Detailed information for compound 705654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.455 | Formula: C21H25N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)Cn1c(=O)c(CC)c(nc1n1nc(cc1C)C)C
  • InChi: 1S/C21H25N5O3/c1-6-18-15(4)22-21(26-14(3)10-13(2)24-26)25(20(18)28)12-19(27)23-16-8-7-9-17(11-16)29-5/h7-11H,6,12H2,1-5H3,(H,23,27)
  • InChiKey: MRLCGFZDAQWUER-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0031
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.0706 0.0674
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.1998
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0046 0.0259
Entamoeba histolytica hypothetical protein 0.0025 0.0102 0.1734
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0265
Entamoeba histolytica protein kinase, putative 0.0097 0.0585 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0102 0.01
Echinococcus granulosus dual specificity 0.0097 0.0585 0.0553
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0056 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.029 0.2913
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.073 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.0039
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0956
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0095 0.0604
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0175 0.2366
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0329 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Echinococcus granulosus geminin 0.0369 0.2422 0.2395
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0755
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0318 0.4509
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0175 0.1415
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1002
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.045 0.4985
Brugia malayi CXXC zinc finger family protein 0.0063 0.0352 0.2136
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.028 0.1701
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.045 0.4985
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.029 0.2913
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0175 0.2064
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0077 0.045 0.2737
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0011
Giardia lamblia DINP protein human, muc B family 0.0086 0.051 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0756
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Entamoeba histolytica deoxycytidyl transferase, putative 0.0079 0.0462 0.7885
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Echinococcus multilocularis cpg binding protein 0.0066 0.0376 0.0343
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0082 0.0903
Giardia lamblia DNA damage repair protein 0.0024 0.0095 0.0864
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.045 0.0954
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0011
Echinococcus multilocularis pyruvate kinase 0.0019 0.0056 0.0021
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0541 0.0508
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000093611
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.045 0.0954
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0082 0.1167
Brugia malayi cytosol aminopeptidase 0.0023 0.0084 0.0494
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0031
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.0706 0.8439
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0318 0.404
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Schistosoma mansoni cpg binding protein 0.0066 0.0376 0.0376
Echinococcus granulosus pyruvate kinase 0.0036 0.0175 0.0141
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0113 0.0693 0.9498
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0297 0.18
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.0657 0.7674
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.1491 1 1
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.098
Entamoeba histolytica hypothetical protein 0.0097 0.0585 1
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0048
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2016
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0082 0.0041
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.045 0.0954
Treponema pallidum licC protein (licC) 0.0113 0.0693 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0079 0.0462 0.0462
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0095 0.0095
Leishmania major pyruvate kinase 0.0036 0.0175 0.1415
Echinococcus multilocularis geminin 0.0369 0.2422 0.2395
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0175 0.2476
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0329 0.0295
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0329 0.0295
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0095 0.0377
Trypanosoma brucei DNA polymerase IV, putative 0.0101 0.0609 0.7045
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.028 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0462 0.2809
Echinococcus multilocularis pyruvate kinase 0.0036 0.0175 0.0141
Schistosoma mansoni hypothetical protein 0.032 0.2088 0.2088
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0617 0.4093 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0352 0.2141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0035 0.0035
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.0039
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0102 0.1391
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0095 0.1104
Brugia malayi AMP-binding enzyme family protein 0.0077 0.045 0.2737
Schistosoma mansoni pyruvate kinase 0.0036 0.0175 0.0175
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0082 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0079 0.0462 0.0429
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.0706 0.8439
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0345 0.3624
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0318 0.0638
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0585 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.051 0.5767
Loa Loa (eye worm) hypothetical protein 0.0134 0.0836 0.511
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0082 0.0041
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.0657 0.7674
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0082 0.0216
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0082 0.0041
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0059 0.0336
Echinococcus granulosus pyruvate kinase 0.0019 0.0056 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.0706 0.159
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0082 0.0041
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0084 0.0494
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0101 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0084 0.0242
Schistosoma mansoni hypothetical protein 0.0369 0.2422 0.2422
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.4093 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0266 0.0232
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0175 0.0282
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0084 0.0494
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0095 0.1104
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0095 0.0377
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.0706 0.8311
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0082 0.0216
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0617 0.4093 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0056 0.0021
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2016
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0082 0.0048
Trypanosoma brucei DNA polymerase eta, putative 0.0134 0.0836 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0143 0.1963
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Schistosoma mansoni DNA polymerase eta 0.0134 0.0836 0.0836
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0082 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0345 0.3624
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0693 0.1567
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0082 0.0488
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0617 0.4093 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0079 0.0462 0.0429
Leishmania major DNA polymerase eta, putative 0.008 0.0469 0.5239
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0084 0.0084
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0095
Brugia malayi ImpB/MucB/SamB family protein 0.0134 0.0836 0.5107
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.0706 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0086 0.051 0.5767
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0377
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.0707
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Echinococcus granulosus GPCR family 2 0.0017 0.0046 0.0011
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0082 0.0048
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0755
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.045 0.0954
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0082 0.0041
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.028 0.0246
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0082 0.1129
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0329 0.0329
Onchocerca volvulus 0.0063 0.0352 0.5884
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.1634 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Brugia malayi mbt repeat family protein 0.0052 0.028 0.1695
Loa Loa (eye worm) hypothetical protein 0.0052 0.028 0.1701
Leishmania major pyruvate kinase 0.0036 0.0175 0.1415
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0095 0.0377
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0082 0.0053
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0585 0.6991
Brugia malayi Protein kinase domain containing protein 0.0097 0.0585 0.3569
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1248
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.0039
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0082 0.1408
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0175 0.1049
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0101 0.1719
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.0706 0.0674
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0082 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0038
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0175 0.2366
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.1055
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0377
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Echinococcus granulosus pyruvate kinase 0.0019 0.0056 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.028 0.0246
Trypanosoma brucei unspecified product 0.0054 0.0297 0.2995
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.045 0.0954
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0102 0.0089
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Schistosoma mansoni pyruvate kinase 0.0036 0.0175 0.0175
Echinococcus multilocularis pyruvate kinase 0.0019 0.0056 0.0021
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0216
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0082 0.0956
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0585 0.6746
Echinococcus multilocularis pyruvate kinase 0.0029 0.0123 0.0089
Leishmania major DNA polymerase kappa, putative 0.0024 0.0095 0.0377
Brugia malayi polk-prov protein 0.0053 0.029 0.1757
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0095 0.1104
Leishmania major DNA damage repair protein, putative 0.0024 0.0095 0.0377
Loa Loa (eye worm) hypothetical protein 0.0097 0.0582 0.3552
Giardia lamblia Pyruvate kinase 0.0036 0.0175 0.2624
Echinococcus multilocularis microtubule associated protein 2 0.1491 1 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.045 0.2741
Leishmania major DNA polymerase kappa, putative 0.0086 0.051 0.5767
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Schistosoma mansoni terminal deoxycytidyl transferase 0.0079 0.0462 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0102 0.0464
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0329 0.1993
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.045 0.0954
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0113 0.0693 0.1558
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0488
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0425
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.045 0.7684
Loa Loa (eye worm) hypothetical protein 0.0053 0.029 0.1762
Entamoeba histolytica protein kinase, putative 0.0097 0.0585 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0082 0.0488
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0158
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0079 0.0462 0.2814
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0329 0.0295
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0901
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0086 0.051 0.1113
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.0706 0.1555
Trichomonas vaginalis DNA polymerase eta, putative 0.0108 0.0657 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0082 0.0041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0693 0.1567
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0541 0.3293
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.028 0.0246
Mycobacterium ulcerans hypothetical protein 0.0077 0.045 0.0954
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0095 0.1104
Loa Loa (eye worm) hypothetical protein 0.0077 0.045 0.2741
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0216
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0102 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0082 0.0956
Brugia malayi AMP-binding enzyme family protein 0.0077 0.045 0.2737
Echinococcus granulosus pyruvate kinase 0.0036 0.0175 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0082 0.1129
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.0585 0.6746
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.005
Schistosoma mansoni cpg binding protein 0.0066 0.0376 0.0376
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0175 0.023
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0639
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.045 0.0916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0266 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0657 0.7674
Leishmania major DNA polymerase eta, putative 0.0134 0.0836 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0134 0.0836 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.0706 0.8311
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Echinococcus multilocularis dna polymerase eta 0.0134 0.0836 0.0804
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.028 0.0246
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0056 0.0786
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000093611
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0462 0.0993
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0095 0.1299
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Echinococcus granulosus dnaJ subfamily B 0.0891 0.5945 0.5931
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0108 0.0657 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Echinococcus multilocularis pyruvate kinase 0.0036 0.0175 0.0141
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.028 0.028
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0084 0.0494
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0266 0.1615
Mycobacterium ulcerans hypothetical protein 0.0113 0.0693 0.1558
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0175 0.1415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.1438
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0102 0.1391
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0297 0.18
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0756
Echinococcus multilocularis dnaJ subfamily B 0.0891 0.5945 0.5931
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0089
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0046 0.0265
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0425
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.045 0.0916
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0175 0.0271
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0082 0.0903
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0585 0.0585
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0425
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0082 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.06
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.045 0.0964
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0082 0.0482
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0082 0.0482
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0082 0.0041
Onchocerca volvulus 0.009 0.0541 1
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0175 0.2395
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0102 0.0464
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Trypanosoma brucei unspecified product 0.0101 0.0609 0.7045
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0082 0.0041
Loa Loa (eye worm) MBCTL1 0.0059 0.0329 0.1998
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1002
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0084 0.005
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0585 0.6991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0266 0.0232
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0082 0.0053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0318 0.3587
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0046 0.0259
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.028 0.4316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Loa Loa (eye worm) hypothetical protein 0.0077 0.045 0.2741
Schistosoma mansoni pyruvate kinase 0.0019 0.0056 0.0056
Onchocerca volvulus 0.0077 0.045 0.8019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.045 0.0954
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.0657 0.1468
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Echinococcus multilocularis dual specificity 0.0097 0.0585 0.0553
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.0657 0.1468
Mycobacterium ulcerans hypothetical protein 0.0024 0.0095 0.0072
Toxoplasma gondii ImpB/MucB/SamB family protein 0.008 0.0469 0.6432
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0082 0.0414
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0318 0.0627
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0082 0.0956
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0084 0.0501
Loa Loa (eye worm) hypothetical protein 0.0097 0.0582 0.3552
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0082 0.0053
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0082 0.1129
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0084 0.0501
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Echinococcus multilocularis GPCR, family 2 0.0017 0.0046 0.0011
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.027
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.0039
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0912
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.028 0.028
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0082 0.0053
Echinococcus granulosus cpg binding protein 0.0066 0.0376 0.0343
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1338 0.1308
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1338 0.1308
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0175 0.2064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0266 0.161
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0541 0.0541
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.0706 0.1599
Onchocerca volvulus 0.0052 0.028 0.4316
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0095 0.1342
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0844
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0345 0.3624
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036256
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0488
Echinococcus multilocularis dna polymerase kappa 0.0108 0.0657 0.0625
Loa Loa (eye worm) oxidoreductase 0.0023 0.0082 0.0488
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.0706 1
Schistosoma mansoni cpg binding protein 0.0063 0.0352 0.0352
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0639
Trypanosoma brucei unspecified product 0.0054 0.0297 0.2995
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.0226
Chlamydia trachomatis pyruvate kinase 0.0036 0.0175 0.1212
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0084 0.0084
Echinococcus granulosus dna polymerase eta 0.0134 0.0836 0.0804
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.045 0.7684
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0469 0.5598
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.0706 0.9675
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.1123
Schistosoma mansoni hypothetical protein 0.0369 0.2422 0.2422
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Echinococcus granulosus dna polymerase kappa 0.0108 0.0657 0.0625
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Loa Loa (eye worm) hypothetical protein 0.009 0.0541 0.3298
Loa Loa (eye worm) hypothetical protein 0.0037 0.0181 0.1093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0266 0.0232
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.038
Loa Loa (eye worm) hypothetical protein 0.0054 0.0297 0.1806
Brugia malayi mbt repeat family protein 0.0052 0.028 0.1695
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.0585 0.3573
Plasmodium falciparum pyruvate kinase 0.0036 0.0175 0.1834
Brugia malayi follicle stimulating hormone receptor 0.0252 0.1634 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.045 0.0964
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.0039
Schistosoma mansoni hypothetical protein 0.0037 0.0181 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0181 0.1087
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.0706 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.0657 0.785
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0082 0.0053
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0082 0.0082
Echinococcus multilocularis pyruvate kinase 0.0019 0.0056 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.045 0.4985
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0755
Loa Loa (eye worm) hypothetical protein 0.0058 0.0318 0.1935
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0082 0.0041
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0082 0.0053
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.045 0.7684
Mycobacterium ulcerans hypothetical protein 0.0113 0.0693 0.1558
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0175 0.1049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0011
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.098
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0541 0.0508
Loa Loa (eye worm) histone methyltransferase 0.0019 0.006 0.0353
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.0706 0.159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0266 0.0266
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0825 0.0825
Schistosoma mansoni hypothetical protein 0.0891 0.5945 0.5945
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.143
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0082 0.0216
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0297 0.1806

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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