Detailed information for compound 72927

Basic information

Technical information
  • TDR Targets ID: 72927
  • Name: diethyl 5-formyl-3-methyl-1H-pyrrole-2,4-dica rboxylate
  • MW: 253.251 | Formula: C12H15NO5
  • H donors: 1 H acceptors: 3 LogP: 1.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1[nH]c(c(c1C)C(=O)OCC)C=O
  • InChi: 1S/C12H15NO5/c1-4-17-11(15)9-7(3)10(12(16)18-5-2)13-8(9)6-14/h6,13H,4-5H2,1-3H3
  • InChiKey: WPKKEQCPXUTCDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-formyl-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester
  • diethyl 5-methanoyl-3-methyl-1H-pyrrole-2,4-dicarboxylate
  • 2199-60-2
  • NSC10766
  • BAS 00918684
  • Oprea1_172180
  • ZINC00245187
  • 1H-Pyrrole-2,4-dicarboxylic acid, 5-formyl-3-methyl-, diethyl ester
  • Oprea1_729849
  • CBDivE_014445
  • A2429/0102878
  • MLS000717775
  • SMR000279143

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Escherichia coli fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0157 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0382 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0045 0.0045
Brugia malayi hypothetical protein 0.0011 0.0006 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0532 0.4015
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0464 0.1028
Brugia malayi Myosin head containing protein 0.0012 0.0013 0.0026
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0057 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Schistosoma mansoni tar DNA-binding protein 0.013 0.0741 0.1644
Loa Loa (eye worm) RNA binding protein 0.013 0.0741 0.1634
Brugia malayi protein C24B5.3 0.0012 0.0013 0.0026
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0157 0.0348
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0005
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0157 0.0157
Schistosoma mansoni tar DNA-binding protein 0.013 0.0741 0.1644
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0065 0.014
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0018
Brugia malayi protein C24B5.3 0.0012 0.0013 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Loa Loa (eye worm) hypothetical protein 0.0072 0.0382 0.0836
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0127 0.0968
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0065 0.0132
Echinococcus granulosus ryanodine receptor 44f 0.0035 0.0157 0.0348
Schistosoma mansoni transient receptor potential channel 0.0035 0.0157 0.0348
Brugia malayi isocitrate dehydrogenase 0.0019 0.0057 0.0122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0113 0.0251
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0157 0.0157
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0565 0.1254
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0065 0.014
Loa Loa (eye worm) voltage-gated potassium channel 0.0035 0.0157 0.0336
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0112
Brugia malayi DNA 3'-phosphatase family protein 0.0019 0.0056 0.012
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Echinococcus granulosus microtubule associated protein 2 0.072 0.4366 0.9684
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Schistosoma mansoni thyroid hormone receptor 0.002 0.0065 0.0144
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0065 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0532 0.6506
Echinococcus multilocularis sodium channel protein 0.0035 0.0157 0.0157
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0065 0.0144
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0145 0.0521
Echinococcus granulosus transcription factor eb 0.0108 0.0604 0.1341
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.0455 0.274 1
Echinococcus granulosus GPCR family 2 0.0032 0.0135 0.03
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0343 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0113 0.0841
Schistosoma mansoni apoferritin-2 0.001 0.0002 0.0005
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0113 0.0976
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0057 0.0114
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0113 0.0405
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0113 0.0248
Schistosoma mansoni pyruvate kinase 0.0033 0.0145 0.0321
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0113 0.0405
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0035 0.0157 0.1381
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0157 0.0348
Onchocerca volvulus 0.0096 0.0532 0.3679
Echinococcus granulosus calcium activated potassium channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0157 0.0348
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0157 0.0348
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0035 0.0157 0.1381
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0057 0.0126
Leishmania major pyruvate kinase 0.0033 0.0145 0.1208
Loa Loa (eye worm) hypothetical protein 0.0096 0.0532 0.1169
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.03
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.0532 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0065 0.014
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0113 0.0405
Loa Loa (eye worm) oxidoreductase 0.0028 0.0113 0.024
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0065 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0065 0.014
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0045 0.1174
Echinococcus granulosus voltage gated hydrogen channel 1 0.0035 0.0157 0.0348
Onchocerca volvulus 0.0035 0.0157 0.1017
Brugia malayi Pre-B cell enhancing factor precursor 0.0743 0.4508 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.1161 0.1161
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0741 0.1642
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0157 0.0348
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0157 0.0157
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.1161 0.2575
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0138 0.0787 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0035 0.0157 0.0157
Brugia malayi voltage-dependent calcium channel 0.0035 0.0157 0.0344
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0157 0.0157
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0532 0.4015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Schistosoma mansoni transient receptor potential channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus granulosus short transient receptor potential channel 6 0.0035 0.0157 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0113 0.0405
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0057 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0172
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0113 0.0251
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0382 0.1386
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0035 0.0157 0.0157
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0113 0.0405
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0157 0.0157
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Schistosoma mansoni ferritin light chain 0.001 0.0002 0.0005
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0138 0.0787 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0096 0.0532 0.1169
Schistosoma mansoni coup transcription factor 0.002 0.0065 0.0144
Brugia malayi hypothetical protein 0.0035 0.0157 0.0344
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0157 0.0348
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0057 0.165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0065 0.0144
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0045 0.1305
Trichomonas vaginalis ferritin, putative 0.001 0.0002 0.0012
Leishmania major pyruvate kinase 0.0033 0.0145 0.1208
Entamoeba histolytica hypothetical protein 0.0074 0.0395 0.3401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0065 0.0144
Echinococcus granulosus hyperpolarization activated cyclic 0.0035 0.0157 0.0348
Brugia malayi hypothetical protein 0.0074 0.0395 0.0873
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0145 0.031
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0138 0.0787 0.2865
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0057 0.0057
Echinococcus granulosus shaker cognate 0.0035 0.0157 0.0348
Echinococcus granulosus cpg binding protein 0.0037 0.0165 0.0366
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0057 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0035 0.0157 0.0336
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0113 0.0405
Loa Loa (eye worm) hypothetical protein 0.0072 0.0382 0.0836
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0532 0.1176
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Loa Loa (eye worm) hypothetical protein 0.0072 0.0382 0.0836
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0089 0.0317
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0145 0.031
Toxoplasma gondii patched family protein 0.0012 0.0013 0.039
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0145 0.0521
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.0532 0.458
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0157 0.0348
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0113 0.1439
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0065 0.0144
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0145 0.0933
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0113 0.0248
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0113 0.2965
Schistosoma mansoni hypothetical protein 0.0289 0.1714 0.3803
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0157 0.0348
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0035 0.0157 0.0344
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0057 0.0057
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0157 0.0348
Toxoplasma gondii hypothetical protein 0.0012 0.0013 0.039
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0157 0.0157
Echinococcus multilocularis transient receptor potential gamma protein 0.0035 0.0157 0.0157
Schistosoma mansoni polynucleotide kinase-3'-phosphatase 0.0019 0.0056 0.0124
Echinococcus multilocularis pyruvate kinase 0.0033 0.0145 0.0145
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0113 0.0775
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0113 0.0405
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0113 0.0785
Schistosoma mansoni ferritin 0.001 0.0002 0.0005
Onchocerca volvulus 0.002 0.0065 0.0364
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0157 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0065 0.0065
Echinococcus multilocularis X box binding protein 1 0.0289 0.1714 0.1714
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0035 0.0157 0.0344
Echinococcus granulosus sodium channel protein 0.0035 0.0157 0.0348
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0113 0.0785
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0157 0.0348
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0127 0.1609
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0157 0.0157
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0057 0.0199
Echinococcus granulosus two pore calcium channel protein 1 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0096 0.0532 0.1169
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.0362 0.0792
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0104 0.0581 0.128
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0035 0.0157 0.0336
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0035 0.0157 0.0344
Toxoplasma gondii patched family protein 0.0012 0.0013 0.039
Brugia malayi steroid hormone receptor 0.002 0.0065 0.014
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0113 0.0248
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.03
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0113 0.0405
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0035 0.0157 0.0336
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0035 0.0157 0.0348
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0145 0.0735
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0113 0.0785
Echinococcus multilocularis cpg binding protein 0.0037 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0135 0.0296
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0035 0.0157 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0113 0.0248
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0157 0.0348
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0157 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0135 0.0296
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0532 0.458
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.1161 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0065 0.014
Echinococcus multilocularis hyperpolarization activated cyclic 0.0035 0.0157 0.0157
Echinococcus multilocularis protein patched 0.0085 0.0464 0.0464
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0395 0.0876
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0113 0.0248
Echinococcus multilocularis short transient receptor potential channel 6 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0145 0.0318
Schistosoma mansoni hypothetical protein 0.0074 0.0395 0.0876
Brugia malayi TAR-binding protein 0.013 0.0741 0.1642
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.1161 0.2572
Loa Loa (eye worm) hypothetical protein 0.0099 0.055 0.121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Toxoplasma gondii patched family protein 0.0012 0.0013 0.039
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Schistosoma mansoni tar DNA-binding protein 0.013 0.0741 0.1644
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0065 0.0144
Echinococcus multilocularis transfer RNA-Gly 0.0035 0.0157 0.0157
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0113 0.0785
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0532 0.1933
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus multilocularis potassium large conductance calcium activated 0.0035 0.0157 0.0157
Echinococcus multilocularis hyperpolarization activated cyclic 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0145 0.031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.031
Mycobacterium ulcerans hypothetical protein 0.0096 0.0532 0.1933
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0006
Echinococcus multilocularis pyruvate kinase 0.0017 0.0045 0.0045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0135 0.0288
Schistosoma mansoni pyruvate kinase 0.0033 0.0145 0.0321
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0157 0.0344
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0145 0.4218
Schistosoma mansoni apoferritin-2 0.001 0.0002 0.0005
Brugia malayi Cyclic-nucleotide gated cation channel 0.0035 0.0157 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0013 0.017
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0145 0.0318
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0205 0.1198 0.2657
Brugia malayi Patched related family protein 10 0.0012 0.0013 0.0026
Onchocerca volvulus Bifunctional polynucleotide phosphatase\/kinase homolog 0.0019 0.0056 0.0301
Echinococcus multilocularis conserved hypothetical protein 0.0035 0.0157 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Leishmania major hypothetical protein, conserved 0.003 0.0127 0.0957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0225 0.0499
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0065 0.0144
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0145 0.1081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0395 0.0395
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0135 0.03
Schistosoma mansoni hypothetical protein 0.0035 0.0157 0.0348
Onchocerca volvulus 0.0035 0.0153 0.0988
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0532 0.1176
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0065 0.014
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0157 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0065 0.0132
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0157 0.0348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0065 0.0144
Echinococcus granulosus two pore calcium channel protein 2 0.0035 0.0157 0.0348
Schistosoma mansoni hypothetical protein 0.0082 0.0445 0.0986
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0145 0.0933
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0157 0.0157
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0035 0.0157 0.0348
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0113 0.0785
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Schistosoma mansoni cpg binding protein 0.0037 0.0165 0.0366
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0012
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0157 0.0157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0135 0.0135
Echinococcus multilocularis geminin 0.0205 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0035 0.0157 0.0344
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Brugia malayi ion channel NompC 0.0035 0.0157 0.0344
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0157 0.0348
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.03
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0157 0.0348
Onchocerca volvulus 0.0028 0.0113 0.0709
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0057 0.0122
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0382 0.4854
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0065 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Echinococcus multilocularis ryanodine receptor 44f 0.0035 0.0157 0.0157
Echinococcus multilocularis bifunctional polynucleotide 0.0019 0.0056 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0532 0.1176
Echinococcus granulosus X box binding protein 1 0.0289 0.1714 0.3803
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0065 0.0364
Echinococcus multilocularis shaker cognate 0.0035 0.0157 0.0157
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0057 0.0012
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0035 0.0157 0.0344
Echinococcus granulosus expressed conserved protein 0.0187 0.1087 0.2411
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0157 0.0157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0225 0.0488
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0035 0.0157 0.1371
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0135 0.03
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0083 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0065 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0035 0.0157 0.0157
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Brugia malayi hypothetical protein 0.0012 0.0013 0.0026
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0127 0.3314
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Brugia malayi CXXC zinc finger family protein 0.0035 0.0153 0.0335
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Echinococcus granulosus bifunctional polynucleotide 0.0019 0.0056 0.0124
Echinococcus granulosus tumor protein p63 0.0696 0.4217 0.9355
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0065 0.0144
Plasmodium falciparum pyruvate kinase 0.0033 0.0145 0.1841
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0225 0.0499
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0157 0.0348
Schistosoma mansoni ferritin 0.001 0.0002 0.0005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0113 0.024
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.024
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Giardia lamblia Pyruvate kinase 0.0033 0.0145 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0157 0.0157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0225 0.0496
Loa Loa (eye worm) TAR-binding protein 0.013 0.0741 0.1634
Brugia malayi cation channel family protein 0.0035 0.0157 0.0344
Onchocerca volvulus 0.0028 0.0113 0.0709
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0138 0.0787 0.3994
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0065 0.014
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0362 0.08
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0113 0.0248
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0057 0.0126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0358 0.1298
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0108 0.0601 0.1323
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0035 0.0157 0.0344
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0157 0.0348
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0225 0.0499
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0113 0.0841
Loa Loa (eye worm) ryanodine receptor 0.0035 0.0157 0.0336
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.055 0.474
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0382 0.0836
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0065 0.0065
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0113 0.0405
Loa Loa (eye worm) hypothetical protein 0.0108 0.0601 0.1323
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0113 0.0405
Onchocerca volvulus 0.0241 0.1422 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0157 0.0348
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0113 0.0775
Trichomonas vaginalis glutaminase, putative 0.033 0.197 1
Brugia malayi hypothetical protein 0.002 0.006 0.013
Brugia malayi hypothetical protein 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0138 0.0787 0.1745
Schistosoma mansoni glutaminase 0.033 0.197 0.4369
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0464 0.1018
Echinococcus multilocularis short transient receptor potential channel 6 0.0035 0.0157 0.0157
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0113 0.0405
Plasmodium falciparum bifunctional polynucleotide phosphatase/kinase 0.0019 0.0056 0.071
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0035 0.0157 0.0157
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0035 0.0157 0.1381
Echinococcus granulosus ferritin 0.001 0.0002 0.0005
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0157 0.0348
Schistosoma mansoni two-pore calcium channel 0.0035 0.0157 0.0348
Schistosoma mansoni hypothetical protein 0.0082 0.0445 0.0986
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0065 0.0065
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0532 0.458
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0045 0.057
Loa Loa (eye worm) hypothetical protein 0.0101 0.0558 0.1227
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0113 0.0405
Echinococcus multilocularis GPCR, family 2 0.0032 0.0135 0.0135
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0138 0.0787 0.1745
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0035 0.0157 0.0344
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0018
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.0743 0.4508 0.4508
Loa Loa (eye worm) ion channel NompC 0.0035 0.0157 0.0336
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0157 0.0348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0065 0.0144
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0157 0.0796
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0157 0.0348
Echinococcus multilocularis two pore calcium channel protein 1 0.0035 0.0157 0.0157
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0035 0.0157 0.0344
Loa Loa (eye worm) voltage-dependent calcium channel 0.0035 0.0157 0.0336
Loa Loa (eye worm) glutaminase 2 0.033 0.197 0.4363
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0145 0.1218
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0018
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0035 0.0157 0.0348
Echinococcus granulosus pyruvate kinase 0.0017 0.0045 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Loa Loa (eye worm) hypothetical protein 0.0032 0.0135 0.0288
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.118 0.2617
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0065 0.0144
Treponema pallidum nicotinate phosphoribosyltransferase 0.0138 0.0787 1
Schistosoma mansoni vesicular amine transporter 0.0035 0.0157 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0532 0.1933
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0532 0.6506
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0464 0.0464
Entamoeba histolytica hypothetical protein 0.0074 0.0395 0.3401
Entamoeba histolytica polynucleotide kinase-3-phosphatase, putative 0.0019 0.0056 0.0481
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0065 0.0065
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0057 0.1484
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0108 0.0604 0.1338
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0145 0.3793
Schistosoma mansoni ryanodine receptor related 0.0035 0.0157 0.0348
Echinococcus granulosus pyruvate kinase 0.0017 0.0045 0.0099
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0035 0.0157 0.0344
Brugia malayi hypothetical protein 0.0012 0.0013 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0065 0.014
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0035 0.0157 0.1017
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Brugia malayi nuclear hormone receptor 0.002 0.0065 0.014
Echinococcus multilocularis calcium activated potassium channel 0.0035 0.0157 0.0157
Echinococcus granulosus expressed protein 0.001 0.0002 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0065 0.0065
Schistosoma mansoni ferritin 0.001 0.0002 0.0005
Schistosoma mansoni nuclear hormone receptor 0.002 0.0065 0.0144
Brugia malayi hypothetical protein 0.0012 0.0013 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0065 0.014
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0065 0.0364
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0065 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0157 0.0344
Schistosoma mansoni transient receptor potential channel 0.0035 0.0157 0.0348
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0157 0.0157
Echinococcus granulosus hypothetical protein 0.0035 0.0157 0.0348
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0009
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0035 0.0157 0.0344
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0157 0.4564
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0065 0.0132
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0145 0.1218
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0113 0.0785
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0035 0.0157 0.0348
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0002 0.5
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) calcium channel 0.0035 0.0157 0.0336
Echinococcus granulosus hyperpolarization activated cyclic 0.0035 0.0157 0.0348
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0065 0.0065
Onchocerca volvulus 0.0028 0.0113 0.0709
Entamoeba histolytica hypothetical protein 0.0074 0.0395 0.3401
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus multilocularis pyruvate kinase 0.0026 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Schistosoma mansoni hypothetical protein 0.0205 0.1198 0.2657
Leishmania major hypothetical protein, unknown function 0.0035 0.0157 0.1371
Echinococcus multilocularis sodium leak channel non selective protein 0.0035 0.0157 0.0157
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0065 0.0144
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.072 0.4366 0.4366
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0157 0.0348
Brugia malayi ecdysteroid receptor 0.002 0.0065 0.014
Schistosoma mansoni pyruvate kinase 0.0017 0.0045 0.0099
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0157 0.4564
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0138 0.0787 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0113 0.0405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0558 0.1234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0145 0.1218
Echinococcus granulosus transient receptor potential gamma protein 0.0035 0.0157 0.0348
Echinococcus multilocularis pyruvate kinase 0.0033 0.0145 0.0145
Loa Loa (eye worm) pre-B cell enhancing factor 0.0743 0.4508 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0065 0.0144
Leishmania major hypothetical protein, conserved 0.0035 0.0157 0.1371
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0358 0.1298
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0157 0.4564
Schistosoma mansoni ferritin 0.001 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Schistosoma mansoni voltage-dependent calcium channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0065 0.0132
Brugia malayi Pax transcription factor protein 2 0.0241 0.1422 0.3152
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0113 0.0405
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0157 0.0157
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0464 0.1028
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0157 0.0157
Brugia malayi HSF-type DNA-binding domain containing protein 0.0099 0.055 0.1218
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0065 0.014
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.0532 0.1933
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0532 0.1933
Loa Loa (eye worm) glutaminase 0.033 0.197 0.4363
Echinococcus multilocularis tumor protein p63 0.0696 0.4217 0.4217
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0113 0.0405
Schistosoma mansoni voltage-gated ion channel 0.0035 0.0157 0.0348
Echinococcus multilocularis expressed conserved protein 0.0187 0.1087 0.1087
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0532 0.1933
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0072 0.0382 0.0836
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0138 0.0787 0.6778
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0035 0.0157 0.1017
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0157 0.0157
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0157 0.0796
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0157 0.0157
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0113 0.0575
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0035 0.0157 0.0348
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0395 0.0876
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0065 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0464 0.2353
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0157 0.0348
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0113 0.0405
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus multilocularis tar DNA binding protein 0.013 0.0741 0.0741
Echinococcus granulosus sodium leak channel non selective protein 0.0035 0.0157 0.0348
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0225 0.0499
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Onchocerca volvulus 0.0102 0.0565 0.3919
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0138 0.0787 1
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0018
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0157 0.0157
Loa Loa (eye worm) voltage-gated calcium channel 0.0035 0.0157 0.0336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0225 0.0225
Schistosoma mansoni ferritin light chain 0.001 0.0002 0.0005
Echinococcus granulosus potassium large conductance calcium activated 0.0035 0.0157 0.0348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0065 0.0144
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0157 0.0348
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0035 0.0157 0.0157
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0157 0.0157
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.055 0.474
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus multilocularis pyruvate kinase 0.0017 0.0045 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0065 0.0132
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.0532 0.1933
Schistosoma mansoni thyroid hormone receptor 0.002 0.0065 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0157 0.0348
Loa Loa (eye worm) hypothetical protein 0.0085 0.0464 0.1018
Plasmodium vivax patched family protein, putative 0.0012 0.0013 0.0351
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0023 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Entamoeba histolytica hypothetical protein 0.0074 0.0395 0.3401
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0558 0.1227
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0157 0.0348
Echinococcus granulosus Niemann Pick C1 protein 0.0284 0.1685 0.3738
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0099 0.055 0.3811
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0035 0.0157 0.0348
Schistosoma mansoni calcium-activated potassium channel 0.0035 0.0157 0.0348
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.0455 0.274 1
Brugia malayi cation channel family protein 0.0035 0.0157 0.0344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0558 0.1234
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0153 0.0327
Schistosoma mansoni hypothetical protein 0.0082 0.0445 0.0986
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0035 0.0157 0.0348
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.0532 0.1933
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0358 0.1298
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0157 0.0348
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0127 0.0968
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0138 0.0787 0.2865
Echinococcus multilocularis protein dispatched 1 0.0097 0.0538 0.0538
Schistosoma mansoni hypothetical protein 0.0082 0.0445 0.0986
Schistosoma mansoni cpg binding protein 0.0035 0.0153 0.0339
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0157 0.4564
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0035 0.0157 0.0344
Echinococcus granulosus tar DNA binding protein 0.013 0.0741 0.1644
Brugia malayi RNA binding protein 0.013 0.0741 0.1642
Schistosoma mansoni hypothetical protein 0.0069 0.0362 0.0803
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0065 0.0065
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0157 0.0348
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0113 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0065 0.014
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0035 0.0157 0.0344
Toxoplasma gondii patched family protein 0.0012 0.0013 0.039
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0145 0.0933
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0065 0.014
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0035 0.0157 0.0348
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0035 0.0157 0.0344
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0065 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0225 0.0499
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0157 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0065 0.014
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.0743 0.4508 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0127 0.1609
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.055 0.474
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0065 0.014
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0113 0.0775
Brugia malayi Patched related family protein 12 0.0012 0.0013 0.0026
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0157 0.0157
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0145 0.0735
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Plasmodium falciparum phosphatase, putative 0.0019 0.0056 0.071
Schistosoma mansoni 60S ribosomal protein L21 0.0035 0.0157 0.0348
Brugia malayi hypothetical protein 0.003 0.0127 0.0277
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0113 0.0841
Brugia malayi hypothetical protein 0.0012 0.0013 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0382 0.1386
Mycobacterium ulcerans glutaminase 0.033 0.197 0.7185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Echinococcus multilocularis expressed protein 0.001 0.0002 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0065 0.0364
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Brugia malayi Patched related family protein 4 0.0012 0.0013 0.0026
Loa Loa (eye worm) pax transcription factor protein 2 0.0241 0.1422 0.3147
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0035 0.0157 0.0348
Echinococcus multilocularis transcription factor eb 0.0108 0.0604 0.0604
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0113 0.024
Brugia malayi CHE-14 protein 0.0085 0.0464 0.1025
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0157 0.0157
Echinococcus multilocularis Niemann Pick C1 protein 0.0284 0.1685 0.1685
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0532 0.6506
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0035 0.0157 0.0157
Brugia malayi olfactory channel protein osm-9 0.0035 0.0157 0.0344
Schistosoma mansoni transient receptor potential channel 4 0.0035 0.0157 0.0348
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0113 0.3297
Schistosoma mansoni tar DNA-binding protein 0.013 0.0741 0.1644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0065 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0127 0.0968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0065 0.0132
Toxoplasma gondii hypothetical protein 0.0035 0.0157 0.4564
Toxoplasma gondii hypothetical protein 0.0035 0.0157 0.4564
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0057 0.165
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0157 0.0348
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0113 0.0405
Loa Loa (eye worm) voltage-gated potassium channel 0.0035 0.0157 0.0336
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0743 0.4508 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0113 0.0405
Schistosoma mansoni microtubule-associated protein tau 0.072 0.4366 0.9684
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0392 0.0869
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0012
Plasmodium vivax bifunctional polynucleotide phosphatase/kinase, putative 0.0019 0.0056 0.1462
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.03
Giardia lamblia Pyruvate kinase 0.0017 0.0045 0.3095
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0741 0.1634
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0157 0.0348
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0157 0.0348
Schistosoma mansoni patched 1 0.0085 0.0464 0.1028
Echinococcus granulosus pyruvate kinase 0.0033 0.0145 0.0321
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0199 0.1161 0.2566
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0018
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0113 0.0575
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0012
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Onchocerca volvulus 0.0028 0.0113 0.0709
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0127 0.3685
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0065 0.0144
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0023 0.0023
Schistosoma mansoni tar DNA-binding protein 0.013 0.0741 0.1644
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0157 0.0348
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0132
Echinococcus granulosus geminin 0.0205 0.1198 0.2657
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0157 0.4564
Schistosoma mansoni cpg binding protein 0.0037 0.0165 0.0366
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0035 0.0157 0.0348
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0113 0.0405
Echinococcus granulosus pyruvate kinase 0.0033 0.0145 0.0321
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0532 0.1933
Plasmodium vivax phosphatase, putative 0.0019 0.0056 0.1462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0358 0.1298
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0035 0.0157 0.1381
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0035 0.0157 0.0348
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0113 0.0405
Brugia malayi glutaminase DH11.1 0.033 0.197 0.4367
Brugia malayi Patched family protein 0.0012 0.0013 0.0026
Echinococcus multilocularis two pore calcium channel protein 2 0.0035 0.0157 0.0157
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0083 0.0172
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0113 0.3297
Echinococcus granulosus FTZ F1 alpha 0.002 0.0065 0.0144
Echinococcus multilocularis ferritin 0.001 0.0002 0.0002
Brugia malayi Patched protein homolog 1 0.0012 0.0013 0.0026
Brugia malayi nuclear receptor NHR-88 0.002 0.0065 0.014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0057 0.072
Schistosoma mansoni hypothetical protein 0.0014 0.0023 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0225 0.0225
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0113 0.3297
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0145 0.1218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0336
Echinococcus granulosus pyruvate kinase 0.0017 0.0045 0.0099
Echinococcus granulosus short transient receptor potential channel 6 0.0035 0.0157 0.0348
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0102 0.0565 0.1244
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.0225 0.1321 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 2.7 uM Displacement of fluorescent ATP competitive ligand from IGF1R ChEMBL. 19610618
Activity (binding) = 12 uM Inhibition of IRK ChEMBL. 19610618
Activity (binding) = 15 uM Inhibition of IGF1R by cell based assay ChEMBL. 19610618
IC50 (binding) = 5.1 uM Compound was evaluated in the imidazole glycerol phosphate dehydratase (IGPD) endpoint assay for inhibition of the IGPD enzyme Starlite. 12067551
IC50 (binding) = 5.1 uM Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to substrate addition measured for 16 min by spectrophotometric analysis ChEMBL. 12067551
Potency (functional) 1.636 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.5821 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) = 23.7558 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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