Detailed information for compound 795953

Basic information

Technical information
  • TDR Targets ID: 795953
  • Name: N-(4-chlorophenyl)-3-piperidin-1-ylpropanamid e
  • MW: 266.766 | Formula: C14H19ClN2O
  • H donors: 1 H acceptors: 1 LogP: 2.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)CCN1CCCCC1
  • InChi: 1S/C14H19ClN2O/c15-12-4-6-13(7-5-12)16-14(18)8-11-17-9-2-1-3-10-17/h4-7H,1-3,8-11H2,(H,16,18)
  • InChiKey: QXNMREHXOZCNMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-3-(1-piperidyl)propanamide
  • N-(4-chlorophenyl)-3-piperidino-propionamide
  • N-(4-chlorophenyl)-3-piperidin-1-yl-propanamide
  • Oprea1_873180
  • TimTec1_000988
  • A0550/0025405
  • Oprea1_419873

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0244 0.0328
Onchocerca volvulus 0.0048 0.0169 0.2264
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0406 0.1876
Mycobacterium tuberculosis Conserved protein 0.0071 0.0299 0.0291
Loa Loa (eye worm) hypothetical protein 0.0071 0.0299 0.1398
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0996 0.1336
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.04 0.2119 0.2843
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0302 0.0405
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.002 0.0077
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0068 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0034
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0148 0.0198
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0299 0.0291
Trypanosoma brucei glucosidase, putative 0.0044 0.0148 0.065
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0169 0.0227
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0206 0.0276
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0011 0.0004
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0506 0.2347
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0299 0.1398
Giardia lamblia Ribonuclease H 0.0043 0.0144 0.0632
Trypanosoma brucei unspecified product 0.0047 0.0164 0.0727
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0506 0.2347
Echinococcus multilocularis muscleblind protein 0.0291 0.1515 0.2033
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0039 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0506 0.2347
Echinococcus multilocularis muscleblind protein 1 0.0291 0.1515 0.2033
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0144 0.0632
Onchocerca volvulus Ribonuclease H1 homolog 0.0043 0.0144 0.1732
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0148 0.0682
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0169 0.0227
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0003 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0299 0.0401
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.04 0.2119 0.2843
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0003 0.0005
Echinococcus multilocularis GPCR, family 2 0.0019 0.0011 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1219 0.5746
Onchocerca volvulus 0.0114 0.0536 1
Trypanosoma brucei ingi protein (ORF1) 0.0047 0.0164 0.0727
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0299 0.0291
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0506 0.2347
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0182 0.0914 0.1226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0406 0.0545
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0002
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0131 0.0634 0.0851
Brugia malayi PHD-finger family protein 0.0026 0.0052 0.0197
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0169 0.0227
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0026
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0182 0.0914 0.4302
Echinococcus granulosus dna polymerase kappa 0.0019 0.0011 0.0014
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0047 0.0164 0.0727
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0011 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0506 0.2347
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0169 0.0227
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0011 0.0015
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.04 0.2119 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0588 0.2765
Schistosoma mansoni phosphoglucomutase 0.0043 0.0144 0.0193
Loa Loa (eye worm) hypothetical protein 0.0291 0.1515 0.7145
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0506 0.0497
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0011 0.0015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0244 0.0328
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.2457 0.3297
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0038
Trypanosoma brucei ribonuclease H1 0.0043 0.0144 0.0632
Brugia malayi 6-phosphofructokinase 0.0108 0.0506 0.2347
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0299 0.1369
Loa Loa (eye worm) hypothetical protein 0.0071 0.0299 0.1398
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0588 0.0789
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0506 0.2347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0406 0.0545
Onchocerca volvulus 0.0071 0.0299 0.5007
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.2457 0.3297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0214 0.0712
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0015
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0182 0.0914 0.1226
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0068 0.0272
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.04 0.2119 1
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0015
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0148 0.0198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0011 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0588 0.0789
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0299 0.1369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0406 0.0545
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0131 0.0634 0.2956
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0239 0.1085
Trichomonas vaginalis ribonuclease H1, putative 0.0043 0.0144 0.0632
Loa Loa (eye worm) hypothetical protein 0.0071 0.0299 0.1398
Schistosoma mansoni hypothetical protein 0.0071 0.0302 0.0405
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.2457 0.3297
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.2419 0.2412
Brugia malayi Bromodomain containing protein 0.0076 0.0329 0.1508
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0588 0.0789
Echinococcus granulosus geminin 0.0164 0.0813 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0406 0.0545
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.04 0.2119 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.0014
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.04 0.2119 1
Entamoeba histolytica hypothetical protein 0.0071 0.0302 0.138
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.04 0.2119 1
Brugia malayi RNA binding protein 0.0123 0.0588 0.274
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0182 0.0914 0.4123
Brugia malayi mbt repeat family protein 0.0048 0.0169 0.0751
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.04 0.2119 1
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0506 0.2347
Schistosoma mansoni hypothetical protein 0.0041 0.0134 0.018
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0506 0.2347
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0011 0.0038
Echinococcus multilocularis dna polymerase eta 0.0019 0.0011 0.0014
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0144 0.0632
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0015
Schistosoma mansoni phosphoglucomutase 0.0043 0.0144 0.0193
Loa Loa (eye worm) beta-lactamase 0.0071 0.0299 0.1398
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0148 0.065
Mycobacterium tuberculosis Conserved protein 0.0071 0.0299 0.0291
Loa Loa (eye worm) hypothetical protein 0.0071 0.0299 0.1398
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0131 0.0634 0.2956
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0043 0.0144 0.0135
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0148 0.065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0406 0.0545
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0299 0.1369
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0506 0.189
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0506 0.2374
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0011 0.0034
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0104 0.014
Echinococcus multilocularis microtubule associated protein 2 0.1363 0.7453 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0302 0.0405
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0617
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0039 0.0053
Loa Loa (eye worm) hypothetical protein 0.0071 0.0299 0.1398
Schistosoma mansoni cpg binding protein 0.0032 0.0081 0.0109
Loa Loa (eye worm) hypothetical protein 0.0054 0.0206 0.0955
Brugia malayi phosphofructokinase 0.0108 0.0506 0.2347
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0302 0.0405
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0182 0.0914 0.4283
Brugia malayi RNase H family protein 0.0043 0.0144 0.0632
Loa Loa (eye worm) hypothetical protein 0.007 0.0296 0.1383
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1822 1 1
Brugia malayi beta-lactamase 0.0071 0.0299 0.1369
Plasmodium falciparum phenylalanine--tRNA ligase 0.0182 0.0914 0.4123
Echinococcus granulosus neuropeptide s receptor 0.0461 0.2457 0.3297
Echinococcus granulosus muscleblind protein 0.0291 0.1515 0.2033
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0148 0.065
Toxoplasma gondii ribonuclease HI protein 0.0043 0.0144 0.037
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0169 0.0783
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0299 0.1369
Brugia malayi beta-lactamase family protein 0.0071 0.0299 0.1369
Leishmania major hypothetical protein, conserved 0.0071 0.0299 0.1369
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0506 0.0678
Trypanosoma brucei RNA helicase, putative 0.0161 0.0798 0.3734
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0169 0.2264
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.04 0.2119 1
Brugia malayi Muscleblind-like protein 0.0291 0.1515 0.7136
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0506 0.2374
Brugia malayi 6-phosphofructokinase 0.0108 0.0506 0.2347
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0131 0.0634 0.276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0299 0.0401
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0148 0.065
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0996 0.1336
Echinococcus granulosus zinc finger protein 0.0021 0.0023 0.0031
Trichomonas vaginalis esterase, putative 0.0071 0.0299 0.1369
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0148 0.065
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0068 0.0272
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1822 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0239 0.1115
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0299 0.1369
Brugia malayi MH2 domain containing protein 0.0237 0.1219 0.5732
Loa Loa (eye worm) hypothetical protein 0.0038 0.0118 0.054
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0588 0.0789
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0148 0.065
Entamoeba histolytica hypothetical protein 0.0071 0.0302 0.138
Schistosoma mansoni microtubule-associated protein tau 0.1363 0.7453 1
Brugia malayi TAR-binding protein 0.0123 0.0588 0.274
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0011 0.0004
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0148 0.065
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0011 0.0014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0039 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0299 0.1369
Schistosoma mansoni bromodomain containing protein 0.0065 0.0264 0.0354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0011 0.0002
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0169 0.0227
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0206 0.0276
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0182 0.0914 0.4123
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0299 0.1398
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1219 0.5746
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0068 0.0272
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0588 0.2765
Loa Loa (eye worm) hypothetical protein 0.0291 0.1515 0.7145
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0068 0.0272
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0506 0.0678
Schistosoma mansoni cpg binding protein 0.0028 0.0062 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0131 0.0602
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0148 0.0389
Loa Loa (eye worm) hypothetical protein 0.04 0.2119 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0506 0.0497
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0588 0.274
Treponema pallidum ribonuclease H (rnhA) 0.0043 0.0144 0.037
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0588 0.0789
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0206 0.0276
Plasmodium falciparum phenylalanine--tRNA ligase 0.015 0.0737 0.326
Trypanosoma brucei ingi protein (ORF1) 0.0047 0.0164 0.0727
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.04 0.2119 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0996 0.4689
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0299 0.1369
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0011 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0148 0.065
Schistosoma mansoni phosphoglucomutase 0.0043 0.0144 0.0193
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0134 0.0584
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0588 0.0789
Echinococcus granulosus ribonuclease H1 0.0043 0.0144 0.0193
Mycobacterium ulcerans beta-lactamase 0.0071 0.0299 0.0291
Echinococcus granulosus tar DNA binding protein 0.0123 0.0588 0.0789
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0299 0.0401
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0068 0.0272
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0506 0.2347
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0299 0.0291
Brugia malayi Bromodomain containing protein 0.0038 0.0117 0.0505
Mycobacterium tuberculosis Conserved protein 0.0071 0.0299 0.0291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0406 0.1904
Loa Loa (eye worm) RNA binding protein 0.0123 0.0588 0.2765
Schistosoma mansoni alpha glucosidase 0.0044 0.0148 0.0198
Schistosoma mansoni hypothetical protein 0.0289 0.1506 0.202
Brugia malayi beta-lactamase family protein 0.0071 0.0299 0.1369
Schistosoma mansoni alpha-glucosidase 0.0169 0.0844 0.1132
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0239 0.1085
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0299 0.0291
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0299 0.0401
Schistosoma mansoni zinc finger protein 0.0021 0.0023 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0068 0.0272
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0011 0.0002
Echinococcus multilocularis ribonuclease H1 0.0043 0.0144 0.0193
Loa Loa (eye worm) hypothetical protein 0.006 0.0239 0.1115
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0506 0.0678
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0299 0.0291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0406 0.0545
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0299 0.1369
Schistosoma mansoni cpg binding protein 0.0032 0.0081 0.0109
Brugia malayi CXXC zinc finger family protein 0.0028 0.0062 0.0242
Echinococcus granulosus GPCR family 2 0.0019 0.0011 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0299 0.0291
Brugia malayi mbt repeat family protein 0.0048 0.0169 0.0751
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.04 0.2119 1
Leishmania major ribonuclease H1, putative 0.0043 0.0144 0.0632
Brugia malayi RNase H family protein 0.0043 0.0144 0.0632
Onchocerca volvulus 0.0071 0.0299 0.5007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0236 0.0317
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.04 0.2119 0.2843
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0003 0.0005
Echinococcus multilocularis cpg binding protein 0.0032 0.0081 0.0109
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0268 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.015 0.0693
Loa Loa (eye worm) MBCTL1 0.0054 0.0206 0.0955
Echinococcus multilocularis zinc finger protein 0.0021 0.0023 0.0031
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0068 0.0059
Brugia malayi RNase H family protein 0.0043 0.0144 0.0632
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0506 0.0678
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.04 0.2119 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0003 0.0005
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0206 0.0276
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0206 0.0924
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0148 0.065
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0943 0.1265
Schistosoma mansoni DNA polymerase eta 0.0019 0.0011 0.0014
Mycobacterium ulcerans hypothetical protein 0.0071 0.0299 0.0291
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0996 0.1336
Brugia malayi hypothetical protein 0.0071 0.0302 0.138
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0148 0.065
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0068 0.0272
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0506 0.2134
Echinococcus multilocularis geminin 0.0164 0.0813 0.109
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0148 0.065
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0148 0.065
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0164 0.0727
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0068 0.0272
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0206 0.0276
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0996 0.4671
Schistosoma mansoni hypothetical protein 0.0164 0.0813 0.109
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0148 0.065
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0169 0.0227
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0068 0.0059
Schistosoma mansoni alpha-glucosidase 0.0169 0.0844 0.1132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0406 0.0545
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0104 0.014
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0299 0.1369
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0299 0.0291
Onchocerca volvulus 0.0071 0.0299 0.5007
Entamoeba histolytica hypothetical protein 0.0071 0.0302 0.138
Mycobacterium ulcerans lipase LipD 0.0071 0.0299 0.0291
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0002
Entamoeba histolytica hypothetical protein 0.0071 0.0302 0.138
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0015
Toxoplasma gondii ABC1 family protein 0.0071 0.0299 0.1128
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0299 0.0291
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0148 0.065
Echinococcus granulosus cpg binding protein 0.0032 0.0081 0.0109
Schistosoma mansoni hypothetical protein 0.0161 0.0798 0.1071
Loa Loa (eye worm) hypothetical protein 0.0048 0.0169 0.0783
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.0014
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0506 0.2347
Echinococcus granulosus microtubule associated protein 2 0.1363 0.7453 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0943 0.1265
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0182 0.0914 0.1226
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0169 0.0227
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0148 0.065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0062 0.0275
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.04 0.2119 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0506 0.2374
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0299 0.1128
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0299 0.0291
Echinococcus granulosus dna polymerase eta 0.0019 0.0011 0.0014
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1822 1 1
Schistosoma mansoni hypothetical protein 0.0164 0.0813 0.109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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