Detailed information for compound 704636

Basic information

Technical information
  • TDR Targets ID: 704636
  • Name: 1-(4-chlorophenyl)-N-(2,3-dimethoxyphenyl)-3, 4-dihydro-1H-pyrrolo[2,1-c]pyrazine-2-carboxa mide
  • MW: 411.881 | Formula: C22H22ClN3O3
  • H donors: 1 H acceptors: 1 LogP: 3.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1OC)NC(=O)N1CCn2c(C1c1ccc(cc1)Cl)ccc2
  • InChi: 1S/C22H22ClN3O3/c1-28-19-7-3-5-17(21(19)29-2)24-22(27)26-14-13-25-12-4-6-18(25)20(26)15-8-10-16(23)11-9-15/h3-12,20H,13-14H2,1-2H3,(H,24,27)
  • InChiKey: KCDDCZGVQCNZLR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.031
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0033
Schistosoma mansoni hypothetical protein 0.0355 0.2386 0.2386
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0445 0.097
Giardia lamblia Pyruvate kinase 0.0034 0.0168 0.2601
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.086
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0317 0.1934
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0081 0.0054
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0796
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0718 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0168 0.2333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Loa Loa (eye worm) MBCTL1 0.0056 0.0317 0.1929
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0091 0.1084
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0168 0.1354
Brugia malayi Protein kinase domain containing protein 0.0092 0.0567 0.3463
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0091 0.1272
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0097 0.0079
Schistosoma mansoni pyruvate kinase 0.0018 0.0052 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0266 0.0234
Entamoeba histolytica hypothetical protein 0.0092 0.0567 1
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0084 0.0084
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0315 0.4456
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0112 0.0706 0.8608
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0445 0.0935
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0081 0.0039
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Brugia malayi cytosol aminopeptidase 0.0022 0.0084 0.0507
Onchocerca volvulus 0.0074 0.0445 0.8229
Onchocerca volvulus 0.0086 0.0523 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0019
Echinococcus multilocularis cpg binding protein 0.0064 0.037 0.0338
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0451 0.0419
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0097 0.1404
Mycobacterium ulcerans hypothetical protein 0.0023 0.0091 0.0065
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0084 0.0507
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0445 0.7849
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0212
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0081 0.0048
Giardia lamblia DINP protein human, muc B family 0.0082 0.0498 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0015
Brugia malayi CXXC zinc finger family protein 0.006 0.0346 0.2109
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0096 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0445 0.0935
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.164
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0445 0.7849
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Schistosoma mansoni hypothetical protein 0.0355 0.2386 0.2386
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0168 0.2333
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0051
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0451 0.2745
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0671 0.1562
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0567 0.3458
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Echinococcus multilocularis microtubule associated protein 2 0.1454 1 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0168 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0103 0.064 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000095929
Echinococcus granulosus cpg binding protein 0.0064 0.037 0.0338
Mycobacterium ulcerans DNA polymerase IV 0.0103 0.064 0.147
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0081 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0771
Echinococcus multilocularis leucine aminopeptidase protein 0.0112 0.0706 0.0675
Mycobacterium ulcerans hypothetical protein 0.0107 0.0671 0.1549
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0096 0.169
Leishmania major DNA polymerase kappa, putative 0.0082 0.0498 0.5727
Trypanosoma brucei DNA polymerase eta, putative 0.0129 0.082 1
Entamoeba histolytica protein kinase, putative 0.0092 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0317 0.1929
Giardia lamblia DNA damage repair protein 0.0023 0.0091 0.0885
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0091 0.0339
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0796
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0336 0.3584
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0451 0.0451
Mycobacterium ulcerans leucyl aminopeptidase 0.0112 0.0706 0.1638
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0445 0.097
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.1012
Schistosoma mansoni hypothetical protein 0.0303 0.2027 0.2027
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0168 0.1354
Onchocerca volvulus 0.006 0.0346 0.5993
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0584 0.3975 1
Trypanosoma brucei unspecified product 0.0096 0.0593 0.6996
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0317 0.0285
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0315 0.0651
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0168 0.1018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0451 0.0998
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Trichomonas vaginalis DNA polymerase eta, putative 0.0103 0.064 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0168 0.0223
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0112 0.0706 0.1606
Leishmania major DNA polymerase kappa, putative 0.0023 0.0091 0.0339
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0091 0.1294
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.0323
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0168 0.2336
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0584 0.3975 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Echinococcus granulosus pyruvate kinase 0.0034 0.0168 0.0135
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0168 0.2377
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0584 0.3975 1
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0051
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0112 0.0706 0.8608
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.0924
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0081 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Echinococcus granulosus geminin 0.0355 0.2386 0.2361
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0097 0.004
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0081 0.1147
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0081 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.064 0.762
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0315 0.0637
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0081 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0033 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0097 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0498 0.5727
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0081 0.0039
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0112 0.0706 0.8492
Brugia malayi ImpB/MucB/SamB family protein 0.0129 0.082 0.5013
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0942
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0957
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0957
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0107 0.0671 0.1549
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0077 0.0461 0.6412
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0081 0.1127
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0451 0.0451
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0584 0.3975 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0129 0.082 1
Echinococcus multilocularis dna polymerase kappa 0.0103 0.064 0.0609
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0957
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0336 0.3584
Leishmania major DNA polymerase eta, putative 0.0129 0.082 1
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0084 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0096 0.057
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0112 0.0706 0.8492
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0081 0.0054
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0097 0.0094
Echinococcus multilocularis pyruvate kinase 0.0034 0.0168 0.0135
Chlamydia trachomatis pyruvate kinase 0.0034 0.0168 0.1168
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0168 0.1964
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0796
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0771
Echinococcus multilocularis pyruvate kinase 0.0027 0.0118 0.0085
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0266 0.0234
Schistosoma mansoni pyruvate kinase 0.0034 0.0168 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Echinococcus granulosus dual specificity 0.0092 0.0567 0.0536
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0567 0.6904
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0317 0.0317
Schistosoma mansoni cpg binding protein 0.006 0.0346 0.0346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0266 0.0234
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0081 0.1428
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Loa Loa (eye worm) hypothetical protein 0.0074 0.0445 0.2711
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.1634 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0081 0.0039
Leishmania major DNA damage repair protein, putative 0.0023 0.0091 0.0339
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.027 0.0238
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0097 0.0683
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0567 0.0567
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0445 0.097
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0168 0.1012
Schistosoma mansoni microtubule-associated protein tau 0.1454 1 1
Entamoeba histolytica protein kinase, putative 0.0092 0.0567 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0081 0.0054
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0081 0.0485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0437
Brugia malayi polk-prov protein 0.0051 0.0281 0.1712
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0168 0.1018
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0091 0.0339
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0445 0.0983
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0081 0.0039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0479
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.027 0.0238
Schistosoma mansoni pyruvate kinase 0.0034 0.0168 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0112 0.0706 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.0498 0.5727
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0317 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0451 0.275
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0392
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0445 0.097
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0475
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.027 0.0238
Loa Loa (eye worm) hypothetical protein 0.0092 0.0564 0.3438
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0451 0.7949
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0081 0.0485
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.0498 0.1118
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0084 0.0051
Mycobacterium ulcerans hypothetical protein 0.0107 0.0671 0.1549
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0445 0.2715
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0091 0.1084
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0168 0.1012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Schistosoma mansoni cpg binding protein 0.0064 0.037 0.037
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Loa Loa (eye worm) hypothetical protein 0.0129 0.082 0.501
Mycobacterium ulcerans DNA polymerase IV 0.0103 0.064 0.147
Trypanosoma brucei unspecified product 0.0052 0.0289 0.2959
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0266 0.0234
Mycobacterium ulcerans hypothetical protein 0.0074 0.0445 0.097
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0445 0.0983
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0081 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0567 0.6904
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0084 0.0507
Entamoeba histolytica hypothetical protein 0.0024 0.0097 0.1705
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0445 0.097
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0091 0.0339
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0097 0.1345
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0074 0.0445 0.2711
Onchocerca volvulus 0.0049 0.027 0.4279
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0523 0.0492
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0671 0.1562
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Brugia malayi mbt repeat family protein 0.0049 0.027 0.1645
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0084 0.0507
Trypanosoma brucei unspecified product 0.0052 0.0289 0.2959
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0138 0.1927
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0107 0.0671 0.9346
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Schistosoma mansoni hypothetical protein 0.0856 0.5859 0.5859
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0091 0.1084
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0039
Echinococcus multilocularis pyruvate kinase 0.0034 0.0168 0.0135
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.027 0.164
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0097 0.0079
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0019
Echinococcus multilocularis dna polymerase eta 0.0129 0.082 0.0789
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.027 0.4279
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0451 0.0419
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Echinococcus granulosus leucine aminopeptidase protein 0.0112 0.0706 0.0675
Echinococcus granulosus dna polymerase eta 0.0129 0.082 0.0789
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.004
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0317 0.0285
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0567 0.6645
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0091 0.0339
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0523 0.0492
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0097 0.1368
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0999
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0084 0.0051
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0593 0.6996
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0567 0.6645
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Leishmania major pyruvate kinase 0.0034 0.0168 0.1354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0445 0.7849
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0677
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.004
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0999
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0097 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0445 0.5028
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1289
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0081 0.1127
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0097 0.1345
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0091 0.0603
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0097 0.0409
Echinococcus multilocularis dnaJ subfamily B 0.0856 0.5859 0.5845
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0281 0.2857
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0567 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0479
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0315 0.3577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0342
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0084 0.0248
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0461 0.5604
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0084 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0479
Loa Loa (eye worm) hypothetical protein 0.0092 0.0564 0.3438
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.064 0.762
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0168 0.0276
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0445 0.097
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0315 0.4016
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0084 0.0501
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.027 0.0238
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0445 0.5028
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0445 0.5028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000095929
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0317 0.0285
Brugia malayi mbt repeat family protein 0.0049 0.027 0.1645
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.1707
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0915
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0346 0.2104
Plasmodium falciparum M17 leucyl aminopeptidase 0.0112 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0479
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0091 0.1084
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.027 0.027
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0112 0.0706 0.1638
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0336 0.3584
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Leishmania major pyruvate kinase 0.0034 0.0168 0.1354
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1299 0.127
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1299 0.127
Schistosoma mansoni cpg binding protein 0.0064 0.037 0.037
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0957
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0266 0.1615
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0523 0.3195
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.027 0.027
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0019
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0266 0.1621
Echinococcus multilocularis dual specificity 0.0092 0.0567 0.0536
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0168 0.0261
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0168 0.1964
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0677
Brugia malayi follicle stimulating hormone receptor 0.0246 0.1634 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0445 0.097
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0168 0.202
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0081 0.0054
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0168 0.1964
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0281 0.2857
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0057 0.0338
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Echinococcus granulosus dna polymerase kappa 0.0103 0.064 0.0609
Plasmodium falciparum pyruvate kinase 0.0034 0.0168 0.1772
Loa Loa (eye worm) hypothetical protein 0.0086 0.0523 0.3191
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0081 0.0081
Schistosoma mansoni DNA polymerase eta 0.0129 0.082 0.082
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0168 0.1012
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Echinococcus multilocularis geminin 0.0355 0.2386 0.2361
Chlamydia trachomatis cytosol aminopeptidase 0.0112 0.0706 1
Leishmania major DNA polymerase eta, putative 0.0077 0.0461 0.5236
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0052 0.0723
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0445 0.2715
Echinococcus granulosus dnaJ subfamily B 0.0856 0.5859 0.5845
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0813 0.0813
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.0924
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0091 0.0339
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.027 0.027
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0168 0.202
Treponema pallidum licC protein (licC) 0.0107 0.0671 1
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0445 0.2715
Toxoplasma gondii leucyl aminopeptidase LAP 0.0112 0.0706 0.9829
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0019
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0523 0.0523
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0049
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Loa Loa (eye worm) hypothetical protein 0.0074 0.0445 0.2711
Loa Loa (eye worm) oxidoreductase 0.0022 0.0081 0.0479
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0052 0.0735
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0084 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0112 0.0706 0.1651
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0081 0.0444
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0081 0.1127

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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