Detailed information for compound 702411

Basic information

Technical information
  • TDR Targets ID: 702411
  • Name: 2-[1,3-dimethyl-6-(2-methylpropyl)-2,4-dioxop yrido[2,3-d]pyrimidin-5-yl]sulfanyl-N-(1,3-th iazol-2-yl)acetamide
  • MW: 419.521 | Formula: C18H21N5O3S2
  • H donors: 1 H acceptors: 5 LogP: 2.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nccs1)CSc1c(cnc2c1c(=O)n(C)c(=O)n2C)CC(C)C
  • InChi: 1S/C18H21N5O3S2/c1-10(2)7-11-8-20-15-13(16(25)23(4)18(26)22(15)3)14(11)28-9-12(24)21-17-19-5-6-27-17/h5-6,8,10H,7,9H2,1-4H3,(H,19,21,24)
  • InChiKey: SBQCZHUPDVMHHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(6-isobutyl-1,3-dimethyl-2,4-dioxo-pyrido[2,3-d]pyrimidin-5-yl)sulfanyl-N-thiazol-2-yl-acetamide
  • 2-[(6-isobutyl-1,3-dimethyl-2,4-dioxo-5-pyrido[2,3-d]pyrimidinyl)thio]-N-(2-thiazolyl)acetamide
  • 2-[(6-isobutyl-2,4-diketo-1,3-dimethyl-pyrido[2,3-d]pyrimidin-5-yl)thio]-N-thiazol-2-yl-acetamide
  • 2-[1,3-dimethyl-6-(2-methylpropyl)-2,4-dioxo-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0301 0.0331
Schistosoma mansoni importin beta-1 0.0028 0.055 0.0535
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0362 0.0693
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0103 0.0149
Loa Loa (eye worm) cytochrome P450 0.0011 0.0103 0.0063
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.0172
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0103 0.0149
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0103 0.0149
Loa Loa (eye worm) hypothetical protein 0.0057 0.1263 0.1634
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.7341 1
Schistosoma mansoni ran 0.0021 0.0362 0.0347
Echinococcus granulosus ring and YY1 binding protein 0.0057 0.1263 0.1249
Schistosoma mansoni apoferritin-2 0.0008 0.0048 0.0032
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0057 0.1263 0.2659
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0416 0.1081
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.055 0.0617
Echinococcus granulosus snurportin 1 0.0303 0.7437 0.7433
Toxoplasma gondii hypothetical protein 0.0048 0.1049 0.2528
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0057 0.1263 0.1602
Schistosoma mansoni apoferritin-2 0.0008 0.0048 0.0032
Trypanosoma cruzi WLM domain containing protein, putative 0.0057 0.1263 0.1602
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.3389 0.454
Schistosoma mansoni RNA binding protein 0.0057 0.1263 0.1249
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0301 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0103 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0991 0.0977
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0991 0.0977
Leishmania major hypothetical protein, conserved 0.0057 0.1263 0.1602
Onchocerca volvulus 0.0057 0.1263 0.2659
Onchocerca volvulus 0.0049 0.1056 0.2071
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0322 0.0359
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0301 0.0274
Entamoeba histolytica hypothetical protein 0.0023 0.0416 1
Schistosoma mansoni ferritin light chain 0.0008 0.0048 0.0032
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0578
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.016 0.3843 1
Schistosoma mansoni TRABID protein (C64 family) 0.0057 0.1263 0.1249
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0057 0.1263 0.1602
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0057 0.1263 0.1249
Echinococcus granulosus expressed protein 0.0008 0.0048 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.1263 0.1602
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0301 0.0678
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0103 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1124 0.141
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.055 0.0617
Onchocerca volvulus 0.0057 0.1263 0.2659
Trichomonas vaginalis ferritin, putative 0.0008 0.0048 0.0124
Echinococcus granulosus importin subunit beta 1 0.0028 0.055 0.0535
Echinococcus multilocularis ring and YY1 binding protein 0.0057 0.1263 0.1249
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0057 0.1263 0.1602
Schistosoma mansoni lipoxygenase 0.0082 0.1887 0.1874
Echinococcus multilocularis SWI:SNF matrix associated 0.016 0.3843 0.3834
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0103 0.0149
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0416 0.1081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0893 0.1092
Loa Loa (eye worm) hypothetical protein 0.0028 0.055 0.0668
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0103 0.0149
Plasmodium falciparum importin beta, putative 0.0028 0.055 0.0702
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.016 0.3843 0.3834
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0103 0.0149
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.016 0.3843 1
Echinococcus granulosus Zinc finger RanBP2 type 0.0057 0.1263 0.1249
Loa Loa (eye worm) hypothetical protein 0.0049 0.1056 0.1354
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0103 0.0149
Onchocerca volvulus 0.0028 0.0552 0.0636
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.0414
Schistosoma mansoni hypothetical protein 0.016 0.3843 0.3834
Leishmania major importin beta-1 subunit, putative 0.0023 0.0416 0.0432
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0103 0.0149
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0103 0.0149
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1263 0.3186
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0103 0.0149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1352 0.1338
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0103 0.0149
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0057 0.1263 0.1249
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0057 0.1263 0.3101
Echinococcus multilocularis tumor protein p63 0.0332 0.8158 0.8156
Schistosoma mansoni brg-1 associated factor 0.016 0.3843 0.3834
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0103 0.0149
Echinococcus granulosus zinc finger protein Ran binding 0.0057 0.1263 0.1249
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0301 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0991 0.0977
Brugia malayi brahma associated protein 60 kDa 0.016 0.3843 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0003
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0103 0.0149
Schistosoma mansoni ferritin light chain 0.0008 0.0048 0.0032
Brugia malayi Importin beta-1 subunit 0.0028 0.055 0.1304
Echinococcus multilocularis snurportin 1 0.0303 0.7437 0.7433
Chlamydia trachomatis DNA topoisomerase I 0.016 0.3843 0.5
Echinococcus multilocularis expressed protein 0.0008 0.0048 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0103 0.0149
Schistosoma mansoni cytochrome P450 0.0011 0.0103 0.0088
Onchocerca volvulus 0.0057 0.1263 0.2659
Echinococcus multilocularis zinc finger protein Ran binding 0.0057 0.1263 0.1249
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0103 0.0149
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0328 0.0313
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0103 0.0149
Onchocerca volvulus 0.016 0.3843 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1263 0.3186
Leishmania major hypothetical protein, conserved 0.0057 0.1263 0.1602
Echinococcus multilocularis SWI:SNF matrix associated 0.016 0.3843 0.3834
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1263 0.1602
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0103 0.0149
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.016 0.3843 1
Schistosoma mansoni ap endonuclease 0.0018 0.0301 0.0286
Leishmania major hypothetical protein, conserved 0.0057 0.1263 0.1602
Schistosoma mansoni ran 0.0021 0.0362 0.0347
Echinococcus multilocularis importin subunit beta 1 0.0028 0.055 0.0535
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0362 0.0347
Schistosoma mansoni rab6-interacting 0.002 0.0328 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0103 0.0149
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0103 0.0149
Schistosoma mansoni hypothetical protein 0.0057 0.1263 0.1249
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1263 0.1602
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0322 0.0359
Schistosoma mansoni hypothetical protein 0.0011 0.0103 0.0088
Trypanosoma cruzi WLM domain containing protein, putative 0.0057 0.1263 0.1602
Leishmania major hypothetical protein, conserved 0.0057 0.1263 0.1602
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.055 0.1195
Schistosoma mansoni hypothetical protein 0.016 0.3843 0.3834
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0362 0.0172
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0103 0.0088
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0322 0.0359
Plasmodium vivax hypothetical protein, conserved 0.016 0.3843 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0893 0.1092
Echinococcus multilocularis ferritin 0.0008 0.0048 0.0032
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0301 0.0784
Schistosoma mansoni ferritin 0.0008 0.0048 0.0032
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.7437 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0103 0.0124
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0301 0.0784
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0103 0.0149
Schistosoma mansoni loxhd1 0.002 0.0328 0.0313
Brugia malayi Cytochrome P450 family protein 0.0048 0.1055 0.2638
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.1263 0.1602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0301 0.0274
Schistosoma mansoni hypothetical protein 0.0303 0.7437 0.7433
Schistosoma mansoni rab6-interacting 0.002 0.0328 0.0313
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0362 0.0358
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0057 0.1263 0.1602
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0328 0.0076
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0322 0.0302
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0103 0.0149
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0322 0.0302
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.7341 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.016 0.3843 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1263 0.3186
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2768 0.2757
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0362 0.0358
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0991 0.1266
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0362 0.0358
Entamoeba histolytica Ran family GTPase 0.0021 0.0362 0.5328
Plasmodium vivax importin-beta 2, putative 0.0028 0.055 0.0702
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0103 0.0149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0301 0.0286
Brugia malayi cytochrome P450 0.0011 0.0103 0.0124
Schistosoma mansoni hypothetical protein 0.002 0.0328 0.0313
Brugia malayi hypothetical protein 0.002 0.0328 0.0718
Schistosoma mansoni hypothetical protein 0.016 0.3843 0.3834
Chlamydia trachomatis SWIB complex protein 0.016 0.3843 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0301 0.0678
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.0808
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0103 0.0149
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0057 0.1263 0.1602
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0322 0.0733
Onchocerca volvulus 0.0057 0.1263 0.2659
Echinococcus granulosus tumor protein p63 0.0332 0.8158 0.8156
Schistosoma mansoni ap endonuclease 0.0018 0.0301 0.0286
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0301 0.0647
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0328 0.0076
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0057 0.1263 0.2715
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.016 0.3843 0.513
Brugia malayi CXXC zinc finger family protein 0.0028 0.0552 0.1309
Echinococcus multilocularis RUN 0.002 0.0328 0.0313
Echinococcus granulosus Upstream activation factor subunit UAF30 0.016 0.3843 0.3834
Brugia malayi SWIB/MDM2 domain containing protein 0.016 0.3843 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0301 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0103 0.0149
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0322 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.1055 0.1353
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0991 0.2468
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0103 0.0149
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0103 0.0149
Brugia malayi RNA, U transporter 1 0.0081 0.1863 0.477
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0103 0.0149
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0416 0.1081
Leishmania major cytochrome p450-like protein 0.0019 0.0322 0.0302
Echinococcus multilocularis 0.0011 0.0103 0.0088
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0103 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0991 0.0977
Loa Loa (eye worm) hypothetical protein 0.0057 0.1263 0.1634
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0057 0.1263 0.1602
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.379 1
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1263 0.1602
Brugia malayi hypothetical protein 0.002 0.0328 0.0718
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0103 0.0149
Trichomonas vaginalis ran, putative 0.0021 0.0362 0.0942
Echinococcus granulosus SWI:SNF matrix associated 0.016 0.3843 0.3834
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0328 0.0313
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.3389 0.454
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1263 0.3186
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0328 0.0313
Schistosoma mansoni polycystin 1-related 0.002 0.0328 0.0313
Schistosoma mansoni ferritin 0.0008 0.0048 0.0032
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0328 0.0313
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.1056 0.1042
Loa Loa (eye worm) hypothetical protein 0.0057 0.1263 0.1634
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Mycobacterium leprae putative cytochrome p450 0.0011 0.0103 1
Schistosoma mansoni ferritin 0.0008 0.0048 0.0032
Echinococcus multilocularis SWI:SNF matrix associated 0.016 0.3843 0.3834
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0893 0.1092
Schistosoma mansoni zinc finger protein 0.0057 0.1263 0.1249
Brugia malayi Cytochrome P450 family protein 0.0019 0.0322 0.0701
Schistosoma mansoni fusion 0.0057 0.1263 0.1249
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0103 0.0149
Brugia malayi YY1-associated factor 2 0.0057 0.1263 0.3186
Schistosoma mansoni hypothetical protein 0.0405 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0301 0.0286
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.7341 1
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0578
Schistosoma mansoni cpg binding protein 0.0028 0.0552 0.0537
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.7341 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0328 0.0313
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0103 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0103 0.0149
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.3389 0.454
Loa Loa (eye worm) doublecortin family protein 0.002 0.0328 0.0368
Loa Loa (eye worm) hypothetical protein 0.002 0.0328 0.0368
Leishmania major hypothetical protein, conserved 0.0057 0.1263 0.1602
Brugia malayi brahma associated protein 60 kDa 0.016 0.3843 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0103 0.0149
Toxoplasma gondii exonuclease III APE 0.0018 0.0301 0.053
Brugia malayi Doublecortin family protein 0.002 0.0328 0.0718
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0057 0.1263 0.1249
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.016 0.3843 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2768 0.2757
Loa Loa (eye worm) hypothetical protein 0.002 0.0328 0.0368
Loa Loa (eye worm) hypothetical protein 0.0057 0.1263 0.1634
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0103 0.0149
Loa Loa (eye worm) brahma associated protein 0.016 0.3843 0.513
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0103 0.0149
Loa Loa (eye worm) hypothetical protein 0.0057 0.1263 0.1634
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0103 0.0149
Echinococcus granulosus RUN 0.002 0.0328 0.0313
Mycobacterium ulcerans hypothetical protein 0.0157 0.379 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0103 0.0149
Leishmania major GTP-binding protein, putative 0.0021 0.0362 0.0358
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0991 0.0977
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0057 0.1263 0.1602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0991 0.0977
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0893 0.1092
Echinococcus multilocularis dnaJ subfamily B 0.0405 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0301 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0103 0.0149
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0103 0.0149
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0578
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0416 0.0432
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0362 0.0347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0991 0.0977
Brugia malayi Cytochrome P450 family protein 0.0019 0.0322 0.0701
Toxoplasma gondii ran binding protein 0.0057 0.1263 0.3101
Echinococcus granulosus ferritin 0.0008 0.0048 0.0032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.119 0.2906
Schistosoma mansoni lipoxygenase 0.0117 0.2768 0.2757
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0328 0.0313
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0552 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.016 0.3843 1
Schistosoma mansoni ferritin 0.0008 0.0048 0.0032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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