Detailed information for compound 705805

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.463 | Formula: C21H18FN5O3S
  • H donors: 2 H acceptors: 4 LogP: 3.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)C(=O)NCCc1csc2n1nc(n2)c1ccccc1F
  • InChi: 1S/C21H18FN5O3S/c1-30-15-8-6-13(7-9-15)24-20(29)19(28)23-11-10-14-12-31-21-25-18(26-27(14)21)16-4-2-3-5-17(16)22/h2-9,12H,10-11H2,1H3,(H,23,28)(H,24,29)
  • InChiKey: MGWVRPBAKLHMJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0096 0.0552 0.3369
Schistosoma mansoni microtubule-associated protein tau 0.1553 1 1
Echinococcus multilocularis dual specificity 0.0096 0.0555 0.0525
Echinococcus granulosus pyruvate kinase 0.0036 0.0164 0.0132
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0474
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0057 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.1553 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.008 0.0037
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0089 0.1071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0266 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0276 0.2821
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0024 0.0084 0.0514
Echinococcus granulosus pyruvate kinase 0.0019 0.005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0000000003626
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0442 0.2703
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.033 0.3558
Schistosoma mansoni ap endonuclease 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0059 0.031 0.1886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0089 0.1254
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.1012
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0474
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0342 0.2082
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0264 0.1603
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.033 0.3558
Trypanosoma brucei DNA polymerase eta, putative 0.0136 0.081 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0442 0.7955
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0711 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0474
Echinococcus multilocularis pyruvate kinase 0.0036 0.0164 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Brugia malayi Protein kinase domain containing protein 0.0096 0.0555 0.3398
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0164 0.0218
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0066 0.0702
Entamoeba histolytica hypothetical protein 0.0025 0.0094 0.1686
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0555 0.0555
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0073 0.1316
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0455 0.5607
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0073
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0164 0.2299
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.2693
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0487
Echinococcus granulosus pyruvate kinase 0.0019 0.005 0.0018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0079 0.0444 0.0444
Echinococcus multilocularis leucine aminopeptidase protein 0.012 0.0706 0.0676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0266 0.0266
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0037
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0084 0.0052
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0084 0.0501
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0431
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0164 0.2313
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0094 0.1316
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0073 0.0356
Brugia malayi mbt repeat family protein 0.0052 0.0264 0.1615
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0093 0.0552
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.012 0.0706 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.012 0.0706 0.1669
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0164 0.0986
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0513 0.0513
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0442 0.098
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0555 0.6848
Schistosoma mansoni pyruvate kinase 0.0036 0.0164 0.0164
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.1012
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.063 0.7587
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0112 0.0658 0.1544
Giardia lamblia DINP protein human, muc B family 0.0086 0.049 1
Trypanosoma brucei unspecified product 0.0101 0.0584 0.6965
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0073 0.0041
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.031 0.0279
Trypanosoma brucei unspecified product 0.0055 0.0284 0.2936
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.009 0.0513 0.3126
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0164 0.1993
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0164 0.1315
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Mycobacterium ulcerans leucyl aminopeptidase 0.012 0.0706 0.1669
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0442 0.2703
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0445
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0164 0.0986
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0084 0.0052
Echinococcus granulosus pyruvate kinase 0.0019 0.005 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0442 0.5055
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.2693
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.008 0.0037
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0264 0.0233
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0164 0.1315
Schistosoma mansoni hypothetical protein 0.0318 0.199 0.199
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.012 0.0706 0.8715
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0442 0.098
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0312 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.2693
Giardia lamblia DNA damage repair protein 0.0025 0.0089 0.0897
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0613 0.3903 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0264 0.0264
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0079 0.0442 0.0996
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.008 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0094 0.0669
Schistosoma mansoni DNA polymerase eta 0.0136 0.081 0.081
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0094 0.0073
Brugia malayi CXXC zinc finger family protein 0.0064 0.0342 0.2093
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0066 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0089 0.1071
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0474
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0066 0.0961
Trypanosoma brucei unspecified product 0.0055 0.0284 0.2936
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0094 0.1326
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0958
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0264 0.0264
Schistosoma mansoni hypothetical protein 0.0375 0.2364 0.2364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0266 0.0235
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0164 0.0999
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0613 0.3903 1
Schistosoma mansoni cpg binding protein 0.0067 0.0366 0.0366
Leishmania major DNA polymerase eta, putative 0.0081 0.0455 0.5235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1134
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0192
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.008 0.0037
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.031 0.0279
Mycobacterium ulcerans hypothetical protein 0.0025 0.0089 0.0061
Entamoeba histolytica hypothetical protein 0.0096 0.0555 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.005 0.0704
Entamoeba histolytica protein kinase, putative 0.0096 0.0555 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0066 0.1184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Echinococcus granulosus dna polymerase kappa 0.0108 0.063 0.06
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.063 0.7587
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0375
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.1027
Schistosoma mansoni cpg binding protein 0.0064 0.0342 0.0342
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0089 0.0315
Echinococcus multilocularis pyruvate kinase 0.0028 0.0114 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0266 0.0235
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.1275 0.1247
Schistosoma mansoni pyruvate kinase 0.0036 0.0164 0.0164
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0958
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0079 0.0442 0.098
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0555 1
Loa Loa (eye worm) histone methyltransferase 0.002 0.0057 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0613 0.3903 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.008 0.0037
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0073 0.0822
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Loa Loa (eye worm) MBCTL1 0.0059 0.031 0.1886
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.012 0.0706 0.8606
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.049 0.5702
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0192
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1125
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0164 0.0986
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0513 0.3136
Schistosoma mansoni hypothetical protein 0.0375 0.2364 0.2364
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0487
Trypanosoma cruzi DNA polymerase eta, putative 0.0136 0.081 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0164 0.2313
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0555 0.6582
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0089 0.0315
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0112 0.0658 0.9251
Onchocerca volvulus 0.0052 0.0264 0.4255
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0084 0.0501
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0079 0.0444 0.2704
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0079 0.0444 0.0413
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0056 0.0338
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0164 0.0999
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0555 0.6582
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1125
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0445
Loa Loa (eye worm) hypothetical protein 0.0052 0.0264 0.1603
Toxoplasma gondii exonuclease III APE 0.0021 0.0066 0.0924
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0079 0.0442 0.098
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0958
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0093 0.1671
Trichomonas vaginalis DNA polymerase eta, putative 0.0108 0.063 1
Leishmania major pyruvate kinase 0.0036 0.0164 0.1315
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0089 0.1071
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0066 0.04
Schistosoma mansoni terminal deoxycytidyl transferase 0.0079 0.0444 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.1634 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.031 0.0279
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0164 0.2317
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0442 0.098
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.031 0.0279
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0089 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0084 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0086 0.049 0.5702
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0937
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0108 0.063 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0276 0.2821
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0089 0.0602
Mycobacterium ulcerans hypothetical protein 0.0112 0.0658 0.1544
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0555 0.3389
Entamoeba histolytica acyl-coA synthetase, putative 0.0079 0.0442 0.7955
Plasmodium falciparum pyruvate kinase 0.0036 0.0164 0.1735
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.008 0.0037
Chlamydia trachomatis cytosol aminopeptidase 0.012 0.0706 1
Plasmodium falciparum M17 leucyl aminopeptidase 0.012 0.0706 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0613 0.3903 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.033 0.3558
Brugia malayi cytosol aminopeptidase 0.0024 0.0084 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0266 0.0266
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0136 0.1905
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0164 0.1993
Echinococcus multilocularis dna polymerase eta 0.0136 0.081 0.078
Brugia malayi follicle stimulating hormone receptor 0.0263 0.1634 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0442 0.5055
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0073 0.0822
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0164 0.0255
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.008 0.0037
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0264 0.0233
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0444 0.2714
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.012 0.0706 0.1683
Mycobacterium ulcerans hypothetical protein 0.0112 0.0658 0.1544
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0086 0.049 0.1121
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Loa Loa (eye worm) hypothetical protein 0.0136 0.081 0.4948
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Mycobacterium ulcerans hypothetical protein 0.0079 0.0442 0.098
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0057 0.0025
Echinococcus granulosus dna polymerase eta 0.0136 0.081 0.078
Schistosoma mansoni cpg binding protein 0.0067 0.0366 0.0366
Echinococcus granulosus dnaJ subfamily B 0.0906 0.5807 0.5793
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0089 0.0315
Echinococcus multilocularis dnaJ subfamily B 0.0906 0.5807 0.5793
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0312 0.4002
Echinococcus granulosus dual specificity 0.0096 0.0555 0.0525
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0054
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0192
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0079 0.0444 0.0413
Treponema pallidum licC protein (licC) 0.0112 0.0658 1
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0513 0.0482
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0084 0.0052
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0192
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0264 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0264 0.0233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0312 0.3572
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0054
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0084 0.0084
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0073 0.0041
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.012 0.0706 0.8715
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0442 0.2703
Loa Loa (eye worm) hypothetical protein 0.0096 0.0552 0.3369
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0552
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0066 0.0781
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0089 0.1264
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Toxoplasma gondii leucyl aminopeptidase LAP 0.012 0.0706 0.9924
Schistosoma mansoni pyruvate kinase 0.0019 0.005 0.005
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0089 0.0089
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0073 0.0356
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0084 0.0514
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.00000000097411
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.1027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0986
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0805 0.0805
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0442 0.5055
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0958
Echinococcus multilocularis pyruvate kinase 0.0019 0.005 0.0018
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0937
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0442 0.7955
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0164 0.1931
Leishmania major DNA polymerase kappa, putative 0.0086 0.049 0.5702
Schistosoma mansoni DNA helicase recq1 0.0022 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0089 0.1071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0066 0.0364
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0871
Brugia malayi mbt repeat family protein 0.0052 0.0264 0.1615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0266 0.0266
Schistosoma mansoni DNA helicase recq5 0.0022 0.0073 0.0073
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0266 0.1627
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.1275 0.1247
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.063 0.1471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0442 0.0996
Echinococcus granulosus pyruvate kinase 0.0036 0.0164 0.0132
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0054
Echinococcus multilocularis dna polymerase kappa 0.0108 0.063 0.06
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Loa Loa (eye worm) hypothetical protein 0.0053 0.0276 0.1673
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0094 0.009
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0073 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0513 0.0482
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0094 0.1316
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.012 0.0706 0.8606
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0066 0.0244
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0462
Echinococcus granulosus leucine aminopeptidase protein 0.012 0.0706 0.0676
Leishmania major DNA damage repair protein, putative 0.0025 0.0089 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Echinococcus multilocularis pyruvate kinase 0.0019 0.005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0081 0.0455 0.6399
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0048
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0098
Schistosoma mansoni hypothetical protein 0.0906 0.5807 0.5807
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0474
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0073 0.0041
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0658 0.1559
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0032 0.0032
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.1386
Chlamydia trachomatis pyruvate kinase 0.0036 0.0164 0.1142
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0084 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0066 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0442 0.0947
Onchocerca volvulus 0.0079 0.0442 0.8364
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0101 0.0584 0.6965
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0164 0.0272
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0658 0.1559
Echinococcus granulosus cpg binding protein 0.0067 0.0366 0.0335
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0048
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0164 0.1931
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0089 0.0315
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0073 0.0431
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0094 0.0375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0266 0.0235
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0054
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0084 0.0052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0266 0.1615
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.00000000097411
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0066 0.0034
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0264 0.0233
Leishmania major pyruvate kinase 0.0036 0.0164 0.1315
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0084 0.0251
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0054
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0024 0.0084 0.0514
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Brugia malayi polk-prov protein 0.0053 0.0276 0.1685
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.031 0.1898
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0444 0.1001
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0073 0.0041
Echinococcus multilocularis geminin 0.0375 0.2364 0.234
Echinococcus multilocularis cpg binding protein 0.0067 0.0366 0.0335
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0079 0.0442 0.098
Echinococcus multilocularis pyruvate kinase 0.0036 0.0164 0.0132
Entamoeba histolytica protein kinase, putative 0.0096 0.0555 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0442 0.0947
Schistosoma mansoni ap endonuclease 0.0021 0.0066 0.0066
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0264 0.4255
Echinococcus multilocularis pyruvate kinase 0.0019 0.005 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.005 0.0699
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0073 0.053
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0073 0.0445
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0054
Leishmania major DNA polymerase eta, putative 0.0136 0.081 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0164 0.1931
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0312 0.4425
Leishmania major DNA polymerase kappa, putative 0.0025 0.0089 0.0315
Loa Loa (eye worm) RecQ helicase 0.0022 0.0073 0.0431
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0094 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0136 0.081 0.4956
Entamoeba histolytica deoxycytidyl transferase, putative 0.0079 0.0444 0.7989
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0084 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Onchocerca volvulus 0.009 0.0513 1
Echinococcus granulosus geminin 0.0375 0.2364 0.234
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0066 0.0386
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.063 0.1471
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0442 0.098
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.012 0.0706 0.1638
Echinococcus granulosus bloom syndrome protein 0.0022 0.0073 0.0041
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1442
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0555 0.6848
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0073 0.0822
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Giardia lamblia Pyruvate kinase 0.0036 0.0164 0.2586
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0066 0.0932
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0312 0.0659
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0066 0.0702
Onchocerca volvulus 0.0064 0.0342 0.6063
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0066 0.0781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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