Detailed information for compound 705678

Basic information

Technical information
  • TDR Targets ID: 705678
  • Name: N'-butyl-N-(2-methylphenyl)-1-phenylpyrazolo[ 4,5-e]pyrimidine-4,6-diamine
  • MW: 372.466 | Formula: C22H24N6
  • H donors: 2 H acceptors: 3 LogP: 5.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1nc(Nc2ccccc2C)c2c(n1)n(nc2)c1ccccc1
  • InChi: 1S/C22H24N6/c1-3-4-14-23-22-26-20(25-19-13-9-8-10-16(19)2)18-15-24-28(21(18)27-22)17-11-6-5-7-12-17/h5-13,15H,3-4,14H2,1-2H3,(H2,23,25,26,27)
  • InChiKey: OYBFZHFEZKJJIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-butyl-N-(2-methylphenyl)-1-phenyl-pyrazolo[4,5-e]pyrimidine-4,6-diamine
  • butyl-[4-[(2-methylphenyl)amino]-1-phenyl-pyrazolo[5,4-d]pyrimidin-6-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.038
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0541 0.3294
Echinococcus granulosus geminin 0.0365 0.2422 0.2396
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093587
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.045 0.0964
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0095 0.1104
Brugia malayi ImpB/MucB/SamB family protein 0.0133 0.0836 0.5108
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0114 0.0706 0.1555
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0657 0.1468
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.045 0.0954
Leishmania major DNA polymerase eta, putative 0.0133 0.0836 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0082 0.0053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1001
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0073 0.0386
Schistosoma mansoni pyruvate kinase 0.0018 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0082 0.0482
Echinococcus multilocularis pyruvate kinase 0.0018 0.0056 0.0021
Loa Loa (eye worm) RecQ helicase 0.0021 0.0073 0.0431
Giardia lamblia DNA damage repair protein 0.0024 0.0095 0.0864
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0329 0.0295
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2017
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0352 0.2142
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0639
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0329 0.0295
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0639
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0755
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0038
Entamoeba histolytica protein kinase, putative 0.0096 0.0586 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0082 0.1408
Echinococcus granulosus bloom syndrome protein 0.0021 0.0073 0.0039
Echinococcus granulosus pyruvate kinase 0.0036 0.0175 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000093587
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0329 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.029 0.2913
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0084 0.0494
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0082 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0076 0.045 0.2737
Loa Loa (eye worm) hypothetical protein 0.0057 0.0318 0.1935
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.0912
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093587
Loa Loa (eye worm) hypothetical protein 0.0051 0.028 0.1702
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0931
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.028 0.0247
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0082 0.0053
Schistosoma mansoni cpg binding protein 0.0065 0.0376 0.0376
Echinococcus multilocularis geminin 0.0365 0.2422 0.2396
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0073 0.0039
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0586 0.3574
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.045 0.0954
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0175 0.023
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.045 0.0954
Leishmania major pyruvate kinase 0.0036 0.0175 0.1416
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.045 0.0916
Trypanosoma brucei unspecified product 0.0099 0.0609 0.7045
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.0462 0.7884
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0082 0.0048
Echinococcus multilocularis cpg binding protein 0.0065 0.0376 0.0343
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0693 0.1567
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0095 0.0604
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0035 0.0035
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0082 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0693 0.1567
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0084 0.0084
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0175 0.0282
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0095 0.0377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0266 0.161
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0084 0.0242
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0082 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093587
Echinococcus multilocularis pyruvate kinase 0.0036 0.0175 0.0141
Mycobacterium ulcerans hypothetical protein 0.0024 0.0095 0.0072
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.1001
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0082 0.0413
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0095 0.1299
Echinococcus granulosus leucine aminopeptidase protein 0.0114 0.0706 0.0674
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0756
Schistosoma mansoni hypothetical protein 0.0881 0.5946 0.5946
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0095
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0073 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0488
Loa Loa (eye worm) hypothetical protein 0.0057 0.0318 0.1935
Echinococcus multilocularis pyruvate kinase 0.0018 0.0056 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0082 0.0048
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0469 0.5598
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.045 0.0954
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0082 0.0053
Echinococcus granulosus pyruvate kinase 0.0036 0.0175 0.0141
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0657 0.1468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0266 0.0232
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0206 0.1339 0.1309
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0031
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0843
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0095 0.1343
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0318 0.4509
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0266 0.0232
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0082 0.0216
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0541 0.0541
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0095 0.1104
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0114 0.0706 0.8309
Trichomonas vaginalis DNA polymerase eta, putative 0.0107 0.0657 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.0707
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0082 0.0482
Loa Loa (eye worm) hypothetical protein 0.0053 0.029 0.1763
Echinococcus multilocularis dna polymerase kappa 0.0107 0.0657 0.0625
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093587
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0073 0.0039
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2017
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0082 0.0053
Schistosoma mansoni DNA helicase recq1 0.0021 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0076 0.045 0.2742
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0826 0.0826
Toxoplasma gondii leucyl aminopeptidase LAP 0.0114 0.0706 0.9674
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0082 0.0482
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.06
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093587
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0084 0.0494
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0073 0.027
Echinococcus granulosus pyruvate kinase 0.0018 0.0056 0.0021
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0102 0.0465
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0175 0.2017
Loa Loa (eye worm) hypothetical protein 0.0076 0.045 0.2742
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0318 0.3587
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0073 0.0431
Giardia lamblia DINP protein human, muc B family 0.0085 0.051 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0082 0.0956
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0082 0.0903
Echinococcus granulosus pyruvate kinase 0.0018 0.0056 0.0021
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0082 0.0216
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0541 0.0508
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0084 0.005
Treponema pallidum licC protein (licC) 0.0112 0.0693 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.028 0.4317
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.028 0.1702
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0057 0.0318 0.1935
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0082 0.0216
Mycobacterium ulcerans hypothetical protein 0.0076 0.045 0.0954
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0082 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.045 0.0916
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0082 0.1129
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0377
Loa Loa (eye worm) hypothetical protein 0.0096 0.0582 0.3553
Loa Loa (eye worm) hypothetical protein 0.0057 0.0318 0.1935
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0114 0.0706 0.8437
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0073 0.0039
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0084 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0318 0.0627
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0082 0.0053
Brugia malayi follicle stimulating hormone receptor 0.025 0.1634 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0073 0.0755
Loa Loa (eye worm) hypothetical protein 0.0076 0.045 0.2742
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0175 0.0271
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0143 0.1963
Brugia malayi cytosol aminopeptidase 0.0023 0.0084 0.0494
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0345 0.3625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0266 0.0266
Echinococcus multilocularis dna polymerase eta 0.0133 0.0836 0.0805
Schistosoma mansoni pyruvate kinase 0.0036 0.0175 0.0175
Schistosoma mansoni cpg binding protein 0.0065 0.0376 0.0376
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0095 0.0377
Echinococcus granulosus dnaJ subfamily B 0.0881 0.5946 0.5931
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0082 0.0053
Echinococcus multilocularis dnaJ subfamily B 0.0881 0.5946 0.5931
Mycobacterium ulcerans hypothetical protein 0.0112 0.0693 0.1558
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Loa Loa (eye worm) hypothetical protein 0.0133 0.0836 0.5111
Leishmania major DNA polymerase kappa, putative 0.0085 0.051 0.5768
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0114 0.0706 0.1599
Brugia malayi mbt repeat family protein 0.0051 0.028 0.1696
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.045 0.0954
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0082 0.0041
Echinococcus granulosus dna polymerase eta 0.0133 0.0836 0.0805
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.0462 0.2814
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0082 0.0053
Onchocerca volvulus 0.0076 0.045 0.8017
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0057 0.0318 0.1935
Loa Loa (eye worm) hypothetical protein 0.0058 0.0329 0.1999
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1634 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.045 0.7682
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0011
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0175 0.2477
Plasmodium falciparum M17 leucyl aminopeptidase 0.0114 0.0706 1
Chlamydia trachomatis cytosol aminopeptidase 0.0114 0.0706 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0082 0.0041
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.061 0.4095 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0025 0.00000000093587
Echinococcus granulosus dual specificity 0.0096 0.0586 0.0553
Mycobacterium ulcerans hypothetical protein 0.0112 0.0693 0.1558
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0084 0.0501
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0085 0.051 0.5768
Brugia malayi polk-prov protein 0.0053 0.029 0.1757
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0082 0.0903
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0657 0.7675
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0089
Plasmodium falciparum pyruvate kinase 0.0036 0.0175 0.1834
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.0462 0.0429
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.028 0.0247
Leishmania major DNA polymerase kappa, putative 0.0024 0.0095 0.0377
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0112 0.0693 0.9499
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Onchocerca volvulus 0.009 0.0541 1
Schistosoma mansoni hypothetical protein 0.0365 0.2422 0.2422
Entamoeba histolytica hypothetical protein 0.0096 0.0586 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0175 0.2366
Trypanosoma cruzi DNA polymerase eta, putative 0.0133 0.0836 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0082 0.0482
Echinococcus multilocularis pyruvate kinase 0.0036 0.0175 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.1438
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.1123
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0082 0.0956
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.0462 0.0462
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.028 0.028
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0102 0.0048
Loa Loa (eye worm) histone methyltransferase 0.0019 0.006 0.0353
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0462 0.0993
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.045 0.0964
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0084 0.0501
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0073 0.0425
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0082 0.1129
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0175 0.1049
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0586 0.6992
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0102 0.1391
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0095 0.0377
Schistosoma mansoni cpg binding protein 0.0062 0.0352 0.0352
Schistosoma mansoni DNA helicase recq5 0.0021 0.0073 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0107 0.0657 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0175 0.1416
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0206 0.1339 0.1309
Onchocerca volvulus 0.0051 0.028 0.4317
Echinococcus multilocularis pyruvate kinase 0.0028 0.0123 0.0089
Echinococcus granulosus pyruvate kinase 0.0018 0.0056 0.0021
Brugia malayi Protein kinase domain containing protein 0.0096 0.0586 0.357
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0586 0.6746
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.143
Echinococcus granulosus dna polymerase kappa 0.0107 0.0657 0.0625
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0756
Trypanosoma brucei unspecified product 0.0054 0.0297 0.2996
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0114 0.0706 0.8309
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0329 0.0295
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.00000000036255
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0082 0.1129
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0082 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.051 0.5768
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0657 0.785
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0082 0.0956
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0082 0.0041
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0073 0.0755
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.061 0.4095 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0082 0.0482
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0059 0.0336
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0462 0.2809
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0586 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0102 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0082 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.045 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0157
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0095 0.1104
Brugia malayi CXXC zinc finger family protein 0.0062 0.0352 0.2136
Schistosoma mansoni DNA polymerase eta 0.0133 0.0836 0.0836
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.045 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0329 0.1994
Entamoeba histolytica hypothetical protein 0.0025 0.0102 0.1734
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.061 0.4095 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.028 0.028
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0082 0.1167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0025 0.00000000093587
Leishmania major DNA polymerase eta, putative 0.0079 0.0469 0.5239
Echinococcus granulosus cpg binding protein 0.0065 0.0376 0.0343
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.061 0.4095 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0318 0.0638
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0082 0.0041
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0082 0.0216
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0082 0.0488
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0101 0.06
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0657 0.785
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0175 0.2064
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.028 0.0247
Schistosoma mansoni hypothetical protein 0.0365 0.2422 0.2422
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0082 0.0956
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0266 0.1615
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0102 0.1391
Trypanosoma brucei unspecified product 0.0054 0.0297 0.2996
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0386
Giardia lamblia Pyruvate kinase 0.0036 0.0175 0.2625
Leishmania major pyruvate kinase 0.0036 0.0175 0.1416
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0242
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0073 0.0039
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0541 0.0508
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0082 0.0082
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0318 0.4041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0657 0.785
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0114 0.0706 0.8437
Schistosoma mansoni hypothetical protein 0.0316 0.2089 0.2089
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.0462 0.0429
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0056 0.0761
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.1055
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Mycobacterium ulcerans leucyl aminopeptidase 0.0114 0.0706 0.1589
Brugia malayi AMP-binding enzyme family protein 0.0076 0.045 0.2737
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0073 0.0425
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.0048
Brugia malayi mbt repeat family protein 0.0051 0.028 0.1696
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0175 0.2064
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0082 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.045 0.4985
Brugia malayi AMP-binding enzyme family protein 0.0076 0.045 0.2737
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0175 0.2366
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0084 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0431
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0084 0.005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0082 0.0041
Echinococcus multilocularis leucine aminopeptidase protein 0.0114 0.0706 0.0674
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.028 0.0247
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0073 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0095 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0082 0.0041
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0102 0.0089
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0469 0.6432
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0073 0.1248
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0586 0.6746
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0101 0.1719
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.045 0.4985
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0082 0.0482
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.045 0.7682
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0056 0.0787
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0175 0.2396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0073 0.0095
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0979
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0657 0.7675
Schistosoma mansoni pyruvate kinase 0.0036 0.0175 0.0175
Echinococcus multilocularis dual specificity 0.0096 0.0586 0.0553
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.0462 0.0462
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0112 0.0693 0.1558
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0085 0.051 0.1113
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0609 0.7045
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0114 0.0706 0.1589
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0657 0.7675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0266 0.0232
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0114 0.0706 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0095 0.1104
Loa Loa (eye worm) hypothetical protein 0.009 0.0541 0.3299
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0175 0.1049
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.045 0.4985
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0345 0.3625
Loa Loa (eye worm) MBCTL1 0.0058 0.0329 0.1999
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0266 0.0232
Trypanosoma brucei DNA polymerase eta, putative 0.0133 0.0836 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0586 0.6992
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0657 0.785
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0901
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0175 0.1416
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0082 0.0053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.073 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0175 0.1055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0488
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0102 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.029 0.2913
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.028 0.028
Chlamydia trachomatis pyruvate kinase 0.0036 0.0175 0.1213
Entamoeba histolytica protein kinase, putative 0.0096 0.0586 1
Schistosoma mansoni microtubule-associated protein tau 0.1475 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0582 0.3553
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0082 0.0041
Echinococcus multilocularis microtubule associated protein 2 0.1475 1 1
Loa Loa (eye worm) oxidoreductase 0.0022 0.0082 0.0488
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.006 0.0026
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0082 0.0488
Onchocerca volvulus 0.0062 0.0352 0.5883
Leishmania major DNA damage repair protein, putative 0.0024 0.0095 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0345 0.3625
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.045 0.7682
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0084 0.0494
Echinococcus multilocularis pyruvate kinase 0.0018 0.0056 0.0021
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0089
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0084 0.0979
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0297 0.0585
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0329 0.0329
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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