Detailed information for compound 791276

Basic information

Technical information
  • TDR Targets ID: 791276
  • Name: 1-(3-fluorophenyl)-4-(2-methoxyphenyl)-4,7-di hydro-3H-furo[3,4-e]pyridine-2,5-dione
  • MW: 353.344 | Formula: C20H16FNO4
  • H donors: 0 H acceptors: 2 LogP: 2.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C1CC(=O)N(C2=C1C(=O)OC2)c1cccc(c1)F
  • InChi: 1S/C20H16FNO4/c1-25-17-8-3-2-7-14(17)15-10-18(23)22(13-6-4-5-12(21)9-13)16-11-26-20(24)19(15)16/h2-9,15H,10-11H2,1H3
  • InChiKey: CQMFVZASRFPSOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-fluorophenyl)-4-(2-methoxyphenyl)-4,7-dihydro-3H-furo[3,4-e]pyridine-2,5-quinone
  • A3709/0157166

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0038 0.0571 0.1262
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.189 0.4631
Loa Loa (eye worm) hypothetical protein 0.0043 0.067 0.1481
Echinococcus granulosus dna polymerase kappa 0.0019 0.0137 0.0336
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0156 0.0796
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0237 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2123 0.4087
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0237 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0135 0.0298
Brugia malayi Sugar transporter family protein 0.0106 0.2123 0.4692
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0424 0.0936
Schistosoma mansoni zinc finger protein 0.0015 0.0045 0.007
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0085 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0287 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0448 0.0861
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0137 0.0013
Onchocerca volvulus 0.0042 0.0649 0.1188
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0786 0.1925
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0237 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0448 0.0861
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0406 0.0995
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0406 0.0995
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0004
Schistosoma mansoni ap endonuclease 0.0019 0.0135 0.021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Brugia malayi mbt repeat family protein 0.0048 0.0786 0.1737
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0137 0.0336
Brugia malayi Pre-SET motif family protein 0.0211 0.4525 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1924 0.3
Brugia malayi mbt repeat family protein 0.0048 0.0786 0.1737
Loa Loa (eye worm) hypothetical protein 0.005 0.0849 0.1876
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0085 0.0209
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0786 0.1925
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0156 0.0796
Loa Loa (eye worm) hypothetical protein 0.0071 0.1312 0.29
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0037 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0778 0.1719
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1084 0.1652
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0786 0.1225
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0424 0.0936
Entamoeba histolytica protein kinase, putative 0.0033 0.0439 0.1732
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0037 0.0324
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0137 0.0214
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Trypanosoma brucei trypanothione reductase 0.0039 0.0579 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0237 0.2177
Plasmodium vivax hexose transporter 0.0106 0.2123 0.2122
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0448 0.4127
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0135 0.0688
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0037 0.0181
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0937 0.1461
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0135 0.033
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1084 0.2656
Brugia malayi hypothetical protein 0.0016 0.0061 0.0136
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0037 0.009
Echinococcus granulosus chromobox protein 1 0.007 0.129 0.3161
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0135 0.123
Schistosoma mansoni glucose transport protein 0.0106 0.2123 0.3311
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0137 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0786 0.1737
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3619 0.3618
Echinococcus granulosus chromobox protein 1 0.007 0.129 0.3161
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0137 0.0336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0406 0.0897
Brugia malayi major facilitator superfamily protein 0.0015 0.0037 0.0081
Brugia malayi Cam kinase protein 1 0.0033 0.0439 0.097
Loa Loa (eye worm) hypothetical protein 0.0025 0.0262 0.058
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Brugia malayi chromobox protein homolog 3 0.0039 0.0589 0.1302
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0135 0.0256
Schistosoma mansoni glucose transport protein 0.0106 0.2123 0.3311
Leishmania major DNA polymerase kappa, putative 0.0019 0.0137 0.1251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0388 0.0605
Entamoeba histolytica protein kinase, putative 0.0033 0.0439 0.1732
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0068
Leishmania major hypothetical protein, conserved 0.0015 0.0037 0.0324
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0135 0.2305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0875
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1941 0.429
Echinococcus granulosus zinc finger protein 0.002 0.0143 0.035
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1936 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.129 0.2482
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.4081 1
Loa Loa (eye worm) sugar transporter 0.0106 0.2123 0.4692
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Plasmodium vivax SET domain protein, putative 0.003 0.0388 0.0387
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0135 0.2305
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.1711 0.8737
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0137 0.2345
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.189 0.4631
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.4525 1
Plasmodium falciparum protein kinase 7 0.03 0.6555 0.6554
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0037 0.0057
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.189 0.4177
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0448 0.7734
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0439 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0068
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0037 0.0081
Echinococcus multilocularis chromobox protein 1 0.007 0.129 0.3161
Brugia malayi hypothetical protein 0.0154 0.3226 0.7129
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.129 0.2851
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0649 0.1012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0589 0.1072
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0439 0.0438
Loa Loa (eye worm) hypothetical protein 0.0032 0.0424 0.0936
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0579 0.128
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0439 0.0668
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Loa Loa (eye worm) hypothetical protein 0.0067 0.1231 0.272
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0237 0.0581
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0037 0.2637
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0637 0.1561
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0424 0.1038
Brugia malayi Heterochromatin protein 1 0.007 0.129 0.2851
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0037 0.0324
Brugia malayi hypothetical protein 0.0015 0.0037 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Brugia malayi Thioredoxin reductase 0.0039 0.0579 0.128
Onchocerca volvulus 0.0154 0.3226 0.6186
Schistosoma mansoni hypothetical protein 0.0015 0.0045 0.007
Plasmodium vivax glutathione reductase, putative 0.0039 0.0579 0.0578
Echinococcus granulosus GPCR family 2 0.0031 0.0406 0.0995
Echinococcus multilocularis solute carrier family 22 0.0015 0.0037 0.009
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0786 0.1225
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Brugia malayi Bromodomain containing protein 0.0075 0.141 0.3116
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0085 0.0133
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0002 0.0004
Echinococcus multilocularis solute carrier family 22 0.0015 0.0037 0.009
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0037 0.0054
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0579 0.0578
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0778 0.1906
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0237 0.408
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0786 0.1453
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Schistosoma mansoni sugar transporter 0.0015 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0054 0.0937 0.207
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0448 0.7734
Schistosoma mansoni hypothetical protein 0.004 0.0603 0.0941
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0657 0.1203
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0068
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0135 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Loa Loa (eye worm) hypothetical protein 0.0048 0.0786 0.1737
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Schistosoma mansoni hypothetical protein 0.0031 0.0406 0.0633
Schistosoma mansoni hypothetical protein 0.0021 0.0167 0.026
Schistosoma mansoni sugar transporter 0.0015 0.0037 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Schistosoma mansoni hypothetical protein 0.004 0.0603 0.0941
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0517 0.1266
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1936 1
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0393 0.0962
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0137 0.2345
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0135 0.033
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0579 0.2985
Schistosoma mansoni hypothetical protein 0.0031 0.0406 0.0633
Schistosoma mansoni chromobox protein 0.007 0.129 0.2011
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0037 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0068
Brugia malayi Pre-SET motif family protein 0.003 0.0388 0.0858
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0786 0.1925
Brugia malayi Sugar transporter family protein 0.0015 0.0037 0.0081
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0037 0.0608
Toxoplasma gondii sugar transporter ST2 0.0015 0.0037 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0439 0.0842
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0439 0.0684
Loa Loa (eye worm) hypothetical protein 0.0039 0.0589 0.1302
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0439 0.0438
Brugia malayi hypothetical protein 0.0015 0.0037 0.0081
Toxoplasma gondii thioredoxin reductase 0.0039 0.0579 0.0881
Trypanosoma brucei glucose transporter 2A 0.0033 0.0448 0.7734
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Giardia lamblia Hexose transporter 0.0015 0.0037 0.0832
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0237 0.5583
Onchocerca volvulus 0.0048 0.0786 0.1453
Brugia malayi major facilitator superfamily protein 0.0015 0.0037 0.0081
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0211 0.0516
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0037 0.0035
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.2832 0.6938
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1084 0.5595
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0037 0.0068
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1084 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0424 0.0661
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0544 0.5015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0068
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0037 0.0324
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0262 0.4516
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0424 0.1038
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0657 0.1263
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1936 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0448 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0448 0.0861
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0393 0.0962
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Trichomonas vaginalis chromobox protein, putative 0.007 0.129 0.2482
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.1711 0.8837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0778 0.1213
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0237 0.0524
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0637 0.1408
Toxoplasma gondii exonuclease III APE 0.0019 0.0135 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0328 0.0629
Loa Loa (eye worm) hypothetical protein 0.0041 0.0627 0.1385
Echinococcus multilocularis zinc finger protein 0.002 0.0143 0.035
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0135 0.3154
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Schistosoma mansoni protein kinase 0.0033 0.0439 0.0684
Plasmodium falciparum hexose transporter 0.0106 0.2123 0.2122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0388 0.059
Toxoplasma gondii sugar transporter ST3 0.0015 0.0037 0.0054
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0211 0.0329
Trypanosoma cruzi hexose transporter 0.0033 0.0448 0.7734
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0037 0.0068
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0237 0.0581
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0037 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0262 0.0398
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0424 0.0813
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0439 0.097
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.1711 0.8837
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0037 0.0081
Echinococcus granulosus expressed conserved protein 0.009 0.1757 0.4305
Echinococcus multilocularis GPCR, family 2 0.0031 0.0406 0.0995
Schistosoma mansoni hypothetical protein 0.0031 0.0406 0.0633
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0448 0.0861
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0262 0.0261
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Schistosoma mansoni hypothetical protein 0.0031 0.0406 0.0633
Schistosoma mansoni patched 1 0.0041 0.0637 0.0993
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0591 0.1448
Schistosoma mansoni hypothetical protein 0.004 0.0603 0.0941
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1084 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0448 0.7734
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0544 0.9399
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0544 0.0543
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0137 0.1251
Echinococcus granulosus solute carrier family 22 0.0015 0.0037 0.009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0406 0.0897
Leishmania major glucose transporter, lmgt2 0.0033 0.0448 0.4127
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0778 0.1213
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0167 0.0369
Echinococcus multilocularis expressed conserved protein 0.009 0.1757 0.4305
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Echinococcus multilocularis General substrate transporter 0.0091 0.1782 0.4366
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0137 0.0214
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1936 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.1941 0.429
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1084 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.189 0.4177
Leishmania major protein kinase, putative 0.0033 0.0439 0.4039
Schistosoma mansoni hypothetical protein 0.0294 0.6413 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1231 0.272
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0085 0.0133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0406 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0589 0.1132
Echinococcus granulosus solute carrier family 22 0.0015 0.0037 0.009
Echinococcus granulosus solute carrier family 22 0.0015 0.0037 0.009
Schistosoma mansoni bromodomain containing protein 0.0063 0.1142 0.1781
Leishmania major glucose transporter, lmgt3 0.0033 0.0448 0.4127
Brugia malayi hypothetical protein 0.0015 0.0037 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0262 0.4516
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0135 0.0133
Leishmania major hypothetical protein, conserved 0.0025 0.0262 0.241
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0135 0.0133
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0591 0.1448
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0262 0.0261
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.2832 0.6938
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0637 0.1561
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1941 0.429
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0237 0.408
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Schistosoma mansoni hypothetical protein 0.0106 0.2123 0.3311
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.1711 0.8837
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0137 0.0336
Toxoplasma gondii sugar transporter ST1 0.0015 0.0037 0.0054
Echinococcus multilocularis protein patched 0.0041 0.0637 0.1561
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0657 0.1263
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0137 0.2345
Echinococcus multilocularis solute carrier family 22 0.0015 0.0037 0.009
Schistosoma mansoni glucose transport protein 0.0106 0.2123 0.3311
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0237 0.2177
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0363 0.0888
Echinococcus multilocularis solute carrier family 22 0.0015 0.0037 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0937 0.2295
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0544 0.0543
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0137 0.0303
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0544 0.5015
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0448 0.7734
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0439 0.0438
Plasmodium vivax sugar transporter, putative 0.0015 0.0037 0.0035
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0237 0.0459
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0099 0.0219
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0439 0.0438
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0135 0.0256
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0137 0.0303
Leishmania major trypanothione reductase 0.0039 0.0579 0.5336
Giardia lamblia DINP protein human, muc B family 0.0019 0.0137 0.3208
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0439 0.0438
Brugia malayi CHE-14 protein 0.0041 0.0637 0.1408
Schistosoma mansoni glucose transporter 0.0015 0.0037 0.0057
Echinococcus granulosus solute carrier family 22 0.0015 0.0037 0.009
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0211 0.0516
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0579 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0637 0.1408
Trypanosoma brucei sugar transporter, putative 0.0015 0.0037 0.0608
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.4081 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2123 0.3237
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0137 0.1251
Loa Loa (eye worm) glutathione reductase 0.0039 0.0579 0.128
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0544 0.0828
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0262 0.0261
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0937 0.2295
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Echinococcus multilocularis chromobox protein 1 0.007 0.129 0.3161
Entamoeba histolytica hypothetical protein 0.0024 0.0237 0.0584
Onchocerca volvulus 0.024 0.5192 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1084 0.169
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0135 0.2305
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0137 0.07
Toxoplasma gondii protein kinase, putative 0.03 0.6555 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0439 0.0438
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0406 0.0995
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Plasmodium falciparum glutathione reductase 0.0039 0.0579 0.0578
Trypanosoma brucei ISWI complex protein 0.0015 0.0045 0.0753
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1941 0.429
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0037 0.009
Loa Loa (eye worm) sugar transporter 0.0015 0.0037 0.0081
Schistosoma mansoni hypothetical protein 0.0067 0.1231 0.1919
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0137 0.2345
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0439 0.097
Brugia malayi PHD-finger family protein 0.0025 0.0265 0.0585
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Leishmania major DNA polymerase eta, putative 0.0019 0.0137 0.1251
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.106 0.2598
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.106 0.2598
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0786 0.1925
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Schistosoma mansoni protein kinase 0.0033 0.0439 0.0684
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0237 0.037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0439 0.0668
Loa Loa (eye worm) MBCTL1 0.0054 0.0937 0.207
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Giardia lamblia Sugar-proton symporter 0.0015 0.0037 0.0832
Schistosoma mansoni hypothetical protein 0.004 0.0603 0.0941
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Brugia malayi hypothetical protein 0.0025 0.0262 0.058
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0424 0.1506
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0517 0.1266
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1084 0.2656
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0448 0.0861
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0937 0.2295
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2123 0.5202
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0448 0.7734
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0237 0.2177
Echinococcus multilocularis protein dispatched 1 0.0047 0.077 0.1887
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0137 0.07
Loa Loa (eye worm) hypothetical protein 0.0032 0.0424 0.0936
Echinococcus granulosus dna polymerase eta 0.0019 0.0137 0.0336
Trypanosoma cruzi ISWI complex protein 0.0015 0.0045 0.0753
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0135 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0137 0.1251
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Brugia malayi glutathione reductase 0.0039 0.0579 0.128
Echinococcus granulosus General substrate transporter 0.0091 0.1782 0.4366
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.189 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0448 0.0861
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0237 0.0236
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Loa Loa (eye worm) hypothetical protein 0.0024 0.0237 0.0524
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0137 0.0261
Mycobacterium tuberculosis Probable reductase 0.0088 0.1711 0.8837
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0439 0.1075
Plasmodium falciparum thioredoxin reductase 0.0039 0.0579 0.0578
Schistosoma mansoni chromobox protein 0.007 0.129 0.2011
Schistosoma mansoni sugar transporter 0.0015 0.0037 0.0057
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0037 0.009
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0637 0.1561
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0439 0.0438
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0037 0.0608
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Schistosoma mansoni protein kinase 0.0033 0.0439 0.0684
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0037 0.0181
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0237 0.037
Brugia malayi Sugar transporter family protein 0.0015 0.0037 0.0081
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0937 0.207
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0778 0.1906
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0037 0.009
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0439 0.097
Mycobacterium ulcerans sugar transporter 0.0015 0.0037 0.0324
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.1711 0.8837
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0424 0.1646
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3619 0.3618
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0424 1
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0037 0.0608
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0237 0.0454
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0037 0.0324
Plasmodium vivax CDK-related protein kinase 6, putative 0.0451 1 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2123 0.5202
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0448 0.7734
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Leishmania major glucose transporter, lmgt1 0.0033 0.0448 0.4127
Schistosoma mansoni sugar transporter 0.0015 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0637 0.1224
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0786 0.1225
Trypanosoma cruzi ISWI complex protein 0.0015 0.0045 0.0753
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3619 0.5519
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0137 0.0261
Schistosoma mansoni DNA polymerase eta 0.0019 0.0137 0.0214
Trypanosoma brucei glucose transporter, putative 0.0033 0.0448 0.7734
Onchocerca volvulus 0.0031 0.0396 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0328 0.0629
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0406 0.0897
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0135 0.123
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0388 0.0951
Trichomonas vaginalis set domain proteins, putative 0.024 0.5192 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0439 0.0668
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Schistosoma mansoni ap endonuclease 0.0019 0.0135 0.021
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0037 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0589 0.1132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0081
Echinococcus multilocularis dna polymerase eta 0.0019 0.0137 0.0336
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0439 0.757
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.2345
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0439 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0068
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0439 0.1075
Leishmania major hypothetical protein, conserved 0.0015 0.0045 0.0402
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0303
Loa Loa (eye worm) hypothetical protein 0.0038 0.0573 0.1265
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0544 0.9399
Loa Loa (eye worm) hypothetical protein 0.0154 0.3226 0.7129
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0135 0.0298
Trypanosoma brucei unspecified product 0.0019 0.0137 0.2345
Trypanosoma brucei glucose transporter 1E 0.0033 0.0448 0.7734
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0424 0.0661
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0003
Schistosoma mansoni zinc finger protein 0.002 0.0143 0.0223
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.017 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1084 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0544 0.9399
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0107 0.1824
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.1711 0.8837
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0037 0.0068
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0406 0.0897
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0262 0.4516
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0937 0.2295
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0137 0.2345
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1084 0.169

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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