0.0112119 0.0366004 0.222266
Loa Loa (eye worm) hypothetical protein 0.0357437 0.340345 0.788548
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0147032 0.0798289 0.36667
Trichomonas vaginalis AGC family protein kinase 0.00959904 0.0166311 0.100997
Trichomonas vaginalis cyclins, putative 0.0215553 0.164669 1
Schistosoma mansoni serine/threonine protein kinase 0.0147032 0.0798289 0.154063
Trypanosoma cruzi cyclin, putative 0.0215553 0.164669 1
Trichomonas vaginalis cyclin B, putative 0.0215553 0.164669 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0107361 0.0307098 0.0307098
Loa Loa (eye worm) norepinephrine transporter 0.0109496 0.0333538 0.0772776
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0411009 0.406675 0.437482
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0147032 0.0798289 0.121678
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0171834 0.110538 0.168487
Loa Loa (eye worm) hypothetical protein 0.0196415 0.140973 0.326622
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0147032 0.0798289 0.36667
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0147032 0.0798289 0.36667
Entamoeba histolytica cell division protein kinase 2, putative 0.0120793 0.047341 0.287491
Schistosoma mansoni biogenic amine (5HT) receptor 0.0160505 0.0965107 0.186257
Trichomonas vaginalis cyclin B, putative 0.0215553 0.164669 1
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Trichomonas vaginalis cyclin D, putative 0.0112119 0.0366004 0.222266
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.0798289
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0411009 0.406675 0.784848
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171834 0.110538 0.595915
Trichomonas vaginalis cyclin B3, putative 0.0112119 0.0366004 0.222266
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107361 0.0307098 0.0711518
Brugia malayi Cyclin, N-terminal domain containing protein 0.0215553 0.164669 0.250995
Echinococcus multilocularis serotonin receptor 0.0160505 0.0965107 0.103822
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0289946 0.25678 0.276231
Trichomonas vaginalis CMGC family protein kinase 0.0107361 0.0307098 0.186494
Trichomonas vaginalis cyclin B, putative 0.0215553 0.164669 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0107361 0.0307098 0.0330361
Loa Loa (eye worm) hypothetical protein 0.0411009 0.406675 0.942229
Schistosoma mansoni sodium/chloride dependent transporter 0.0109496 0.0333538 0.0643699
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0147032 0.0798289 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0501048 0.518158 0.518158
Echinococcus multilocularis cyclin dependent kinase 0.0107361 0.0307098 0.0330361
Leishmania major carbonic anhydrase-like protein 0.0171834 0.110538 0.595915
Schistosoma mansoni serine/threonine protein kinase 0.0107361 0.0307098 0.0592672
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0142764 0.074544 0.074544
Echinococcus granulosus cyclin dependent kinase 9 0.00901494 0.00939899 0.00939899
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0411009 0.406675 0.406675
Echinococcus granulosus cyclins 0.0112119 0.0366004 0.0366004
Leishmania major cyclin 0.0215553 0.164669 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0215553 0.164669 1
Loa Loa (eye worm) hypothetical protein 0.0109496 0.0333538 0.0772776
Echinococcus granulosus biogenic amine 5HT receptor 0.0160505 0.0965107 0.0965107
Trichomonas vaginalis CMGC family protein kinase 0.0107361 0.0307098 0.186494
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171834 0.110538 0.213329
Echinococcus multilocularis serotonin transporter 0.0109496 0.0333538 0.0358804
Loa Loa (eye worm) hypothetical protein 0.0431147 0.43161 1
Echinococcus granulosus cyclin dependent kinase 5 0.0107361 0.0307098 0.0307098
Trypanosoma cruzi CYC2-like cyclin, putative 0.0215553 0.164669 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0147032 0.0798289 0.36667
Echinococcus multilocularis carbonic anhydrase II 0.0171834 0.110538 0.118912
Loa Loa (eye worm) hypothetical protein 0.0147032 0.0798289 0.184956
Echinococcus multilocularis cyclins 0.0112119 0.0366004 0.039373
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0501048 0.518158 0.55741
Loa Loa (eye worm) hypothetical protein 0.0160505 0.0965107 0.223606
Schistosoma mansoni cyclins 0.0112119 0.0366004 0.0706356
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109496 0.0333538 0.0772776
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147032 0.0798289 0.085876
Echinococcus granulosus cyclin b3 0.0112119 0.0366004 0.0366004
Loa Loa (eye worm) hypothetical protein 0.0109496 0.0333538 0.0772776
Trichomonas vaginalis cyclin A, putative 0.0215553 0.164669 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0289946 0.25678 0.25678
Loa Loa (eye worm) hypothetical protein 0.0196415 0.140973 0.326622
Giardia lamblia Kinase, AGC PKA 0.0147032 0.0798289 0.36667
Schistosoma mansoni serine/threonine protein kinase 0.0147032 0.0798289 0.154063
Loa Loa (eye worm) hypothetical protein 0.0103093 0.025425 0.0589073
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0171834 0.110538 0.256107

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) uM Inhibition of Casein kinase I (CK1) (Not tested) ChEMBL. 15026054
IC50 (binding) 0 uM Inhibition of Casein kinase I (CK1) (Not tested) ChEMBL. 15026054
IC50 (functional) 0 uM Inhibition of PTP foreskin fibroblast cell proliferation; Not tested ChEMBL. 15026054
IC50 (functional) 0 uM Inhibition of Hep-2 human larynx carcinoma cell proliferation; inactive ChEMBL. 15026054
IC50 (functional) 0 uM Inhibition of HT-29 colon carcinoma cell proliferation; inactive ChEMBL. 15026054
IC50 (functional) 0 uM Inhibition of RD rhabdomyocarcinoma cell proliferation; Not tested ChEMBL. 15026054
IC50 (functional) 0 uM Inhibition of U937 cell proliferation; Not tested ChEMBL. 15026054
IC50 (functional) 0 uM Inhibition of LMM3 cell proliferation (derived from the BALB/c transplantable mammaryadenocarcinoma MM3) in human; inactive ChEMBL. 15026054
IC50 (binding) = 1.3 uM Inhibition of glycogen synthase kinase-3 beta ChEMBL. 15026054
IC50 (binding) = 1.3 uM Inhibition of glycogen synthase kinase-3 beta ChEMBL. 15026054
IC50 (binding) = 1.3 uM Inhibition of GSK3-beta ChEMBL. 21907583
IC50 (binding) = 2.4 uM Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as pRB fragment (773 to 928) phosphorylation using [33P]gamma-ATP after 30 mins by scintillation counting ChEMBL. 21907583
IC50 (binding) = 2.5 uM Inhibition of cyclin-dependent kinase 1-cyclin B ChEMBL. 15026054
IC50 (binding) = 2.5 uM Inhibition of cyclin-dependent kinase 1-cyclin B ChEMBL. 15026054
IC50 (binding) = 2.5 uM Inhibition of CDK1 ChEMBL. 21907583
IC50 (binding) = 3 uM Inhibition of human Cyclin-dependent kinase 5-p35nck5a ChEMBL. 15026054
IC50 (binding) = 3 uM Inhibition of human Cyclin-dependent kinase 5-p35nck5a ChEMBL. 15026054
IC50 (binding) = 3.1 uM Inhibition of human recombinant CDK2/cyclin A expressed in insect cells assessed as histone phosphorylation using [33P]gamma-ATP after 30 mins by scintillation counting ChEMBL. 21907583
IC50 (binding) = 3.5 uM Inhibition of CDK5 ChEMBL. 21907583
IC50 (binding) = 5.4 uM Inhibition of human PDK1 ChEMBL. 27217002
IC50 (binding) > 10 uM Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
IC50 (binding) > 10 uM Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
IC50 (binding) = 11 uM Inhibition of PKA (protein kinase A) ChEMBL. 15026054
IC50 (binding) = 11 uM Inhibition of PKA (protein kinase A) ChEMBL. 15026054
IC50 (functional) = 12 uM Antimalarial activity against transgenic Plasmodium falciparum 3D7 infected in human A positive erythrocytes after 72 hrs by luciferase reporter gene assay ChEMBL. 21907583
IC50 (functional) = 12 uM Antimalarial activity against Plasmodium falciparum D7 ChEMBL. 26005918
IC50 (ADMET) = 15 uM Cytotoxicity against human A549 cells after 72 hrs ChEMBL. 21907583
IC50 (ADMET) > 30 uM Cytotoxicity against human SH-SY5Y cells by MTS assay ChEMBL. 21907583
IC50 (ADMET) > 100 uM Cytotoxicity against human Hep2 cells ChEMBL. 21907583
IC50 (ADMET) > 100 uM Cytotoxicity against human HT-29 cells ChEMBL. 21907583
IC50 (binding) = 200 uM Inhibition of PKG (protein kinase G) ChEMBL. 15026054
Ki (binding) = 0.15 uM Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
Ki (binding) = 0.684 uM Displacement of [3H]8-OH-DPAT from 5-HT1A receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
Ki (binding) = 2.35 uM Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation counting ChEMBL. 21907583
Ki (binding) > 10 uM Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
Ki (binding) > 10 uM Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
Ki (binding) > 10 uM Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583
Ki (binding) > 10 uM Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation counting ChEMBL. 21907583

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21907583
Homo sapiens ChEMBL23 21907583

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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