Detailed information for compound 704675

Basic information

Technical information
  • TDR Targets ID: 704675
  • Name: 1-(3,4-dimethoxyphenyl)-2-(4-nitrophenyl)sulf onyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine
  • MW: 443.473 | Formula: C21H21N3O6S
  • H donors: 0 H acceptors: 4 LogP: 2.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)C1c2cccn2CCN1S(=O)(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C21H21N3O6S/c1-29-19-10-5-15(14-20(19)30-2)21-18-4-3-11-22(18)12-13-23(21)31(27,28)17-8-6-16(7-9-17)24(25)26/h3-11,14,21H,12-13H2,1-2H3
  • InChiKey: RCMCFGLBSIEDRB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0082 0.0051
Leishmania major DNA polymerase eta, putative 0.0132 0.0793 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0535
Schistosoma mansoni DNA polymerase eta 0.0132 0.0793 0.0791
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0617 0.7569
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0324 0.351
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.095
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.011 0.0645 0.1532
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0147
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1119
Leishmania major DNA polymerase eta, putative 0.0079 0.0446 0.5199
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0598 0.3825 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.044 0.0985
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0117 0.0692 0.1657
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0055
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0084 0.048 0.1117
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0091 0.1347
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.1073
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0069 0.1004
Loa Loa (eye worm) hypothetical protein 0.0132 0.0793 0.4939
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Trichomonas vaginalis DNA polymerase eta, putative 0.0105 0.0617 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0304 0.0274
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1127
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0469
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0031 0.0029
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0117 0.0692 0.1633
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.008 0.0028
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0971
Mycobacterium ulcerans DNA polymerase IV 0.0105 0.0617 0.1459
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0077 0.0444
Trypanosoma cruzi DNA polymerase kappa, putative 0.0105 0.0617 0.7767
Schistosoma mansoni hypothetical protein 0.0366 0.2317 0.2316
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0091 0.1628
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.016 0.125
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0598 0.3825 1
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.016 0.2313
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0087 0.1219
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0117 0.0692 0.871
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.05
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0077 0.0444
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0087 0.0243
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0598 0.3825 1
Loa Loa (eye worm) pyruvate kinase 0.0035 0.016 0.097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0069 0.1238
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.008 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Trypanosoma brucei pyruvate kinase 1 0.0035 0.016 0.125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0258
Loa Loa (eye worm) hypothetical protein 0.0052 0.027 0.1658
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0087 0.1039
Entamoeba histolytica deoxycytidyl transferase, putative 0.0077 0.0435 0.7979
Schistosoma mansoni DNA helicase recq1 0.0022 0.0077 0.0075
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.016 0.0999
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0055
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.05
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0077 0.048
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.0544 0.6556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0258
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0087 0.0085
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0091 0.0058
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0087 0.1229
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0078 0.044 0.0985
Entamoeba histolytica protein kinase, putative 0.0094 0.0544 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.016 0.1892
Schistosoma mansoni microtubule-associated protein tau 0.1546 1 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.008 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0261 0.0258
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1434
Schistosoma mansoni cpg binding protein 0.0062 0.0335 0.0333
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0311 0.4476
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.1073
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.044 0.0985
Brugia malayi follicle stimulating hormone receptor 0.0256 0.1601 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0028
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0055
Brugia malayi mbt repeat family protein 0.005 0.0258 0.1615
Plasmodium vivax pyruvate kinase, putative 0.0035 0.016 0.2286
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0258 0.0228
Entamoeba histolytica hypothetical protein 0.0094 0.0544 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0544 0.6837
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0077 0.0046
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0077 0.0918
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0815
Echinococcus multilocularis pyruvate kinase 0.0028 0.0112 0.0081
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0055
Echinococcus granulosus leucine aminopeptidase protein 0.0117 0.0692 0.0663
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0091 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.016 0.097
Chlamydia trachomatis pyruvate kinase 0.0035 0.016 0.1142
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.016 0.2268
Brugia malayi CXXC zinc finger family protein 0.0062 0.0335 0.2093
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0078 0.044 0.0985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0261 0.023
Entamoeba histolytica hypothetical protein 0.0025 0.0091 0.1643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0261 0.023
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0005 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.044 0.807
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0328
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0049
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0069 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.048 0.567
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0469
Echinococcus granulosus cpg binding protein 0.0066 0.0358 0.0328
Loa Loa (eye worm) MBCTL1 0.0057 0.0304 0.1872
Loa Loa (eye worm) hypothetical protein 0.0078 0.044 0.2722
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0091 0.0303
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0082 0.0514
Mycobacterium ulcerans hypothetical protein 0.0024 0.0087 0.0047
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0082 0.0483
Loa Loa (eye worm) hypothetical protein 0.0078 0.044 0.2722
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0077 0.0435 0.0405
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Brugia malayi cytosol aminopeptidase 0.0023 0.0082 0.0514
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0502 0.0472
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0117 0.0692 0.871
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.048
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0311 0.3657
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0082 0.008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0041
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0087 0.1039
Echinococcus multilocularis dual specificity 0.0094 0.0544 0.0515
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0091 0.1281
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0544 0.6837
Schistosoma mansoni pyruvate kinase 0.0018 0.0048 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0261 0.16
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0697 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.016 0.0999
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0077 0.0918
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0147
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0311 0.0668
Echinococcus multilocularis dna polymerase kappa 0.0105 0.0617 0.0588
Schistosoma mansoni pyruvate kinase 0.0035 0.016 0.0158
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0087 0.0243
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0069 0.0489
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0069 0.0038
Schistosoma mansoni hypothetical protein 0.0366 0.2317 0.2316
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.008 0.0028
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0078 0.044 0.101
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0304 0.0274
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.016 0.1892
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.091
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0082 0.0051
Loa Loa (eye worm) hypothetical protein 0.0058 0.0311 0.1916
Trypanosoma brucei unspecified product 0.0098 0.0572 0.6942
Loa Loa (eye worm) pyruvate kinase 0.0035 0.016 0.097
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0311 0.4081
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.044 0.807
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0258 0.1587
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.016 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0617 0.7569
Schistosoma mansoni hypothetical protein 0.031 0.1952 0.195
Mycobacterium ulcerans pyruvate kinase 0.0035 0.016 0.0241
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0598 0.3825 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0335 0.2068
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0087 0.1039
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0087 0.0243
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0077 0.0046
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0077 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0324 0.351
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0055
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.016 0.1963
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.044 0.5112
Mycobacterium ulcerans leucyl aminopeptidase 0.0117 0.0692 0.1657
Loa Loa (eye worm) hypothetical protein 0.0078 0.044 0.2722
Loa Loa (eye worm) hypothetical protein 0.0094 0.0541 0.3357
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0084 0.048 0.567
Trypanosoma brucei DNA polymerase eta, putative 0.0132 0.0793 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0304 0.0302
Echinococcus multilocularis cpg binding protein 0.0066 0.0358 0.0328
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0117 0.0692 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0069 0.0815
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0304 0.0274
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0091 0.0535
Treponema pallidum licC protein (licC) 0.011 0.0645 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.029 0.0613
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0000000010134
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.05
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0544 0.0542
Echinococcus multilocularis microtubule associated protein 2 0.1546 1 1
Echinococcus granulosus pyruvate kinase 0.0035 0.016 0.0129
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.044 0.5112
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.008 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Echinococcus granulosus geminin 0.0366 0.2317 0.2293
Echinococcus multilocularis pyruvate kinase 0.0035 0.016 0.0129
Mycobacterium ulcerans hypothetical protein 0.011 0.0645 0.1532
Brugia malayi AMP-binding enzyme family protein 0.0078 0.044 0.2745
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0067
Schistosoma mansoni DNA helicase recq5 0.0022 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0449
Schistosoma mansoni cpg binding protein 0.0066 0.0358 0.0356
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.095
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1251 0.1223
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.016 0.0213
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1251 0.1223
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0261 0.1627
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0258 0.0256
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0502 0.0472
Chlamydia trachomatis cytosol aminopeptidase 0.0117 0.0692 1
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0087 0.0243
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0258 0.4228
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0077 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0324 0.351
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.048
Onchocerca volvulus 0.0062 0.0335 0.6044
Plasmodium falciparum M17 leucyl aminopeptidase 0.0117 0.0692 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.027 0.2768
Toxoplasma gondii exonuclease III APE 0.0021 0.0069 0.0966
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0055
Mycobacterium ulcerans DNA polymerase IV 0.0105 0.0617 0.1459
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0082 0.0483
Loa Loa (eye worm) hypothetical protein 0.0058 0.0311 0.1916
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0258 0.0228
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0000000010134
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0435 0.2714
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.0435 0.0997
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0258 0.0256
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0304 0.0274
Trypanosoma cruzi DNA polymerase kappa, putative 0.0105 0.0617 0.7767
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.0544 0.3377
Leishmania major pyruvate kinase 0.0035 0.016 0.125
Trypanosoma cruzi DNA polymerase kappa, putative 0.0105 0.0617 0.7767
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.044 0.101
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0105 0.0617 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0446 0.6384
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0028
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0082 0.0178
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0469
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0049
Entamoeba histolytica protein kinase, putative 0.0094 0.0544 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0055
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0304 0.1898
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0469
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.05
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0054 0.0338
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0000000010134
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.044 0.096
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0469
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0082 0.008
Loa Loa (eye worm) RecQ helicase 0.0022 0.0077 0.0449
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0048 0.0667
Echinococcus multilocularis leucine aminopeptidase protein 0.0117 0.0692 0.0663
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0493
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0311 0.0643
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1119
Plasmodium falciparum pyruvate kinase 0.0035 0.016 0.1735
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.011 0.0645 0.9248
Schistosoma mansoni terminal deoxycytidyl transferase 0.0077 0.0435 0.0432
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0502 0.05
Echinococcus granulosus pyruvate kinase 0.0018 0.0048 0.0017
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0117 0.0692 0.8596
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0005 0.0052
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0258 0.0228
Trypanosoma cruzi DNA polymerase eta, putative 0.0132 0.0793 1
Echinococcus granulosus dnaJ subfamily B 0.0884 0.5692 0.5679
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0077 0.0449
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0971
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.029 0.0613
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0087 0.0602
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0789 0.0787
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.0078
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0067
Echinococcus multilocularis pyruvate kinase 0.0035 0.016 0.0129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.029 0.0613
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.044 0.5112
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0446 0.5591
Echinococcus multilocularis geminin 0.0366 0.2317 0.2293
Toxoplasma gondii leucyl aminopeptidase LAP 0.0117 0.0692 0.9924
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0048 0.0662
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.016 0.1892
Loa Loa (eye worm) hypothetical protein 0.0088 0.0502 0.3114
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0055
Loa Loa (eye worm) pyruvate kinase 0.0035 0.016 0.097
Brugia malayi polk-prov protein 0.0052 0.027 0.1685
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Brugia malayi Protein kinase domain containing protein 0.0094 0.0544 0.3398
Loa Loa (eye worm) hypothetical protein 0.005 0.0258 0.1587
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.016 0.2313
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.016 0.1963
Giardia lamblia Pyruvate kinase 0.0035 0.016 0.2586
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.1601 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0077 0.0435 0.2691
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0792
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0258 0.0228
Onchocerca volvulus 0.0078 0.044 0.8517
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.0645 0.1555
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0502 0.3136
Entamoeba histolytica acyl-coA synthetase, putative 0.0078 0.044 0.807
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0087 0.1039
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0091 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0055
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0077 0.0435 0.0405
Echinococcus granulosus dna polymerase kappa 0.0105 0.0617 0.0588
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.0544 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.029 0.0613
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0091 0.0085
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0082 0.0514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0973
Leishmania major pyruvate kinase 0.0035 0.016 0.125
Schistosoma mansoni cpg binding protein 0.0066 0.0358 0.0356
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0077 0.0103
Echinococcus granulosus dna polymerase eta 0.0132 0.0793 0.0765
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0258 0.0256
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.044 0.096
Trypanosoma brucei unspecified product 0.0053 0.0278 0.2884
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0078 0.044 0.0985
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Giardia lamblia DINP protein human, muc B family 0.0084 0.048 1
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0082 0.0051
Mycobacterium ulcerans hypothetical protein 0.011 0.0645 0.1532
Loa Loa (eye worm) hypothetical protein 0.0058 0.0311 0.1916
Leishmania major DNA damage repair protein, putative 0.0024 0.0087 0.0243
Mycobacterium ulcerans hypothetical protein 0.0078 0.044 0.0985
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0077 0.0662
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0078 0.044 0.0985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0261 0.023
Echinococcus granulosus dual specificity 0.0094 0.0544 0.0515
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0069 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0078 0.044 0.2745
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0057 0.0304 0.1872
Leishmania major DNA polymerase kappa, putative 0.0084 0.048 0.567
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0117 0.0692 0.8596
Loa Loa (eye worm) hypothetical protein 0.0058 0.0311 0.1916
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0056 0.0317
Trypanosoma cruzi DNA polymerase kappa, putative 0.0105 0.0617 0.7767
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0091 0.1281
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0055
Leishmania major DNA polymerase kappa, putative 0.0024 0.0087 0.0243
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0069 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.0884 0.5692 0.5679
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0091 0.0303
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0069 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.027 0.2768
Loa Loa (eye worm) hypothetical protein 0.0094 0.0541 0.3357
Echinococcus granulosus bloom syndrome protein 0.0022 0.0077 0.0046
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0005 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0792
Brugia malayi AMP-binding enzyme family protein 0.0078 0.044 0.2745
Schistosoma mansoni pyruvate kinase 0.0035 0.016 0.0158
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0178
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0077 0.0435 0.0432
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0091 0.1291
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0979
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0077 0.1376
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1119
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0091 0.003
Onchocerca volvulus 0.0088 0.0502 1
Giardia lamblia DNA damage repair protein 0.0024 0.0087 0.0897
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0082 0.0051
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0082 0.0979
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.0572 0.6942
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0058 0.0311 0.1916
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0077 0.0046
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0077 0.0046
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.0544 0.6556
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0147
Brugia malayi ImpB/MucB/SamB family protein 0.0132 0.0793 0.4956
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0117 0.0692 0.1679
Echinococcus multilocularis pyruvate kinase 0.0018 0.0048 0.0017
Brugia malayi mbt repeat family protein 0.005 0.0258 0.1615
Echinococcus multilocularis dna polymerase eta 0.0132 0.0793 0.0765
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.044 0.0985
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0617 0.7569
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.00000000037791
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.008 0.0028
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0087 0.0243
Schistosoma mansoni hypothetical protein 0.0884 0.5692 0.5691
Echinococcus granulosus pyruvate kinase 0.0035 0.016 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0261 0.023
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0091 0.0669
Onchocerca volvulus 0.005 0.0258 0.4228
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.05
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0082 0.0514
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0132 0.1872
Trypanosoma brucei unspecified product 0.0053 0.0278 0.2884
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.0645 0.1555

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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