Detailed information for compound 705654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.455 | Formula: C21H25N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)Cn1c(=O)c(CC)c(nc1n1nc(cc1C)C)C
  • InChi: 1S/C21H25N5O3/c1-6-18-15(4)22-21(26-14(3)10-13(2)24-26)25(20(18)28)12-19(27)23-16-8-7-9-17(11-16)29-5/h7-11H,6,12H2,1-5H3,(H,23,27)
  • InChiKey: MRLCGFZDAQWUER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0082 0.0053
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0541 0.0508
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0095 0.1104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.0706 0.159
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0082 0.0053
Trypanosoma brucei unspecified product 0.0054 0.0297 0.2995
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0175 0.2395
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Echinococcus granulosus pyruvate kinase 0.0019 0.0056 0.0021
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0082 0.1408
Loa Loa (eye worm) hypothetical protein 0.0077 0.045 0.2741
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2016
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0082 0.0903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1338 0.1308
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0102 0.0464
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.0039
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.0039
Brugia malayi mbt repeat family protein 0.0052 0.028 0.1695
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0266 0.161
Schistosoma mansoni hypothetical protein 0.0037 0.0181 0.0181
Onchocerca volvulus 0.0077 0.045 0.8019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Giardia lamblia DINP protein human, muc B family 0.0086 0.051 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0082 0.0903
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1248
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Chlamydia trachomatis pyruvate kinase 0.0036 0.0175 0.1212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0825 0.0825
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.045 0.0954
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0082 0.0053
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.0706 0.0674
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0031
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0084 0.0242
Echinococcus multilocularis pyruvate kinase 0.0019 0.0056 0.0021
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0082 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.06
Echinococcus multilocularis pyruvate kinase 0.0019 0.0056 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.045 0.7684
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036256
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0585 0.6746
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0095 0.1299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0318 0.0627
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0297 0.18
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0095 0.0377
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1002
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.0706 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0318 0.404
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0082 0.0041
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0541 0.0541
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0082 0.0053
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0113 0.0693 0.9498
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.028 0.0246
Loa Loa (eye worm) hypothetical protein 0.0052 0.028 0.1701
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Entamoeba histolytica hypothetical protein 0.0097 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Brugia malayi AMP-binding enzyme family protein 0.0077 0.045 0.2737
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0082 0.1129
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0011
Schistosoma mansoni cpg binding protein 0.0066 0.0376 0.0376
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0095 0.0604
Echinococcus granulosus dnaJ subfamily B 0.0891 0.5945 0.5931
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0891 0.5945 0.5945
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.0706 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Schistosoma mansoni DNA polymerase eta 0.0134 0.0836 0.0836
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0113 0.0693 0.1558
Leishmania major DNA polymerase kappa, putative 0.0086 0.051 0.5767
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0082 0.0048
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.028 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.045 0.0954
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0079 0.0462 0.0429
Loa Loa (eye worm) hypothetical protein 0.0134 0.0836 0.511
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0084 0.0084
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.1634 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.045 0.4985
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0095
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0175 0.1415
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0084 0.0501
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0266 0.1615
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0345 0.3624
Echinococcus granulosus dna polymerase eta 0.0134 0.0836 0.0804
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0756
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0352 0.2141
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0912
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0329 0.0295
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0046 0.0259
Echinococcus multilocularis dual specificity 0.0097 0.0585 0.0553
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0425
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0216
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.0039
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0108 0.0657 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2016
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0059 0.0336
Schistosoma mansoni hypothetical protein 0.0369 0.2422 0.2422
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.0039
Loa Loa (eye worm) hypothetical protein 0.009 0.0541 0.3298
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.1438
Echinococcus multilocularis dna polymerase eta 0.0134 0.0836 0.0804
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.045 0.7684
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.0706 0.8311
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.045 0.0916
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0084 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.027
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0956
Trypanosoma cruzi DNA polymerase eta, putative 0.0134 0.0836 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0056 0.0786
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.038
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0488
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0329 0.0295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1002
Leishmania major DNA polymerase kappa, putative 0.0024 0.0095 0.0377
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0175 0.023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0035 0.0035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000093611
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.029 0.2913
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0084 0.0084
Echinococcus multilocularis cpg binding protein 0.0066 0.0376 0.0343
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Schistosoma mansoni hypothetical protein 0.0369 0.2422 0.2422
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.045 0.4985
Brugia malayi Protein kinase domain containing protein 0.0097 0.0585 0.3569
Brugia malayi AMP-binding enzyme family protein 0.0077 0.045 0.2737
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0175 0.1049
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0082 0.0053
Loa Loa (eye worm) MBCTL1 0.0059 0.0329 0.1998
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0297 0.18
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0082 0.1129
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.045 0.0954
Schistosoma mansoni pyruvate kinase 0.0019 0.0056 0.0056
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0095
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.028 0.028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0266 0.0232
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.028 0.4316
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0266 0.0232
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0095 0.0377
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0377
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0082 0.0956
Echinococcus granulosus GPCR family 2 0.0017 0.0046 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0181 0.1093
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.027
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0102 0.0464
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0046 0.0265
Trypanosoma brucei DNA polymerase IV, putative 0.0101 0.0609 0.7045
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.045 0.4985
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0082 0.0482
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0639
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0462 0.0993
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0082 0.0053
Treponema pallidum licC protein (licC) 0.0113 0.0693 1
Echinococcus granulosus cpg binding protein 0.0066 0.0376 0.0343
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0095 0.1342
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0082 0.0482
Mycobacterium ulcerans hypothetical protein 0.0113 0.0693 0.1558
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0082 0.0216
Echinococcus granulosus pyruvate kinase 0.0019 0.0056 0.0021
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0266 0.0232
Echinococcus multilocularis dnaJ subfamily B 0.0891 0.5945 0.5931
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.0039
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.005
Echinococcus multilocularis GPCR, family 2 0.0017 0.0046 0.0011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Loa Loa (eye worm) histone methyltransferase 0.0019 0.006 0.0353
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0318 0.3587
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0082 0.0414
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0469 0.5598
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0082 0.1167
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.143
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.0706 0.8439
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Schistosoma mansoni hypothetical protein 0.032 0.2088 0.2088
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.0706 0.8439
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0079 0.0462 0.0462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Leishmania major DNA damage repair protein, putative 0.0024 0.0095 0.0377
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0056 0.0761
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.0706 0.1599
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0755
Loa Loa (eye worm) hypothetical protein 0.0077 0.045 0.2741
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.028 0.1701
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0175 0.2366
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.045 0.0954
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.045 0.0964
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0082 0.0488
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0175 0.0271
Schistosoma mansoni pyruvate kinase 0.0036 0.0175 0.0175
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0095 0.0095
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0425
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Onchocerca volvulus 0.009 0.0541 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Plasmodium falciparum pyruvate kinase 0.0036 0.0175 0.1834
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.0657 0.7674
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0082 0.0041
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.0585 0.3573
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0462 0.2809
Trypanosoma brucei unspecified product 0.0101 0.0609 0.7045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0693 0.1567
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.051 0.5767
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.0706 1
Brugia malayi mbt repeat family protein 0.0052 0.028 0.1695
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0095 0.1104
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.0706 0.9675
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.0657 0.1468
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0181 0.1087
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0541 0.0508
Mycobacterium ulcerans hypothetical protein 0.0024 0.0095 0.0072
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.1055
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.028 0.0246
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.0706 0.8311
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0082 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0084 0.0494
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0488
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0082 0.0488
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0102 0.1391
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Leishmania major DNA polymerase eta, putative 0.008 0.0469 0.5239
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0755
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0102 0.1391
Loa Loa (eye worm) hypothetical protein 0.0097 0.0582 0.3552
Echinococcus granulosus pyruvate kinase 0.0036 0.0175 0.0141
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0046 0.0259
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.1123
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.045 0.0916
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0082 0.0041
Mycobacterium ulcerans hypothetical protein 0.0077 0.045 0.0954
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0175 0.0282
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0425
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0585 0.6991
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000093611
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0639
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0175 0.2064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.073 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0082 0.1129
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2016
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0082 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0265
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.045 0.0954
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0329 0.1993
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0345 0.3624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0266 0.0232
Leishmania major DNA polymerase eta, putative 0.0134 0.0836 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Onchocerca volvulus 0.0063 0.0352 0.5884
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0095 0.1104
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.045 0.7684
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0345 0.3624
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Echinococcus multilocularis pyruvate kinase 0.0019 0.0056 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0011
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0101 0.1719
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0082 0.0041
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0297 0.1806
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0329 0.0329
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0089
Loa Loa (eye worm) hypothetical protein 0.0054 0.0297 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.028 0.028
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Echinococcus granulosus dual specificity 0.0097 0.0585 0.0553
Echinococcus multilocularis microtubule associated protein 2 0.1491 1 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.0585 0.6746
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0901
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.098
Schistosoma mansoni microtubule-associated protein tau 0.1491 1 1
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0084 0.0501
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.0706 0.0674
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.0706 0.159
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0038
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0617 0.4093 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0056 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0585 0.0585
Trypanosoma brucei unspecified product 0.0054 0.0297 0.2995
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0086 0.051 0.1113
Echinococcus granulosus dna polymerase kappa 0.0108 0.0657 0.0625
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0084 0.0494
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0143 0.1963
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0095 0.0377
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0048
Mycobacterium ulcerans hypothetical protein 0.0113 0.0693 0.1558
Echinococcus multilocularis pyruvate kinase 0.0036 0.0175 0.0141
Schistosoma mansoni terminal deoxycytidyl transferase 0.0079 0.0462 0.0462
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.045 0.0954
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0082 0.0041
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0102 0.0089
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0318 0.4509
Brugia malayi follicle stimulating hormone receptor 0.0252 0.1634 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0329 0.0295
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.045 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0175 0.1415
Echinococcus granulosus pyruvate kinase 0.0036 0.0175 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Schistosoma mansoni pyruvate kinase 0.0036 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0053 0.029 0.1762
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0079 0.0462 0.2814
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0082 0.0956
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0082 0.0041
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.0707
Entamoeba histolytica deoxycytidyl transferase, putative 0.0079 0.0462 0.7885
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.045 0.0964
Loa Loa (eye worm) oxidoreductase 0.0023 0.0082 0.0488
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0585 0.6991
Giardia lamblia Pyruvate kinase 0.0036 0.0175 0.2624
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.029 0.2913
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0095 0.1104
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0693 0.1567
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0541 0.3293
Echinococcus multilocularis geminin 0.0369 0.2422 0.2395
Brugia malayi ImpB/MucB/SamB family protein 0.0134 0.0836 0.5107
Entamoeba histolytica protein kinase, putative 0.0097 0.0585 1
Leishmania major pyruvate kinase 0.0036 0.0175 0.1415
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0082 0.0041
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0329 0.0295
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.0706 0.1555
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0175 0.2366
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0086 0.051 0.5767
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.0657 0.7674
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0844
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.4093 1
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0079 0.0462 0.0429
Loa Loa (eye worm) hypothetical protein 0.0097 0.0582 0.3552
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0956
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Echinococcus multilocularis pyruvate kinase 0.0029 0.0123 0.0089
Giardia lamblia DNA damage repair protein 0.0024 0.0095 0.0864
Schistosoma mansoni cpg binding protein 0.0063 0.0352 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0084 0.0494
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1338 0.1308
Leishmania major pyruvate kinase 0.0036 0.0175 0.1415
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0175 0.1049
Onchocerca volvulus 0.0052 0.028 0.4316
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0011
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0585 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Entamoeba histolytica hypothetical protein 0.0025 0.0102 0.1734
Entamoeba histolytica protein kinase, putative 0.0097 0.0585 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0755
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.0657 0.1468
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.098
Schistosoma mansoni cpg binding protein 0.0066 0.0376 0.0376
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0617 0.4093 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.008 0.0469 0.6432
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0318 0.0638
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Brugia malayi cytosol aminopeptidase 0.0023 0.0084 0.0494
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0082 0.0216
Echinococcus multilocularis dna polymerase kappa 0.0108 0.0657 0.0625
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0101 0.06
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.028 0.0246
Echinococcus granulosus geminin 0.0369 0.2422 0.2395
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0175 0.2476
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.028 0.028
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0102 0.0048
Echinococcus multilocularis pyruvate kinase 0.0036 0.0175 0.0141
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0082 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0077 0.045 0.2737
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0082 0.0053
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0102 0.01
Brugia malayi CXXC zinc finger family protein 0.0063 0.0352 0.2136
Trichomonas vaginalis DNA polymerase eta, putative 0.0108 0.0657 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0134 0.0836 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Loa Loa (eye worm) hypothetical protein 0.0077 0.045 0.2741
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.1998
Brugia malayi polk-prov protein 0.0053 0.029 0.1757
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.4093 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0175 0.2064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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