Detailed information for compound 767486

Basic information

Technical information
  • TDR Targets ID: 767486
  • Name: N-(3-chloro-4-methylphenyl)-1-(4-methylphenyl )-5-oxopyrrolidine-3-carboxamide
  • MW: 342.819 | Formula: C19H19ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.19 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)N1CC(CC1=O)C(=O)Nc1ccc(c(c1)Cl)C
  • InChi: 1S/C19H19ClN2O2/c1-12-3-7-16(8-4-12)22-11-14(9-18(22)23)19(24)21-15-6-5-13(2)17(20)10-15/h3-8,10,14H,9,11H2,1-2H3,(H,21,24)
  • InChiKey: AXTDHLQDXMBFNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chloro-4-methyl-phenyl)-1-(4-methylphenyl)-5-oxo-pyrrolidine-3-carboxamide
  • N-(3-chloro-4-methylphenyl)-1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxamide
  • N-(3-chloro-4-methyl-phenyl)-5-keto-1-(4-methylphenyl)pyrrolidine-3-carboxamide
  • Oprea1_541889
  • AG-690/36004052
  • 5-Oxo-1-p-tolyl-pyrrolidine-3-carboxylic acid (3-chloro-4-methyl-phenyl)-amide
  • BAS 00313361
  • Oprea1_689473
  • ST057286

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0174
Plasmodium vivax hypothetical protein, conserved 0.003 0.0084 0.011
Schistosoma mansoni hypothetical protein 0.0341 0.2651 0.2651
Echinococcus multilocularis microtubule associated protein 2 0.069 0.5533 0.5533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0724 0.0637
Schistosoma mansoni hypothetical protein 0.008 0.049 0.049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.049 0.049
Echinococcus granulosus intermediate filament protein 0.0027 0.0056 0.0056
Onchocerca volvulus 0.0096 0.0629 0.1729
Echinococcus granulosus transcription factor btf3 0.0037 0.0142 0.0142
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0043 0.0045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0724 0.0637
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0043 0.0043
Echinococcus granulosus peregrin 0.0034 0.0112 0.0112
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1408 0.6629
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.021 0.021
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0142 0.0268
Echinococcus multilocularis peregrin 0.0034 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.008 0.049 0.049
Brugia malayi beta-NAC-like protein 0.0037 0.0142 0.0142
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0049 0.0236 0.0144
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.005 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0072 0.0077
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0307 0.0216
Schistosoma mansoni lamin 0.0027 0.0056 0.0056
Plasmodium vivax glutathione reductase, putative 0.0047 0.0224 0.0491
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0043 0.0043
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0072 0.0077
Echinococcus granulosus chromobox protein 1 0.0072 0.0432 0.0432
Onchocerca volvulus Cell death protein 3 homolog 0.0059 0.032 0.0879
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0735 0.0735
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0333 0.0242
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0109 0.0735 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0224 0.0534
Brugia malayi Bromodomain containing protein 0.0034 0.0112 0.0112
Echinococcus granulosus phd:f box containing protein 0.0025 0.0043 0.0043
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0176 0.0362
Echinococcus granulosus lamin 0.0027 0.0056 0.0056
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0056 0.0056
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0824 0.0737
Brugia malayi Heterochromatin protein 1 0.0072 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus multilocularis caspase 2 0.0059 0.032 0.032
Echinococcus granulosus dihydrofolate reductase 0.1231 1 1
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0142 0.1624
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0142 0.0312
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0307 0.0307
Schistosoma mansoni jumonji/arid domain-containing protein 0.0095 0.062 0.062
Echinococcus granulosus caspase 2 0.0059 0.032 0.032
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0224 0.0224
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0432 0.1944
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0169
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0043 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.211 1
Schistosoma mansoni hypothetical protein 0.0096 0.0629 0.0629
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243
Onchocerca volvulus 0.0041 0.0174 0.0478
Brugia malayi jmjC domain containing protein 0.0158 0.1137 0.1137
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0043 0.0043
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0037 0.0142 0.1624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.049 0.049
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.062 0.062
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0109 0.0735 1
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0999 0.0999
Schistosoma mansoni jumonji domain containing protein 0.0137 0.0969 0.0969
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.211 1
Brugia malayi Cytochrome P450 family protein 0.0049 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0341 0.2651 0.2651
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.021 0.021
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0084 0.011
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.211 0.211
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.049 0.049
Schistosoma mansoni chromobox protein 0.0072 0.0432 0.0432
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0172 0.1253 0.1253
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1231 1 1
Leishmania major cytochrome p450-like protein 0.0031 0.0093 0.0181
Echinococcus granulosus snurportin 1 0.0308 0.2376 0.2376
Brugia malayi jmjC domain containing protein 0.0025 0.0043 0.0043
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0148 0.1709
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0174 0.0174
Echinococcus multilocularis Protein lozenge 0.0058 0.031 0.031
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0072 0.0072
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0275 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0169 0.0682
Loa Loa (eye worm) hypothetical protein 0.0068 0.0392 0.0392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.191 0.191
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0043 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0194 0.0805
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.049 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243
Leishmania major hypothetical protein, conserved 0.0025 0.0043 0.0045
Brugia malayi jmjC domain containing protein 0.0095 0.062 0.062
Echinococcus granulosus survival motor neuron protein 1 0.0472 0.3732 0.3732
Schistosoma mansoni hypothetical protein 0.0031 0.0093 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.005 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.211 1
Brugia malayi cytochrome P450 0.0031 0.0093 0.0093
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0148 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0307 0.076
Loa Loa (eye worm) glutathione reductase 0.0047 0.0224 0.0224
Schistosoma mansoni chromobox protein 0.0072 0.0432 0.0432
Leishmania major basic transcription factor 3a, putative 0.0037 0.0142 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0169 0.0682
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0043 0.0043
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0866 0.6982 0.6982
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0471 0.3721 1
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0043 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.211 1
Brugia malayi hypothetical protein 0.0041 0.0174 0.0174
Brugia malayi PHD-finger family protein 0.003 0.0084 0.0084
Brugia malayi jmjC domain containing protein 0.0025 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0142 0.0552
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0432 0.1944
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0471 0.3721 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0194 0.0534
Echinococcus multilocularis dihydrofolate reductase 0.1231 1 1
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0043 0.0043
Echinococcus granulosus chromobox protein 1 0.0072 0.0432 0.0432
Schistosoma mansoni microtubule-associated protein tau 0.069 0.5533 0.5533
Echinococcus granulosus lysine specific demethylase 5A 0.0095 0.062 0.062
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.049 0.049
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0724 0.0637
Onchocerca volvulus Alhambra homolog 0.003 0.0084 0.023
Onchocerca volvulus 0.0027 0.0056 0.0154
Echinococcus multilocularis lamin dm0 0.0027 0.0056 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0109 0.0735 0.0735
Brugia malayi hypothetical protein 0.046 0.3636 0.3636
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0735 0.0735
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0176 0.0362
Schistosoma mansoni transcription factor btf3 0.0037 0.0142 0.0142
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0176 0.0176
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0289 0.0289
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0289 0.0289
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0142 0.0268
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0966 0.0966
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0307 0.0307
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.211 0.211
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0043 0.0043
Brugia malayi jmjC domain containing protein 0.0025 0.0043 0.0043
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0471 0.3721 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1231 1 1
Brugia malayi Cell death protein 3 precursor 0.0059 0.032 0.032
Toxoplasma gondii thioredoxin reductase 0.0047 0.0224 0.0491
Brugia malayi Latrophilin receptor protein 2 0.008 0.049 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1231 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0095 0.062 0.062
Entamoeba histolytica hypothetical protein 0.0109 0.0735 1
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0236 0.0568
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0333 0.0333
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.1327 0.365
Schistosoma mansoni caspase-7 (C14 family) 0.0059 0.032 0.032
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.005 0.0018
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0072 0.0077
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0043 0.0045
Leishmania major cytochrome p450-like protein 0.0031 0.0093 0.0181
Schistosoma mansoni lamin 0.0027 0.0056 0.0056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.2376 0.2376
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0084 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0333 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0142 0.0552
Plasmodium falciparum phd finger protein, putative 0.003 0.0084 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.211 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0824 0.0737
Schistosoma mansoni dihydrofolate reductase 0.1231 1 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0043 0.0043
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.008 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0308 0.2376 0.2376
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0148 0.0284
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0333 0.0242
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0084 0.0084
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.005 0.0018
Echinococcus multilocularis chromobox protein 1 0.0072 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.008 0.049 0.049
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0056 0.0056
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0093 0.0181
Echinococcus multilocularis musashi 0.0027 0.0056 0.0056
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0307 0.0216
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0056 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.005 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0142 0.0552
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0224 0.0224
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0142 0.0142
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.021 0.021
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0093 0.0136
Echinococcus multilocularis transcription factor btf3 0.0037 0.0142 0.0142
Leishmania major trypanothione reductase 0.0047 0.0224 0.0534
Brugia malayi hypothetical protein 0.0026 0.005 0.005
Echinococcus multilocularis geminin 0.0341 0.2651 0.2651
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0724 0.0637
Brugia malayi Cytochrome P450 family protein 0.0031 0.0093 0.0093
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0142 0.0268
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0724 0.0637
Onchocerca volvulus 0.046 0.3636 1
Chlamydia trachomatis dihydrofolate reductase 0.1231 1 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.005 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0096 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0071 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0071 0.0213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0251 0.191 0.191
Schistosoma mansoni lozenge 0.0058 0.031 0.031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.021 0.021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0093 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0052
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0093 0.0181
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0471 0.3721 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0095 0.062 0.062
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0333 0.0333
Echinococcus granulosus lamin dm0 0.0027 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0059 0.032 0.032
Echinococcus multilocularis snurportin 1 0.0308 0.2376 0.2376
Schistosoma mansoni hypothetical protein 0.0172 0.1253 0.1253
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0176 0.0719
Schistosoma mansoni intermediate filament proteins 0.0027 0.0056 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0716 0.0716
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.1253 0.1253
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0043
Mycobacterium tuberculosis Probable reductase 0.0108 0.0724 0.0637
Brugia malayi chromobox protein homolog 3 0.0041 0.0169 0.0169
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0735 0.0735
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0824 0.0737
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0043 0.0043
Echinococcus multilocularis chromobox protein 1 0.0072 0.0432 0.0432
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.035 0.035
Brugia malayi hypothetical protein 0.0109 0.0735 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0194 0.0805
Loa Loa (eye worm) hypothetical protein 0.0472 0.3732 0.3732
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0043 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0333 0.0242
Schistosoma mansoni hypothetical protein 0.0041 0.0174 0.0174
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.003 0.0084 0.0084
Brugia malayi Importin beta-1 subunit 0.0029 0.0072 0.0072
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0142 0.0268
Leishmania major hypothetical protein, conserved 0.0026 0.005 0.0063
Onchocerca volvulus 0.0027 0.0056 0.0154
Loa Loa (eye worm) runx1 0.0058 0.031 0.031
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0043 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.005 0.0063
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0724 0.0637
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0236 0.0236
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0224 0.0491
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.191 0.191
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.005
Loa Loa (eye worm) dihydrofolate reductase 0.1231 1 1
Loa Loa (eye worm) hypothetical protein 0.046 0.3636 0.3636
Loa Loa (eye worm) acetyltransferase 0.0141 0.0999 0.0999
Plasmodium falciparum glutathione reductase 0.0047 0.0224 0.0491
Brugia malayi intermediate filament protein 0.0027 0.0056 0.0056
Echinococcus granulosus geminin 0.0341 0.2651 0.2651
Entamoeba histolytica hypothetical protein 0.0109 0.0735 1
Brugia malayi RNA, U transporter 1 0.0082 0.0511 0.0511
Brugia malayi jmjC domain containing protein 0.0025 0.0043 0.0043
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0093 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243
Echinococcus multilocularis GPCR, family 2 0.008 0.049 0.049
Plasmodium falciparum importin beta, putative 0.0029 0.0072 0.0077
Trypanosoma brucei cytochrome P450, putative 0.0049 0.0236 0.0525
Loa Loa (eye worm) CYP4Cod1 0.0049 0.0236 0.0236
Trypanosoma brucei trypanothione reductase 0.0047 0.0224 0.0491
Brugia malayi glutathione reductase 0.0047 0.0224 0.0224
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0084 0.0084
Echinococcus multilocularis lamin 0.0027 0.0056 0.0056
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0224 0.0224
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0084 0.0084
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0158 0.1137 0.1137
Schistosoma mansoni cytochrome P450 0.0031 0.0093 0.0093
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0629 0.0629
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0999 0.0999
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0176 0.0719
Brugia malayi hypothetical protein 0.0157 0.1131 0.1131
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0182 0.0182
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0176 0.0362
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0333 0.083
Loa Loa (eye worm) cytochrome P450 0.0031 0.0093 0.0093
Schistosoma mansoni lipoxygenase 0.0055 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0158 0.1137 0.1137
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0432 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1408 0.6629
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0236 0.0568
Loa Loa (eye worm) hypothetical protein 0.046 0.3636 0.3636
Schistosoma mansoni importin beta-1 0.0029 0.0072 0.0072
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0471 0.3721 1
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0043 0.0043
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0084 0.011
Leishmania major cytochrome p450-like protein 0.0049 0.0236 0.0568
Echinococcus granulosus GPCR family 2 0.008 0.049 0.049
Echinococcus multilocularis survival motor neuron protein 1 0.0472 0.3732 0.3732
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.191 0.191
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.211 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.049 0.049
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0824 0.0737
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0333 0.0788
Brugia malayi Cytochrome P450 family protein 0.0107 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0072
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0471 0.3721 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0333 0.0333
Brugia malayi hypothetical protein 0.0472 0.3732 0.3732
Brugia malayi Dihydrofolate reductase 0.1231 1 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0072 0.0077
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0999 0.0999
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0307 0.0216
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0333 0.0333
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0169 0.0464
Plasmodium falciparum thioredoxin reductase 0.0047 0.0224 0.0491
Loa Loa (eye worm) hypothetical protein 0.0157 0.1131 0.1131
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0224 0.0132
Echinococcus granulosus importin subunit beta 1 0.0029 0.0072 0.0072
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0093 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.021 0.021
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0093 0.0093
Brugia malayi Thioredoxin reductase 0.0047 0.0224 0.0224
Echinococcus granulosus microtubule associated protein 2 0.069 0.5533 0.5533
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.021 0.021
Schistosoma mansoni hypothetical protein 0.008 0.049 0.049
Echinococcus multilocularis 0.0031 0.0093 0.0093
Brugia malayi Cytochrome P450 family protein 0.0049 0.0236 0.0236
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0174 0.0174
Onchocerca volvulus 0.0032 0.0096 0.0265
Onchocerca volvulus 0.0157 0.1131 0.311
Schistosoma mansoni survival motor neuron protein 0.0096 0.0629 0.0629
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0142 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1327 0.6243

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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