Detailed information for compound 704636

Basic information

Technical information
  • TDR Targets ID: 704636
  • Name: 1-(4-chlorophenyl)-N-(2,3-dimethoxyphenyl)-3, 4-dihydro-1H-pyrrolo[2,1-c]pyrazine-2-carboxa mide
  • MW: 411.881 | Formula: C22H22ClN3O3
  • H donors: 1 H acceptors: 1 LogP: 3.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1OC)NC(=O)N1CCn2c(C1c1ccc(cc1)Cl)ccc2
  • InChi: 1S/C22H22ClN3O3/c1-28-19-7-3-5-17(21(19)29-2)24-22(27)26-14-13-25-12-4-6-18(25)20(26)15-8-10-16(23)11-9-15/h3-12,20H,13-14H2,1-2H3,(H,24,27)
  • InChiKey: KCDDCZGVQCNZLR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0081 0.1127
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0451 0.0451
Trypanosoma brucei DNA polymerase eta, putative 0.0129 0.082 1
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0084 0.0051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.027 0.4279
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0445 0.0935
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0112 0.0706 0.8492
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0051
Trypanosoma cruzi DNA polymerase eta, putative 0.0129 0.082 1
Mycobacterium ulcerans hypothetical protein 0.0107 0.0671 0.1549
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.0498 0.1118
Echinococcus granulosus dnaJ subfamily B 0.0856 0.5859 0.5845
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0084 0.0084
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0091 0.1084
Schistosoma mansoni cpg binding protein 0.0064 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0856 0.5859 0.5859
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0168 0.0276
Schistosoma mansoni DNA polymerase eta 0.0129 0.082 0.082
Brugia malayi mbt repeat family protein 0.0049 0.027 0.1645
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0336 0.3584
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0054
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0138 0.1927
Schistosoma mansoni pyruvate kinase 0.0034 0.0168 0.0168
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0445 0.097
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.1634 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0112 0.0706 0.1651
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0315 0.3577
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0567 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0091 0.1084
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0999
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0445 0.097
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0084 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0445 0.097
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0081 0.1428
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0567 0.3458
Onchocerca volvulus 0.0049 0.027 0.4279
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0266 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Mycobacterium ulcerans hypothetical protein 0.0107 0.0671 0.1549
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0081 0.0039
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0523 0.3195
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0019
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0081 0.1127
Giardia lamblia DINP protein human, muc B family 0.0082 0.0498 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0317 0.0285
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0445 0.5028
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0168 0.0261
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0097 0.0079
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0019
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.0323
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0771
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0097 0.1404
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0084 0.0501
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0112 0.0706 0.8492
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0813 0.0813
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0445 0.7849
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0796
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0081 0.0485
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0168 0.1012
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0957
Brugia malayi polk-prov protein 0.0051 0.0281 0.1712
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0097 0.1368
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Toxoplasma gondii leucyl aminopeptidase LAP 0.0112 0.0706 0.9829
Leishmania major DNA damage repair protein, putative 0.0023 0.0091 0.0339
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0523 0.0523
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.027 0.027
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0796
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0315 0.0637
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0091 0.0339
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0097
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0677
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.027 0.027
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1299 0.127
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Echinococcus granulosus pyruvate kinase 0.0034 0.0168 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0445 0.097
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0084 0.0507
Leishmania major DNA polymerase eta, putative 0.0077 0.0461 0.5236
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0479
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0315 0.4016
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0081 0.0054
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0856 0.5859 0.5845
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0212
Echinococcus multilocularis leucine aminopeptidase protein 0.0112 0.0706 0.0675
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0091 0.0339
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0091 0.1084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Plasmodium falciparum pyruvate kinase 0.0034 0.0168 0.1772
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0081 0.0485
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.027 0.0238
Leishmania major DNA polymerase kappa, putative 0.0023 0.0091 0.0339
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0168 0.1964
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0084 0.0051
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0107 0.0671 0.9346
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0479
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0081 0.1147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0091 0.1084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0671 0.1562
Schistosoma mansoni cpg binding protein 0.0064 0.037 0.037
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0081 0.0054
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0999
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0451 0.0419
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Trypanosoma brucei unspecified product 0.0096 0.0593 0.6996
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0445 0.0935
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0168 0.0223
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0445 0.0983
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0168 0.202
Loa Loa (eye worm) hypothetical protein 0.0074 0.0445 0.2711
Echinococcus granulosus dual specificity 0.0092 0.0567 0.0536
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0437
Echinococcus multilocularis geminin 0.0355 0.2386 0.2361
Echinococcus multilocularis cpg binding protein 0.0064 0.037 0.0338
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0081 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0266 0.0234
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Brugia malayi mbt repeat family protein 0.0049 0.027 0.1645
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0168 0.2377
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0081 0.0039
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.027 0.164
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0942
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000095929
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Loa Loa (eye worm) hypothetical protein 0.0074 0.0445 0.2711
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0081 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0281 0.2857
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0317 0.0285
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000095929
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0168 0.2336
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0796
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0092 0.0564 0.3438
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1289
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0317 0.0285
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.116
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Onchocerca volvulus 0.006 0.0346 0.5993
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0033
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0168 0.1012
Loa Loa (eye worm) MBCTL1 0.0056 0.0317 0.1929
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.004
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0091 0.0091
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0019
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0084 0.0051
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0057 0.0338
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Echinococcus granulosus dna polymerase eta 0.0129 0.082 0.0789
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0081 0.0054
Mycobacterium ulcerans hypothetical protein 0.0074 0.0445 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Echinococcus granulosus leucine aminopeptidase protein 0.0112 0.0706 0.0675
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0091 0.0603
Echinococcus multilocularis dna polymerase eta 0.0129 0.082 0.0789
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0081 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0445 0.2715
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Echinococcus granulosus geminin 0.0355 0.2386 0.2361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0771
Loa Loa (eye worm) hypothetical protein 0.0086 0.0523 0.3191
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0392
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0317 0.0317
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0051
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0097 0.0094
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0081 0.0039
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0052 0.0735
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0445 0.2715
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0336 0.3584
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0091 0.0339
Schistosoma mansoni cpg binding protein 0.006 0.0346 0.0346
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Echinococcus multilocularis microtubule associated protein 2 0.1454 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Schistosoma mansoni microtubule-associated protein tau 0.1454 1 1
Entamoeba histolytica hypothetical protein 0.0092 0.0567 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0567 0.6904
Echinococcus multilocularis pyruvate kinase 0.0034 0.0168 0.0135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0266 0.1615
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.0281 0.2857
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0097 0.0409
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0248
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0168 0.1964
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0718 1
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0084 0.0507
Leishmania major pyruvate kinase 0.0034 0.0168 0.1354
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0915
Mycobacterium ulcerans DNA polymerase IV 0.0103 0.064 0.147
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0567 0.6645
Loa Loa (eye worm) hypothetical protein 0.0129 0.082 0.501
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0266 0.0234
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0336 0.3584
Onchocerca volvulus 0.0074 0.0445 0.8229
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0168 0.1964
Onchocerca volvulus 0.0086 0.0523 1
Chlamydia trachomatis cytosol aminopeptidase 0.0112 0.0706 1
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0091 0.1294
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0266 0.1621
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.064 0.762
Plasmodium falciparum M17 leucyl aminopeptidase 0.0112 0.0706 1
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0107 0.0671 0.1549
Leishmania major DNA polymerase kappa, putative 0.0082 0.0498 0.5727
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0593 0.6996
Echinococcus multilocularis dual specificity 0.0092 0.0567 0.0536
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0451 0.0998
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0168 0.202
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0103 0.064 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0475
Echinococcus granulosus pyruvate kinase 0.0034 0.0168 0.0135
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0081 0.1127
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0445 0.7849
Loa Loa (eye worm) hypothetical protein 0.0074 0.0445 0.2711
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0052 0.0723
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0567 1
Entamoeba histolytica hypothetical protein 0.0024 0.0097 0.1705
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0077 0.0461 0.6412
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0097 0.1345
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0957
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Giardia lamblia DNA damage repair protein 0.0023 0.0091 0.0885
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0437
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.027 0.0238
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0112 0.0706 0.1606
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0081 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.0323
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0084 0.0501
Chlamydia trachomatis pyruvate kinase 0.0034 0.0168 0.1168
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0445 0.5028
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0445 0.097
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.164
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036253
Echinococcus multilocularis pyruvate kinase 0.0034 0.0168 0.0135
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0112 0.0706 0.1638
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0445 0.097
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0081 0.0039
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0168 0.2333
Schistosoma mansoni pyruvate kinase 0.0018 0.0052 0.0052
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0451 0.2745
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Schistosoma mansoni hypothetical protein 0.0303 0.2027 0.2027
Mycobacterium ulcerans leucyl aminopeptidase 0.0112 0.0706 0.1638
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Trypanosoma brucei unspecified product 0.0052 0.0289 0.2959
Loa Loa (eye worm) hypothetical protein 0.0056 0.0315 0.1912
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0081 0.0202
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0523 0.0492
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.004
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0051
Leishmania major pyruvate kinase 0.0034 0.0168 0.1354
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0168 0.1018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0084 0.0248
Trypanosoma brucei unspecified product 0.0052 0.0289 0.2959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0097 0.1345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0266 0.0234
Schistosoma mansoni hypothetical protein 0.0355 0.2386 0.2386
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0168 0.1018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 0.064 0.7804
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0097 0.004
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.0924
Brugia malayi cytosol aminopeptidase 0.0022 0.0084 0.0507
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0081 0.0444
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0081 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0317 0.1929
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0584 0.3975 1
Echinococcus granulosus cpg binding protein 0.0064 0.037 0.0338
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0461 0.5604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0081 0.0485
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.027 0.0238
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0584 0.3975 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0096 0.057
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0315 0.4456
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0445 0.5028
Leishmania major DNA polymerase eta, putative 0.0129 0.082 1
Brugia malayi CXXC zinc finger family protein 0.006 0.0346 0.2109
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0091 0.1272
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0445 0.7849
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0957
Loa Loa (eye worm) oxidoreductase 0.0022 0.0081 0.0479
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0097 0.0079
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0451 0.0451
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0342
Entamoeba histolytica protein kinase, putative 0.0092 0.0567 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0081 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0584 0.3975 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.004
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0081 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.064 0.762
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0498 0.5727
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0081 0.0202
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0168 0.1354
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0315 0.0651
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0112 0.0706 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 0.064 0.762
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0097 0.0079
Brugia malayi Protein kinase domain containing protein 0.0092 0.0567 0.3463
Entamoeba histolytica protein kinase, putative 0.0092 0.0567 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0019
Echinococcus multilocularis pyruvate kinase 0.0027 0.0118 0.0085
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.027 0.027
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1299 0.127
Schistosoma mansoni pyruvate kinase 0.0034 0.0168 0.0168
Trichomonas vaginalis DNA polymerase eta, putative 0.0103 0.064 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0084 0.0507
Mycobacterium ulcerans hypothetical protein 0.0023 0.0091 0.0065
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0097 0.0683
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0346 0.2104
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0567 0.6904
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0168 0.1012
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0081 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0445 0.097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0479
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0451 0.0419
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0019
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0097 0.0409
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0081 0.0957
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.027 0.0238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0081 0.0054
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0451 0.275
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0033
Mycobacterium ulcerans DNA polymerase IV 0.0103 0.064 0.147
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0096 0.169
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.1012
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0081 0.0054
Brugia malayi ImpB/MucB/SamB family protein 0.0129 0.082 0.5013
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0168 0.2333
Loa Loa (eye worm) hypothetical protein 0.0092 0.0564 0.3438
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0523 0.0492
Schistosoma mansoni hypothetical protein 0.0355 0.2386 0.2386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0294 0.0597
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0671 0.1562
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0091 0.0339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0451 0.7949
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0168 0.1354
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.0498 0.5727
Echinococcus granulosus dna polymerase kappa 0.0103 0.064 0.0609
Loa Loa (eye worm) hypothetical protein 0.0051 0.0281 0.1707
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0081 0.0924
Loa Loa (eye worm) hypothetical protein 0.0024 0.0096 0.057
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Treponema pallidum licC protein (licC) 0.0107 0.0671 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0567 0.6645
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000095929
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0081 0.0039
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0584 0.3975 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0081 0.0039
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0112 0.0706 0.8608
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0112 0.0706 0.8608
Giardia lamblia Pyruvate kinase 0.0034 0.0168 0.2601
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0677
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0445 0.0983
Echinococcus multilocularis dna polymerase kappa 0.0103 0.064 0.0609
Brugia malayi follicle stimulating hormone receptor 0.0246 0.1634 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0317 0.0285
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0091 0.0339
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0317 0.1934
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0081 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0445 0.2715

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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