Detailed information for compound 704641

Basic information

Technical information
  • TDR Targets ID: 704641
  • Name: N-(4-chlorophenyl)-1-phenyl-3,4-dihydro-1H-py rrolo[2,1-c]pyrazine-2-carboxamide
  • MW: 351.829 | Formula: C20H18ClN3O
  • H donors: 1 H acceptors: 1 LogP: 3.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)N1CCn2c(C1c1ccccc1)ccc2
  • InChi: 1S/C20H18ClN3O/c21-16-8-10-17(11-9-16)22-20(25)24-14-13-23-12-4-7-18(23)19(24)15-5-2-1-3-6-15/h1-12,19H,13-14H2,(H,22,25)
  • InChiKey: QQUWJKDXZFVXEN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.008 0.008
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0059 0.0848
Loa Loa (eye worm) RecQ helicase 0.0021 0.0075 0.0449
Loa Loa (eye worm) oxidoreductase 0.0022 0.0083 0.0501
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.2828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092915
Echinococcus multilocularis leucine aminopeptidase protein 0.0109 0.069 0.0658
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0673 0.7927
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0083 0.0385
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0083 0.1128
Loa Loa (eye worm) hypothetical protein 0.0056 0.0322 0.1995
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0109 0.069 0.1494
Echinococcus multilocularis pyruvate kinase 0.0036 0.0182 0.0148
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0455 0.4958
Mycobacterium ulcerans hypothetical protein 0.0113 0.0718 0.1562
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0561 0.0561
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0025
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0168
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0259 0.1589
Echinococcus granulosus dnaJ subfamily B 0.0868 0.5992 0.5978
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0831 0.0831
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0075 0.0449
Trypanosoma brucei unspecified product 0.0054 0.0303 0.3015
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0083 0.0895
Giardia lamblia DNA damage repair protein 0.0024 0.0097 0.0827
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0083 0.0083
Schistosoma mansoni DNA polymerase eta 0.0132 0.0849 0.0849
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0182 0.1121
Schistosoma mansoni ap endonuclease 0.002 0.0067 0.0067
Brugia malayi polk-prov protein 0.0053 0.0299 0.1842
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0471 0.0981
Schistosoma mansoni pyruvate kinase 0.0019 0.0059 0.0059
Echinococcus multilocularis geminin 0.036 0.244 0.2414
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0109 0.069 1
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0455 0.2818
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0083 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Schistosoma mansoni pyruvate kinase 0.0036 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0091 0.0561 0.3491
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0182 0.2075
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0083 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0299 0.2968
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0259 0.0225
Echinococcus multilocularis dual specificity 0.0097 0.0607 0.0575
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0182 0.2118
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0182 0.0289
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0067 0.0651
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0182 0.1109
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1601 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0455 0.4958
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0059 0.0797
Schistosoma mansoni ap endonuclease 0.002 0.0067 0.0067
Schistosoma mansoni DNA helicase recq5 0.0021 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0075 0.0449
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1386 0.1356
Schistosoma mansoni pyruvate kinase 0.0036 0.0182 0.0182
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1386 0.1356
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0083 0.0946
Echinococcus multilocularis cpg binding protein 0.0064 0.0378 0.0345
Brugia malayi mbt repeat family protein 0.0052 0.0291 0.1792
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0561 0.3482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0259 0.0259
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0097 0.0381
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0291 0.0258
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0109 0.069 0.1462
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0353 0.3656
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0075 0.0041
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.03 0.0572
Toxoplasma gondii exonuclease III APE 0.002 0.0067 0.0912
Chlamydia trachomatis cytosol aminopeptidase 0.0109 0.069 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0353 0.3656
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0083 0.0038
Echinococcus granulosus dna polymerase kappa 0.0107 0.0673 0.0642
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.008 0.0484
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0322 0.4659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0259 0.0225
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0455 0.0929
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000092915
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0455 0.2818
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Loa Loa (eye worm) hypothetical protein 0.0056 0.0322 0.1995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0097 0.0604 0.376
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0455 0.0929
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0182 0.1121
Trypanosoma brucei aminopeptidase, putative 0.0022 0.008 0.0168
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0083 0.0038
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0078 0.0474 0.6456
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Loa Loa (eye worm) hypothetical protein 0.0022 0.0083 0.0501
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0607 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0083 0.0038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0322 0.0623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0083 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0083 0.0487
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0025
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0083 0.0202
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0106 0.0056
Leishmania major DNA damage repair protein, putative 0.0024 0.0097 0.0381
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0083 0.0051
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0106 0.1444
Echinococcus multilocularis dnaJ subfamily B 0.0868 0.5992 0.5978
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0067 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0299 0.2968
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0067 0.0402
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.0607 0.6907
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0455 0.749
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0168
Echinococcus granulosus pyruvate kinase 0.0036 0.0182 0.0148
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0067 0.0651
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Echinococcus granulosus bloom syndrome protein 0.0021 0.0075 0.0041
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0914
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0455 0.4958
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0641
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0075 0.1227
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0083 0.1128
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0097 0.0381
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0106 0.0094
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0561 0.0528
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0914
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.008 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0623 0.7115
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0083 0.0038
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0075 0.0041
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0075 0.0041
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0341 0.0308
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0607 0.6907
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0083 0.0202
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0109 0.069 0.7971
Echinococcus granulosus dna polymerase eta 0.0132 0.0849 0.0818
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0025
Onchocerca volvulus 0.0052 0.0291 0.4358
Trypanosoma cruzi DNA polymerase eta, putative 0.0132 0.0849 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.0471 0.0439
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000037723
Schistosoma mansoni hypothetical protein 0.0868 0.5992 0.5992
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0097 0.0381
Echinococcus granulosus pyruvate kinase 0.0036 0.0182 0.0148
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0291 0.4358
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0105 0.0641
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0083 0.0487
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0259 0.0225
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.008 0.0471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.03 0.0572
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0147 0.2
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0109 0.069 0.7971
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.2828
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0291 0.1804
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0561 0.0528
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0109 0.069 0.1506
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0455 0.0929
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0097 0.1111
Trichomonas vaginalis DNA polymerase eta, putative 0.0107 0.0673 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0168
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0106 0.0094
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0083 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0455 0.0942
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0673 0.7927
Trypanosoma brucei unspecified product 0.0054 0.0303 0.3015
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0607 0.7141
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.008 0.0471
Entamoeba histolytica hypothetical protein 0.0025 0.0106 0.1749
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0067 0.0971
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0182 0.2424
Schistosoma mansoni cpg binding protein 0.0064 0.0378 0.0378
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0075 0.0095
Loa Loa (eye worm) hypothetical protein 0.0132 0.0849 0.5295
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0673 0.1454
Mycobacterium ulcerans hypothetical protein 0.0075 0.0455 0.0929
Loa Loa (eye worm) hypothetical protein 0.0053 0.0299 0.1854
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0259 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0083 0.0487
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.0471 0.0471
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0085 0.0521 0.1102
Echinococcus granulosus leucine aminopeptidase protein 0.0109 0.069 0.0658
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.008 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0455 0.2818
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0097 0.0097
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0341 0.0308
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0455 0.0929
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0075 0.0345
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0097 0.0604 0.376
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0471 0.2922
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0067 0.0388
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0056 0.0322 0.1995
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0718 0.1573
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0085 0.0521 0.5812
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0058 0.0334
Loa Loa (eye worm) MBCTL1 0.0059 0.0341 0.2118
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0067 0.1104
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0083 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0083 0.0501
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0182 0.2424
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0291 0.0291
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092915
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.03 0.0572
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0182 0.1471
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0097 0.1111
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0455 0.0942
Schistosoma mansoni DNA helicase recq1 0.0021 0.0075 0.0075
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0083 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0083 0.0487
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092915
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0075 0.0435
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0083 0.0051
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0097 0.1403
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0106 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0607 0.0607
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0291 0.0258
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0097 0.0381
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0455 0.0929
Plasmodium falciparum pyruvate kinase 0.0036 0.0182 0.1955
Schistosoma mansoni microtubule-associated protein tau 0.1442 1 1
Entamoeba histolytica protein kinase, putative 0.0097 0.0607 1
Onchocerca volvulus 0.0061 0.0354 0.5677
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0341 0.0341
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0083 0.1365
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0291 0.0258
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.2828
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.1014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1601 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0291 0.0291
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0182 0.1121
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.008 0.0046
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0083 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0259 0.0225
Echinococcus granulosus dual specificity 0.0097 0.0607 0.0575
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0607 0.7141
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0075 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0067 0.0759
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0075 0.0766
Echinococcus multilocularis pyruvate kinase 0.0029 0.0129 0.0095
Mycobacterium ulcerans hypothetical protein 0.0113 0.0718 0.1562
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0083 0.0051
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0106 0.0754
Echinococcus multilocularis pyruvate kinase 0.0036 0.0182 0.0148
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0182 0.0239
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0182 0.2637
Leishmania major DNA polymerase eta, putative 0.0132 0.0849 1
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.008 0.0046
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0106 0.1538
Echinococcus multilocularis dna polymerase eta 0.0132 0.0849 0.0818
Echinococcus multilocularis dna polymerase kappa 0.0107 0.0673 0.0642
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0083 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0353 0.3656
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0083 0.0946
Mycobacterium ulcerans leucyl aminopeptidase 0.0109 0.069 0.1494
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0083 0.0202
Leishmania major DNA polymerase eta, putative 0.0078 0.0474 0.5211
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0083 0.1128
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.0471 0.0471
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.4237 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0106 0.05
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0083 0.0051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.1014
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0521 0.5812
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0109 0.069 0.8125
Brugia malayi ImpB/MucB/SamB family protein 0.0132 0.0849 0.5289
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0067 0.0897
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0083 0.0946
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092915
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0083 0.0501
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0083 0.12
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0673 0.7927
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0322 0.4164
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0034 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092915
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Plasmodium falciparum M17 leucyl aminopeptidase 0.0109 0.069 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0083 0.0895
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0673 0.7756
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0673 0.1454
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0075 0.0253
Echinococcus granulosus geminin 0.036 0.244 0.2414
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0106 0.0107
Leishmania major pyruvate kinase 0.0036 0.0182 0.1471
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0075 0.0095
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0182 0.1109
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0617 0.4237 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0168
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0113 0.0718 0.1562
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0097 0.1111
Mycobacterium ulcerans hypothetical protein 0.0024 0.0097 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0083 0.0487
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0075 0.0253
Giardia lamblia Pyruvate kinase 0.0036 0.0182 0.2667
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.4237 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000092915
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.008 0.0484
Trypanosoma brucei unspecified product 0.01 0.0623 0.7115
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0341 0.2107
Leishmania major pyruvate kinase 0.0036 0.0182 0.1471
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0341 0.0308
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.0471 0.7763
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0107 0.0673 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0259 0.1601
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0182 0.2075
Schistosoma mansoni hypothetical protein 0.032 0.2161 0.2161
Chlamydia trachomatis pyruvate kinase 0.0036 0.0182 0.1299
Schistosoma mansoni cpg binding protein 0.0061 0.0354 0.0354
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0617 0.4237 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0097 0.0606
Leishmania major DNA polymerase kappa, putative 0.0024 0.0097 0.0381
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0075 0.0766
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0075 0.0041
Brugia malayi CXXC zinc finger family protein 0.0061 0.0354 0.2187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0718 0.1573
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.0471 0.2932
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0455 0.0929
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0083 0.0051
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0182 0.0276
Leishmania major DNA polymerase kappa, putative 0.0085 0.0521 0.5812
Trypanosoma brucei DNA polymerase eta, putative 0.0132 0.0849 1
Entamoeba histolytica protein kinase, putative 0.0097 0.0607 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0322 0.3688
Echinococcus granulosus cpg binding protein 0.0064 0.0378 0.0345
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0083 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0673 0.7927
Loa Loa (eye worm) hypothetical protein 0.0056 0.0322 0.1995
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0067 0.0759
Treponema pallidum licC protein (licC) 0.0113 0.0718 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0109 0.069 0.9392
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0106 0.1444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.03 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000092915
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.0607 0.3782
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0083 0.0487
Echinococcus multilocularis microtubule associated protein 2 0.1442 1 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0182 0.2118
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0455 0.749
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0083 0.0038
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0182 0.2477
Schistosoma mansoni hypothetical protein 0.036 0.244 0.244
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0083 0.0038
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.0471 0.0439
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0109 0.069 0.8125
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0354 0.2198
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0455 0.0895
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0106 0.05
Loa Loa (eye worm) hypothetical protein 0.0052 0.0291 0.1804
Brugia malayi mbt repeat family protein 0.0052 0.0291 0.1792
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0455 0.749
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0041
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0083 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0067 0.0135
Giardia lamblia DINP protein human, muc B family 0.0085 0.0521 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0067 0.0014
Schistosoma mansoni cpg binding protein 0.0064 0.0378 0.0378
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0083 0.0501
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0474 0.5575
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0322 0.061
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0106 0.1444
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0097 0.1111
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.008 0.0471
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0025
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0455 0.0895
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0083 0.0049
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.008 0.0168
Brugia malayi cytosol aminopeptidase 0.0022 0.008 0.0471
Onchocerca volvulus 0.0075 0.0455 0.7782
Onchocerca volvulus 0.0091 0.0561 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0025
Schistosoma mansoni leucine aminopeptidase 0.0022 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0059 0.0341 0.2118
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0113 0.0718 0.9776
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.0435
Loa Loa (eye worm) histone methyltransferase 0.0019 0.006 0.0358
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0097 0.1318
Brugia malayi Protein kinase domain containing protein 0.0097 0.0607 0.3773
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0105 0.1734
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0291 0.0258
Entamoeba histolytica hypothetical protein 0.0097 0.0607 1
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0083 0.0202
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0083 0.0051
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0075 0.0766
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0735 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0182 0.1471
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0673 0.7756
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0673 0.7756
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0341 0.0308
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0097 0.0381
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0182 0.2075
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0067 0.0184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0067 0.0033
Schistosoma mansoni hypothetical protein 0.036 0.244 0.244
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.008 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0455 0.0929
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0075 0.0847
Loa Loa (eye worm) hypothetical protein 0.0036 0.0182 0.1121
Loa Loa (eye worm) hypothetical protein 0.0056 0.0322 0.1995

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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