Detailed information for compound 705805

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.463 | Formula: C21H18FN5O3S
  • H donors: 2 H acceptors: 4 LogP: 3.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)C(=O)NCCc1csc2n1nc(n2)c1ccccc1F
  • InChi: 1S/C21H18FN5O3S/c1-30-15-8-6-13(7-9-15)24-20(29)19(28)23-11-10-14-12-31-21-25-18(26-27(14)21)16-4-2-3-5-17(16)22/h2-9,12H,10-11H2,1H3,(H,23,28)(H,24,29)
  • InChiKey: MGWVRPBAKLHMJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0019 0.005 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0136 0.081 0.4956
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0264 0.0233
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0442 0.0947
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0048
Leishmania major DNA polymerase eta, putative 0.0136 0.081 1
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.012 0.0706 0.1638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0266 0.0266
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0136 0.1905
Trypanosoma brucei unspecified product 0.0055 0.0284 0.2936
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0658 0.1559
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0552
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Echinococcus granulosus dnaJ subfamily B 0.0906 0.5807 0.5793
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0266 0.1615
Echinococcus granulosus pyruvate kinase 0.0036 0.0164 0.0132
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0094 0.0669
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.0555 0.3389
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0073 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0066 0.04
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0003 0.005
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0164 0.1993
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0937
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.2693
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0089 0.0089
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0442 0.5055
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0958
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0073 0.0822
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0073
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0192
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0094 0.0036
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0066 0.0932
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0089 0.1071
Schistosoma mansoni hypothetical protein 0.0906 0.5807 0.5807
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0066 0.0961
Brugia malayi polk-prov protein 0.0053 0.0276 0.1685
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Loa Loa (eye worm) RecQ helicase 0.0022 0.0073 0.0431
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0073 0.053
Brugia malayi Protein kinase domain containing protein 0.0096 0.0555 0.3398
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0094 0.009
Loa Loa (eye worm) hypothetical protein 0.009 0.0513 0.3126
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0089 0.1071
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1125
Trypanosoma brucei unspecified product 0.0101 0.0584 0.6965
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.008 0.0037
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.1012
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0442 0.2703
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.0555 0.6582
Loa Loa (eye worm) hypothetical protein 0.0052 0.0264 0.1603
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0054
Entamoeba histolytica acyl-coA synthetase, putative 0.0079 0.0442 0.7955
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0086 0.049 0.1121
Mycobacterium ulcerans hypothetical protein 0.0112 0.0658 0.1544
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.031 0.031
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0089 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0442 0.098
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0086 0.049 0.5702
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.012 0.0706 0.8606
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.031 0.0279
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0057 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Schistosoma mansoni ap endonuclease 0.0021 0.0066 0.0066
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0079 0.0442 0.098
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.008 0.0037
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.031 0.0279
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0442 0.2703
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1442
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0094 0.1326
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0084 0.0052
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0264 0.0264
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0079 0.0444 0.0444
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0112 0.0658 0.9251
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0513 0.3136
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0066 0.0034
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0164 0.1931
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0871
Schistosoma mansoni cpg binding protein 0.0067 0.0366 0.0366
Trypanosoma brucei DNA polymerase eta, putative 0.0136 0.081 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0442 0.098
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0264 0.1603
Trypanosoma brucei unspecified product 0.0055 0.0284 0.2936
Trichomonas vaginalis DNA polymerase eta, putative 0.0108 0.063 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0079 0.0442 0.098
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Echinococcus multilocularis dual specificity 0.0096 0.0555 0.0525
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Entamoeba histolytica hypothetical protein 0.0025 0.0094 0.1686
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0474
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0108 0.063 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0164 0.1931
Onchocerca volvulus 0.009 0.0513 1
Echinococcus multilocularis dna polymerase eta 0.0136 0.081 0.078
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Schistosoma mansoni ap endonuclease 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.0986
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Entamoeba histolytica deoxycytidyl transferase, putative 0.0079 0.0444 0.7989
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.012 0.0706 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0081 0.0455 0.6399
Echinococcus granulosus pyruvate kinase 0.0019 0.005 0.0018
Echinococcus multilocularis geminin 0.0375 0.2364 0.234
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0555 0.6848
Brugia malayi mbt repeat family protein 0.0052 0.0264 0.1615
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0164 0.0986
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0164 0.1931
Schistosoma mansoni pyruvate kinase 0.0036 0.0164 0.0164
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.1634 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0079 0.0444 0.2704
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0066 0.0364
Chlamydia trachomatis pyruvate kinase 0.0036 0.0164 0.1142
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0276 0.2821
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.005 0.0699
Echinococcus multilocularis pyruvate kinase 0.0036 0.0164 0.0132
Mycobacterium ulcerans hypothetical protein 0.0112 0.0658 0.1544
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0442 0.2703
Echinococcus multilocularis pyruvate kinase 0.0019 0.005 0.0018
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0513 0.0482
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.012 0.0706 0.8606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0000000003626
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0445
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0442 0.0947
Echinococcus granulosus pyruvate kinase 0.0019 0.005 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.012 0.0706 0.8715
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0192
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0312 0.4002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0487
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0805 0.0805
Echinococcus multilocularis dnaJ subfamily B 0.0906 0.5807 0.5793
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0073 0.0445
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0474
Leishmania major DNA damage repair protein, putative 0.0025 0.0089 0.0315
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0266 0.1627
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.0555 0.6848
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0164 0.1993
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.2693
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0266 0.0235
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.2693
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.00000000097411
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0442 0.7955
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0264 0.0233
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0555 0.0555
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0024 0.0084 0.0514
Brugia malayi cytosol aminopeptidase 0.0024 0.0084 0.0514
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0312 0.3572
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0958
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.008 0.0037
Loa Loa (eye worm) histone methyltransferase 0.002 0.0057 0.0335
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0054
Echinococcus granulosus dna polymerase kappa 0.0108 0.063 0.06
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0084 0.0501
Leishmania major DNA polymerase eta, putative 0.0081 0.0455 0.5235
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0958
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0487
Echinococcus granulosus cpg binding protein 0.0067 0.0366 0.0335
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0164 0.0218
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.1275 0.1247
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.1275 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0266 0.0235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0266 0.0266
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0513 0.0482
Echinococcus multilocularis pyruvate kinase 0.0019 0.005 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0066 0.0781
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0073 0.0098
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0073 0.0431
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0073 0.0356
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.012 0.0706 0.1669
Schistosoma mansoni cpg binding protein 0.0064 0.0342 0.0342
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0066 0.0702
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.0276 0.2821
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0084 0.0501
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Mycobacterium ulcerans leucyl aminopeptidase 0.012 0.0706 0.1669
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0266 0.0235
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0094 0.1386
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0073 0.0822
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.033 0.3558
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0292 0.0604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.063 0.7587
Schistosoma mansoni cpg binding protein 0.0067 0.0366 0.0366
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0066 0.0781
Echinococcus granulosus leucine aminopeptidase protein 0.012 0.0706 0.0676
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0024 0.0084 0.0514
Treponema pallidum licC protein (licC) 0.0112 0.0658 1
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0093 0.1671
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0442 0.5055
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.1012
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0164 0.2313
Schistosoma mansoni hypothetical protein 0.0375 0.2364 0.2364
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.0658 0.1559
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0442 0.098
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1134
Echinococcus granulosus dual specificity 0.0096 0.0555 0.0525
Echinococcus multilocularis microtubule associated protein 2 0.1553 1 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0164 0.0132
Schistosoma mansoni hypothetical protein 0.0318 0.199 0.199
Plasmodium falciparum pyruvate kinase 0.0036 0.0164 0.1735
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0613 0.3903 1
Onchocerca volvulus 0.0064 0.0342 0.6063
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0312 0.0659
Trypanosoma brucei DNA polymerase IV, putative 0.0101 0.0584 0.6965
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0084 0.0084
Loa Loa (eye worm) MBCTL1 0.0059 0.031 0.1886
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0164 0.0999
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0442 0.098
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0164 0.0272
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0264 0.0264
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.063 0.7587
Entamoeba histolytica protein kinase, putative 0.0096 0.0555 1
Giardia lamblia DINP protein human, muc B family 0.0086 0.049 1
Echinococcus granulosus dna polymerase eta 0.0136 0.081 0.078
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.031 0.0279
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0089 0.0315
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0094 0.1316
Schistosoma mansoni DNA helicase recq5 0.0022 0.0073 0.0073
Schistosoma mansoni DNA helicase recq1 0.0022 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.033 0.3558
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0192
Leishmania major pyruvate kinase 0.0036 0.0164 0.1315
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0079 0.0444 0.0413
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.012 0.0706 0.8715
Mycobacterium ulcerans hypothetical protein 0.0079 0.0442 0.098
Entamoeba histolytica hypothetical protein 0.0096 0.0555 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0094 0.0073
Mycobacterium ulcerans hypothetical protein 0.0025 0.0089 0.0061
Loa Loa (eye worm) hypothetical protein 0.0096 0.0552 0.3369
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0264 0.4255
Echinococcus granulosus pyruvate kinase 0.0019 0.005 0.0018
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0056 0.0338
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0073 0.0041
Plasmodium falciparum M17 leucyl aminopeptidase 0.012 0.0706 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0312 0.0643
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0054
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0003 0.0039
Toxoplasma gondii exonuclease III APE 0.0021 0.0066 0.0924
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0066 0.1184
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0375 0.2364 0.2364
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0442 0.5055
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.031 0.0279
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0164 0.2317
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0073 0.0041
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0711 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0164 0.0986
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0054
Echinococcus granulosus bloom syndrome protein 0.0022 0.0073 0.0041
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0312 0.4425
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.063 0.1471
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0089 0.0315
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0164 0.0986
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0079 0.0442 0.0996
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0066 0.0244
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1125
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0066 0.0017
Leishmania major DNA polymerase kappa, putative 0.0086 0.049 0.5702
Brugia malayi CXXC zinc finger family protein 0.0064 0.0342 0.2093
Onchocerca volvulus 0.0079 0.0442 0.8364
Giardia lamblia DNA damage repair protein 0.0025 0.0089 0.0897
Onchocerca volvulus 0.0052 0.0264 0.4255
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0264 0.0233
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.005 0.0704
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0057 0.0025
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0084 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0444 0.2714
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0442 0.7955
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0462
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.008 0.0037
Schistosoma mansoni pyruvate kinase 0.0019 0.005 0.005
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0513 0.0513
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Echinococcus multilocularis cpg binding protein 0.0067 0.0366 0.0335
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.031 0.1898
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0079 0.0444 0.0413
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0089 0.1264
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0375
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0264 0.0233
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0192
Schistosoma mansoni pyruvate kinase 0.0036 0.0164 0.0164
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0084 0.0052
Brugia malayi mbt repeat family protein 0.0052 0.0264 0.1615
Entamoeba histolytica protein kinase, putative 0.0096 0.0555 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.0555 0.6582
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0084 0.0514
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0266 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0342 0.2082
Loa Loa (eye worm) hypothetical protein 0.0059 0.031 0.1886
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0073 0.1316
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0444 0.1001
Brugia malayi follicle stimulating hormone receptor 0.0263 0.1634 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0048
Toxoplasma gondii leucyl aminopeptidase LAP 0.012 0.0706 0.9924
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0089 0.1254
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0164 0.2313
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0164 0.1315
Echinococcus multilocularis pyruvate kinase 0.0036 0.0164 0.0132
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0073 0.0041
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0066 0.0386
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.1027
Echinococcus multilocularis pyruvate kinase 0.0028 0.0114 0.0082
Loa Loa (eye worm) hypothetical protein 0.0053 0.0276 0.1673
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0089 0.0315
Schistosoma mansoni terminal deoxycytidyl transferase 0.0079 0.0444 0.0444
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.1027
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0164 0.1315
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0084 0.0251
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0066 0.0702
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0164 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0266 0.0266
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0084 0.0052
Loa Loa (eye worm) hypothetical protein 0.0096 0.0552 0.3369
Leishmania major DNA polymerase kappa, putative 0.0025 0.0089 0.0315
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0089 0.0315
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0264 0.0264
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0094 0.1316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0442 0.0996
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0555 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0164 0.0999
Schistosoma mansoni microtubule-associated protein tau 0.1553 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.00000000097411
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0474
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0073 0.0041
Chlamydia trachomatis cytosol aminopeptidase 0.012 0.0706 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0487
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0937
Mycobacterium ulcerans DNA polymerase IV 0.0108 0.063 0.1471
Echinococcus multilocularis dna polymerase kappa 0.0108 0.063 0.06
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0073 0.0356
Echinococcus granulosus geminin 0.0375 0.2364 0.234
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0089 0.1071
Loa Loa (eye worm) hypothetical protein 0.0059 0.0312 0.1899
Trypanosoma cruzi DNA polymerase kappa, putative 0.0108 0.063 0.7775
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0037
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0084 0.0052
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.008 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0032 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0094 0.0375
Echinococcus multilocularis leucine aminopeptidase protein 0.012 0.0706 0.0676
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0474
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0431
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0093 0.0552
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Giardia lamblia Pyruvate kinase 0.0036 0.0164 0.2586
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0613 0.3903 1
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0164 0.2299
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0613 0.3903 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0073 0.0822
Leishmania major pyruvate kinase 0.0036 0.0164 0.1315
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0084 0.0251
Loa Loa (eye worm) hypothetical protein 0.0136 0.081 0.4948
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.063 0.7587
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.033 0.3558
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.008 0.0037
Schistosoma mansoni DNA polymerase eta 0.0136 0.081 0.081
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0089 0.0602
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.012 0.0706 0.1683
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.049 0.5702
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0089 0.1071
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0073 0.0445
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0084 0.0052
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0066 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.0136 0.081 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.008 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.00000000097411
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.008 0.0037
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0112 0.0658 0.1544
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1125
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0054
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0455 0.5607
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0613 0.3903 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0079 0.0442 0.098

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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