Detailed information for compound 793912

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.135 | Formula: C18H15BrCl2N2O
  • H donors: 0 H acceptors: 1 LogP: 5.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)C1N2CCCC2C(=O)N1c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C18H15BrCl2N2O/c19-12-5-3-11(4-6-12)17-22-9-1-2-16(22)18(24)23(17)13-7-8-14(20)15(21)10-13/h3-8,10,16-17H,1-2,9H2
  • InChiKey: OJEQSTMEUWWUNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0542 0.0542
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1087 0.1574
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0542 0.1115
Schistosoma mansoni chromobox protein 0.0068 0.1791 0.1966
Brugia malayi Heterochromatin protein 1 0.0068 0.1791 0.2007
Schistosoma mansoni smad1 5 8 and 0.0016 0.0149 0.0163
Brugia malayi MH2 domain containing protein 0.0016 0.0149 0.0167
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0368 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.6977 0.7656
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.034 0.034
Trichomonas vaginalis ran, putative 0.0021 0.0302 0.0437
Brugia malayi RNA binding protein 0.0126 0.3607 0.4041
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3607 0.3957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Loa Loa (eye worm) hypothetical protein 0.0019 0.0243 0.0266
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1604 0.61
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0536 0.1102
Echinococcus multilocularis tar DNA binding protein 0.0126 0.3607 0.3607
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3607 0.3957
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0302 0.0755
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0172 0.0189
Plasmodium vivax SET domain protein, putative 0.0029 0.0564 0.1159
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0166 0.4864 1
Brugia malayi Smad1 0.0016 0.0149 0.0167
Echinococcus multilocularis expressed protein 0.0033 0.0676 0.0676
Echinococcus granulosus peregrin 0.0031 0.0615 0.0615
Leishmania major importin beta-1 subunit, putative 0.0023 0.0368 0.0527
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0162 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1087 0.1574
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0302 0.0621
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0243 0.0738
Loa Loa (eye worm) fibroinase 0.0016 0.0162 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.1086 0.1192
Entamoeba histolytica Ran family GTPase 0.0021 0.0302 0.0621
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0243 0.0738
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.6977 0.7656
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0059 0.0064
Loa Loa (eye worm) hypothetical protein 0.0069 0.1816 0.1992
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0243 0.0738
Echinococcus granulosus chromobox protein 1 0.0068 0.1791 0.1791
Trypanosoma brucei ISWI complex protein 0.0015 0.0118 0.0238
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1604 0.61
Brugia malayi Cathepsin L-like precursor 0.0016 0.0162 0.0182
Schistosoma mansoni zinc finger protein 0.0015 0.0118 0.013
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0243 0.0272
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0941 0.1363
Leishmania major DNA polymerase eta, putative 0.0019 0.0243 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0564 0.0619
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0162 0.0162
Schistosoma mansoni DNA polymerase eta 0.0019 0.0243 0.0266
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.053 0.053
Brugia malayi Cathepsin L-like precursor 0.0016 0.0162 0.0182
Brugia malayi Cathepsin L-like precursor 0.0016 0.0162 0.0182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0243 0.0266
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0162 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0914 0.1003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0512
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0892 0.0892
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0243 0.5
Leishmania major cathepsin L-like protease 0.0062 0.1604 0.313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0162 0.0178
Loa Loa (eye worm) hypothetical protein 0.0048 0.1164 0.1278
Trichomonas vaginalis rotamase, putative 0.0033 0.0676 0.0979
Echinococcus granulosus tar DNA binding protein 0.0126 0.3607 0.3607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Schistosoma mansoni bromodomain containing protein 0.0062 0.1588 0.1742
Onchocerca volvulus 0.0016 0.0162 0.0182
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.2554 0.525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.05 0.0723
Echinococcus granulosus zinc finger protein 0.0019 0.0249 0.0249
Plasmodium falciparum macrophage migration inhibitory factor 0.0166 0.4864 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0149 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.05 0.0723
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2554 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0542 0.0595
Plasmodium vivax vivapain-2 0.0016 0.0162 0.0334
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0162 0.0178
Leishmania major cathepsin L-like protease 0.0016 0.0162 0.0093
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0243 0.0243
Echinococcus multilocularis zinc finger protein 0.0019 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.004 0.0897 0.0985
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0676 0.0979
Brugia malayi Bm-MIF-1, identical 0.0166 0.4864 0.545
Leishmania major cathepsin L-like protease 0.0016 0.0162 0.0093
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0676 0.0742
Brugia malayi Importin beta-1 subunit 0.0028 0.0536 0.0601
Echinococcus granulosus snurportin 1 0.0301 0.9113 0.9113
Brugia malayi Bromodomain containing protein 0.0037 0.0823 0.0922
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0542 0.0542
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0564 0.0564
Echinococcus multilocularis chromobox protein 1 0.0068 0.1791 0.1791
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0789 0.0866
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Echinococcus granulosus cathepsin l1 0.0016 0.0162 0.0162
Leishmania major cathepsin L-like protease 0.0062 0.1604 0.313
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0368 0.0533
Echinococcus granulosus Smad4 0.0016 0.0149 0.0149
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0652 0.2379
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0302 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2554 0.2802
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0149 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Brugia malayi Bromodomain containing protein 0.0031 0.0615 0.0689
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0302 0.0302
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0243 0.0243
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0542 0.1115
Onchocerca volvulus 0.0016 0.0162 0.0182
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3607 0.3957
Brugia malayi hypothetical protein 0.0295 0.8924 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.085 0.1231
Trypanosoma brucei polo-like protein kinase 0.0092 0.2554 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0243 0.0272
Echinococcus granulosus Chromobox protein 3 0.0011 0.000000038302 0.000000038302
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.9113 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Echinococcus multilocularis Smad4 0.0016 0.0149 0.0149
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0243 0.0499
Echinococcus multilocularis tumor protein p63 0.0329 1 1
Onchocerca volvulus 0.0016 0.0162 0.0182
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0302 0.0302
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0941 0.1363
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0162 0.0182
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.085 0.0933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Loa Loa (eye worm) hypothetical protein 0.0037 0.0825 0.0905
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0166 0.4864 1
Schistosoma mansoni ran 0.0021 0.0302 0.0331
Loa Loa (eye worm) TAR-binding protein 0.0126 0.3607 0.3957
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.2554 0.2554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Brugia malayi Bromodomain containing protein 0.0073 0.1947 0.2182
Brugia malayi Pre-SET motif family protein 0.0029 0.0564 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.4864 0.7044
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Echinococcus multilocularis cysteine protease 0.0016 0.0162 0.0162
Schistosoma mansoni rotamase 0.0033 0.0676 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0892 0.0892
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.2554 0.2802
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0243 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0166 0.4864 0.5337
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0536 0.1913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0542 0.1115
Echinococcus granulosus expressed protein 0.0033 0.0676 0.0676
Loa Loa (eye worm) hypothetical protein 0.0046 0.1086 0.1192
Schistosoma mansoni zinc finger protein 0.0019 0.0249 0.0273
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0191 0.0209
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0302 0.0128
Schistosoma mansoni smad1 5 8 and 0.0016 0.0149 0.0163
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0162 0.0182
Schistosoma mansoni hypothetical protein 0.002 0.0281 0.0309
Entamoeba histolytica hypothetical protein 0.0023 0.0368 0.0757
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0162 0.0334
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0166 0.4864 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0652 0.1341
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0172 0.0172
Onchocerca volvulus 0.0016 0.0162 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0512
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0162 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Brugia malayi MH2 domain containing protein 0.0233 0.6977 0.7818
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Onchocerca volvulus 0.023 0.6905 0.7738
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0162 0.0162
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0536 0.0536
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0243 0.5
Onchocerca volvulus 0.003 0.0591 0.0662
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.085 0.0953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Onchocerca volvulus 0.004 0.0914 0.1025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0302 0.0331
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0162 0.0334
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.3607 0.3957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0243 0.0243
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0172 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Echinococcus granulosus dna polymerase eta 0.0019 0.0243 0.0243
Leishmania major macrophage migration inhibitory factor-like protein 0.0166 0.4864 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0368 0.0533
Loa Loa (eye worm) Smad1 0.0016 0.0149 0.0163
Loa Loa (eye worm) RNA binding protein 0.0126 0.3607 0.3957
Loa Loa (eye worm) hypothetical protein 0.0028 0.0542 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Brugia malayi CHD4 protein 0.0013 0.0059 0.0066
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.075 0.075
Brugia malayi Pre-SET motif family protein 0.0202 0.6025 0.6751
Plasmodium falciparum phd finger protein, putative 0.0028 0.0542 0.1115
Onchocerca volvulus 0.0016 0.0162 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1604 0.61
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2554 1
Brugia malayi jmjC domain containing protein 0.0036 0.0789 0.0884
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0162 0.0162
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0162 0.0178
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1478 0.1478
Plasmodium falciparum importin beta, putative 0.0028 0.0536 0.1102
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1791 0.2594
Brugia malayi Cathepsin L-like precursor 0.0016 0.0162 0.0182
Leishmania major macrophage migration inhibitory factor-like protein 0.0166 0.4864 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0162 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0243 0.0512
Brugia malayi RNA, U transporter 1 0.008 0.217 0.2432
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0652 0.1125
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0243 0.0263
Giardia lamblia PHD finger protein 15 0.0028 0.0542 0.0649
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.2554 0.2861
Brugia malayi MH2 domain containing protein 0.0016 0.0149 0.0167
Schistosoma mansoni hypothetical protein 0.0301 0.9113 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0652 0.1341
Echinococcus multilocularis smad 0.0016 0.0149 0.0149
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0789 0.0789
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0243 0.5
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0162 0.0334
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1973 0.2165
Trichomonas vaginalis set domain proteins, putative 0.023 0.6905 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.075 0.075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0162 0.0235
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1478 0.1478
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0243 0.0512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Echinococcus granulosus importin subunit beta 1 0.0028 0.0536 0.0536
Schistosoma mansoni Smad4 0.0016 0.0149 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Onchocerca volvulus 0.0011 0.000000038302 0.00000004292
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0162 0.0334
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0243 0.0266
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.034 0.034
Schistosoma mansoni kinase 0.0047 0.1125 0.1235
Entamoeba histolytica cysteine protease, putative 0.0016 0.0162 0.0334
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0302 0.0975
Onchocerca volvulus 0.0016 0.0162 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0149 0.0163
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0652 0.2193
Echinococcus granulosus smad 0.0016 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0162 0.0235
Echinococcus granulosus dna polymerase kappa 0.0019 0.0243 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.034 0.0373
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0368 0.1027
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0542 0.0595
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0071 0.1874 0.2056
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0149 0.0149
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1434 0.5403
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0162 0.0162
Brugia malayi Cathepsin L-like precursor 0.0016 0.0162 0.0182
Leishmania major cathepsin L-like protease 0.0016 0.0162 0.0093
Onchocerca volvulus 0.0295 0.8924 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0149 0.0149
Schistosoma mansoni importin beta-1 0.0028 0.0536 0.0588
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0166 0.4864 0.7044
Leishmania major cathepsin L-like protease 0.0016 0.0162 0.0093
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0243 0.0352
Brugia malayi PHD-finger family protein 0.0024 0.0412 0.0462
Echinococcus multilocularis peregrin 0.0031 0.0615 0.0615
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0652 0.2193
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0676 0.0758
Loa Loa (eye worm) hypothetical protein 0.0295 0.8924 0.9792
Giardia lamblia Kinase, PLK 0.0092 0.2554 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.073 0.073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.1086 0.1086
Loa Loa (eye worm) hypothetical protein 0.0028 0.0536 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0564 0.1159
Loa Loa (eye worm) hypothetical protein 0.0049 0.118 0.1295
Brugia malayi jmjC domain containing protein 0.0093 0.2574 0.2885
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3607 0.3957
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1791 0.2594
Plasmodium vivax vivapain-2 0.0016 0.0162 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Trichomonas vaginalis rotamase, putative 0.0032 0.0652 0.0944
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0033 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Giardia lamblia Macrophage migration inhibitory factor 0.0166 0.4864 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0302 0.0621
Loa Loa (eye worm) cysteine protease 0.0016 0.0162 0.0178
Loa Loa (eye worm) ctsf protein 0.0016 0.0162 0.0178
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0243 0.0266
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0149 0.0163
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0071 0.1874 0.2056
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0162 0.0162
Brugia malayi SET domain containing protein 0.0012 0.0034 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.3607 0.4041
Schistosoma mansoni ran 0.0021 0.0302 0.0331
Schistosoma mansoni smad 0.0016 0.0149 0.0163
Loa Loa (eye worm) hypothetical protein 0.0041 0.0956 0.1049
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Schistosoma mansoni chromobox protein 0.0068 0.1791 0.1966
Onchocerca volvulus 0.0048 0.1164 0.1305
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1493 0.1639
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0149 0.0149
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1791 0.1966
Echinococcus multilocularis cysteine protease 0.0016 0.0162 0.0162
Brugia malayi MH1 domain containing protein 0.0016 0.0149 0.0167
Leishmania major cathepsin L-like protease 0.0016 0.0162 0.0093
Schistosoma mansoni hypothetical protein 0.0015 0.0118 0.013
Onchocerca volvulus 0.0016 0.0162 0.0182
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0789 0.0866
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Echinococcus granulosus chromobox protein 1 0.0068 0.1791 0.1791
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Echinococcus multilocularis dna polymerase eta 0.0019 0.0243 0.0243
Brugia malayi Cathepsin L-like precursor 0.0016 0.0162 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.085 0.1231
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0281 0.0309
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0536 0.1913
Leishmania major DNA polymerase kappa, putative 0.0019 0.0243 0.0263
Leishmania major cathepsin L-like protease 0.0062 0.1604 0.313
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.2554 0.5132
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.2554 0.2554
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.2554 0.2861
Schistosoma mansoni hypothetical protein 0.0028 0.0542 0.0595
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0162 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Echinococcus multilocularis snurportin 1 0.0301 0.9113 0.9113
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0059 0.0059
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0243 0.5
Echinococcus multilocularis chromobox protein 1 0.0068 0.1791 0.1791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0162 0.0182
Brugia malayi MH1 domain containing protein 0.0016 0.0149 0.0167
Plasmodium vivax importin-beta 2, putative 0.0028 0.0536 0.1102
Brugia malayi chromobox protein homolog 3 0.0038 0.085 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.1086 0.1192
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0172 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0302 0.0755
Onchocerca volvulus Alhambra homolog 0.0028 0.0542 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0243 0.0738
Leishmania major GTP-binding protein, putative 0.0021 0.0302 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3607 0.3957
Toxoplasma gondii cathepsin CPL 0.0016 0.0162 0.0334
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6025 0.6611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.2574 0.2574
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1164 0.1278
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2554 0.3698
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0302 0.0621
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0941 0.1055
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1185 0.4382
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0243 0.0352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0789 0.0866
Trypanosoma brucei unspecified product 0.0019 0.0243 0.0738
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.2574 0.2574
Brugia malayi PHD-finger family protein 0.0028 0.0542 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0162 0.0235
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0162 0.0182
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.1086 0.1086
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0059 0.0064
Echinococcus multilocularis Chromobox protein 3 0.0011 0.000000038302 0.000000038302
Brugia malayi TAR-binding protein 0.0126 0.3607 0.4041
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1604 0.61
Loa Loa (eye worm) hypothetical protein 0.003 0.0591 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.6193

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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