Detailed information for compound 704678

Basic information

Technical information
  • TDR Targets ID: 704678
  • Name: 1-(4-bromophenyl)-N-(3,4-dimethoxyphenyl)-3,4 -dihydro-1H-pyrrolo[2,1-c]pyrazine-2-carboxam ide
  • MW: 456.332 | Formula: C22H22BrN3O3
  • H donors: 1 H acceptors: 1 LogP: 3.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)NC(=O)N1CCn2c(C1c1ccc(cc1)Br)ccc2
  • InChi: 1S/C22H22BrN3O3/c1-28-19-10-9-17(14-20(19)29-2)24-22(27)26-13-12-25-11-3-4-18(25)21(26)15-5-7-16(23)8-6-15/h3-11,14,21H,12-13H2,1-2H3,(H,24,27)
  • InChiKey: QUYWFQHNZDMNEJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0085 0.0085
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0299 0.0262
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0401
Echinococcus multilocularis geminin 0.0368 0.2488 0.246
Schistosoma mansoni cpg binding protein 0.0066 0.0388 0.0388
Echinococcus multilocularis pyruvate kinase 0.0037 0.0188 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0459 0.093
Echinococcus granulosus dual specificity 0.0099 0.062 0.0585
Loa Loa (eye worm) hypothetical protein 0.0076 0.0459 0.2798
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0085 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0307 0.3011
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.035 0.0314
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Loa Loa (eye worm) hypothetical protein 0.0076 0.0459 0.2798
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0325 0.0611
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0299 0.4379
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000089547
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0862
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0085 0.0046
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0188 0.1107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0266 0.0266
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0028
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.035 0.2104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.106
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.0062 0.0363 0.0363
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0684
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0233
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1178
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0099 0.0617 0.3765
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Giardia lamblia Pyruvate kinase 0.0037 0.0188 0.2666
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0028 0.00000000089547
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0459 0.2776
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0085 0.0048
Leishmania major DNA damage repair protein, putative 0.0025 0.0101 0.0443
Trypanosoma cruzi DNA polymerase eta, putative 0.0135 0.0867 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0729
Loa Loa (eye worm) hypothetical protein 0.0093 0.0573 0.3497
Echinococcus granulosus geminin 0.0368 0.2488 0.246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000089547
Trypanosoma brucei DNA polymerase IV, putative 0.0109 0.0688 0.7769
Mycobacterium ulcerans hypothetical protein 0.0076 0.0459 0.0926
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0112 0.0706 0.7992
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0084 0.0047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0064 0.0027
Echinococcus multilocularis pyruvate kinase 0.0019 0.0062 0.0025
Echinococcus granulosus dna polymerase eta 0.0135 0.0867 0.0833
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0085 0.0051
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.0036
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0188 0.2422
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.0036
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0101 0.0443
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.035 0.0314
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0889 0.6105 0.609
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0085 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0401
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0505
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0325 0.4607
Echinococcus granulosus pyruvate kinase 0.0019 0.0062 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0482 0.0985
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0085 0.0242
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0233
Treponema pallidum licC protein (licC) 0.0116 0.0734 1
Giardia lamblia DNA damage repair protein 0.0025 0.0101 0.0828
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0101 0.1139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0266 0.023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0085 0.0476
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0085 0.0051
Schistosoma mansoni pyruvate kinase 0.0037 0.0188 0.0188
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000089547
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0101 0.0101
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.008 0.0482 0.0447
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0945
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0188 0.2105
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Trypanosoma brucei unspecified product 0.0102 0.0637 0.7132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0459 0.0884
Echinococcus multilocularis cpg binding protein 0.0066 0.0388 0.0352
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0112 0.0706 0.8138
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0085 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0037 0.0037
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0085 0.1206
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0505
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0084 0.0047
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0112 0.0706 0.7992
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0101 0.0443
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0188 0.2105
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0047
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0459 0.0926
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0188 0.0292
Giardia lamblia DINP protein human, muc B family 0.0087 0.0534 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0325 0.1978
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0085 0.1134
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0233
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0062 0.0828
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0085 0.0476
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0188 0.1135
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0684
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0459 0.74
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0849 0.0849
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0729
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0111 0.1474
Mycobacterium ulcerans hypothetical protein 0.0116 0.0734 0.1572
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0084 0.0501
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0656
Echinococcus granulosus pyruvate kinase 0.0019 0.0062 0.0025
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000089547
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.0169
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0573 0.0573
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0101 0.1434
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0085 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0688 0.7932
Mycobacterium ulcerans hypothetical protein 0.0116 0.0734 0.1572
Mycobacterium ulcerans DNA polymerase IV 0.0109 0.0688 0.1465
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0111 0.0106
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0085 0.0953
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0304 0.0565
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000089547
Trypanosoma brucei DNA polymerase IV, putative 0.0109 0.0688 0.7769
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0213 0.1412 0.138
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0266 0.1589
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0084 0.0471
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0188 0.2142
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0459 0.0926
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0325 0.4086
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0573
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0101 0.0443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0266 0.0266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0266 0.023
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0684
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0101 0.0443
Schistosoma mansoni cpg binding protein 0.0066 0.0388 0.0388
Schistosoma mansoni hypothetical protein 0.0889 0.6105 0.6105
Echinococcus granulosus dnaJ subfamily B 0.0889 0.6105 0.609
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0084 0.0084
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0459 0.0884
Onchocerca volvulus 0.0053 0.0299 0.4379
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0084 0.0047
Echinococcus multilocularis dna polymerase eta 0.0135 0.0867 0.0833
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0087 0.0534 0.1105
Echinococcus granulosus leucine aminopeptidase protein 0.0112 0.0706 0.0671
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0112 0.0706 0.8138
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0085 0.1134
Trypanosoma brucei DNA polymerase eta, putative 0.0135 0.0867 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.008 0.0482 0.2941
Echinococcus granulosus pyruvate kinase 0.0019 0.0062 0.0025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.1634 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0091
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0188 0.2422
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0459 0.0926
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0085 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0266 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0362 0.3696
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0152 0.2028
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0188 0.1135
Schistosoma mansoni DNA polymerase eta 0.0135 0.0867 0.0867
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0459 0.0926
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0101 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.062 0.062
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0945
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0304 0.0565
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0325 0.0616
Loa Loa (eye worm) hypothetical protein 0.0057 0.0325 0.1978
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0085 0.0476
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0814
Echinococcus multilocularis leucine aminopeptidase protein 0.0112 0.0706 0.0671
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0084 0.0501
Toxoplasma gondii leucyl aminopeptidase LAP 0.0112 0.0706 0.9401
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0085 0.0051
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0573 0.3477
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0085 0.0046
Trichomonas vaginalis DNA polymerase eta, putative 0.0109 0.0688 1
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0299 0.0299
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0299 0.1816
Loa Loa (eye worm) hypothetical protein 0.0057 0.0325 0.1978
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0099 0.062 0.3787
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0084 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0459 0.0926
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0085 0.1372
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0482 0.2919
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0085 0.0051
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0299 0.0299
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0188 0.0287
Mycobacterium ulcerans DNA polymerase IV 0.0109 0.0688 0.1465
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0111 0.1474
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0111 0.0561
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0085 0.0953
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0459 0.491
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0085 0.0046
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0064 0.0374
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0486 0.5589
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0085 0.0048
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0099 0.062 0.7147
Plasmodium falciparum pyruvate kinase 0.0037 0.0188 0.1952
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0973
Leishmania major DNA polymerase kappa, putative 0.0025 0.0101 0.0443
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0112 0.0706 0.1511
Loa Loa (eye worm) hypothetical protein 0.0053 0.0299 0.1816
Schistosoma mansoni hypothetical protein 0.0368 0.2488 0.2488
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0573 0.0538
Brugia malayi polk-prov protein 0.0054 0.0307 0.184
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Loa Loa (eye worm) hypothetical protein 0.0099 0.0617 0.3765
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0188 0.2501
Brugia malayi ImpB/MucB/SamB family protein 0.0135 0.0867 0.5284
Plasmodium falciparum M17 leucyl aminopeptidase 0.0112 0.0706 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0085 0.0046
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0116 0.0734 0.977
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000089547
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0631 0.4315 1
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0112 0.0706 0.1507
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0085 0.0867
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0111 0.1567
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0304 0.0565
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0087 0.0534 0.5838
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0084 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0099 0.062 0.6923
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.0482 0.0482
Chlamydia trachomatis pyruvate kinase 0.0037 0.0188 0.1297
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0459 0.2776
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0101 0.1139
Loa Loa (eye worm) hypothetical protein 0.0057 0.0325 0.1978
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0085 0.0505
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0459 0.093
Echinococcus multilocularis dna polymerase kappa 0.0109 0.0688 0.0653
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0573
Loa Loa (eye worm) MBCTL1 0.0061 0.035 0.2129
Brugia malayi follicle stimulating hormone receptor 0.0245 0.1634 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.1135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.00000000089547
Toxoplasma gondii ImpB/MucB/SamB family protein 0.008 0.0486 0.6468
Echinococcus granulosus cpg binding protein 0.0066 0.0388 0.0352
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0631 0.4315 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0085 0.0476
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0085 0.0356
Brugia malayi cytosol aminopeptidase 0.0022 0.0084 0.0471
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0325 0.3605
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0085 0.0505
Echinococcus granulosus dna polymerase kappa 0.0109 0.0688 0.0653
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0111 0.0111
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0085 0.0867
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0084 0.0233
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0266 0.1615
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0111 0.0106
Loa Loa (eye worm) hypothetical protein 0.0054 0.0307 0.1866
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Leishmania major pyruvate kinase 0.0037 0.0188 0.1524
Schistosoma mansoni hypothetical protein 0.0368 0.2488 0.2488
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0299 0.0262
Loa Loa (eye worm) oxidoreductase 0.0022 0.0085 0.0505
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0459 0.74
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0085 0.0953
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.011 0.0656
Leishmania major DNA polymerase eta, putative 0.0135 0.0867 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0005
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0101 0.1348
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0363 0.221
Loa Loa (eye worm) hypothetical protein 0.0061 0.035 0.2129
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0459 0.2776
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0111 0.0561
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0299 0.0262
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0631 0.4315 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0734 0.1577
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.035 0.0314
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0085 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0534 0.5838
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0085 0.0051
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0188 0.2105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0688 0.7932
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0085 0.0051
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0085 0.0051
Echinococcus multilocularis pyruvate kinase 0.0019 0.0062 0.0025
Entamoeba histolytica protein kinase, putative 0.0099 0.062 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.008 0.0482 0.0482
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0631 0.4315 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0084 0.0471
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0109 0.0688 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0101 0.1139
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0362 0.3696
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0111 0.0106
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0299 0.0262
Echinococcus multilocularis pyruvate kinase 0.0029 0.0133 0.0096
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0188 0.1135
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0213 0.1412 0.138
Brugia malayi Protein kinase domain containing protein 0.0099 0.062 0.3768
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.011 0.1769
Echinococcus multilocularis pyruvate kinase 0.0019 0.0062 0.0025
Entamoeba histolytica protein kinase, putative 0.0099 0.062 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Trypanosoma brucei unspecified product 0.0055 0.0311 0.3059
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.0075
Entamoeba histolytica deoxycytidyl transferase, putative 0.008 0.0482 0.7776
Echinococcus multilocularis dual specificity 0.0099 0.062 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0085 0.0046
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0188 0.1107
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.0637 0.7132
Mycobacterium ulcerans leucyl aminopeptidase 0.0112 0.0706 0.1507
Leishmania major DNA polymerase kappa, putative 0.0087 0.0534 0.5838
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Mycobacterium ulcerans hypothetical protein 0.0025 0.0101 0.0083
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0112 0.0706 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0266 0.023
Chlamydia trachomatis cytosol aminopeptidase 0.0112 0.0706 1
Onchocerca volvulus 0.0093 0.0573 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0188 0.2142
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0085 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0299 0.0299
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0116 0.0734 0.1572
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0085 0.0046
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.0169
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0188 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0101 0.0606
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0085 0.0953
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0401
Entamoeba histolytica hypothetical protein 0.0026 0.0111 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.062 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0973
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0111 0.006
Leishmania major DNA polymerase eta, putative 0.008 0.0486 0.5243
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0231
Leishmania major pyruvate kinase 0.0037 0.0188 0.1524
Schistosoma mansoni pyruvate kinase 0.0019 0.0062 0.0062
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0085 0.1134
Loa Loa (eye worm) hypothetical protein 0.0076 0.0459 0.2798
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0459 0.74
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0734 0.1577
Schistosoma mansoni hypothetical protein 0.0327 0.2202 0.2202
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.7769
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0688 0.7932
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.008 0.0482 0.0447
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0459 0.0926
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0112 0.0706 0.1468
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0064 0.0027
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0188 0.1524
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0085 0.0051
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0085 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0459 0.0926
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0459 0.491
Echinococcus multilocularis pyruvate kinase 0.0037 0.0188 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036255
Brugia malayi mbt repeat family protein 0.0053 0.0299 0.179
Echinococcus granulosus pyruvate kinase 0.0037 0.0188 0.0151
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0188 0.1524
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0304 0.0565
Loa Loa (eye worm) hypothetical protein 0.0057 0.0325 0.1978
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0573 0.0538
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0085 0.0242
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0085 0.0242
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0101 0.1139
Onchocerca volvulus 0.0062 0.0363 0.5699
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0045
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0085 0.0046
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0062 0.0881
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0362 0.3696
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0459 0.491
Trypanosoma brucei unspecified product 0.0055 0.0311 0.3059
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.035 0.035
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0356
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0085 0.0046
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0111 0.0753
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0111 0.1476
Brugia malayi mbt repeat family protein 0.0053 0.0299 0.179
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0307 0.3011
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0099 0.062 0.7147
Entamoeba histolytica hypothetical protein 0.0099 0.062 1
Schistosoma mansoni microtubule-associated protein tau 0.145 1 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0188 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0085 0.0476
Echinococcus multilocularis microtubule associated protein 2 0.145 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0233
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0062 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0688 0.7932
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0099 0.062 0.6923
Schistosoma mansoni pyruvate kinase 0.0037 0.0188 0.0188
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0876
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0084 0.0471
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0751 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0084 0.0233
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0188 0.2661
Onchocerca volvulus 0.0076 0.0459 0.7663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0266 0.0266
Brugia malayi CXXC zinc finger family protein 0.0062 0.0363 0.2186
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.035 0.0314
Loa Loa (eye worm) hypothetical protein 0.0135 0.0867 0.5299

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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