Detailed information for compound 704497

Basic information

Technical information
  • TDR Targets ID: 704497
  • Name: N,1-bis(3,4-dimethoxyphenyl)-3,4-dihydro-1H-p yrrolo[2,1-c]pyrazine-2-carboxamide
  • MW: 437.488 | Formula: C24H27N3O5
  • H donors: 1 H acceptors: 1 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)NC(=O)N1CCn2c(C1c1ccc(c(c1)OC)OC)ccc2
  • InChi: 1S/C24H27N3O5/c1-29-19-9-7-16(14-21(19)31-3)23-18-6-5-11-26(18)12-13-27(23)24(28)25-17-8-10-20(30-2)22(15-17)32-4/h5-11,14-15,23H,12-13H2,1-4H3,(H,25,28)
  • InChiKey: OCTTYQDJLWTPQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0893 0.599 0.599
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0831 0.0831
Schistosoma mansoni leucine aminopeptidase 0.0022 0.008 0.008
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0914
Brugia malayi polk-prov protein 0.0055 0.0299 0.1842
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0097 0.1402
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0258 0.1589
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0182 0.2075
Mycobacterium ulcerans leucyl aminopeptidase 0.0112 0.069 0.1494
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.0455 0.4959
Mycobacterium ulcerans hypothetical protein 0.0116 0.0718 0.1562
Echinococcus granulosus pyruvate kinase 0.0019 0.0058 0.0025
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.056 0.056
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000037748
Echinococcus multilocularis pyruvate kinase 0.0019 0.0058 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.0455 0.4959
Trypanosoma brucei aminopeptidase, putative 0.0022 0.008 0.0167
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.008 0.0471
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0083 0.0896
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092972
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0112 0.069 0.7971
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0167
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0083 0.0946
Loa Loa (eye worm) hypothetical protein 0.0058 0.0322 0.1995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.0607 0.7141
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0182 0.2117
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0182 0.0239
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0067 0.0185
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0455 0.7491
Brugia malayi follicle stimulating hormone receptor 0.0246 0.16 1
Schistosoma mansoni pyruvate kinase 0.0037 0.0182 0.0182
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0182 0.0275
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0299 0.2967
Loa Loa (eye worm) histone methyltransferase 0.0019 0.006 0.0358
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Leishmania major pyruvate kinase 0.0037 0.0182 0.147
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.056 0.0528
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0083 0.0051
Leishmania major DNA polymerase eta, putative 0.0136 0.0849 1
Leishmania major pyruvate kinase 0.0037 0.0182 0.147
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0067 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.03 0.0572
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0471 0.2922
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0112 0.069 0.8125
Echinococcus multilocularis geminin 0.037 0.244 0.2414
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0455 0.2818
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.03 0.0572
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0067 0.0389
Plasmodium falciparum M17 leucyl aminopeptidase 0.0112 0.069 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0353 0.3656
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0083 0.0038
Echinococcus multilocularis dna polymerase kappa 0.011 0.0673 0.0641
Leishmania major DNA polymerase kappa, putative 0.0025 0.0097 0.038
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0291 0.0258
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0112 0.069 1
Brugia malayi CXXC zinc finger family protein 0.0063 0.0354 0.2187
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0075 0.0041
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0182 0.147
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.1385 0.1356
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.1385 0.1356
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0083 0.12
Schistosoma mansoni cpg binding protein 0.0066 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0053 0.0291 0.1804
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.056 0.0528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0067 0.0759
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0075 0.0768
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.008 0.0046
Entamoeba histolytica protein kinase, putative 0.01 0.0607 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0083 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0322 0.1995
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.008 0.0471
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0058 0.0796
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0083 0.0946
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0083 0.0202
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0075 0.0436
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0474 0.5574
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.011 0.0673 1
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.008 0.0484
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0607 1
Giardia lamblia Pyruvate kinase 0.0037 0.0182 0.2667
Loa Loa (eye worm) hypothetical protein 0.0078 0.0455 0.2828
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0673 0.7927
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.008 0.0471
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0322 0.061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0258 0.0225
Entamoeba histolytica acyl-coA synthetase, putative 0.0078 0.0455 0.7491
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0455 0.0942
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000092972
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0322 0.0623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0258 0.0225
Echinococcus granulosus bloom syndrome protein 0.0022 0.0075 0.0041
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0914
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0341 0.0308
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.01 0.0607 0.3781
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0097 0.1111
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0106 0.0107
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.056 0.3482
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0083 0.0202
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0083 0.0488
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0083 0.0049
Trypanosoma brucei unspecified product 0.0102 0.0623 0.7114
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0083 0.1127
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.01 0.0607 0.6906
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0182 0.2424
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0075 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0455 0.093
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0047
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0075 0.1228
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0067 0.0653
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0488
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0106 0.0094
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0078 0.0455 0.0942
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0083 0.0202
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0075 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0106 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0097 0.1111
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.0436
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0106 0.1443
Echinococcus granulosus dnaJ subfamily B 0.0893 0.599 0.5976
Toxoplasma gondii exonuclease III APE 0.002 0.0067 0.0913
Trypanosoma brucei unspecified product 0.0055 0.0303 0.3014
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0067 0.0898
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0083 0.0051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0258 0.16
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0083 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.03 0.0572
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0147 0.2
Echinococcus multilocularis leucine aminopeptidase protein 0.0112 0.069 0.0658
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Echinococcus multilocularis dnaJ subfamily B 0.0893 0.599 0.5976
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0083 0.0501
Leishmania major DNA damage repair protein, putative 0.0025 0.0097 0.038
Entamoeba histolytica hypothetical protein 0.0026 0.0106 0.1748
Echinococcus granulosus pyruvate kinase 0.0037 0.0182 0.0148
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0291 0.0258
Echinococcus granulosus pyruvate kinase 0.0019 0.0058 0.0025
Schistosoma mansoni DNA polymerase eta 0.0136 0.0849 0.0849
Onchocerca volvulus 0.0053 0.0291 0.4358
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.008 0.0471 0.0439
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.0096
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0112 0.069 0.8125
Brugia malayi ImpB/MucB/SamB family protein 0.0136 0.0849 0.5289
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0067 0.0136
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0182 0.2075
Schistosoma mansoni cpg binding protein 0.0066 0.0378 0.0378
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0075 0.0041
Echinococcus multilocularis dna polymerase eta 0.0136 0.0849 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Trypanosoma brucei unspecified product 0.0055 0.0303 0.3014
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0455 0.2818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0258 0.0225
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0083 0.0896
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0455 0.7491
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Loa Loa (eye worm) hypothetical protein 0.0055 0.0299 0.1854
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.01 0.0607 0.6906
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0083 0.0051
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0105 0.0641
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0455 0.093
Giardia lamblia DNA damage repair protein 0.0025 0.0097 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0106 0.0499
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0167
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0455 0.2818
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0093 0.056 0.3491
Chlamydia trachomatis cytosol aminopeptidase 0.0112 0.069 1
Mycobacterium ulcerans hypothetical protein 0.0116 0.0718 0.1562
Leishmania major DNA polymerase kappa, putative 0.0087 0.0521 0.5811
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0058 0.0334
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0341 0.0308
Trichomonas vaginalis DNA polymerase eta, putative 0.011 0.0673 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.008 0.0471 0.2932
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0067 0.0972
Loa Loa (eye worm) oxidoreductase 0.0023 0.0083 0.0501
Loa Loa (eye worm) hypothetical protein 0.0058 0.0322 0.1995
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0455 0.093
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.008 0.0046
Echinococcus granulosus dual specificity 0.01 0.0607 0.0575
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0291 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0083 0.0051
Leishmania major DNA polymerase eta, putative 0.008 0.0474 0.5211
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0087 0.0521 0.1102
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0488
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0112 0.069 0.1506
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.0455 0.0895
Loa Loa (eye worm) MBCTL1 0.0061 0.0341 0.2118
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0097 0.0097
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0083 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0097 0.1111
Mycobacterium ulcerans hypothetical protein 0.0025 0.0097 0.0071
Loa Loa (eye worm) hypothetical protein 0.0099 0.0603 0.3759
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0106 0.0094
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0291 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.0455 0.4959
Echinococcus multilocularis microtubule associated protein 2 0.1484 1 1
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0182 0.2636
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0607 0.0607
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0083 0.0051
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0075 0.0254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092972
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.008 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0299 0.2967
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0182 0.2424
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0097 0.1111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0449
Loa Loa (eye worm) hypothetical protein 0.0078 0.0455 0.2828
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0501
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0083 0.0051
Brugia malayi mbt repeat family protein 0.0053 0.0291 0.1792
Chlamydia trachomatis pyruvate kinase 0.0037 0.0182 0.1299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092972
Treponema pallidum licC protein (licC) 0.0116 0.0718 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0075 0.0254
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0106 0.1444
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0182 0.1109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.1121
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0182 0.1121
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.008 0.0046
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0075 0.0768
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0067 0.1105
Echinococcus multilocularis pyruvate kinase 0.003 0.0128 0.0095
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.0436
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0083 0.0051
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0182 0.1121
Brugia malayi mbt repeat family protein 0.0053 0.0291 0.1792
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Echinococcus multilocularis dual specificity 0.01 0.0607 0.0575
Entamoeba histolytica protein kinase, putative 0.01 0.0607 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0341 0.0308
Schistosoma mansoni cpg binding protein 0.0063 0.0354 0.0354
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0291 0.0258
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0501
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0083 0.0038
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0075 0.0347
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0078 0.0455 0.093
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.16 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0106 0.1444
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Loa Loa (eye worm) RecQ helicase 0.0022 0.0075 0.0449
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0521 0.5811
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0112 0.069 0.7971
Trypanosoma cruzi DNA polymerase eta, putative 0.0136 0.0849 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0067 0.0653
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0083 0.0202
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000092972
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0488
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.0096
Echinococcus granulosus leucine aminopeptidase protein 0.0112 0.069 0.0658
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0471 0.0981
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0083 0.0386
Schistosoma mansoni terminal deoxycytidyl transferase 0.008 0.0471 0.0471
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0635 0.4236 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0849 0.5295
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0673 0.7756
Onchocerca volvulus 0.0063 0.0354 0.5677
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0083 0.1127
Echinococcus granulosus dna polymerase eta 0.0136 0.0849 0.0817
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0083 0.0488
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0105 0.1733
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0718 0.1573
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0097 0.038
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0097 0.038
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0075 0.0449
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0083 0.0488
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0635 0.4236 1
Echinococcus multilocularis pyruvate kinase 0.0037 0.0182 0.0148
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092972
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0182 0.1121
Echinococcus multilocularis pyruvate kinase 0.0037 0.0182 0.0148
Schistosoma mansoni DNA helicase recq1 0.0022 0.0075 0.0075
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0635 0.4236 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0083 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0112 0.069 0.1462
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.0848
Mycobacterium ulcerans DNA polymerase IV 0.011 0.0673 0.1454
Echinococcus granulosus geminin 0.037 0.244 0.2414
Echinococcus granulosus dna polymerase kappa 0.011 0.0673 0.0641
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.1014
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0106 0.0094
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0083 0.0049
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0083 0.0946
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0673 0.7927
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0322 0.4165
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0083 0.0946
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0083 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0034 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092972
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0087 0.0521 0.5811
Trypanosoma brucei DNA polymerase eta, putative 0.0136 0.0849 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.0607 0.7141
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0322 0.369
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0097 0.0606
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0097 0.038
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.008 0.0484
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.1014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0354 0.2198
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0718 0.1573
Toxoplasma gondii ImpB/MucB/SamB family protein 0.008 0.0474 0.6456
Brugia malayi cytosol aminopeptidase 0.0022 0.008 0.0471
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0078 0.0455 0.093
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0182 0.2075
Schistosoma mansoni hypothetical protein 0.0329 0.2161 0.2161
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0182 0.1109
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0353 0.3656
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0635 0.4236 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0341 0.0341
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0623 0.7114
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0083 0.0038
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0182 0.2117
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0341 0.0308
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.008 0.0471 0.0439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0258 0.0225
Schistosoma mansoni pyruvate kinase 0.0037 0.0182 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.011 0.0673 0.7756
Loa Loa (eye worm) hypothetical protein 0.0078 0.0455 0.2828
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0083 0.0501
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0182 0.2476
Schistosoma mansoni hypothetical protein 0.037 0.244 0.244
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0083 0.0038
Entamoeba histolytica deoxycytidyl transferase, putative 0.008 0.0471 0.7763
Toxoplasma gondii leucyl aminopeptidase LAP 0.0112 0.069 0.9392
Loa Loa (eye worm) hypothetical protein 0.0099 0.0603 0.3759
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0083 0.0202
Schistosoma mansoni microtubule-associated protein tau 0.1484 1 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0182 0.0148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.03 0.0572
Trypanosoma brucei DNA polymerase IV, putative 0.011 0.0673 0.7756
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092972
Echinococcus granulosus cpg binding protein 0.0066 0.0378 0.0345
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0673 0.7927
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0322 0.466
Schistosoma mansoni ap endonuclease 0.002 0.0067 0.0067
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0116 0.0718 0.9776
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0112 0.069 0.1494
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0641
Schistosoma mansoni pyruvate kinase 0.0019 0.0058 0.0058
Echinococcus granulosus pyruvate kinase 0.0019 0.0058 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Onchocerca volvulus 0.0078 0.0455 0.7785
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0083 0.0051
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0083 0.1127
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0078 0.0455 0.093
Onchocerca volvulus 0.0093 0.056 1
Echinococcus multilocularis pyruvate kinase 0.0019 0.0058 0.0025
Echinococcus multilocularis cpg binding protein 0.0066 0.0378 0.0345
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0083 0.0038
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0058 0.0322 0.1995
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0106 0.0499
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0097 0.038
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0083 0.0051
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.0455 0.0895
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0067 0.0759
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0083 0.1365
Giardia lamblia DINP protein human, muc B family 0.0087 0.0521 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0067 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0353 0.3656
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0106 0.0754
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0291 0.0291
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0078 0.0455 0.093
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0291 0.4358
Schistosoma mansoni ap endonuclease 0.002 0.0067 0.0067
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0067 0.0402
Schistosoma mansoni hypothetical protein 0.037 0.244 0.244
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0083 0.0038
Mycobacterium ulcerans hypothetical protein 0.0078 0.0455 0.093
Schistosoma mansoni DNA helicase recq5 0.0022 0.0075 0.0075
Plasmodium falciparum pyruvate kinase 0.0037 0.0182 0.1955
Loa Loa (eye worm) hypothetical protein 0.0058 0.0322 0.1995
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0075 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0083 0.0051
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0075 0.0768
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0735 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0182 0.0289
Trypanosoma cruzi DNA polymerase kappa, putative 0.011 0.0673 0.7927
Mycobacterium ulcerans DNA polymerase IV 0.011 0.0673 0.1454
Loa Loa (eye worm) hypothetical protein 0.0061 0.0341 0.2118
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0182 0.147
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0097 0.038
Brugia malayi Protein kinase domain containing protein 0.01 0.0607 0.3773
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0097 0.1317
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0106 0.1537
Echinococcus multilocularis pyruvate kinase 0.0019 0.0058 0.0025
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0291 0.1804
Entamoeba histolytica hypothetical protein 0.01 0.0607 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0083 0.0051
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.008 0.0046
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0116 0.0718 0.1562
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0341 0.2107
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0058 0.0847
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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