Detailed information for compound 704752

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.323 | Formula: C21H13BrN4OS
  • H donors: 0 H acceptors: 4 LogP: 4.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C(=O)N(c1nc2c(s1)cc(cc2)Br)Cc1cccnc1
  • InChi: 1S/C21H13BrN4OS/c22-17-7-8-18-19(10-17)28-21(25-18)26(13-15-2-1-9-24-12-15)20(27)16-5-3-14(11-23)4-6-16/h1-10,12H,13H2
  • InChiKey: QTJIEAXOJBMMIP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0336 0.358
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.032 0.0289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0133 0.0818 0.5102
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0445 0.0977
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.008 0.0494
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0713 1
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0169 0.2447
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0572 0.6723
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0642 0.1457
Toxoplasma gondii exonuclease III APE 0.0021 0.0067 0.094
Schistosoma mansoni pyruvate kinase 0.0036 0.0169 0.0169
Echinococcus granulosus pyruvate kinase 0.0036 0.0169 0.0138
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0572 0.6982
Entamoeba histolytica hypothetical protein 0.0096 0.0572 1
Schistosoma mansoni microtubule-associated protein tau 0.1506 1 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Echinococcus multilocularis microtubule associated protein 2 0.1506 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0056 0.0336
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0097 0.1394
Loa Loa (eye worm) hypothetical protein 0.0053 0.0282 0.1748
Brugia malayi mbt repeat family protein 0.0051 0.0272 0.1696
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0336 0.358
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0445 0.5039
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0052 0.075
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0097 0.0707
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.032 0.032
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0067 0.0413
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Onchocerca volvulus 0.0062 0.0343 0.5865
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1073
Echinococcus granulosus bloom syndrome protein 0.0022 0.0075 0.0043
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0528 0.0498
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0315 0.4119
Trypanosoma brucei unspecified product 0.0054 0.0288 0.2946
Echinococcus granulosus pyruvate kinase 0.0036 0.0169 0.0138
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0169 0.1355
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Schistosoma mansoni pyruvate kinase 0.0018 0.0052 0.0052
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0053
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0169 0.1355
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0445 0.0958
Loa Loa (eye worm) RecQ helicase 0.0022 0.0075 0.0449
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0114 0.069 0.1578
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000037764
Echinococcus multilocularis pyruvate kinase 0.0036 0.0169 0.0138
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0445 0.0958
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0445 0.5039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Mycobacterium ulcerans leucyl aminopeptidase 0.0114 0.069 0.1578
Schistosoma mansoni hypothetical protein 0.0317 0.2047 0.2047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.045 0.2801
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.1045
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0097 0.0043
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0458 0.6418
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0572 1
Entamoeba histolytica hypothetical protein 0.0025 0.0097 0.1694
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0445 0.7788
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0052 0.0725
Loa Loa (eye worm) hypothetical protein 0.0077 0.0445 0.2771
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1123
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0075 0.0512
Leishmania major pyruvate kinase 0.0036 0.0169 0.1355
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0169 0.0226
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.008 0.0033
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0075 0.0358
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Loa Loa (eye worm) hypothetical protein 0.0051 0.0272 0.1687
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0114 0.069 0.155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.009 0.0604
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0948
Plasmodium falciparum M17 leucyl aminopeptidase 0.0114 0.069 1
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0642 0.7658
Chlamydia trachomatis cytosol aminopeptidase 0.0114 0.069 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Onchocerca volvulus 0.009 0.0528 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0169 0.2037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0107 0.0642 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.008 0.0033
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0169 0.1049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.045 0.0989
Echinococcus multilocularis dual specificity 0.0096 0.0572 0.0542
Leishmania major DNA polymerase kappa, putative 0.0085 0.0498 0.5738
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0594 0.7024
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0112 0.0677 0.1546
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0021
Entamoeba histolytica protein kinase, putative 0.0096 0.0572 1
Brugia malayi Protein kinase domain containing protein 0.0096 0.0572 0.3569
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0096 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0067 0.0344
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Schistosoma mansoni DNA helicase recq1 0.0022 0.0075 0.0075
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0343 0.2128
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0097 0.0076
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1073
Trichomonas vaginalis DNA polymerase eta, putative 0.0107 0.0642 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.008 0.0494
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0169 0.1039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.1311 0.1284
Brugia malayi mbt repeat family protein 0.0051 0.0272 0.1696
Echinococcus multilocularis pyruvate kinase 0.0028 0.0118 0.0087
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0642 0.7658
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0053
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0075 0.0043
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0611 0.4013 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0053
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.045 0.045
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0055 0.0336
Entamoeba histolytica protein kinase, putative 0.0096 0.0572 1
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0114 0.069 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.032 0.0289
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0041
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0169 0.1982
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0498 0.5738
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0445 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Loa Loa (eye worm) hypothetical protein 0.0059 0.032 0.1985
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0272 0.0242
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0611 0.4013 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0097 0.0397
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0096 0.0583
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0484
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0445 0.7788
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0948
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0067 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.009 0.1266
Brugia malayi CXXC zinc finger family protein 0.0062 0.0343 0.2136
Leishmania major DNA polymerase eta, putative 0.0133 0.0818 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0097 0.0096
Leishmania major pyruvate kinase 0.0036 0.0169 0.1355
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0272 0.1687
Schistosoma mansoni hypothetical protein 0.0365 0.2373 0.2373
Trypanosoma brucei unspecified product 0.0054 0.0288 0.2946
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0097 0.0076
Trypanosoma brucei aminopeptidase, putative 0.0023 0.008 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0258 0.0228
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0067 0.0402
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0458 0.5583
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0611 0.4013 1
Schistosoma mansoni cpg binding protein 0.0065 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0484
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0444
Brugia malayi cytosol aminopeptidase 0.0023 0.008 0.0494
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.032 0.1994
Brugia malayi follicle stimulating hormone receptor 0.025 0.16 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0445 0.5039
Echinococcus multilocularis dna polymerase kappa 0.0107 0.0642 0.0613
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0067 0.0725
Loa Loa (eye worm) hypothetical protein 0.0036 0.0169 0.1039
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0445 0.2779
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0484
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1073
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0572 0.6723
Treponema pallidum licC protein (licC) 0.0112 0.0677 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0935
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0097 0.1404
Echinococcus granulosus dna polymerase kappa 0.0107 0.0642 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0282 0.2863
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0085 0.0498 0.5738
Chlamydia trachomatis pyruvate kinase 0.0036 0.0169 0.1213
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.045 0.7874
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0114 0.069 0.8432
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0114 0.069 0.8432
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.008 0.0033
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0611 0.4013 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Schistosoma mansoni hypothetical protein 0.0365 0.2373 0.2373
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0528 0.0498
Loa Loa (eye worm) hypothetical protein 0.0096 0.0568 0.3541
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0169 0.2367
Brugia malayi ImpB/MucB/SamB family protein 0.0133 0.0818 0.5108
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0272 0.0242
Leishmania major DNA polymerase kappa, putative 0.0024 0.009 0.0309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0677 0.1564
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.045 0.042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0445 0.0977
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.008 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.1045
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0049
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0572 0.6982
Plasmodium falciparum pyruvate kinase 0.0036 0.0169 0.1834
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0169 0.0258
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0642 0.1457
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0097 0.1358
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0067 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.045 0.2809
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0272 0.0272
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0948
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0097 0.0397
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0572 0.3562
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1401
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0445 0.0958
Schistosoma mansoni leucine aminopeptidase 0.0023 0.008 0.008
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0528 0.3294
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0033
Mycobacterium ulcerans hypothetical protein 0.0112 0.0677 0.1546
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0272 0.4292
Onchocerca volvulus 0.0051 0.0272 0.4292
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0293 0.0593
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0114 0.069 0.1595
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.088
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.008 0.0484
Loa Loa (eye worm) hypothetical protein 0.0058 0.0315 0.1952
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0494
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0445 0.0958
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0948
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0572 0.0572
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0138 0.1933
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.008 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0258 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0336 0.358
Schistosoma mansoni DNA polymerase eta 0.0133 0.0818 0.0818
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0169 0.1039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.16 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0169 0.2366
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0445 0.0958
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.01
Trypanosoma cruzi DNA polymerase eta, putative 0.0133 0.0818 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0085 0.0498 0.111
Mycobacterium ulcerans hypothetical protein 0.0112 0.0677 0.1546
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0114 0.069 0.8298
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0445 0.0928
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0272 0.0272
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.008 0.0049
Trypanosoma brucei DNA polymerase eta, putative 0.0133 0.0818 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.045 0.045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0056 0.0025
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1123
Echinococcus multilocularis cpg binding protein 0.0065 0.0366 0.0336
Schistosoma mansoni hypothetical protein 0.0882 0.5828 0.5828
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0309
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.008 0.008
Echinococcus granulosus dnaJ subfamily B 0.0882 0.5828 0.5815
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0067 0.0725
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0075 0.01
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.009 0.0309
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0315 0.0627
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0075 0.0845
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0258 0.0258
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0258 0.16
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.008 0.0494
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0169 0.2037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0445 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.1311 0.1284
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0258 0.161
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0097 0.0076
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0948
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0282 0.2863
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0075 0.0043
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0053
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.009 0.1308
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0528 0.0528
Toxoplasma gondii leucyl aminopeptidase LAP 0.0114 0.069 0.9673
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0114 0.069 0.8298
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.008 0.0484
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0067 0.0788
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0097 0.1358
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0075 0.0358
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.0583
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0169 0.1039
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0494
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0075 0.0845
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0445 0.7788
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0807 0.0807
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1123
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0021
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0169 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0445 0.2779
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0315 0.0646
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0075 0.0043
Giardia lamblia DINP protein human, muc B family 0.0085 0.0498 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0309
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0031 0.0031
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1161
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0484
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.008 0.0049
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0112 0.0677 0.9497
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.008 0.0049
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0169 0.1982
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0169 0.1982
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0445 0.0928
Trypanosoma brucei unspecified product 0.01 0.0594 0.7024
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.045 0.042
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0948
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0067 0.0972
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0053
Schistosoma mansoni cpg binding protein 0.0065 0.0366 0.0366
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0677 0.1564
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Schistosoma mansoni pyruvate kinase 0.0036 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0449
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.009 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0258 0.0228
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0494
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0067 0.024
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Giardia lamblia DNA damage repair protein 0.0024 0.009 0.0864
Echinococcus multilocularis leucine aminopeptidase protein 0.0114 0.069 0.0661
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0315 0.456
Echinococcus granulosus pyruvate kinase 0.0018 0.0052 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0484
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0173
Leishmania major DNA polymerase eta, putative 0.0079 0.0458 0.5205
Echinococcus multilocularis dnaJ subfamily B 0.0882 0.5828 0.5815
Schistosoma mansoni DNA helicase recq5 0.0022 0.0075 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0075 0.046
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0053
Echinococcus granulosus dna polymerase eta 0.0133 0.0818 0.0789
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0053
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0075 0.0449
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0075 0.0043
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0021
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.008 0.0049
Echinococcus multilocularis pyruvate kinase 0.0018 0.0052 0.0021
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0309
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0075 0.0043
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.032 0.0289
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0169 0.2366
Echinococcus granulosus geminin 0.0365 0.2373 0.2349
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0067 0.0788
Loa Loa (eye worm) hypothetical protein 0.009 0.0528 0.3287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.00000000097312
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0445 0.2779
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0049
Echinococcus multilocularis dna polymerase eta 0.0133 0.0818 0.0789
Leishmania major DNA damage repair protein, putative 0.0024 0.009 0.0309
Echinococcus granulosus leucine aminopeptidase protein 0.0114 0.069 0.0661
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0642 0.7658
Mycobacterium ulcerans hypothetical protein 0.0077 0.0445 0.0958
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0075 0.1304
Loa Loa (eye worm) hypothetical protein 0.0096 0.0568 0.3541
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.004
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.008 0.0173
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0075 0.0845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0642 0.7843
Giardia lamblia Pyruvate kinase 0.0036 0.0169 0.2625
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.00000000097312
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0067 0.0036
Schistosoma mansoni ap endonuclease 0.0021 0.0067 0.0067
Schistosoma mansoni cpg binding protein 0.0062 0.0343 0.0343
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.032 0.0289
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0067 0.1173
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0067 0.0952
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.00000000097312
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0272 0.0242
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.008 0.0033
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0169 0.1049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0258 0.0228
Brugia malayi polk-prov protein 0.0053 0.0282 0.1757
Loa Loa (eye worm) MBCTL1 0.0059 0.032 0.1985
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0033
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0173
Loa Loa (eye worm) hypothetical protein 0.0077 0.0445 0.2771
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0315 0.3671
Echinococcus granulosus cpg binding protein 0.0065 0.0366 0.0336
Echinococcus multilocularis geminin 0.0365 0.2373 0.2349
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0075 0.046
Echinococcus granulosus dual specificity 0.0096 0.0572 0.0542
Loa Loa (eye worm) hypothetical protein 0.0077 0.0445 0.2771
Onchocerca volvulus 0.0077 0.0445 0.8159
Echinococcus multilocularis pyruvate kinase 0.0036 0.0169 0.0138
Schistosoma mansoni ap endonuclease 0.0021 0.0067 0.0067
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0272 0.0242
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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