Detailed information for compound 796953

Basic information

Technical information
  • TDR Targets ID: 796953
  • Name: 2-[(5-bromothiophen-2-yl)sulfonylamino]-N-(4- fluorophenyl)-3-phenylpropanamide
  • MW: 483.374 | Formula: C19H16BrFN2O3S2
  • H donors: 2 H acceptors: 3 LogP: 4.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)C(NS(=O)(=O)c1ccc(s1)Br)Cc1ccccc1
  • InChi: 1S/C19H16BrFN2O3S2/c20-17-10-11-18(27-17)28(25,26)23-16(12-13-4-2-1-3-5-13)19(24)22-15-8-6-14(21)7-9-15/h1-11,16,23H,12H2,(H,22,24)
  • InChiKey: LIFMHYGWBXRFPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-bromo-2-thienyl)sulfonylamino]-N-(4-fluorophenyl)-3-phenyl-propanamide
  • 2-[(5-bromo-2-thienyl)sulfonylamino]-N-(4-fluorophenyl)-3-phenylpropanamide
  • 2-[(5-bromo-2-thienyl)sulfonylamino]-N-(4-fluorophenyl)-3-phenyl-propionamide
  • 2-[(5-bromothiophen-2-yl)sulfonylamino]-N-(4-fluorophenyl)-3-phenyl-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0016 0.0038
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0518 0.6808
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0023 0.0293
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0238 0.1134
Trypanosoma cruzi GMP reductase 0.0107 0.0307 0.1662
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0016 0.0085
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0075 0.018
Schistosoma mansoni hypothetical protein 0.0082 0.0228 0.1089
Brugia malayi hypothetical protein 0.0009 0.0002 0.003
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0129 0.1695
Schistosoma mansoni tar DNA-binding protein 0.0187 0.0555 0.2648
Echinococcus granulosus expressed conserved protein 0.0186 0.0552 0.2632
Onchocerca volvulus 0.0097 0.0276 0.4919
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.002
Schistosoma mansoni inositol monophosphatase 0.0037 0.0087 0.0416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.003
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0002 0.0012
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Brugia malayi protein C24B5.3 0.0012 0.0011 0.0142
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0107 0.0307 0.4033
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0117 0.0559
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.2096 1
Onchocerca volvulus 0.0021 0.0039 0.0665
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0073 0.0073
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0002 0.0012
Brugia malayi MAP kinase sur-1 0.005 0.0129 0.1693
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0137 0.0137
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0206
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0087 0.0209
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0319
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0016 0.0038
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0016 0.0038
Entamoeba histolytica cysteine protease, putative 0.0017 0.0025 0.0424
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0129 0.0129
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0307 0.1662
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0016 0.0038
Leishmania major cathepsin L-like protease 0.0017 0.0025 0.0051
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0603 0.1845 1
Schistosoma mansoni cpg binding protein 0.003 0.0067 0.0319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Echinococcus multilocularis geminin 0.0168 0.0495 0.0495
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0104
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0016 0.0075
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0016 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0189 0.2479
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0518 0.6808
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0087 0.1147
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.076 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0129 0.1695
Mycobacterium ulcerans TetR family transcriptional regulator 0.1354 0.4179 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0117 0.0559
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.1053
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0087 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.0555 0.7295
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0589 0.0589
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0087 0.1147
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0025 0.0424
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0104
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0107 0.0307 0.0734
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0025 0.0025
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0117 0.0281
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0968
Onchocerca volvulus 0.0012 0.0011 0.0153
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0016 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0016 0.0038
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0016 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0307 0.1662
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.011
Brugia malayi protein C24B5.3 0.0012 0.0011 0.0142
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0081 0.5
Schistosoma mansoni hypothetical protein 0.0082 0.0228 0.1089
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0016 0.0196
Brugia malayi N-terminal motif family protein 0.0188 0.0559 0.7346
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0051 0.1663
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0 0.0001
Onchocerca volvulus 0.0012 0.0011 0.0153
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0107 0.0307 0.0734
Onchocerca volvulus 0.0015 0.002 0.031
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0087 0.0417
Echinococcus granulosus cysteine protease 0.0009 0 0.0001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0129 0.0698
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0073 0.096
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0087 0.0417
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0294 0.1595
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0095
Loa Loa (eye worm) oxidoreductase 0.0014 0.0016 0.0196
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0051 0.0276
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0038
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0082 0.0228 0.1089
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0085
Treponema pallidum bacterioferrin (TpF1) 0.0008 0 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0117 0.0281
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0095
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0129 0.1685
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0107 0.0307 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0016 0.051
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0087 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0237 0.1282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0 0.0002
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0328
Loa Loa (eye worm) GMP reductase 0.0047 0.0121 0.1579
Brugia malayi hypothetical protein 0.0012 0.0011 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Brugia malayi RNA binding protein 0.0187 0.0555 0.7297
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0047 0.0121 0.1587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0025 0.0328
Echinococcus multilocularis protein patched 0.0085 0.0238 0.0238
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0129 0.1695
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0237 0.1282
Onchocerca volvulus 0.0014 0.0016 0.024
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0285 0.0859 0.4657
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Onchocerca volvulus 0.0017 0.0025 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0141 0.4539
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0073 0.0951
Leishmania major cathepsin L-like protease 0.0017 0.0025 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0025 0.0135
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0129 0.0615
Brugia malayi Muscle positioning protein 4 0.0015 0.002 0.0257
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0016 0.0265
Leishmania major guanosine monophosphate reductase 0.0107 0.0307 0.1591
Loa Loa (eye worm) hypothetical protein 0.006 0.0161 0.2103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Onchocerca volvulus 0.0028 0.0062 0.1066
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0117 0.0117
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0117 0.0559
Brugia malayi cathepsin L-like precursor 0.0011 0.0008 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0129 0.1695
Loa Loa (eye worm) IMP dehydrogenase 1 0.0107 0.0307 0.4027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.0859 0.4657
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0016 0.0439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0137 0.0654
Onchocerca volvulus 0.0016 0.0023 0.0373
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0071 0.0195 0.0931
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Loa Loa (eye worm) hypothetical protein 0.0046 0.0117 0.1531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0008 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0117 0.0281
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0016 0.0038
Onchocerca volvulus 0.0014 0.0016 0.024
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0206
Onchocerca volvulus Protein patched homolog 0.0012 0.0011 0.0153
Brugia malayi Patched related family protein 4 0.0012 0.0011 0.0142
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0171 0.0814
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0073 0.0349
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0117 0.0555
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0293
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0129 0.4155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0137 0.0654
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0016 0.0038
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0051 0.0276
Onchocerca volvulus 0.0015 0.002 0.031
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0117 0.0555
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Echinococcus granulosus MAM 0.0016 0.0023 0.011
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0016 0.0038
Plasmodium vivax vivapain-2 0.0017 0.0025 0.0814
Loa Loa (eye worm) inositol-1 0.0037 0.0087 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Loa Loa (eye worm) fibroinase 0.0017 0.0025 0.0319
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0132
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0084 0.1108
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0085
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0117 0.0281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0016 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0073 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0187 0.0555 0.7295
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0025 0.012
Plasmodium vivax vivapain-2 0.0017 0.0025 0.0814
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.1053
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0107 0.0307 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0117 0.0281
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0087 0.0391
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0084 0.0403
Brugia malayi CHE-14 protein 0.0085 0.0238 0.3124
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0107 0.0307 0.1662
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0117 0.0281
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0271 0.1295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0394 0.188
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0012
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0087 0.0472
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0589 0.281
Schistosoma mansoni tar DNA-binding protein 0.0187 0.0555 0.2648
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0328
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0238 0.0238
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0087 0.0472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.076 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0307 0.1662
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0129 0.0698
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0237 0.1282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Brugia malayi CXXC zinc finger family protein 0.0028 0.0062 0.081
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.011
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0025 0.0424
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0002 0.002
Leishmania major inosine-5-monophosphate dehydrogenase 0.0107 0.0307 0.1591
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0025 0.012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.002
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0025 0.0814
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0025 0.0814
Schistosoma mansoni hypothetical protein 0.0032 0.0073 0.0349
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0081 0.2634
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0129 0.0618
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0117 0.1988
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0129 0.0698
Toxoplasma gondii patched family protein 0.0012 0.0011 0.028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0062 0.0801
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.1139
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0328
Loa Loa (eye worm) hypothetical protein 0.0096 0.0271 0.3562
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0051 0.1663
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.006 0.016 0.0382
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.076 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0016 0.0439
Leishmania major cathepsin L-like protease 0.0063 0.017 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0589 0.7744
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0051 0.1601
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0095
Toxoplasma gondii patched family protein 0.0012 0.0011 0.028
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0081 0.2634
Leishmania major cathepsin L-like protease 0.0063 0.017 0.0842
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0153 0.0828
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0117 0.0559
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0051 0.0276
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0002 0.002
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0025 0.0051
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0075 0.018
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0288 0.3787
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0129 0.0618
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0129 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0195 0.0931
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0117 0.1531
Mycobacterium tuberculosis Conserved hypothetical protein 0.0317 0.0959 0.2295
Brugia malayi hypothetical protein 0.0012 0.0011 0.0142
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0016 0.051
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0002
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0081 0.0194
Onchocerca volvulus 0.0017 0.0025 0.0408
Brugia malayi mbt repeat family protein 0.0046 0.0117 0.1539
Loa Loa (eye worm) cysteine protease 0.0017 0.0025 0.0319
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0016 0.0208
Brugia malayi hypothetical protein 0.0016 0.0023 0.0302
Brugia malayi Patched related family protein 10 0.0012 0.0011 0.0142
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0025 0.012
Brugia malayi SEA domain containing protein 0.0015 0.002 0.0257
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0008 0.0008
Echinococcus multilocularis tumor protein p63 0.0665 0.204 0.204
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0085 0.0238 0.3117
Schistosoma mansoni cpg binding protein 0.0028 0.0062 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0008 0.0107
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.3311
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.0094
Brugia malayi GMP reductase 0.0047 0.0121 0.1587
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0012
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0087 0.0417
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0087 0.2844
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0016 0.0038
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0328
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Brugia malayi TAR-binding protein 0.0187 0.0555 0.7297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0075 0.018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0195 0.0195
Brugia malayi Myosin head containing protein 0.0012 0.0011 0.0142
Loa Loa (eye worm) hypothetical protein 0.0069 0.0189 0.2471
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0087 0.0416
Loa Loa (eye worm) RNA binding protein 0.0187 0.0555 0.7295
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Schistosoma mansoni hypothetical protein 0.0082 0.0228 0.1089
Onchocerca volvulus 0.0015 0.002 0.031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0087 0.1149
Mycobacterium ulcerans hypothetical protein 0.0046 0.0117 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.076 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0117 0.1988
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0016 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.017 0.092
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0002 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0394 0.0394
Leishmania major hypothetical protein, conserved 0.0025 0.0051 0.0193
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0025 0.0319
Schistosoma mansoni hypothetical protein 0.0032 0.0073 0.0349
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0008 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0087 0.0417
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0132
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0107 0.0307 0.0734
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0261 0.1248
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0117 0.1539
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.0555 0.7297
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Echinococcus granulosus dnaJ subfamily B 0.0404 0.1229 0.5861
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0087 0.1147
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0016 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0288 0.3782
Mycobacterium ulcerans hypothetical protein 0.0317 0.0959 0.2295
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0117 0.0281
Echinococcus multilocularis cysteine protease 0.0017 0.0025 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0161 0.0766
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.1845 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0117 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Echinococcus granulosus tar DNA binding protein 0.0187 0.0555 0.2648
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0002
Onchocerca volvulus 0.0017 0.0025 0.0408
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1354 0.4179 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.049 0.8764
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0016 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0087 0.0473
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0117 0.0555
Schistosoma mansoni hypothetical protein 0.0168 0.0495 0.2361
Leishmania major cathepsin L-like protease 0.0017 0.0025 0.0051
Onchocerca volvulus 0.0011 0.0008 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0008 0.0135
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0011 0.0352
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0025 0.0408
Echinococcus granulosus cathepsin l1 0.0017 0.0025 0.012
Brugia malayi hypothetical protein 0.0009 0.0002 0.003
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.076 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0025 0.0331
Echinococcus multilocularis GPCR, family 2 0.0032 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0187 0.0555 0.2648
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0047 0.0121 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0085
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0016 0.0085
Schistosoma mansoni patched 1 0.0085 0.0238 0.1134
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0107 0.0307 0.0734
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0307 1
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0276 0.1317
Brugia malayi Inositol-1 0.0037 0.0087 0.1145
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0087 0.1479
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0328
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0025 0.0408
Brugia malayi hypothetical protein 0.0025 0.0051 0.0671
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Leishmania major cathepsin L-like protease 0.0017 0.0025 0.0051
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0025 0.0319
Onchocerca volvulus Protein patched homolog 0.0012 0.0011 0.0153
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0117 0.0281
Brugia malayi hypothetical protein 0.0012 0.0011 0.0142
Schistosoma mansoni inositol monophosphatase 0.0037 0.0087 0.0416
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0129 0.0698
Toxoplasma gondii patched family protein 0.0012 0.0011 0.028
Brugia malayi hypothetical protein 0.0012 0.0011 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Onchocerca volvulus 0.0012 0.0011 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus granulosus cathepsin L 0.0009 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.076 1
Schistosoma mansoni hypothetical protein 0.0032 0.0073 0.0349
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0196
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.2096 0.2096
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0047 0.0121 0.1587
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0087 0.0472
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0087 0.1481
Brugia malayi mbt repeat family protein 0.0046 0.0117 0.1539
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0016 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0129 0.0615
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0016 0.0208
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0237 0.1282
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0132
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0047 0.0121 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.3311
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0319
Onchocerca volvulus 0.0046 0.0117 0.2064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0075 0.018
Toxoplasma gondii hypothetical protein 0.0097 0.0275 0.8969
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0087 0.0417
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0117 0.0559
Toxoplasma gondii hypothetical protein 0.0012 0.0011 0.028
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0038
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.0853 0.0853
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0025 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0187 0.0555 0.2648
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0002
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0025 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1354 0.4179 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0394 0.188
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0137 0.18
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0288 0.3787
Loa Loa (eye worm) hypothetical protein 0.0198 0.0589 0.7742
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0238 0.3126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Echinococcus granulosus cpg binding protein 0.003 0.0067 0.0319
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0117 0.1539
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0087 0.0087
Onchocerca volvulus Putative GMP reductase 0.0047 0.0121 0.2129
Loa Loa (eye worm) hypothetical protein 0.0188 0.0559 0.7343
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0053 0.0137 0.1792
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0087 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0394 0.188
Loa Loa (eye worm) patched family protein 0.0012 0.0011 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0016 0.0439
Trypanosoma cruzi GMP reductase 0.0107 0.0307 0.1662
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0012
Echinococcus granulosus tumor protein p63 0.0665 0.204 0.9731
Schistosoma mansoni hypothetical protein 0.0404 0.1229 0.5861
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0107 0.0307 0.1464
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.1053
Schistosoma mansoni transient receptor potential channel 0.0063 0.0171 0.0814
Schistosoma mansoni hypothetical protein 0.0168 0.0495 0.2361
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0117 0.1988
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0129 0.0129
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.0559 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Echinococcus multilocularis protein dispatched 1 0.0097 0.0275 0.0275
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.006 0.016 0.0382
Leishmania major cathepsin L-like protease 0.0063 0.017 0.0842
Loa Loa (eye worm) hypothetical protein 0.0046 0.0117 0.1531
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0025 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) hypothetical protein 0.0104 0.0297 0.39
Brugia malayi DIX domain containing protein 0.0009 0.0002 0.003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0087 0.1149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.017 0.092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0394 0.518
Schistosoma mansoni hypothetical protein 0.0032 0.0073 0.0349
Loa Loa (eye worm) hypothetical protein 0.0097 0.0276 0.3623
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0238 0.3117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0075 0.018
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0012
Onchocerca volvulus 0.0012 0.0011 0.0153
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0117 0.0281
Loa Loa (eye worm) hypothetical protein 0.0046 0.0117 0.1531
Schistosoma mansoni dep domain containing protein 0.0009 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Loa Loa (eye worm) MBCTL1 0.0053 0.0137 0.1792
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0171 0.0171
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0081 0.0194
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0137 0.0654
Brugia malayi hypothetical protein 0.0071 0.0195 0.2564
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0107 0.0307 0.0307
Onchocerca volvulus 0.0016 0.0023 0.0373
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.017 0.092
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0271 0.0271
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0117 0.1531
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.1053
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0271 0.1295
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0129 0.0698
Onchocerca volvulus 0.0017 0.0025 0.0408
Loa Loa (eye worm) hypothetical protein 0.0032 0.0073 0.0951
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0107 0.0307 0.1464
Schistosoma mansoni tar DNA-binding protein 0.0187 0.0555 0.2648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0394 0.188
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.0853 0.4069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0394 0.188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.1053
Loa Loa (eye worm) ctsf protein 0.0017 0.0025 0.0319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0394 0.0394
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0051 0.1663
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.1845 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0087 0.0473
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Leishmania major cathepsin L-like protease 0.0017 0.0025 0.0051
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0171 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Echinococcus granulosus GPCR family 2 0.0032 0.0073 0.0349
Brugia malayi Patched related family protein 12 0.0012 0.0011 0.0142
Schistosoma mansoni transient receptor potential channel 0.0063 0.0171 0.0814
Echinococcus multilocularis expressed conserved protein 0.0186 0.0552 0.0552
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.3311
Echinococcus granulosus geminin 0.0168 0.0495 0.2361
Onchocerca volvulus 0.0015 0.002 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.017 0.092
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0195 0.0931
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0 0.0001
Leishmania major mitochondrial DNA polymerase beta 0.0603 0.1845 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0196
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Onchocerca volvulus 0.0012 0.0011 0.0153
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0016 0.0038
Onchocerca volvulus 0.0012 0.0011 0.0153
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0394 0.5176
Brugia malayi hypothetical protein 0.0016 0.0024 0.0309
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1354 0.4179 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0117 0.0281
Echinococcus multilocularis cysteine protease 0.0017 0.0025 0.0025
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.002 0.0247
Toxoplasma gondii cathepsin CPL 0.0017 0.0025 0.0746
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0117 0.1539
Brugia malayi Patched protein homolog 1 0.0012 0.0011 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0075 0.018
Plasmodium vivax patched family protein, putative 0.0012 0.0011 0.0352
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0662
Onchocerca volvulus 0.0015 0.002 0.031
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Loa Loa (eye worm) hypothetical protein 0.0101 0.0288 0.3782
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0087 0.0087
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.0859 0.4611
Toxoplasma gondii patched family protein 0.0012 0.0011 0.028
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0171 0.0814
Schistosoma mansoni hypothetical protein 0.0281 0.0846 0.4037
Onchocerca volvulus 0.0017 0.0025 0.0408
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0016 0.0038
Onchocerca volvulus 0.0017 0.0025 0.0408
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0539 0.2573
Trypanosoma brucei GMP reductase 0.0107 0.0307 0.1662
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.1099
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0539 0.0539
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0073 0.096
Schistosoma mansoni transient receptor potential channel 0.0096 0.0271 0.1295
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0025 0.0408
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0008 0.0104
Echinococcus multilocularis MAM 0.0016 0.0023 0.0023
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0002 0.003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0598 0.2855
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0025 0.0331
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Echinococcus granulosus microtubule associated protein 2 0.0684 0.2096 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0117 0.0281
Mycobacterium ulcerans transcriptional regulator 0.1354 0.4179 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0247
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0016 0.0038
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0238 0.1134
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.0206
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0025 0.0814
Toxoplasma gondii IMP dehydrogenas 0.0107 0.0307 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0128 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0025 0.0331
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.017 0.092
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0129 0.0615
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0038
Echinococcus multilocularis cpg binding protein 0.003 0.0067 0.0067
Echinococcus granulosus cathepsin l1 0.0011 0.0008 0.0039
Onchocerca volvulus 0.0046 0.0117 0.2063
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.3311
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0016 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Brugia malayi Protein kinase domain containing protein 0.0016 0.0023 0.0302
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0087 0.1147
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.076 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0132
Echinococcus multilocularis tar DNA binding protein 0.0187 0.0555 0.0555
Onchocerca volvulus 0.0017 0.0025 0.0408
Schistosoma mansoni hypothetical protein 0.0069 0.0189 0.09
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.003
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0002 0.0012
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0328
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0016 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.049 0.6442
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.076 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0 0.0001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0087 0.2787
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0087 0.1149
Onchocerca volvulus 0.0014 0.0016 0.024
Brugia malayi Patched family protein 0.0012 0.0011 0.0142
Trypanosoma brucei protein kinase, putative 0.005 0.0129 0.0698
Onchocerca volvulus 0.0012 0.0011 0.0153
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.1229 0.1229

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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