Detailed information for compound 730875

Basic information

Technical information
  • TDR Targets ID: 730875
  • Name: N,N'-bis(3-cyanophenyl)butanediamide
  • MW: 318.329 | Formula: C18H14N4O2
  • H donors: 2 H acceptors: 4 LogP: 1.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)NC(=O)CCC(=O)Nc1cccc(c1)C#N
  • InChi: 1S/C18H14N4O2/c19-11-13-3-1-5-15(9-13)21-17(23)7-8-18(24)22-16-6-2-4-14(10-16)12-20/h1-6,9-10H,7-8H2,(H,21,23)(H,22,24)
  • InChiKey: QIBSBSWIECZUNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N'-bis(3-cyanophenyl)succinamide
  • Oprea1_758950
  • AN-329/40675066
  • STK123348
  • ZINC00358388
  • ARONIS005109

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0082 0.0453
Treponema pallidum NADH oxidase 0.0018 0.0041 0.0351
Brugia malayi Smad1 0.0025 0.012 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0241 0.072
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0068 0.047
Entamoeba histolytica peptidase, C54 family 0.0024 0.0107 0.0841
Mycobacterium tuberculosis Conserved protein 0.0147 0.1439 0.1423
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0068 0.0132
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0018 0.0123
Brugia malayi steroid hormone receptor 0.002 0.0068 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0068 0.0067
Entamoeba histolytica peptidase, C54 family 0.0061 0.051 0.4621
Schistosoma mansoni alpha-glucosidase 0.0136 0.1325 0.1746
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0177 0.0213
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0532 0.1352
Brugia malayi Peptidase family C54 containing protein 0.0061 0.051 0.1294
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.051 0.3464
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0068 0.0067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1564 0.4067
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0312 0.0393
Entamoeba histolytica peptidase, C54 family 0.0024 0.0107 0.0841
Leishmania major DNA polymerase eta, putative 0.002 0.0068 0.0351
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0532 0.0686
Echinococcus multilocularis protein dispatched 1 0.0049 0.0377 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.023 0.0685
Brugia malayi nuclear receptor NHR-88 0.002 0.0068 0.0132
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0068 0.0067
Schistosoma mansoni hypothetical protein 0.0175 0.1746 0.2307
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0276
Schistosoma mansoni cpg binding protein 0.003 0.0176 0.0211
Echinococcus multilocularis protein patched 0.0043 0.0312 0.0393
Echinococcus granulosus FTZ F1 alpha 0.002 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Echinococcus granulosus Aminotransferase class III 0.0043 0.0315 0.0397
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0041 0.0285
Loa Loa (eye worm) hypothetical protein 0.01 0.093 0.2399
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.0388
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.012 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.023 0.0685
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1108 0.1092
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0018 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0241 0.072
Onchocerca volvulus 0.002 0.0068 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0041 0.0075
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0043 0.0315 0.0782
Schistosoma mansoni ap endonuclease 0.0077 0.0681 0.0886
Brugia malayi MH1 domain containing protein 0.0025 0.012 0.027
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.023 0.0685
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0068 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1439 0.4577
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0385 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0061 0.051 0.1294
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0351
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0068 0.0211
Brugia malayi ecdysteroid receptor 0.002 0.0068 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.023 0.0685
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.7509 1
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0107 0.063
Toxoplasma gondii thioredoxin reductase 0.0051 0.0401 0.2701
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0068 0.0211
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0122 0.0738
Echinococcus granulosus dna polymerase eta 0.002 0.0068 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0165 0.1149
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0943 0.1236
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.0681 0.4734
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0532 0.0686
Schistosoma mansoni Smad4 0.0025 0.012 0.0137
Entamoeba histolytica hypothetical protein 0.0024 0.0106 0.0826
Entamoeba histolytica hypothetical protein 0.0114 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0927 0.2391
Trypanosoma brucei glucosidase, putative 0.0035 0.023 0.1601
Onchocerca volvulus 0.0236 0.24 1
Schistosoma mansoni ran 0.0021 0.0082 0.0086
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0681 0.4669
Schistosoma mansoni hypothetical protein 0.0041 0.0295 0.0371
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0068 0.0067
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1108 0.1092
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0082 0.057
Leishmania major hypothetical protein, conserved 0.0147 0.1439 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0041 0.0061
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.051 0.1585
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0082 0.0453
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.051 0.1585
Schistosoma mansoni hypothetical protein 0.0049 0.0385 0.0491
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.0681 0.4669
Leishmania major GTP-binding protein, putative 0.0021 0.0082 0.0453
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0158 0.037
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0516 0.0665
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.1439 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0312 0.0948
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.051 0.1585
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0043 0.0315 0.089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1439 0.1897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.2005 0.5226
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0041 0.0351
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1439 0.4577
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.0681 0.4669
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0068 0.0351
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0401 0.1009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1382 0.1821
Echinococcus multilocularis Peptidase C54 0.0061 0.051 0.0657
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0018 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1439 0.4577
Schistosoma mansoni hypothetical protein 0.0041 0.0295 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0068 0.0132
Brugia malayi hypothetical protein 0.0016 0.0026 0.0022
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0068 0.0067
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.012 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0068 0.0132
Toxoplasma gondii exonuclease III APE 0.0077 0.0681 0.4669
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.0213
Mycobacterium ulcerans hypothetical protein 0.0302 0.3122 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0158 0.037
Schistosoma mansoni hypothetical protein 0.0175 0.1746 0.2307
Schistosoma mansoni hypothetical protein 0.0041 0.0295 0.0371
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0122 0.0851
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0043 0.0315 0.089
Onchocerca volvulus 0.0147 0.1439 0.5964
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1564 0.4067
Brugia malayi hypothetical protein 0.0025 0.0122 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1439 1
Schistosoma mansoni cpg binding protein 0.003 0.0176 0.0211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0068 0.0067
Mycobacterium ulcerans lipase LipD 0.0147 0.1439 0.4536
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0927 0.8536
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0068 0.0067
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0241 0.3368
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0041 0.0164
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0041 0.0351
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0107 0.063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.0681 0.4669
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0068 0.0132
Schistosoma mansoni importin beta-1 0.0029 0.0165 0.0197
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4242 0.5639
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Giardia lamblia DINP protein human, muc B family 0.002 0.0068 0.0752
Leishmania major basic transcription factor 3a, putative 0.0036 0.0241 0.1573
Loa Loa (eye worm) hypothetical protein 0.0136 0.1323 0.3433
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0686
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0068 0.0469
Schistosoma mansoni autophagin-1 (C54 family) 0.0061 0.051 0.0657
Echinococcus multilocularis snurportin 1 0.0311 0.3217 0.427
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0927 0.1213
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0131
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.023 0.1496
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0018 0.0123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0532 0.0686
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0041 0.0164
Echinococcus granulosus importin subunit beta 1 0.0029 0.0165 0.0197
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.1439 0.1423
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Echinococcus granulosus Smad4 0.0025 0.012 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0122 0.0738
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.3217 0.8414
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2475 0.3279
Mycobacterium tuberculosis Conserved protein 0.0147 0.1439 0.1423
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0068 0.0161
Echinococcus multilocularis tumor protein p63 0.0682 0.7229 0.9626
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.012 0.027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.2005 0.5226
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.0681 0.1745
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.023 0.1496
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1564 0.2064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0068 0.0132
Leishmania major DNA polymerase kappa, putative 0.002 0.0068 0.0351
Plasmodium falciparum thioredoxin reductase 0.0018 0.0041 0.0351
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0041 0.0285
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0122 0.0738
Echinococcus multilocularis smad 0.0025 0.012 0.0137
Leishmania major hypothetical protein, conserved 0.0025 0.0122 0.0738
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0068 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Schistosoma mansoni hypothetical protein 0.0136 0.1323 0.1742
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0532 0.1352
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0082 0.0086
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0302 0.3122 0.311
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0041 0.0164
Loa Loa (eye worm) transcription factor SMAD2 0.0367 0.382 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0068 0.0132
Brugia malayi hypothetical protein 0.0243 0.2475 0.6462
Echinococcus granulosus dna polymerase kappa 0.002 0.0068 0.0067
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.023 0.1496
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0681 0.2137
Loa Loa (eye worm) hypothetical protein 0.0147 0.1439 0.3737
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0122 0.158
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0107 0.135
Echinococcus multilocularis Smad4 0.0025 0.012 0.0137
Mycobacterium leprae conserved hypothetical protein 0.0147 0.1439 0.4003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0068 0.0067
Brugia malayi beta-lactamase 0.0147 0.1439 0.3737
Schistosoma mansoni smad1 5 8 and 0.0025 0.012 0.0137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0068 0.0067
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0041 0.0164
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.0969
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0147 0.1439 0.3737
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0082 0.0453
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0315 0.0397
Loa Loa (eye worm) hypothetical protein 0.0199 0.2005 0.5226
Onchocerca volvulus 0.0147 0.1439 0.5964
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0241 0.2098
Loa Loa (eye worm) glutathione reductase 0.0051 0.0401 0.1009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0416 0.1048
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4242 0.5639
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.047
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.0681 0.0886
Plasmodium falciparum glutathione reductase 0.0051 0.0401 0.5784
Mycobacterium tuberculosis Probable reductase 0.0116 0.1108 0.1092
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0018 0.0123
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0401 0.0512
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.1439 0.1423
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Brugia malayi glutathione reductase 0.0051 0.0401 0.1009
Schistosoma mansoni cpg binding protein 0.0029 0.0158 0.0188
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0068 0.0067
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0082 0.0086
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0312 0.0393
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0315 0.089
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0122 0.0738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0068 0.0132
Echinococcus multilocularis Aminotransferase class III 0.0043 0.0315 0.0397
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.051 0.3464
Toxoplasma gondii ABC1 family protein 0.0147 0.1439 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0165 0.1039
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0068 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0367 0.382 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.1439 0.1897
Brugia malayi beta-lactamase family protein 0.0147 0.1439 0.3737
Entamoeba histolytica hypothetical protein 0.0114 0.1083 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1564 0.2064
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.1439 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.0169
Echinococcus granulosus Peptidase C54 0.0061 0.051 0.0657
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.023 0.0284
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0302 0.3122 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0068 0.0067
Plasmodium falciparum importin beta, putative 0.0029 0.0165 0.2225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1382 0.1821
Leishmania major importin beta-1 subunit, putative 0.0024 0.0106 0.0619
Brugia malayi MH2 domain containing protein 0.0025 0.012 0.027
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0068 0.0131
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0068 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1108 0.2825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1382 0.1821
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0068 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.023 0.0685
Entamoeba histolytica Ran family GTPase 0.0021 0.0082 0.0604
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0106 0.0619
Schistosoma mansoni survival motor neuron protein 0.0049 0.0385 0.0491
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0401 0.0512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Echinococcus granulosus snurportin 1 0.0311 0.3217 0.427
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2475 0.3279
Mycobacterium tuberculosis Conserved protein 0.0147 0.1439 0.1423
Brugia malayi MH1 domain containing protein 0.0025 0.012 0.027
Brugia malayi Pre-SET motif family protein 0.0207 0.2092 0.5454
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.023 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Plasmodium vivax glutathione reductase, putative 0.0051 0.0401 0.2701
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0401 0.2701
Mycobacterium tuberculosis Probable aminotransferase 0.0302 0.3122 0.311
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0068 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0068 0.0132
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0068 0.0131
Trichomonas vaginalis esterase, putative 0.0147 0.1439 0.4577
Brugia malayi Thioredoxin reductase 0.0051 0.0401 0.1009
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.047
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0241 0.0588
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0681 0.2137
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0043 0.0315 0.4282
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.012 0.0137
Echinococcus granulosus microtubule associated protein 2 0.0708 0.7509 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0532 0.0686
Mycobacterium leprae Probable lipase LipE 0.0147 0.1439 0.4003
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0043 0.0315 0.2093
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.1323 0.3433
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.0969
Echinococcus granulosus tumor protein p63 0.0682 0.7229 0.9626
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0312 0.0393
Brugia malayi nuclear hormone receptor 0.002 0.0068 0.0132
Schistosoma mansoni ap endonuclease 0.0077 0.0681 0.0886
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0283
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0082 0.0453
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.0681 0.6229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0068 0.0132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0068 0.0067
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0927 0.1213
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.1439 0.4536
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0068 0.0067
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.1439 0.1423
Trypanosoma brucei trypanothione reductase 0.0051 0.0401 0.279
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.0681 1
Echinococcus granulosus GPCR family 2 0.0063 0.0532 0.0686
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0177 0.0213
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0241 0.1573
Schistosoma mansoni thyroid hormone receptor 0.002 0.0068 0.0067
Brugia malayi beta-NAC-like protein 0.0036 0.0241 0.0588
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.1439 0.1897
Echinococcus granulosus transcription factor btf3 0.0036 0.0241 0.0298
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1382 0.3588
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0068 0.0132
Schistosoma mansoni coup transcription factor 0.002 0.0068 0.0067
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0686
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0068 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0068 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0165 0.1149
Plasmodium falciparum ornithine aminotransferase 0.0043 0.0315 0.4483
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0686
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.1083 0.1422
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.0681 0.2078
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.0681 1
Schistosoma mansoni hypothetical protein 0.0114 0.1083 0.1422
Brugia malayi MH2 domain containing protein 0.0367 0.382 1
Schistosoma mansoni alpha glucosidase 0.0035 0.023 0.0284
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0041 0.0031
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.051 0.3544
Trichomonas vaginalis ran, putative 0.0021 0.0082 0.0207
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0351
Brugia malayi Pre-SET motif family protein 0.003 0.0177 0.0419
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.0169
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0041 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0147 0.1439 0.3737
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1382 0.1821
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0241 0.1573
Echinococcus granulosus geminin 0.0175 0.1746 0.2307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Brugia malayi beta-lactamase family protein 0.0147 0.1439 0.3737
Plasmodium vivax importin-beta 2, putative 0.0029 0.0165 0.1039
Mycobacterium ulcerans beta-lactamase 0.0147 0.1439 0.4536
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0041 0.0023
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0041 0.0351
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0024 0.0107 0.063
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0068 0.0132
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0041 0.0285
Onchocerca volvulus 0.003 0.0177 0.0669
Schistosoma mansoni cellular tumor antigen P53 0.01 0.093 0.1218
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1439 0.4577
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0068 0.0067
Echinococcus multilocularis cysteine protease atg4b 0.0061 0.051 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0068 0.0132
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.1439 0.4536
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0302 0.3122 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0068 0.0211
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1439 0.4577
Echinococcus granulosus ornithine aminotransferase 0.0043 0.0315 0.0397
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Schistosoma mansoni alpha-glucosidase 0.0136 0.1325 0.1746
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.023 0.0685
Entamoeba histolytica hypothetical protein 0.0036 0.0241 0.2098
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0927 0.2391
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.023 0.0559
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.0681 0.1745
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0351
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1564 0.2064
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0241 0.1573
Echinococcus granulosus cpg binding protein 0.003 0.0176 0.0211
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0122 0.158
Entamoeba histolytica hypothetical protein 0.0114 0.1083 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0068 0.0067
Brugia malayi RNA, U transporter 1 0.0083 0.0747 0.1917
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0177 0.0213
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.023 0.0284
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0041 0.0164
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0068 0.0086
Echinococcus multilocularis expressed conserved protein 0.0093 0.0861 0.1126
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.0681 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0068 0.0161
Schistosoma mansoni nuclear hormone receptor 0.002 0.0068 0.0067
Echinococcus multilocularis cpg binding protein 0.003 0.0176 0.0211
Brugia malayi CHE-14 protein 0.0043 0.0312 0.0774
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0043 0.0315 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1382 0.1821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1382 0.1821
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1389 0.183
Mycobacterium ulcerans hypothetical protein 0.0147 0.1439 0.4536
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0068 0.005
Brugia malayi hypothetical protein 0.0114 0.1083 0.2801
Echinococcus multilocularis GPCR, family 2 0.0063 0.0532 0.0686
Leishmania major trypanothione reductase 0.0051 0.0401 0.2701
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.1439 0.3737
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0241 0.1573
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0041 0.0031
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0043 0.0315 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0068 0.0067
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.012 0.0137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.023 0.0685
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0068 0.0067
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0018 0.0123
Onchocerca volvulus 0.0147 0.1439 0.5964
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0068 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0241 0.072
Loa Loa (eye worm) beta-lactamase 0.0147 0.1439 0.3737
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1108 0.1092
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0165 0.0197
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1248 0.1233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0681 1
Entamoeba histolytica peptidase, C54 family 0.0024 0.0107 0.0841
Schistosoma mansoni transcription factor btf3 0.0036 0.0241 0.0298
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.1439 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0068 0.0132
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.7509 1
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.1439 0.1423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1382 0.1821
Loa Loa (eye worm) hypothetical protein 0.0147 0.1439 0.3737
Loa Loa (eye worm) hypothetical protein 0.0147 0.1439 0.3737
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0159 0.0188
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.2005 0.5226
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0043 0.0315 0.0298
Trypanosoma brucei unspecified product 0.002 0.0068 0.047
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0686
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0068 0.0067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0041 0.0164
Plasmodium falciparum thioredoxin reductase 0.0051 0.0401 0.5784
Schistosoma mansoni hypothetical protein 0.0041 0.0295 0.0371
Mycobacterium ulcerans acetylornithine aminotransferase 0.0043 0.0315 0.089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0107 0.063
Schistosoma mansoni smad 0.0025 0.012 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0177 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0041 0.0075
Echinococcus multilocularis dna polymerase eta 0.002 0.0068 0.0067
Echinococcus granulosus smad 0.0025 0.012 0.0137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0068 0.0132
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0043 0.0315 0.0298
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0177 0.0213
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0401 0.0384
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0351
Plasmodium vivax ornithine aminotransferase, putative 0.0043 0.0315 0.2093
Onchocerca volvulus 0.0029 0.0158 0.059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2092 0.5454
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1382 0.3588
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0041 0.0164
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0315 0.089
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.051 0.0657
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.023 0.1996
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0068 0.0086
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0018 0.0123
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0041 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0068 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0068 0.0067
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1108 0.1092
Loa Loa (eye worm) Smad1 0.0025 0.012 0.027
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0241 0.1676
Echinococcus multilocularis transcription factor btf3 0.0036 0.0241 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.047
Trichomonas vaginalis set domain proteins, putative 0.0236 0.24 0.7675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0068 0.0132
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0041 0.0164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0446 0.3014
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.023 0.0685
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0315 0.0397
Schistosoma mansoni thyroid hormone receptor 0.002 0.0068 0.0067
Echinococcus granulosus expressed conserved protein 0.0093 0.0861 0.1126
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.1439 0.1423
Brugia malayi MH2 domain containing protein 0.0025 0.012 0.027
Plasmodium vivax hypothetical protein, conserved 0.0147 0.1439 1
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1439 1
Entamoeba histolytica peptidase, C54 family 0.0024 0.0107 0.0841
Loa Loa (eye worm) hypothetical protein 0.0147 0.1439 0.3737
Loa Loa (eye worm) hypothetical protein 0.0243 0.2475 0.6462
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0107 0.0745
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0041 0.0164
Echinococcus multilocularis dna polymerase kappa 0.002 0.0068 0.0067
Schistosoma mansoni smad1 5 8 and 0.0025 0.012 0.0137
Schistosoma mansoni patched 1 0.0043 0.0312 0.0393
Echinococcus multilocularis geminin 0.0175 0.1746 0.2307
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.0681 0.0665
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.051 0.0657
Loa Loa (eye worm) hypothetical protein 0.0063 0.0532 0.1352
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.1439 0.3737
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0043 0.0315 0.0298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0283
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0043 0.0315 0.0397
Echinococcus granulosus cysteine protease atg4b 0.0061 0.051 0.0657
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.012 0.027
Mycobacterium ulcerans L-lysine aminotransferase 0.0043 0.0315 0.089
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0018 0.0123
Onchocerca volvulus 0.0092 0.0841 0.3457
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.023 0.0559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1439 0.1897
Schistosoma mansoni hypothetical protein 0.0311 0.3217 0.427
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0068 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.047
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0312 0.0774
Schistosoma mansoni hypothetical protein 0.0406 0.4242 0.5639
Schistosoma mansoni ran 0.0021 0.0082 0.0086
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.023 0.1996
Schistosoma mansoni smad1 5 8 and 0.0025 0.012 0.0137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.1083 0.1422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0068 0.0132
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.1083 0.1422
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0401 0.2701
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0068 0.0067
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0177 0.1122
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.051 0.1585
Loa Loa (eye worm) hypothetical protein 0.0043 0.0312 0.0774
Entamoeba histolytica hypothetical protein 0.0114 0.1083 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1248 0.1233
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.0681 0.0886
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1248 0.3325
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0068 0.0351
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.051 0.1585
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0532 0.1352
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0041 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1108 0.1092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0068 0.0132
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1389 0.183
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0068 0.0067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0068 0.0067
Plasmodium vivax SET domain protein, putative 0.003 0.0177 0.1122
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0177 0.0213
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1248 0.1233
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0106 0.0283
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0068 0.0067
Schistosoma mansoni DNA polymerase eta 0.002 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0132
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.012 0.0137
Brugia malayi Importin beta-1 subunit 0.0029 0.0165 0.0388
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0302 0.3122 1
Onchocerca volvulus 0.01 0.093 0.3829
Plasmodium falciparum glutathione reductase 0.0018 0.0041 0.0351
Onchocerca volvulus 0.0049 0.0385 0.1543

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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