Detailed information for compound 705628

Basic information

Technical information
  • TDR Targets ID: 705628
  • Name: N-(2,4-difluorophenyl)-2-[1-[(2-methoxyphenyl )methyl]imidazol-2-yl]sulfanylacetamide
  • MW: 389.419 | Formula: C19H17F2N3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.53 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1Cn1ccnc1SCC(=O)Nc1ccc(cc1F)F
  • InChi: 1S/C19H17F2N3O2S/c1-26-17-5-3-2-4-13(17)11-24-9-8-22-19(24)27-12-18(25)23-16-7-6-14(20)10-15(16)21/h2-10H,11-12H2,1H3,(H,23,25)
  • InChiKey: GOOHQKFLQMJCHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-difluorophenyl)-2-[1-[(2-methoxyphenyl)methyl]imidazol-2-yl]sulfanyl-acetamide
  • N-(2,4-difluorophenyl)-2-[[1-[(2-methoxyphenyl)methyl]-2-imidazolyl]thio]acetamide
  • N-(2,4-difluorophenyl)-2-[[1-(2-methoxybenzyl)imidazol-2-yl]thio]acetamide
  • N-(2,4-difluorophenyl)-2-[1-[(2-methoxyphenyl)methyl]imidazol-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0106 0.0635 0.0605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0293 0.0601
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.0337
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0558 0.3403
Loa Loa (eye worm) hypothetical protein 0.0025 0.0094 0.0561
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0166 0.2347
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1287 0.1258
Brugia malayi mbt repeat family protein 0.0051 0.0267 0.163
Echinococcus multilocularis pyruvate kinase 0.0028 0.0116 0.0084
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0095 0.0392
Schistosoma mansoni cpg binding protein 0.0062 0.0344 0.0344
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1078
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0084 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.0041
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.06 0.3939 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0081 0.0054
Brugia malayi Protein kinase domain containing protein 0.0094 0.0561 0.343
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0056 0.0338
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0443 0.0975
Trypanosoma cruzi DNA polymerase kappa, putative 0.0106 0.0635 0.7789
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0081 0.0054
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0166 0.2006
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0081 0.0197
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0081 0.0054
Leishmania major DNA polymerase kappa, putative 0.0084 0.0494 0.5715
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0116 0.0706 0.8549
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0314 0.444
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.06 0.3939 1
Entamoeba histolytica hypothetical protein 0.0025 0.0095 0.1695
Loa Loa (eye worm) hypothetical protein 0.0051 0.0267 0.1621
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0443 0.0975
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Loa Loa (eye worm) MBCTL1 0.0057 0.0314 0.1907
Trichomonas vaginalis DNA polymerase eta, putative 0.0106 0.0635 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0016
Onchocerca volvulus 0.0062 0.0344 0.6028
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.009 0.1263
Echinococcus multilocularis dna polymerase eta 0.0132 0.0815 0.0785
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0095 0.0038
Loa Loa (eye worm) oxidoreductase 0.0023 0.0081 0.0477
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0081 0.0957
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0443 0.0975
Schistosoma mansoni pyruvate kinase 0.0035 0.0166 0.0166
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0267 0.0235
Echinococcus multilocularis geminin 0.0366 0.2375 0.235
Trypanosoma brucei unspecified product 0.0053 0.0287 0.2948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0095 0.0092
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0084 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0081 0.0931
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0095 0.0392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0106 0.0635 0.7789
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0314 0.0282
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.0052
Brugia malayi cytosol aminopeptidase 0.0023 0.0084 0.051
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0081 0.0453
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096669
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0458 0.5605
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.06 0.3939 1
Schistosoma mansoni cpg binding protein 0.0066 0.0368 0.0368
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0166 0.2323
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0314 0.0314
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.1634 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0443 0.5042
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0689
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0314 0.4009
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0327
Entamoeba histolytica deoxycytidyl transferase, putative 0.0077 0.0447 0.7969
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0166 0.2006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0077 0.0447 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0561 0.0561
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.0665 0.156
Loa Loa (eye worm) hypothetical protein 0.0052 0.0278 0.169
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0081 0.0038
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0094 0.168
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0084 0.0494 0.112
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0081 0.0931
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.06 0.3939 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0081 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096669
Echinococcus multilocularis leucine aminopeptidase protein 0.0116 0.0706 0.0676
Toxoplasma gondii leucyl aminopeptidase LAP 0.0116 0.0706 0.9877
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0166 0.1334
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.0561 0.3423
Trypanosoma brucei DNA polymerase eta, putative 0.0132 0.0815 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0081 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0293 0.0601
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0518 0.3165
Schistosoma mansoni hypothetical protein 0.0366 0.2375 0.2375
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0267 0.0235
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0327
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.0665 0.156
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1022
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0081 0.0048
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0166 0.1334
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0561 0.6876
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0443 0.0975
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0443 0.099
Loa Loa (eye worm) hypothetical protein 0.0023 0.0081 0.0477
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0081 0.0957
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0095 0.0076
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0166 0.0999
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0094 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0081 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0443 0.2709
Onchocerca volvulus 0.0051 0.0267 0.4267
Schistosoma mansoni DNA polymerase eta 0.0132 0.0815 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0333 0.3571
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0314 0.0655
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0266 0.1624
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0443 0.5042
Schistosoma mansoni pyruvate kinase 0.0035 0.0166 0.0166
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0249
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0084 0.051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0715 1
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.092
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0166 0.0274
Echinococcus multilocularis dual specificity 0.0094 0.0561 0.053
Mycobacterium ulcerans DNA polymerase IV 0.0106 0.0635 0.1471
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0486
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0338
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0249
Schistosoma mansoni microtubule-associated protein tau 0.1507 1 1
Echinococcus granulosus pyruvate kinase 0.0035 0.0166 0.0133
Entamoeba histolytica protein kinase, putative 0.0094 0.0561 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.0561 0.6613
Echinococcus multilocularis microtubule associated protein 2 0.1507 1 1
Brugia malayi polk-prov protein 0.0052 0.0278 0.1699
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0267 0.1621
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0095 0.1395
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0095 0.0076
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0081 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0293 0.0601
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0314 0.0282
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0333 0.3571
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0447 0.2732
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0051 0.072
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0344 0.2093
Leishmania major DNA polymerase kappa, putative 0.0024 0.009 0.0327
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0081 0.0197
Loa Loa (eye worm) hypothetical protein 0.0088 0.0518 0.3158
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0081 0.0197
Loa Loa (eye worm) hypothetical protein 0.0057 0.0314 0.1907
Trypanosoma brucei unspecified product 0.0053 0.0287 0.2948
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.0041
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.0052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0166 0.0999
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0166 0.1008
Leishmania major pyruvate kinase 0.0035 0.0166 0.1334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036256
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0267 0.0267
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0081 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0443 0.2709
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0443 0.5042
Schistosoma mansoni pyruvate kinase 0.0018 0.0051 0.0051
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0081 0.0038
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0166 0.0221
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0443 0.7902
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0116 0.0706 0.8662
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Mycobacterium ulcerans hypothetical protein 0.0077 0.0443 0.0975
Trypanosoma cruzi DNA polymerase kappa, putative 0.0106 0.0635 0.7789
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0116 0.0706 0.1653
Schistosoma mansoni hypothetical protein 0.0311 0.2009 0.2009
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0051 0.0711
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0077 0.0447 0.2725
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0443 0.0975
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0081 0.1126
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0503
Leishmania major pyruvate kinase 0.0035 0.0166 0.1334
Leishmania major DNA polymerase eta, putative 0.0079 0.0458 0.5236
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0095 0.1331
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1022
Entamoeba histolytica hypothetical protein 0.0094 0.0561 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0095 0.1331
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0441
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0106 0.0635 1
Giardia lamblia DNA damage repair protein 0.0024 0.009 0.0891
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0081 0.0957
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.034
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0166 0.1008
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0486
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0081 0.0038
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0116 0.0706 0.8662
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0267 0.4267
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0518 0.0487
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0166 0.1947
Chlamydia trachomatis cytosol aminopeptidase 0.0116 0.0706 1
Mycobacterium ulcerans DNA polymerase IV 0.0106 0.0635 0.1471
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0266 0.0234
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0116 0.0706 0.1667
Leishmania major DNA damage repair protein, putative 0.0024 0.009 0.0327
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0589 0.698
Mycobacterium ulcerans hypothetical protein 0.011 0.0665 0.1547
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0494 0.5715
Trypanosoma brucei DNA polymerase IV, putative 0.0106 0.0635 0.7603
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0081 0.0038
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0166 0.2323
Entamoeba histolytica protein kinase, putative 0.0094 0.0561 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0443 0.0941
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0166 0.0258
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.009 0.0327
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0081 0.114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0033 0.0033
Treponema pallidum licC protein (licC) 0.011 0.0665 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0081 0.0477
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.0052
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0081 0.0054
Echinococcus granulosus cpg binding protein 0.0066 0.0368 0.0336
Mycobacterium ulcerans hypothetical protein 0.011 0.0665 0.1547
Giardia lamblia Pyruvate kinase 0.0035 0.0166 0.2593
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0443 0.7902
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Trypanosoma brucei unspecified product 0.0099 0.0589 0.698
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0443 0.2709
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.1006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.009 0.1078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096669
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0166 0.1947
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0081 0.0486
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.009 0.0327
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0266 0.1615
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1078
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0116 0.0706 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0249
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0081 0.0197
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0458 0.6405
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0314 0.3575
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0081 0.0477
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0441
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0081 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0883 0.5833 0.5819
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.009 0.0327
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.0041
Loa Loa (eye worm) hypothetical protein 0.0057 0.0314 0.1905
Echinococcus multilocularis pyruvate kinase 0.0035 0.0166 0.0133
Trypanosoma cruzi DNA polymerase eta, putative 0.0132 0.0815 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0081 0.0054
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.0041
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.0052
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0018
Plasmodium falciparum M17 leucyl aminopeptidase 0.0116 0.0706 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0443 0.0975
Echinococcus granulosus dna polymerase kappa 0.0106 0.0635 0.0605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0776
Schistosoma mansoni hypothetical protein 0.0366 0.2375 0.2375
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0518 0.0487
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096669
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0081 0.0038
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0077 0.0447 0.0416
Loa Loa (eye worm) hypothetical protein 0.0132 0.0815 0.4979
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.009 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0166 0.2318
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000096669
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1303
Echinococcus granulosus dual specificity 0.0094 0.0561 0.053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0249
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0809
Brugia malayi CXXC zinc finger family protein 0.0062 0.0344 0.2101
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.1172
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0314 0.0282
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0033
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0084 0.0501
Plasmodium falciparum pyruvate kinase 0.0035 0.0166 0.1753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0024 0.00000000096669
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0951
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0077 0.0443 0.2702
Loa Loa (eye worm) hypothetical protein 0.0057 0.0314 0.1905
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0314 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0278 0.2839
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0081 0.0477
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0081 0.0197
Loa Loa (eye worm) hypothetical protein 0.0094 0.0558 0.3403
Loa Loa (eye worm) hypothetical protein 0.0077 0.0443 0.2702
Echinococcus multilocularis pyruvate kinase 0.0035 0.0166 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.0447 0.0999
Schistosoma mansoni cpg binding protein 0.0066 0.0368 0.0368
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0441
Echinococcus granulosus geminin 0.0366 0.2375 0.235
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0267 0.0235
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0081 0.0081
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0081 0.1435
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0443 0.7902
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0084 0.0084
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.0561 0.6613
Loa Loa (eye worm) hypothetical protein 0.0057 0.0314 0.1905
Trypanosoma brucei DNA polymerase IV, putative 0.0106 0.0635 0.7603
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0267 0.0235
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0267 0.0267
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0081 0.0054
Onchocerca volvulus 0.0088 0.0518 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0081 0.0038
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.011 0.0665 0.1547
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0866
Mycobacterium ulcerans leucyl aminopeptidase 0.0116 0.0706 0.1653
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0081 0.0038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0314 0.064
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0081 0.0486
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0314 0.1916
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0293 0.0601
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.1006
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.009 0.1078
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0561 0.6876
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0443 0.0975
Brugia malayi ImpB/MucB/SamB family protein 0.0132 0.0815 0.4984
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0166 0.0999
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0137 0.1916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0266 0.0234
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0081 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0333 0.3571
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0098
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0077 0.0447 0.0416
Chlamydia trachomatis pyruvate kinase 0.0035 0.0166 0.1155
Brugia malayi follicle stimulating hormone receptor 0.0255 0.1634 1
Leishmania major DNA polymerase eta, putative 0.0132 0.0815 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0443 0.0941
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0081 0.1126
Echinococcus granulosus dna polymerase eta 0.0132 0.0815 0.0785
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.011 0.0665 0.9298
Giardia lamblia DINP protein human, muc B family 0.0084 0.0494 1
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.0052
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0116 0.0706 0.1622
Brugia malayi mbt repeat family protein 0.0051 0.0267 0.163
Loa Loa (eye worm) hypothetical protein 0.0077 0.0443 0.2702
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0084 0.0052
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0084 0.0084
Echinococcus multilocularis dnaJ subfamily B 0.0883 0.5833 0.5819
Schistosoma mansoni hypothetical protein 0.0883 0.5833 0.5833
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.009 0.009
Echinococcus multilocularis cpg binding protein 0.0066 0.0368 0.0336
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0266 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0266 0.0234
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0098
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0689
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.009 0.1279
Loa Loa (eye worm) hypothetical protein 0.0057 0.0314 0.1905
Schistosoma mansoni terminal deoxycytidyl transferase 0.0077 0.0447 0.0447
Echinococcus granulosus pyruvate kinase 0.0035 0.0166 0.0133
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0084 0.051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0106 0.0635 0.7789
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1287 0.1258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096669
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.0041
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0095 0.1347
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0278 0.2839
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0081 0.0957
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0116 0.0706 0.8549
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.0635 0.7603
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0081 0.0054
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0063
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0518 0.0518
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0024 0.00000000096669
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0081 0.0048
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.034
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0095 0.0076
Echinococcus granulosus leucine aminopeptidase protein 0.0116 0.0706 0.0676
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0084 0.0501
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0776
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0095 0.0676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0443 0.099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0809 0.0809
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0081 0.0486
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0166 0.1947
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0809
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0018
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0249
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0081 0.1126
Loa Loa (eye worm) hypothetical protein 0.0057 0.0314 0.1905
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.0041
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0084 0.0494 0.5715
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0166 0.0999
Onchocerca volvulus 0.0077 0.0443 0.8297

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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