Detailed information for compound 704752

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.323 | Formula: C21H13BrN4OS
  • H donors: 0 H acceptors: 4 LogP: 4.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C(=O)N(c1nc2c(s1)cc(cc2)Br)Cc1cccnc1
  • InChi: 1S/C21H13BrN4OS/c22-17-7-8-18-19(10-17)28-21(25-18)26(13-15-2-1-9-24-12-15)20(27)16-5-3-14(11-23)4-6-16/h1-10,12H,13H2
  • InChiKey: QTJIEAXOJBMMIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1123
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0458 0.6418
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.045 0.045
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0611 0.4013 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0948
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0173
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0112 0.0677 0.1546
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0948
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0097 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0498 0.5738
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.1045
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0053
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0114 0.069 0.8298
Brugia malayi ImpB/MucB/SamB family protein 0.0133 0.0818 0.5108
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0067 0.0952
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0097 0.1404
Leishmania major DNA polymerase eta, putative 0.0133 0.0818 1
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.008 0.0049
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0336 0.358
Trypanosoma cruzi DNA polymerase eta, putative 0.0133 0.0818 1
Echinococcus multilocularis dna polymerase kappa 0.0107 0.0642 0.0613
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Leishmania major pyruvate kinase 0.0036 0.0169 0.1355
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.01
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0169 0.1049
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0611 0.4013 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Giardia lamblia Pyruvate kinase 0.0036 0.0169 0.2625
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0611 0.4013 1
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0114 0.069 0.155
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1073
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0075 0.0358
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0031 0.0031
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0484
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1161
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0642 0.7658
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0315 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Echinococcus granulosus geminin 0.0365 0.2373 0.2349
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0075 0.0358
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0097 0.0096
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0114 0.069 0.8432
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0935
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0075 0.046
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0445 0.0958
Schistosoma mansoni microtubule-associated protein tau 0.1506 1 1
Plasmodium falciparum pyruvate kinase 0.0036 0.0169 0.1834
Entamoeba histolytica protein kinase, putative 0.0096 0.0572 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0053
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.009 0.1308
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0572 0.0572
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0309
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0272 0.0242
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0097 0.0076
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0169 0.2366
Loa Loa (eye worm) hypothetical protein 0.0051 0.0272 0.1687
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.008 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0067 0.1173
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0484
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0169 0.1355
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1073
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0445 0.5039
Schistosoma mansoni DNA helicase recq1 0.0022 0.0075 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0282 0.2863
Echinococcus multilocularis pyruvate kinase 0.0028 0.0118 0.0087
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0075 0.0043
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0075 0.0845
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0067 0.0788
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0169 0.0226
Echinococcus multilocularis pyruvate kinase 0.0036 0.0169 0.0138
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0169 0.2447
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0053
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0114 0.069 0.8298
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0097 0.0707
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.16 1
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0272 0.1687
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.032 0.032
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1401
Onchocerca volvulus 0.0062 0.0343 0.5865
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0077 0.0445 0.2771
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.1045
Echinococcus granulosus dual specificity 0.0096 0.0572 0.0542
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0572 0.6982
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0272 0.4292
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0169 0.1039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0258 0.16
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0097 0.1358
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1073
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.008 0.0494
Echinococcus granulosus cpg binding protein 0.0065 0.0366 0.0336
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0484
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.045 0.042
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0315 0.3671
Brugia malayi cytosol aminopeptidase 0.0023 0.008 0.0494
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0445 0.0977
Onchocerca volvulus 0.009 0.0528 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0021
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0049
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0445 0.0928
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0097 0.0397
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0272 0.0242
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0445 0.0928
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0272 0.0272
Brugia malayi CXXC zinc finger family protein 0.0062 0.0343 0.2136
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0067 0.024
Giardia lamblia DINP protein human, muc B family 0.0085 0.0498 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0067 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0445 0.7788
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.032 0.0289
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0309
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0169 0.1982
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0053
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0075 0.0845
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0713 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0169 0.1355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0445 0.0958
Loa Loa (eye worm) hypothetical protein 0.0036 0.0169 0.1039
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.088
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0067 0.0344
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0067 0.0036
Schistosoma mansoni hypothetical protein 0.0365 0.2373 0.2373
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.004
Schistosoma mansoni leucine aminopeptidase 0.0023 0.008 0.008
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0114 0.069 0.8432
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.046
Loa Loa (eye worm) hypothetical protein 0.0059 0.032 0.1985
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0272 0.0242
Schistosoma mansoni pyruvate kinase 0.0018 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0096 0.0572 1
Brugia malayi Protein kinase domain containing protein 0.0096 0.0572 0.3569
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.009 0.1266
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0096 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0336 0.358
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.045 0.045
Mycobacterium ulcerans leucyl aminopeptidase 0.0114 0.069 0.1578
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0445 0.0958
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0169 0.0258
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Leishmania major DNA polymerase kappa, putative 0.0024 0.009 0.0309
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.009 0.0604
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0075 0.0845
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0075 0.0043
Trypanosoma brucei DNA polymerase eta, putative 0.0133 0.0818 1
Leishmania major DNA polymerase kappa, putative 0.0085 0.0498 0.5738
Entamoeba histolytica protein kinase, putative 0.0096 0.0572 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.045 0.0989
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0169 0.1982
Trichomonas vaginalis DNA polymerase eta, putative 0.0107 0.0642 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0258 0.0228
Trypanosoma brucei unspecified product 0.01 0.0594 0.7024
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.008 0.0484
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.032 0.0289
Leishmania major pyruvate kinase 0.0036 0.0169 0.1355
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.032 0.0289
Schistosoma mansoni cpg binding protein 0.0062 0.0343 0.0343
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0611 0.4013 1
Schistosoma mansoni hypothetical protein 0.0317 0.2047 0.2047
Chlamydia trachomatis pyruvate kinase 0.0036 0.0169 0.1213
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0169 0.2037
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0572 0.3562
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Echinococcus multilocularis microtubule associated protein 2 0.1506 1 1
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0169 0.2367
Schistosoma mansoni hypothetical protein 0.0365 0.2373 0.2373
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.045 0.2801
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0677 0.1564
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0445 0.7788
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.008 0.0033
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0097 0.1358
Mycobacterium ulcerans hypothetical protein 0.0112 0.0677 0.1546
Schistosoma mansoni cpg binding protein 0.0065 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0642 0.1457
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.008 0.0033
Echinococcus multilocularis leucine aminopeptidase protein 0.0114 0.069 0.0661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0067 0.0788
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0107 0.0642 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.00000000097312
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0336 0.358
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0075 0.0043
Brugia malayi mbt repeat family protein 0.0051 0.0272 0.1696
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0309
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0114 0.069 0.1578
Toxoplasma gondii exonuclease III APE 0.0021 0.0067 0.094
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0282 0.2863
Plasmodium falciparum M17 leucyl aminopeptidase 0.0114 0.069 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0343 0.2128
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.008 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.046
Schistosoma mansoni ap endonuclease 0.0021 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0449
Schistosoma mansoni DNA helicase recq5 0.0022 0.0075 0.0075
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0021
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0528 0.3294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Schistosoma mansoni pyruvate kinase 0.0036 0.0169 0.0169
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.1311 0.1284
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.1311 0.1284
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0948
Schistosoma mansoni cpg binding protein 0.0065 0.0366 0.0366
Brugia malayi mbt repeat family protein 0.0051 0.0272 0.1696
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0484
Trypanosoma brucei aminopeptidase, putative 0.0023 0.008 0.0173
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0458 0.5583
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.008 0.0033
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0055 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0572 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.008 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0445 0.2779
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0445 0.0958
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.00000000097312
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0258 0.0228
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0315 0.0646
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.008 0.0484
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0315 0.456
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0258 0.0228
Loa Loa (eye worm) hypothetical protein 0.0096 0.0568 0.3541
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0445 0.0958
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0169 0.1039
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0642 0.7658
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0258 0.161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0935
Giardia lamblia DNA damage repair protein 0.0024 0.009 0.0864
Echinococcus granulosus dnaJ subfamily B 0.0882 0.5828 0.5815
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0807 0.0807
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0075 0.0449
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0444
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1123
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Loa Loa (eye worm) hypothetical protein 0.0077 0.0445 0.2771
Loa Loa (eye worm) RecQ helicase 0.0022 0.0075 0.0449
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0484
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0052 0.075
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.008 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0114 0.069 0.1595
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Toxoplasma gondii leucyl aminopeptidase LAP 0.0114 0.069 0.9673
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0528 0.0528
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0021
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Treponema pallidum licC protein (licC) 0.0112 0.0677 1
Echinococcus multilocularis pyruvate kinase 0.0036 0.0169 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0445 0.5039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0282 0.1748
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0021
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0169 0.1982
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0169 0.0278
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0169 0.2037
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0067 0.0725
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0169 0.1049
Brugia malayi follicle stimulating hormone receptor 0.025 0.16 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0445 0.0977
Echinococcus multilocularis dual specificity 0.0096 0.0572 0.0542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Chlamydia trachomatis cytosol aminopeptidase 0.0114 0.069 1
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0052 0.0725
Leishmania major DNA polymerase eta, putative 0.0079 0.0458 0.5205
Echinococcus multilocularis geminin 0.0365 0.2373 0.2349
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0445 0.2779
Schistosoma mansoni DNA polymerase eta 0.0133 0.0818 0.0818
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0169 0.1039
Schistosoma mansoni ap endonuclease 0.0021 0.0067 0.0067
Schistosoma mansoni pyruvate kinase 0.0036 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.009 0.0528 0.3287
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Echinococcus granulosus dna polymerase kappa 0.0107 0.0642 0.0613
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0572 0.6982
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.008 0.0494
Entamoeba histolytica hypothetical protein 0.0025 0.0097 0.1694
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0053
Onchocerca volvulus 0.0077 0.0445 0.8159
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Loa Loa (eye worm) hypothetical protein 0.0133 0.0818 0.5102
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0642 0.1457
Trypanosoma brucei unspecified product 0.0054 0.0288 0.2946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Mycobacterium ulcerans hypothetical protein 0.0077 0.0445 0.0958
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0169 0.2366
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0067 0.0972
Echinococcus multilocularis cpg binding protein 0.0065 0.0366 0.0336
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.01
Loa Loa (eye worm) hypothetical protein 0.0077 0.0445 0.2771
Onchocerca volvulus 0.0051 0.0272 0.4292
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0528 0.0498
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0677 0.1564
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0033
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0097 0.0076
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0445 0.0958
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1073
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0315 0.4119
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.045 0.2809
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0067 0.0413
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0114 0.069 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0085 0.0498 0.5738
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0056 0.0336
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.032 0.1994
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.008 0.0049
Mycobacterium ulcerans hypothetical protein 0.0112 0.0677 0.1546
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0445 0.2779
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.032 0.0289
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.009 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.045 0.7874
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0494
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0085 0.0498 0.111
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0096 0.0568 0.3541
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0445 0.0958
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0075 0.0512
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0594 0.7024
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.008 0.0033
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.009 0.0309
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0097 0.0076
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0528 0.0498
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0948
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.008 0.0049
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0572 0.6723
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0075 0.0043
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0075 0.0043
Loa Loa (eye worm) MBCTL1 0.0059 0.032 0.1985
Echinococcus multilocularis dnaJ subfamily B 0.0882 0.5828 0.5815
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0097 0.1394
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0067 0.0036
Brugia malayi polk-prov protein 0.0053 0.0282 0.1757
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0067 0.0402
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0097 0.0043
Leishmania major DNA damage repair protein, putative 0.0024 0.009 0.0309
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0948
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0445 0.5039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.0583
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1123
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0075 0.1304
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0572 0.6723
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0445 0.7788
Echinococcus granulosus pyruvate kinase 0.0036 0.0169 0.0138
Echinococcus granulosus bloom syndrome protein 0.0022 0.0075 0.0043
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0067 0.0725
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0096 0.0583
Echinococcus granulosus pyruvate kinase 0.0036 0.0169 0.0138
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0272 0.0242
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000037764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Schistosoma mansoni hypothetical protein 0.0882 0.5828 0.5828
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Trypanosoma brucei unspecified product 0.0054 0.0288 0.2946
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0138 0.1933
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0112 0.0677 0.9497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0258 0.0228
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.008 0.0494
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Echinococcus granulosus leucine aminopeptidase protein 0.0114 0.069 0.0661
Echinococcus granulosus dna polymerase eta 0.0133 0.0818 0.0789
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.045 0.042
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0021
Echinococcus multilocularis dna polymerase eta 0.0133 0.0818 0.0789
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0272 0.0272

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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