Detailed information for compound 729383

Basic information

Technical information
  • TDR Targets ID: 729383
  • Name: N-(5-chloro-2-methylphenyl)-2-(3-oxothiomorph olin-2-yl)acetamide
  • MW: 298.788 | Formula: C13H15ClN2O2S
  • H donors: 2 H acceptors: 2 LogP: 1.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1NC(=O)CC1SCCNC1=O)Cl
  • InChi: 1S/C13H15ClN2O2S/c1-8-2-3-9(14)6-10(8)16-12(17)7-11-13(18)15-4-5-19-11/h2-3,6,11H,4-5,7H2,1H3,(H,15,18)(H,16,17)
  • InChiKey: MFQRLOFVYZZIJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-chloro-2-methyl-phenyl)-2-(3-oxothiomorpholin-2-yl)acetamide
  • N-(5-chloro-2-methylphenyl)-2-(3-oxo-2-thiomorpholinyl)acetamide
  • N-(5-chloro-2-methyl-phenyl)-2-(3-ketothiomorpholin-2-yl)acetamide
  • N-(5-chloro-2-methyl-phenyl)-2-(3-oxothiomorpholin-2-yl)ethanamide
  • N-(5-Chloro-2-methyl-phenyl)-2-(3-oxo-thiomorpholin-2-yl)-acetamide
  • ST064539
  • BAS 12534395

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1065 0.2884
Brugia malayi hypothetical protein 0.0026 0.0154 0.0377
Loa Loa (eye worm) TAR-binding protein 0.0134 0.1193 0.2982
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.1065 0.1504
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.3992 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1065 0.406
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1193 0.3231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0959 0.3621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0959 0.2597
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0256 0.0562
Echinococcus granulosus cathepsin l1 0.0017 0.0063 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0063 0.0139
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0236 0.0583
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.023 0.2116 0.8885
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1243 0.4539
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2214 0.2214
Onchocerca volvulus 0.0484 0.4557 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0959 0.2395
Loa Loa (eye worm) hypothetical protein 0.0155 0.1396 0.3492
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0154 0.0561
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0486 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0236 0.0518
Echinococcus multilocularis cysteine protease 0.0017 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0014
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0959 0.0959
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0959 0.1343
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0486 0.0486
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0959 0.1343
Entamoeba histolytica hypothetical protein 0.0037 0.0251 0.9823
Echinococcus multilocularis Smad4 0.0024 0.0132 0.0132
Mycobacterium tuberculosis Putative ferredoxin reductase 0.023 0.2116 0.3098
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0256 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0009 0.002
Mycobacterium ulcerans hypothetical protein 0.011 0.0959 0.3621
Mycobacterium tuberculosis Probable oxidoreductase 0.0256 0.2364 0.3473
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0959 0.35
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0145 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.0013
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0236 0.0861
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2214 0.2214
Loa Loa (eye worm) hypothetical protein 0.011 0.0959 0.2395
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.023 0.2116 0.3098
Toxoplasma gondii thioredoxin reductase 0.0101 0.0871 0.236
Plasmodium vivax hypothetical protein, conserved 0.011 0.0959 1
Brugia malayi MH2 domain containing protein 0.0024 0.0132 0.0323
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0236 0.0633
Brugia malayi Cathepsin L-like precursor 0.0017 0.0063 0.015
Loa Loa (eye worm) RNA binding protein 0.0134 0.1193 0.2982
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1243 0.4539
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0154 0.1764
Plasmodium falciparum thioredoxin reductase 0.0035 0.0236 0.2709
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0083 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0154 0.1603
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0959 0.2104
Plasmodium falciparum glutathione reductase 0.0101 0.0871 1
Onchocerca volvulus 0.0153 0.1378 0.3023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.02
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0145 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0352 0.0352
Schistosoma mansoni smad1 5 8 and 0.0024 0.0132 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1065 0.406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Leishmania major hypothetical protein, conserved 0.0026 0.0154 0.0561
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.2739 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0132 0.0359
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0145 0.0257
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.2456 0.6148
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0132 0.0359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0352 0.0954
Onchocerca volvulus 0.011 0.0959 0.2103
Onchocerca volvulus 0.0017 0.0063 0.0138
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0236 0.2461
Schistosoma mansoni glutaminase 0.027 0.2501 0.6775
Brugia malayi MH1 domain containing protein 0.0024 0.0132 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.2456 0.6148
Chlamydia trachomatis hypothetical protein 0.0154 0.1382 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0486 0.1317
Loa Loa (eye worm) hypothetical protein 0.011 0.0959 0.2395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0959 0.1343
Echinococcus granulosus smad 0.0024 0.0132 0.0132
Trichomonas vaginalis glutaminase, putative 0.027 0.2501 0.5488
Giardia lamblia O-linked GlcNAc transferase 0.0389 0.3649 1
Onchocerca volvulus 0.0011 0.0009 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0352 0.0874
Treponema pallidum hypothetical protein 0.0154 0.1382 0.9999
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0003 0.0003
Brugia malayi intermediate filament protein 0.0027 0.016 0.0392
Brugia malayi Cathepsin L-like precursor 0.0017 0.0063 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0959 0.1343
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0154 0.1764
Echinococcus multilocularis stress induced phosphoprotein 1 0.0012 0.0013 0.0013
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0083 0.0865
Onchocerca volvulus 0.0017 0.0063 0.0138
Brugia malayi MH2 domain containing protein 0.0355 0.332 0.8316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0145 0.0257
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.1065 0.1065
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0256 0.2364 0.3473
Leishmania major hypothetical protein, conserved 0.011 0.0959 0.35
Echinococcus granulosus lamin dm0 0.0027 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0256 0.0934
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0219 0.0331
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0014
Echinococcus multilocularis cysteine protease 0.0017 0.0063 0.0063
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0132 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0003 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0063 0.0063
Mycobacterium tuberculosis Conserved protein 0.011 0.0959 0.1343
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0486 0.1301
Brugia malayi Pre-SET motif family protein 0.0061 0.0486 0.1211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.02
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0039 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Schistosoma mansoni survival motor neuron protein 0.0049 0.0371 0.1006
Brugia malayi glutathione reductase 0.0101 0.0871 0.2175
Echinococcus granulosus stress induced phosphoprotein 1 0.0012 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.047 0.1714
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0236 0.0613
Brugia malayi Cathepsin L-like precursor 0.0011 0.0009 0.0014
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0236 0.0861
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0003 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0251 0.0681
Loa Loa (eye worm) glutaminase 0.027 0.2501 0.6262
Mycobacterium ulcerans hypothetical protein 0.0026 0.0145 0.0257
Echinococcus granulosus intermediate filament protein 0.0027 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0014
Echinococcus multilocularis smad 0.0024 0.0132 0.0132
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0063 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0959 0.2104
Onchocerca volvulus 0.0027 0.016 0.035
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0063 0.0171
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0063 0.0171
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0524 0.1911
Echinococcus multilocularis musashi 0.0027 0.016 0.016
Schistosoma mansoni inositol monophosphatase 0.0037 0.0256 0.0693
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0132 0.0323
Mycobacterium leprae conserved hypothetical protein 0.011 0.0959 0.3667
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0063 0.015
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0063 0.2464
Leishmania major cathepsin L-like protease 0.0017 0.0063 0.023
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0256 0.0668
Leishmania major cathepsin L-like protease 0.0017 0.0063 0.023
Schistosoma mansoni intermediate filament proteins 0.0027 0.016 0.0433
Brugia malayi hypothetical protein 0.0037 0.0251 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Brugia malayi Cathepsin L-like precursor 0.0011 0.0009 0.0014
Brugia malayi hypothetical protein 0.024 0.2214 0.5542
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0352 0.0352
Loa Loa (eye worm) fibroinase 0.0017 0.0063 0.015
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0392 0.3678 0.9213
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0256 0.0256
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0236 0.0861
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Loa Loa (eye worm) beta-lactamase 0.011 0.0959 0.2395
Loa Loa (eye worm) cysteine protease 0.0017 0.0063 0.015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0392 0.3678 0.9213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0236 0.0861
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.2456 0.5388
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.6668 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0871 0.121
Loa Loa (eye worm) intermediate filament protein 0.0027 0.016 0.0392
Onchocerca volvulus 0.0017 0.0063 0.0138
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0871 0.9087
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0959 0.35
Loa Loa (eye worm) glutathione reductase 0.0101 0.0871 0.2175
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0256 0.0562
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0009 0.0346
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0959 0.1343
Mycobacterium ulcerans lipase LipD 0.011 0.0959 0.3621
Mycobacterium tuberculosis Conserved protein 0.011 0.0959 0.1343
Echinococcus granulosus lamin 0.0027 0.016 0.016
Echinococcus multilocularis O glycosyltransferase 0.0394 0.3691 0.3691
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0132 0.0132
Leishmania major cathepsin L-like protease 0.0017 0.0063 0.023
Onchocerca volvulus 0.0017 0.0063 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0063 0.0138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0486 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.024 0.2214 0.5542
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0959 0.2104
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0959 0.2104
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.2739 1
Schistosoma mansoni lamin 0.0027 0.016 0.0433
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2136 0.5347
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0063 0.0139
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0063 0.0724
Brugia malayi MH1 domain containing protein 0.0013 0.0028 0.0062
Loa Loa (eye worm) ctsf protein 0.0017 0.0063 0.015
Echinococcus granulosus cathepsin l1 0.0011 0.0009 0.0009
Mycobacterium ulcerans beta-lactamase 0.011 0.0959 0.3621
Plasmodium falciparum thioredoxin reductase 0.0101 0.0871 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Loa Loa (eye worm) hypothetical protein 0.0061 0.0486 0.1211
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0959 0.1343
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1667 0.3657
Brugia malayi beta-lactamase family protein 0.011 0.0959 0.2395
Plasmodium vivax SET domain protein, putative 0.0061 0.0486 0.5072
Brugia malayi MH2 domain containing protein 0.0024 0.0132 0.0323
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Loa Loa (eye worm) nuclear factor I 0.0013 0.0028 0.0062
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0042
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.016 0.0392
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0236 0.0247
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0154 0.0561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0132 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0959 0.0959
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0145 0.567
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0256 0.0174
Brugia malayi hypothetical protein 0.0155 0.1396 0.3492
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0154 0.1382 0.9999
Plasmodium vivax vivapain-2 0.0017 0.0063 0.0658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Loa Loa (eye worm) inositol-1 0.0037 0.0256 0.0633
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0959 0.2597
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0256 0.0934
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.1193 0.2982
Loa Loa (eye worm) TPR domain-containing protein 0.0012 0.0013 0.0025
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0389 0.3649 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0236 0.2709
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0959 0.35
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Brugia malayi cathepsin L-like precursor 0.0011 0.0009 0.0014
Toxoplasma gondii hypothetical protein 0.0048 0.0357 0.0947
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0145 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.2456 0.5388
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0524 0.1911
Brugia malayi Smad1 0.0024 0.0132 0.0323
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.2456 0.5388
Brugia malayi MH1 domain containing protein 0.0013 0.0028 0.0062
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0256 0.2364 0.3473
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0959 0.2395
Loa Loa (eye worm) hypothetical protein 0.0026 0.0154 0.0377
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0871 0.2175
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1667 0.3657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1193 0.3231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0236 0.0861
Leishmania major trypanothione reductase 0.0101 0.0871 0.318
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.1065 0.3887
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.1006
Mycobacterium tuberculosis Conserved protein 0.011 0.0959 0.1343
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1193 0.3231
Mycobacterium ulcerans glutaminase 0.027 0.2501 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Schistosoma mansoni lamin 0.0027 0.016 0.0433
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0145 0.0257
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0009 0.0024
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0132 0.0132
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0871 0.0871
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0465 0.0465
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0386 0.1409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Toxoplasma gondii ABC1 family protein 0.011 0.0959 0.26
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0256 0.0256
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0236 0.2461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0145 0.0109
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1395 0.2005
Mycobacterium tuberculosis Probable reductase 0.023 0.2116 0.3098
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0352 0.0874
Loa Loa (eye worm) hypothetical protein 0.011 0.0959 0.2395
Echinococcus multilocularis tar DNA binding protein 0.0134 0.1193 0.1193
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0145 0.0257
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0871 0.318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Brugia malayi hypothetical protein 0.0017 0.0064 0.0151
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.016 0.0392
Leishmania major cathepsin L-like protease 0.0017 0.0063 0.023
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0063 0.0724
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0959 0.1343
Mycobacterium tuberculosis Probable dehydrogenase 0.023 0.2116 0.3098
Schistosoma mansoni hypothetical protein 0.0037 0.0251 0.0681
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0062
Plasmodium vivax vivapain-2 0.0017 0.0063 0.0658
Leishmania major cathepsin L-like protease 0.0065 0.0524 0.1911
Onchocerca volvulus 0.011 0.0959 0.2103
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.2456 0.5388
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0236 0.0633
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0063 0.0063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0063 0.015
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0063 0.2464
Echinococcus multilocularis tumor protein p63 0.1049 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0236 0.0861
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.2456 0.5388
Entamoeba histolytica hypothetical protein 0.0037 0.0251 0.9823
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0039 0.0089
Schistosoma mansoni smad 0.0011 0.0003 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0063 0.0138
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0083 0.0952
Brugia malayi Inositol-1 0.0037 0.0256 0.0633
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0256 0.0562
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0299 0.109
Brugia malayi Cathepsin L-like precursor 0.0017 0.0063 0.015
Treponema pallidum hypothetical protein 0.0154 0.1382 0.9999
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0154 0.1383 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0959 0.2395
Schistosoma mansoni Smad4 0.0011 0.0003 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Schistosoma mansoni smad1 5 8 and 0.0024 0.0132 0.0359
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0063 0.0724
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0154 0.0387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.023 0.2116 0.3098
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.039 0.1424
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.332 0.8316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0299 0.109
Brugia malayi beta-lactamase family protein 0.011 0.0959 0.2395
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0236 0.2709
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0486 0.1317
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0236 0.0633
Onchocerca volvulus 0.0027 0.016 0.035
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0524 0.1911
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0036
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0236 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0352 0.0954
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0145 0.567
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.2739 1
Onchocerca volvulus 0.0049 0.0371 0.0815
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0236 0.0236
Brugia malayi Pre-SET motif family protein 0.0425 0.3992 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0003 0.0007
Schistosoma mansoni smad 0.0024 0.0132 0.0359
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0025 0.0025
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0871 0.0871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0486 0.1317
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.1193 0.2982
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0236 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Brugia malayi Cathepsin L-like precursor 0.0017 0.0063 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Echinococcus granulosus Smad4 0.0024 0.0132 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.1378 0.3732
Entamoeba histolytica hypothetical protein 0.0037 0.0251 0.9823
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1065 0.2884
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0063 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2136 0.5347
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0145 0.053
Leishmania major cathepsin L-like protease 0.0017 0.0063 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0352 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1193 0.3231
Loa Loa (eye worm) Smad1 0.0024 0.0132 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0524 0.1911
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0063 0.0063
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0236 0.1178
Leishmania major cathepsin L-like protease 0.0065 0.0524 0.1911
Leishmania major cathepsin L-like protease 0.0065 0.0524 0.1911
Echinococcus multilocularis lamin dm0 0.0027 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0392
Toxoplasma gondii cathepsin CPL 0.0017 0.0063 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0145 0.0355
Mycobacterium ulcerans hypothetical protein 0.0154 0.1382 0.5374
Onchocerca volvulus 0.011 0.0959 0.2103
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0299 0.109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0486 0.1317
Schistosoma mansoni Smad4 0.0024 0.0132 0.0359
Onchocerca volvulus 0.0155 0.1396 0.3063
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0154 0.0561
Plasmodium falciparum glutathione reductase 0.0035 0.0236 0.2709
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0256 0.2364 1
Brugia malayi Thioredoxin reductase 0.0101 0.0871 0.2175
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0236 0.0861
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0236 0.0518
Brugia malayi RNA binding protein 0.0134 0.1193 0.2982
Loa Loa (eye worm) glutaminase 2 0.027 0.2501 0.6262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.02
Loa Loa (eye worm) hypothetical protein 0.011 0.0959 0.2395
Schistosoma mansoni inositol monophosphatase 0.0037 0.0256 0.0693
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0063 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.2456 0.5388
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1193 0.3231
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0371 0.0922
Echinococcus granulosus tar DNA binding protein 0.0134 0.1193 0.1193
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0025 0.0025
Echinococcus multilocularis lamin 0.0027 0.016 0.016
Onchocerca volvulus 0.0017 0.0063 0.0138
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.023 0.2116 0.3098
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.332 0.8316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0352 0.0352
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0132 0.0132
Echinococcus granulosus O glycosyltransferase 0.0394 0.3691 0.3691
Brugia malayi Cathepsin L-like precursor 0.0017 0.0063 0.015
Trypanosoma brucei trypanothione reductase 0.0101 0.0871 0.318
Giardia lamblia O-linked GlcNAc transferase 0.0228 0.2094 0.5444
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.1065 0.2892
Entamoeba histolytica cysteine protease, putative 0.0017 0.0063 0.2464
Mycobacterium leprae Probable lipase LipE 0.011 0.0959 0.3667
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0063 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0145 0.0355
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0959 0.3621
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0256 0.0934
Onchocerca volvulus 0.0061 0.0486 0.1067
Brugia malayi beta-lactamase 0.011 0.0959 0.2395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0352 0.0954
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0251 0.0251
Trichomonas vaginalis set domain proteins, putative 0.0484 0.4557 1
Brugia malayi glutaminase DH11.1 0.027 0.2501 0.6262
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0145 0.0257
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0236 0.064
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0145 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1577 0.3459
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0299 0.109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1065 0.406
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0145 0.0355
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0251 0.0251
Onchocerca volvulus 0.0026 0.0145 0.0318
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0063 0.023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0145 0.567
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0236 0.0861
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0063 0.023
Onchocerca volvulus 0.0017 0.0063 0.0138
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0009 0.0014
Treponema pallidum hypothetical protein 0.0154 0.1382 0.9999
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.02
Treponema pallidum hypothetical protein 0.0154 0.1383 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0147 0.0359
Brugia malayi Cathepsin L-like precursor 0.0017 0.0063 0.015
Loa Loa (eye worm) hypothetical protein 0.0153 0.1378 0.3445
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.2739 1
Onchocerca volvulus 0.0017 0.0063 0.0138
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0256 0.0715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.02
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0147 0.0359
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0063 0.0138
Schistosoma mansoni Smad4 0.0011 0.0003 0.0009
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0394 0.3691 1
Plasmodium vivax glutathione reductase, putative 0.0101 0.0871 0.9087
Brugia malayi MH1 domain containing protein 0.0024 0.0132 0.0323
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0236 0.0861
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0145 0.053
Entamoeba histolytica hypothetical protein 0.0037 0.0251 0.9823
Mycobacterium ulcerans hypothetical protein 0.0155 0.1395 0.5427
Loa Loa (eye worm) hypothetical protein 0.011 0.0959 0.2395
Trichomonas vaginalis esterase, putative 0.011 0.0959 0.2104
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0524 0.1911
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0256 0.0934
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0219 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0155 0.038
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1243 0.4539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.1065 0.1065
Brugia malayi TAR-binding protein 0.0134 0.1193 0.2982
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0959 0.2104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0355
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.1577 0.3459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0063 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0355

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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