Detailed information for compound 754218

Basic information

Technical information
  • TDR Targets ID: 754218
  • Name: 5-(4-fluorophenyl)-2-methyl-7-(trifluoromethy l)pyrazolo[1,5-a]pyrimidine
  • MW: 295.235 | Formula: C14H9F4N3
  • H donors: 0 H acceptors: 2 LogP: 3.41 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nc2cc(nn2c(c1)C(F)(F)F)C
  • InChi: 1S/C14H9F4N3/c1-8-6-13-19-11(9-2-4-10(15)5-3-9)7-12(14(16,17)18)21(13)20-8/h2-7H,1H3
  • InChiKey: FAPJCZYHZUMMLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2T-0832
  • ZINC01060098

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0344
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0178 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Echinococcus multilocularis neurogenic locus notch protein 0.0172 0.1222 0.1222
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1137 0.6649
Leishmania major hypothetical protein, conserved 0.0075 0.0453 0.1974
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0015
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0023 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0061 0.0148
Brugia malayi nuclear receptor NHR-88 0.0041 0.0178 0.0434
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0006 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0178 0.0434
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0067 0.0293
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0149 0.0648
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0178 0.0178
Brugia malayi Cadherin domain containing protein 0.0172 0.1222 0.2983
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0006 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0027 0.0027
Trichomonas vaginalis esterase, putative 0.0036 0.0141 0.1323
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0178 0.0178
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0006 0.0006
Onchocerca volvulus Peroxidase homolog 0.0532 0.4097 1
Loa Loa (eye worm) Notch2 0.0172 0.1222 0.2983
Mycobacterium tuberculosis Probable reductase 0.0108 0.071 0.4152
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0005 0.0005
Schistosoma mansoni notch 0.0172 0.1222 0.1222
Schistosoma mansoni notch 0.0172 0.1222 0.1222
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0172 0.1222 0.1222
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.071 0.4152
Giardia lamblia DINP protein human, muc B family 0.002 0.0006 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.1867 0.4556
Echinococcus multilocularis protein jagged 1 0.0172 0.1222 0.1222
Loa Loa (eye worm) animal heme peroxidase 0.0532 0.4097 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Onchocerca volvulus Peroxidase homolog 0.0532 0.4097 1
Brugia malayi hypothetical protein 0.0022 0.0023 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0027
Mycobacterium tuberculosis Conserved protein 0.0036 0.0141 0.0826
Brugia malayi beta-lactamase family protein 0.0036 0.0141 0.0344
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0433 0.406
Brugia malayi hypothetical protein 0.0532 0.4097 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0152 0.1067 0.8727
Brugia malayi hypothetical protein 0.0019 0.0005 0.0011
Schistosoma mansoni cell polarity protein 0.0172 0.1222 0.1222
Schistosoma mansoni peroxidasin 0.0532 0.4097 0.4097
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0178 0.0178
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.071 0.8606
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0806 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Echinococcus granulosus dna polymerase eta 0.002 0.0006 0.0006
Trypanosoma brucei trypanothione reductase 0.0047 0.0227 0.099
Echinococcus multilocularis geminin 0.0344 0.2593 0.2593
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0027
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0152 0.1067 0.1067
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Brugia malayi nuclear receptor RXR 0.0022 0.0023 0.0056
Schistosoma mansoni DNA polymerase eta 0.002 0.0006 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0532 0.4097 1
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0006 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Echinococcus multilocularis fat cadherin tumor suppressor 0.0172 0.1222 0.1222
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0005 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0178 0.0434
Echinococcus multilocularis lamin 0.0026 0.0061 0.0061
Loa Loa (eye worm) beta-lactamase 0.0036 0.0141 0.0344
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0433 0.406
Schistosoma mansoni lamin 0.0026 0.0061 0.0061
Brugia malayi Peroxidasin 0.0532 0.4097 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0005 0.0005
Loa Loa (eye worm) blistered cuticle protein 3 0.0532 0.4097 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0012 0.0108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0178 0.0178
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0005 0.0005
Mycobacterium ulcerans beta-lactamase 0.0036 0.0141 0.1242
Onchocerca volvulus 0.0172 0.1222 0.2975
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1756 0.4287
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0227 0.1328
Echinococcus multilocularis neurogenic locus notch protein 4 0.0172 0.1222 0.1222
Brugia malayi glutathione reductase 0.0047 0.0227 0.0554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0178 0.0178
Echinococcus granulosus delta-like protein 1 0.0172 0.1222 0.1222
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0178 0.0423
Schistosoma mansoni hypothetical protein 0.0344 0.2593 0.2593
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0433 0.406
Leishmania major DNA polymerase eta, putative 0.002 0.0006 0.0027
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0067 0.0153
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0178 0.0434
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0152 0.1067 0.1067
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0141 0.1323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.12 0.982
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0067 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0027 0.0027
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0141 0.0826
Echinococcus multilocularis neurogenic locus protein delta 0.0172 0.1222 0.1222
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0117 0.0687
Plasmodium falciparum thioredoxin reductase 0.0047 0.0227 0.5015
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0067 0.063
Loa Loa (eye worm) animal heme peroxidase 0.0532 0.4097 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.071 0.4152
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0141 0.0826
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0068 0.0165
Brugia malayi hypothetical protein 0.0049 0.0239 0.0584
Schistosoma mansoni cpg binding protein 0.0089 0.0563 0.0563
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0329 0.2477 0.6046
Echinococcus granulosus notch 0.0172 0.1222 0.1222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0108
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0178 0.0178
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0433 0.406
Toxoplasma gondii EGF family domain-containing protein 0.0172 0.1222 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0178 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0178 0.0434
Schistosoma mansoni notch 0.0172 0.1222 0.1222
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0433 0.406
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0178 0.0434
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0178 0.0178
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0488 0.0488
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0006 0.0054
Loa Loa (eye worm) hypothetical protein 0.0075 0.0453 0.1105
Onchocerca volvulus 0.0532 0.4097 1
Schistosoma mansoni lamin 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Echinococcus multilocularis protein jagged 1 0.0172 0.1222 0.1222
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0453 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0141 0.1323
Onchocerca volvulus 0.0041 0.0178 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Echinococcus granulosus neurogenic locus notch protein 0.0172 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Echinococcus granulosus neural cadherin 0.0172 0.1222 0.1222
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0061 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0141 0.1323
Onchocerca volvulus 0.0147 0.1022 0.2487
Echinococcus granulosus intermediate filament protein 0.0026 0.0061 0.0061
Onchocerca volvulus 0.0089 0.0563 0.1364
Echinococcus granulosus ubiquitin specific protease 41 0.0152 0.1067 0.1067
Echinococcus multilocularis cpg binding protein 0.0094 0.0603 0.0603
Schistosoma mansoni notch 0.0172 0.1222 0.1222
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0178 0.0178
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Mycobacterium tuberculosis Conserved protein 0.0036 0.0141 0.0826
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0433 0.406
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0178 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.008 0.0488 0.1191
Brugia malayi Animal haem peroxidase family protein 0.0532 0.4097 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0269 0.1172
Schistosoma mansoni peroxidasin 0.0532 0.4097 0.4097
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0006 0.0057
Brugia malayi hypothetical protein 0.0147 0.1022 0.2495
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0027
Schistosoma mansoni alpha-glucosidase 0.0283 0.2112 0.2112
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0149 0.1394
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0488 0.0488
Plasmodium vivax glutathione reductase, putative 0.0047 0.0227 0.5015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.2293 1
Onchocerca volvulus Chorion peroxidase homolog 0.0532 0.4097 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0067 0.063
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Brugia malayi Calcium binding EGF domain containing protein 0.0172 0.1222 0.2983
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0005 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0178 0.0178
Brugia malayi intermediate filament protein 0.0026 0.0061 0.0148
Echinococcus granulosus geminin 0.0344 0.2593 0.2593
Onchocerca volvulus 0.0172 0.1222 0.2975
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0005 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0141 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0141 0.0616
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0006 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0067 0.063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0108
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0453 1
Onchocerca volvulus 0.0036 0.0141 0.0334
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0433 0.1057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0149 1
Schistosoma mansoni notch 0.0172 0.1222 0.1222
Echinococcus multilocularis lamin dm0 0.0026 0.0061 0.0061
Schistosoma mansoni cpg binding protein 0.0094 0.0603 0.0603
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.1867 0.4556
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0141 0.0141
Brugia malayi Muscle positioning protein 4 0.0172 0.1222 0.2983
Mycobacterium leprae Probable lipase LipE 0.0036 0.0141 0.0345
Brugia malayi Animal haem peroxidase family protein 0.0532 0.4097 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Echinococcus granulosus dna polymerase kappa 0.002 0.0006 0.0006
Onchocerca volvulus Peroxidasin homolog 0.0532 0.4097 1
Schistosoma mansoni slit 0.0172 0.1222 0.1222
Echinococcus granulosus neurogenic locus notch protein 4 0.0172 0.1222 0.1222
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0227 0.0227
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.071 0.4152
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0433 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0178 0.0434
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0071 0.0071
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0141 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0061 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.1362 0.1362
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0178 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0067 0.063
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0488 0.1191
Echinococcus granulosus lysosomal alpha glucosidase 0.0329 0.2477 0.2477
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0453 0.1974
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0067 0.0293
Loa Loa (eye worm) animal heme peroxidase 0.0532 0.4097 1
Echinococcus granulosus protein jagged 1 0.0172 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Echinococcus multilocularis protein jagged 2 0.0172 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.2293 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0005 0.0011
Onchocerca volvulus 0.0172 0.1222 0.2975
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0152 0.1067 0.1067
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0149 0.1216
Onchocerca volvulus 0.0172 0.1222 0.2975
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0178 0.0434
Schistosoma mansoni nuclear receptor 0.0019 0.0005 0.0005
Brugia malayi conserved hypotetical protein 0.0019 0.0005 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0433 0.1889
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Onchocerca volvulus 0.0026 0.0061 0.0137
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0015
Brugia malayi nuclear receptor NHR-67 0.0019 0.0005 0.0011
Onchocerca volvulus Peroxidasin homolog 0.0532 0.4097 1
Echinococcus multilocularis peroxidasin 0.0532 0.4097 0.4097
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Brugia malayi hypothetical protein 0.0022 0.0023 0.0056
Echinococcus multilocularis neurogenic locus protein delta 0.0172 0.1222 0.1222
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0027
Brugia malayi Calcium binding EGF domain containing protein 0.0172 0.1222 0.2983
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Brugia malayi Animal haem peroxidase family protein 0.0532 0.4097 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0563 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.1067 1
Trypanosoma brucei glucosidase, putative 0.0073 0.0433 0.1889
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0108
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0005 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0178 0.0178
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0005 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0488 0.1191
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0067 0.063
Schistosoma mansoni hypothetical protein 0.0344 0.2593 0.2593
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0585 0.0585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0585 0.0585
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0453 0.1974
Brugia malayi ecdysone receptor 0.0019 0.0005 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0227 0.0227
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0227 0.099
Mycobacterium ulcerans hypothetical protein 0.0036 0.0141 0.1242
Brugia malayi Blistered cuticle protein 3 0.0532 0.4097 1
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0178 0.0178
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.1271 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0152 0.1067 1
Schistosoma mansoni hypothetical protein 0.008 0.0488 0.0488
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.012 0.012
Echinococcus granulosus protein jagged 2 0.0172 0.1222 0.1222
Echinococcus granulosus lamin dm0 0.0026 0.0061 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0178 0.0178
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0194 0.0844
Brugia malayi Animal haem peroxidase family protein 0.0532 0.4097 1
Brugia malayi beta-lactamase 0.0036 0.0141 0.0344
Trichomonas vaginalis helicase, putative 0.002 0.0012 0.0108
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0433 0.3543
Echinococcus multilocularis GPCR, family 2 0.008 0.0488 0.0488
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0433 0.406
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0194 0.0844
Brugia malayi hypothetical protein 0.0075 0.0453 0.1105
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0585 0.1427
Brugia malayi Cytochrome P450 family protein 0.0046 0.0216 0.0527
Onchocerca volvulus 0.0036 0.0141 0.0334
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0141 0.3118
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.2293 1
Schistosoma mansoni alpha-glucosidase 0.0283 0.2112 0.2112
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Toxoplasma gondii ABC1 family protein 0.0036 0.0141 0.1155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0006 0.0036
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0071 0.0172
Echinococcus multilocularis fibropellin Ia 0.0172 0.1222 0.1222
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0141 0.1242
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.071 0.4152
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0006 0.0006
Toxoplasma gondii thioredoxin reductase 0.0047 0.0227 0.1857
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0152 0.1067 0.1067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0178 0.0434
Onchocerca volvulus Dual oxidase homolog 0.0532 0.4097 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.171 1
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0178 0.0434
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.071 0.4152
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0006 0.0027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0067 0.0164
Schistosoma mansoni notch 0.0172 0.1222 0.1222
Trypanosoma brucei unspecified product 0.002 0.0006 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0149 0.1394
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0141 0.0826
Echinococcus granulosus neurogenic locus notch protein 0.0172 0.1222 0.1222
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0152 0.1067 0.4652
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0141 0.0141
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0178 0.0434
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0806 0.4714
Loa Loa (eye worm) glutathione reductase 0.0047 0.0227 0.0554
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0056
Brugia malayi Delta serrate ligand family protein 0.0172 0.1222 0.2983
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0152 0.1067 1
Loa Loa (eye worm) DR-78 0.0019 0.0005 0.0011
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0005 0.0011
Brugia malayi Inositol-1 0.0037 0.0149 0.0363
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0141 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0585 0.0585
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0067 0.063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0344
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0173 0.1229 0.2999
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0141 0.0826
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0152 0.1067 0.4652
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0806 0.4714
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0006 0.0015
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0149 0.1394
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0005 0.0005
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0036 0.0141 0.0344
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0152 0.1067 0.1067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0178 0.0434
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Brugia malayi ecdysteroid receptor 0.0041 0.0178 0.0434
Schistosoma mansoni cpg binding protein 0.0094 0.0603 0.0603
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0453 1
Onchocerca volvulus 0.019 0.137 0.3335
Schistosoma mansoni laminin gamma-3 chain 0.0172 0.1222 0.1222
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0149 0.0149
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0152 0.1067 0.4652
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0152 0.1067 0.4652
Echinococcus multilocularis lysosomal alpha glucosidase 0.0329 0.2477 0.2477
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.2293 1
Brugia malayi Calcium binding EGF domain containing protein 0.0172 0.1222 0.2983
Schistosoma mansoni coup transcription factor 0.0041 0.0178 0.0178
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0433 0.406
Schistosoma mansoni hypothetical protein 0.008 0.0488 0.0488
Brugia malayi nuclear hormone receptor 0.0019 0.0005 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0005 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0178 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0433 0.1889
Brugia malayi hypothetical protein 0.0019 0.0005 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.1229 0.2999
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0216 0.0527
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Schistosoma mansoni hypothetical protein 0.008 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Leishmania major trypanothione reductase 0.0047 0.0227 0.099
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1006 0.4388
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0067 0.0293
Schistosoma mansoni intermediate filament proteins 0.0026 0.0061 0.0061
Schistosoma mansoni zinc finger protein 0.0019 0.0005 0.0005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0329 0.2477 0.2477
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0344
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0178 0.0434
Brugia malayi CXXC zinc finger family protein 0.0089 0.0563 0.1373
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0141 0.0616
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0178 0.0434
Leishmania major DNA polymerase kappa, putative 0.002 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0227 0.0554
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0433 0.1889
Onchocerca volvulus Slit protein homolog 0.0172 0.1222 0.2975
Schistosoma mansoni hypothetical protein 0.008 0.0488 0.0488
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0012 0.0108
Echinococcus multilocularis dnaJ subfamily B 0.1271 1 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0253 0.1867 0.4556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0148
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0164
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0178 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0178 0.0178
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0178 0.0178
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0141 0.1323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0178 0.0434
Echinococcus granulosus peroxidasin 0.0532 0.4097 0.4097
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0178 0.0178
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0178 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0178 0.0434
Loa Loa (eye worm) hypothetical protein 0.0147 0.1022 0.2495
Schistosoma mansoni alpha glucosidase 0.0073 0.0433 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0006 0.0027
Schistosoma mansoni inositol monophosphatase 0.0037 0.0149 0.0149
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0027 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0433 0.406
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0067 0.063
Echinococcus granulosus lamin 0.0026 0.0061 0.0061
Brugia malayi Glycosyl hydrolases family 31 protein 0.0329 0.2477 0.6046
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0006 0.0027
Loa Loa (eye worm) notch protein 0.0172 0.1222 0.2983
Echinococcus multilocularis slit 2 protein 0.0172 0.1222 0.1222
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0453 0.1974
Toxoplasma gondii hypothetical protein 0.0049 0.0244 0.1997
Onchocerca volvulus Neurogenic locus notch homolog 0.0172 0.1222 0.2975
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0178 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0178 0.0178
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0152 0.1067 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1006 0.4388
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.1867 0.4556
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0152 0.1067 0.1067
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0006 0.0027
Leishmania major hypothetical protein, conserved 0.0036 0.0141 0.0616
Brugia malayi Latrophilin receptor protein 2 0.008 0.0488 0.1191
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0453 0.3704
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0149 0.1308
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0172 0.1222 0.2983
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0023 0.0056
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0488 0.0488
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0141 0.1323
Schistosoma mansoni hypothetical protein 0.0034 0.012 0.012
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0006 0.0054
Onchocerca volvulus 0.0532 0.4097 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0005 0.0005
Mycobacterium ulcerans lipase LipD 0.0036 0.0141 0.1242
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0178 0.0423
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0067 0.063
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0067 0.0293
Mycobacterium tuberculosis Conserved protein 0.0036 0.0141 0.0826
Giardia lamblia High cysteine protein 0.0172 0.1222 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Echinococcus multilocularis neural cadherin 0.0172 0.1222 0.1222
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0023 0.0056
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0194 0.0844
Brugia malayi Thioredoxin reductase 0.0047 0.0227 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0178 0.0434
Brugia malayi EGF-like domain containing protein 0.0172 0.1222 0.2983
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0585 0.0585
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0585 0.0585
Echinococcus granulosus GPCR family 2 0.008 0.0488 0.0488
Echinococcus multilocularis ubiquitin specific protease 41 0.0152 0.1067 0.1067
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0806 0.4714
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0152 0.1067 0.2603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0585 0.0585
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0585 0.1427
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0344
Loa Loa (eye worm) inositol-1 0.0037 0.0149 0.0363
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0149 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0178 0.0434
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0005 0.0011
Loa Loa (eye worm) animal heme peroxidase 0.0532 0.4097 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0178 0.0434
Mycobacterium ulcerans hypothetical protein 0.0161 0.1137 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0433 0.406
Echinococcus granulosus neurogenic locus protein delta 0.0172 0.1222 0.1222
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0178 0.0178
Onchocerca volvulus 0.0172 0.1222 0.2975
Schistosoma mansoni nuclear receptor 0.0019 0.0005 0.0005
Onchocerca volvulus 0.0532 0.4097 1
Onchocerca volvulus 0.0036 0.0141 0.0334
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0023 0.0023
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0433 0.1057
Echinococcus multilocularis notch 0.0172 0.1222 0.1222
Echinococcus multilocularis musashi 0.0026 0.0061 0.0061
Brugia malayi nuclear receptor RXR 0.0019 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0227 0.5015
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0006 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0178 0.0423
Echinococcus granulosus fibropellin Ia 0.0172 0.1222 0.1222
Brugia malayi steroid hormone receptor 0.0041 0.0178 0.0434
Brugia malayi Cadherin domain containing protein 0.0172 0.1222 0.2983
Brugia malayi nuclear hormone receptor 0.0041 0.0178 0.0434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Brugia malayi tailless protein 0.0019 0.0005 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Schistosoma mansoni hypothetical protein 0.0173 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Schistosoma mansoni inositol monophosphatase 0.0037 0.0149 0.0149
Onchocerca volvulus 0.0026 0.0061 0.0137
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0141 0.1242
Echinococcus granulosus protein jagged 2 0.0172 0.1222 0.1222
Onchocerca volvulus Putative cubilin 0.0172 0.1222 0.2975
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0141 0.0826
Plasmodium falciparum glutathione reductase 0.0047 0.0227 0.5015
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0172 0.1222 0.2975
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0005 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1006 0.4388
Echinococcus granulosus protein jagged 1 0.0172 0.1222 0.1222
Brugia malayi GCC2 and GCC3 family protein 0.0172 0.1222 0.2983
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0006 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0178 0.0434
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0011
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0194 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0012 0.0108
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1756 0.4287
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0149 0.1394
Brugia malayi notch-like transmembrane receptor 0.0172 0.1222 0.2983
Schistosoma mansoni hypothetical protein 0.0172 0.1222 0.1222
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0178 0.0434
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0178 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0433 0.406
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0141 0.0826
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0141 0.0344
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Echinococcus multilocularis dna polymerase eta 0.002 0.0006 0.0006
Schistosoma mansoni septate junction protein 0.0172 0.1222 0.1222
Echinococcus granulosus cpg binding protein 0.0094 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0178 0.0434
Echinococcus multilocularis neurogenic locus notch protein 0.0172 0.1222 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0178 0.0434
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0141 0.0826
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0434
Loa Loa (eye worm) hypothetical protein 0.0152 0.1067 0.2603
Loa Loa (eye worm) hypothetical protein 0.0172 0.1222 0.2983
Loa Loa (eye worm) hypothetical protein 0.0532 0.4097 1
Echinococcus granulosus slit 2 protein 0.0172 0.1222 0.1222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0141 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0178 0.0434
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0005 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0006 0.0015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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